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제품 상세

Antibody

6.5 - 270 kDa 범위를 커버하는 3가지 컬러 밴드를 포함하며,
최대 100%까지의 transfer 효과를 개런티하는 Prestained protein ladder를 소개합니다.

Tetrodotoxin Citrate  


tetrodotoxin

  • Description: Na+ channel blocker; citrate salt of tetrodotoxin 
  • Alternative Names: TTx citrate
  • Chemical Name: (4R,4aR,5R,7S,9S,10S,10aR,11S,12S)-Octahydro-12-(hydroxymethyl)-2-imino-5,9:7,10a-dimethano-10aH-[1,3]dioxocino[6,5-d]pyrimidine-4,7,10,11,12-pentol citrate
  • Purity: ≥98% (HPLC)
  • M. Wt : 319.27
  • Formula : C11H17N3O8
  • CAS Number : 18660-81-6
  • Cat. No : 1069 / T-550


Tetrodotoxin (Citrate free) 

tetrodotoxin-t-500
  • Description: Na+ channel blocker
  • Alternative Names: TTx
  • Chemical Name: (4R,4aR,5R,7S,9S,10S,10aR,11S,12S)-Octahydro-12-(hydroxymethyl)-2-imino-5,9:7,10a-dimethano-10aH-[1,3]dioxocino[6,5-d]pyrimidine-4,7,10,11,12-pentol
  • Purity: ≥98% (HPLC)
  • M. Wt : 319.27
  • Formula : C11H17N3O8
  • CAS Number : 4368-28-9
  • Cat. No : 1078 / T-500

tetrodotoxin-t-500-data
Tetrodotoxin citrate free inhibits native NaV currents in PC12 and ND7-23 cells.
Tetrodotoxin citrate free (#T-500) inhibits PC12 (top) and ND7-23 (bottom) cells at a concentration of 60 nM. Left graphs show the time course of inward current amplitude upon bath application (marked by the horizontal bars) and wash of TTX. Membrane potential was clamped to -120 mV and currents were elicited by 20 ms test pulses to -10 or -20 mV (upper and lower graphs respectively), delivered every 10 sec. Right graphs show the superimposed traces of control current (red) and during perfusion of TTX (black).


ω-Conotoxin GVIA

conotoxin

  • Description: CaV2.2 blocker
  • Purity: ≥95% (HPLC)
  • M. Wt : 3037
  • Formula : C120H182N38O43S6
  • Sequence : CKSXGSSCSXTSYNCCRSCNXYTKRCY (Modifications: X = Hyp, Disulfide bridges: 1-16, 8-19, 15-26, Tyr-27 = C-terminal amide)
  • CAS Number : 106375-28-4
  • Cat. No. : 1085 / C-300

conotoxin-data

ω-Conotoxin GVIA blocks CaV2.2 channel in mouse Calyx of Held.
Calyxes were whole-cell voltage-clamped at -80 mV. Traces were recorded in the presence of 1 mM CaCl2, pharmacological isolation of VGCC subtypes was performed in 2 mM CaCl2. 2 µM ω-Conotoxin GVIA (#C-300) was applied to selectively block CaV2.2.
Adapted from Lubbert, M. et al. (2017) eLife 6, e28412. with permission of eLife Sciences.


Other Toxins

Cat. No. Product Description
STA-500 ω-Agatoxin IVA A Blocker of P/Q-Type CaV Channels
STA-150 Agitoxin-1 A Potent Blocker of KV1.3 Channels
STA-420 Agitoxin-2 A Potent Blocker of KV1.3 K+ Channels
STA-200 Apamin A Blocker of Small Conductance Ca2+-Activated K+ Channels (SK Type)
STB-400 BDS-I A Blocker of KV3 Channels and a Modulator of NaV Channels
STB-470 BeKm-1 A Novel ERG1 (KV11.1) K+ Channel Blocker
B-100 α-Bungarotoxin A Potent Antagonist of α7 and Muscle nAChR and GABA(A) Receptor Subtypes
RTC-460 Chlorotoxin An Inhibitor of Chloride Channels
D-350 α-Dendrotoxin A Blocker of KV1.1, KV1.2, KV1.6 and ASIC Channels
STE-450 Ergtoxin-1 A Novel Blocker of ERG1 (KV11.1) K+ Channel
STG-100 GsMTx-4 A Blocker of NaV1.7, TRPC1, TRPC6 and Piezo1 Channels
STH-400 Hongotoxin-1 A Potent Blocker of Some KV1 K+ Channels
STJ-200 Jingzhaotoxin-III A Blocker of KV2.1 and NaV1.5 Channels
RTL-550 Lq2 A Potent Blocker of Kir1.1 (ROMK1) Channels
STM-340 Maurotoxin A Potent Blocker of KCa and KV1 K+ Channels
M-100 MitTx Toxin An Activator of ASIC1-Containing Channels
M-140 Muscarinic Toxin 3 An Antagonist of M1 and M4 Muscarinic Receptors and Adrenoceptors
STP-700 Phrixotoxin-1 A Potent Blocker of KV4.2 and KV4.3 Channels
STP-720 Phrixotoxin-3 PaurTx3, β-TRTX-Ps1a, β-theraphotoxin-Ps1a, Phrixotoxin 3
P-510 PLTX-II An Inhibitor of CaV Channels
STP-200 Psalmotoxin-1 A Potent Blocker of ASIC1a Channels
STS-410 Slotoxin A Blocker of KCa1.1 Channel
RTS-500 SNX-482 A Blocker of CaV2.3 and KV4.3 Channels
STT-250 Tertiapin A Blocker of Inward Rectifier (Kir) K+ Channels
T-150 Tetanus Toxin An Inhibitor of Neurotransmitter Release
STW-200 Wasabi Receptor Toxin A Cell-Penetrating Activator of TRPA1 Channel

주문정보

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0.5 ml Elite Pre-stained Protein Ladder (2 x 0.25 ml) PAL-EPL-500 0.5ml 500
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