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MASH 패널 분석서비스 | MASH Service 이미지

MASH 패널 분석서비스 | MASH Service

NASH로 알려졌던 Metabolic Dysfunction-Associated Steatohepatitis (MASH)의 MOA를 이해하기 위한 29가지의 panel에 대해 약물의 활성을 screeening service를 해 드립니다.

특징 

 

  • MASH 치료제 개발에 있어 중요한 therapeutic indicator인 총 29가지의 표적에 대한 패널로 구성되어 있습니다. 
  • 스크리닝을 통해 포도당(예: GLP1), 지질(예: THRβ), 담즙산(예: FXR) 대사, 염증(예: VAP1), 세포사멸(예: ASK1), 섬유증(예: LOXL2)에 대한 효과를 확인할 수 있습니다. 
  • 필요한 샘플의 양: 10 mM DMSO stock 520 μL 또는 약 3 mg pre-weighed powder (assuming FW≦500 and purity 100%)

  

 

패널 

 

  • 패널의 모든 29가지 타겟을 분석하거나 (#PP318), 일부 타겟만 지정하여 분석의뢰하실 수 있습니다.  

 

Family Name Item Protein Organism Assay Sub Type
GPCR CCR2 Human Chemokine GPCR Binding Agonist Radioligand  217550 CCR2 Human Binding
GPCR CCR5 Rhesus Macaque Chemokine GPCR Binding Agonist Radioligand  217730 CCR5 Rhesus Macaque Binding
GPCR Glucagon Human Glucagon GPCR Binding Agonist Radioligand  231680 GCGR Human Binding
GPCR GLP-1 Human Glucagon GPCR Binding Agonist Radioligand  231710 GLP1R Human Binding
GPCR TGR5 Human Bile Acid GPCR Cell Based Agonist cAMP  304100-0 TGR5 Human Cell Based
GPCR FFA1 (GPR40) Human Free Fatty Acid GPCR Cell Based Agonist Calcium Flux  311810-0 GPR40 Human Cell Based
GPCR GIP Human Glucagon GPCR GTPgammaS Agonist  312980-0 GIP-R Human GTPgammaS
Kinase ASK1 Human STE Kinase Enzymatic Radiometric 167150 ASK1 Human Enzymatic
Kinase AMPK Human PRKAA1 Kinase Enzymatic Radiometric Activation 199100-0 AMPK Human Enzymatic
Kinase TGFbeta (Non-Selective) Mouse TKL Kinase Binding Agonist Radioligand  286200 TGF beta Mouse Binding
Kinase FGFR1b-Klotho Human RTK Kinase Cell Based Agonist Functional  339210-0 FGFR1b-Klotho Human Cell Based
Kinase FGFR4-b-Klotho Human RTK Kinase Cell Based Agonist Functional  339240-0 FGFR4b-Klotho Human Cell Based
Lipid Metabolism Acetyl-coenzyme A carboxylase 1 Human Enzymatic  101800 ACC1 Human Enzymatic
Lipid Metabolism Lipase Human Enzymatic  133000 Pancreatic Lipase Human Enzymatic
NHR PPARgamma Human NHR Binding Agonist Radioligand  267500 PPARr Human Binding
NHR TR Beta Human Thyroid Hormone NHR Binding Agonist Radioligand  285940 THRB Human Binding
NHR FXR Human Liver X Receptor-Like NHR Functional Agonist Coactivator  311600-0 FXR Human Protein-Protein Interaction
NHR PPARalpha Human NHR Functional Agonist Coactivator Assay, Panlabs 338210-0 PPARa Human Protein-Protein Interaction
NHR PPARdelta Human NHR Cell Based Agonist Protein-Protein Interaction  338260-0 PPARd Human Cell Based
NHR Keap1-Nrf2 Human Transcription Factor Cell Based Agonist Nuclear Translocation  362000-0 NRF2 Human Cell Based
Oxidoreductase Lysyl Oxidase Homolog 2 (LOXL2) Enzymatic  138700 LOXL2 Human Enzymatic
Oxidoreductase VAP-1/AOC3 Human Enzymatic  197000 VAP-1 Human Enzymatic
Protease Caspase 3 Human Caspase Cysteine Peptidase Enzymatic  163200 Caspase 3 Human Enzymatic
Protease Caspase 7 Human Caspase Cysteine Peptidase Enzymatic  163400 Caspase 7 Human Enzymatic
Protease Caspase 8 Human Caspase Cysteine Peptidase Enzymatic  163500 Caspase 8 Human Enzymatic
Protease Dipeptidyl Peptidase 4 Human Prolyl Oligopeptidase Serine Peptidase Enzymatic  199007 DPP4 Human Enzymatic
Protease Caspase 1 Human Caspase Cysteine Peptidase Enzymatic  199011 Caspase 1 Human Enzymatic
Cell Surface (Other) IL-1 R1 Human Interleukin Binding Agonist Radioligand  243530 IL-1R-1 Human Binding
Free Radical Scavenger Free Radical Scavenger Bovine SOD Mimetic Enzymatic  193500 ROS Bovine Enzymatic

 

주문정보

주문정보 - Cat No, PRODUCT, SIZE, 수량 등 항목으로 구성되어있습니다.
  Product Cat.No. Size Maker Qty Data Sheet
MASH Panel 서비스 . . EUROFINS DISCOVERY
Maker
EUROFINS DISCOVERY
Cat.No.
.
Product
MASH Panel 서비스
Size
.
Qty

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0.5 ml Elite Pre-stained Protein Ladder (2 x 0.25 ml) PAL-EPL-500 0.5ml 500
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