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유비퀴틴화 단백질 | Ubiquitination Proteins 이미지

유비퀴틴화 단백질 | Ubiquitination Proteins

Maker : EUROFINS DISCOVERX

유비퀴틴화(Ubiquitination) 과정과 관련 연구를 위한 E1, E2, E3 및 기질 단백질을 제공합니다.

프린트 제품 문의

특징  

 

  • 유비퀴틴화는 유비퀴틴 폴리펩타이드가 효소 의존적 연쇄 반응(cascade)을 통해 표적 단백질에 공유 결합되는 매우 정교한 번역 후 조절 과정입니다. 이 과정은 단백질 분해, 세포 주기 진행, DNA 손상 인식 및 복구 등 광범위한 세포 활동을 지배합니다. 또한 유비퀴틴화는 단백질 품질 관리 시스템의 핵심 구성 요소로서, 잘못 접히거나 손상된 단백질을 확실히 제거하도록 돕습니다.
  • 유비퀴틴 경로의 항상성이 깨지면 암이나 퇴행성 신경질환과 같은 다양한 질병의 원인이 됩니다. 결과적으로, 유비퀴틴화 연쇄 반응의 구성 요소들은 치료적 개입 및 신약 개발의 강력한 표적으로 떠오르고 있습니다. 
  • Eurofins DiscoverX에서 제공하는 유비퀴틴화 관련 단백질 제품군을 소개합니다. 

  

 

주요 활용 분야 

 

  • 효소 스크리닝 (E1, E2, E3 Screening): 유비퀴틴화 과정에 영향을 주는 small molecule을 찾는 실험을 수행합니다.
  • 표적 단백질 분해 (TPD/PROTAC): PROTAC 신약 개발 시, 세포 실험 전 단계에서 E3 연결 효소와 기질을 사용하여 약물의 효능을 미리 검증(In vitro)합니다.
  • 기전 연구 (Mechanistic Biochemistry): 효소의 반응 속도, 특정 기질과의 결합력, 질병 관련 돌연변이가 미치는 영향 등을 분석합니다.
  • 유비퀴틴 사슬 분석: 어떤 형태의 유비퀴틴 사슬이 형성되는지 파악합니다. 이는 단백질이 분해될지, 혹은 신호 전달에 쓰일지를 결정하는 중요한 지표입니다.


주요 제품

 

Cat. No. Product Size Cat. No. Product Size
23-027
 b-catenin activated   10 ug
23-046
 Parkin (c-Myc tagged) active   10 ug
23-055
 Cardiac Troponin I   10 ug
23-048
 Parkin active   10 ug
23-061
 c-Cbl (c-Myc tagged) activated  10 ug
23-026
 SCFbTrCP1 complex active    10 ug
23-041
 c-Cbl active   10 ug
23-030
 SCFFbw7 complex active   10 ug
23-053
 CHIP (c-Myc tagged) active   10 ug
23-023
 SCFSkp2/Cks1 complex active   10 ug
23-050
 CHIP active   10 ug
23-057
 Smac/DIABLO  10 ug
23-031
 Cyclin E1 complex   10 ug
23-058
 Smurf1 active  10 ug
23-045
 HIF-1a   10 ug
23-042
 Src   10 ug
23-052
 Hsp70   10 ug
23-059
 TRAF6 active  10 ug
23-064
 Idol (c-Myc tagged) active  10 ug
23-051
 UbcH13/Uev1A active   10 ug
23-028
 IkBa activated   10 ug
23-022
 UbcH3 active    10 ug
23-060
 IKKg active  10 ug
23-025
 UbcH4 active  50 ug 10 ug
23-043
 Kit   10 ug
23-029
 UbcH5a active  50 ug 10 ug
23-033
 MDM2 (c-Myc tagged) active   10 ug
23-035
 UbcH5c active   10 ug
23-032
 MDM2/CK1d active   10 ug
23-036
 UbcH6 active  10 ug
23-054
 MuRF1 active   10 ug
23-047
 UbcH7 active   10 ug
23-024
 p27 complex activated   10 ug
23-021
 UBE1 active    10 ug
23-049
 p38/JTV-1   10 ug
23-044
 VHL complex active   10 ug
23-034
 p53   10 ug
23-056
 XIAP active  10 ug

주문정보

주문정보 - Cat No, PRODUCT, SIZE, 수량 등 항목으로 구성되어있습니다.
  Product Cat.No. Size Maker Qty Data Sheet MSDS
b-catenin activated, recombinant protein 23-027 10 ug EUROFINS DISCOVERX
c-Cbl (c-Myc tagged) activated, recombinant protein 23-061 10 ug EUROFINS DISCOVERX
c-Cbl active, recombinant protein 23-041 10 ug EUROFINS DISCOVERX
Cardiac Troponin I, recombinant protein 23-055 10 ug EUROFINS DISCOVERX
CHIP (c-Myc tagged) active, recombinant protein 23-053 10 ug EUROFINS DISCOVERX
CHIP active, recombinant protein 23-050 10 ug EUROFINS DISCOVERX
Cyclin E1 complex, recombinant protein 23-031 10 ug EUROFINS DISCOVERX
HIF-1a, recombinant protein 23-045 10 ug EUROFINS DISCOVERX
Hsp70, recombinant protein 23-052 10 ug EUROFINS DISCOVERX
Idol (c-Myc tagged) active, recombinant protein 23-064 10 ug EUROFINS DISCOVERX
IkBa activated, recombinant protein 23-028 10 ug EUROFINS DISCOVERX
IKKg active, recombinant protein 23-060 10 ug EUROFINS DISCOVERX
Kit, recombinant protein 23-043 10 ug EUROFINS DISCOVERX
MDM2 (c-Myc tagged) active, recombinant protein 23-033 10 ug EUROFINS DISCOVERX
MDM2/CK1d active, recombinant protein 23-032 10 ug EUROFINS DISCOVERX
MuRF1 active, recombinant protein 23-054 10 ug EUROFINS DISCOVERX
p27 complex activated, recombinant protein 23-024 10 ug EUROFINS DISCOVERX
p38/JTV-1, recombinant protein 23-049 10 ug EUROFINS DISCOVERX
p53, recombinant protein 23-034 10 ug EUROFINS DISCOVERX
Parkin (c-Myc tagged) active, recombinant protein 23-046 10 ug EUROFINS DISCOVERX
Parkin active, recombinant protein 23-048 10 ug EUROFINS DISCOVERX
SCFbTrCP1 complex active, recombinant protein 23-026 10 ug EUROFINS DISCOVERX
SCFFbw7 complex active, recombinant protein 23-030 10 ug EUROFINS DISCOVERX
SCFSkp2/Cks1 complex active, recombinant protein 23-023 10 ug EUROFINS DISCOVERX
Smac/DIABLO, recombinant protein 23-057 10 ug EUROFINS DISCOVERX
Smurf1 active, recombinant protein 23-058 10 ug EUROFINS DISCOVERX
Src, recombinant protein 23-042 10 ug EUROFINS DISCOVERX
TRAF6 active, recombinant protein 23-059 10 ug EUROFINS DISCOVERX
UbcH13/Uev1A active, recombinant protein 23-051 10 ug EUROFINS DISCOVERX
UbcH3 active, recombinant protein 23-022 10 ug EUROFINS DISCOVERX
UbcH4 active, recombinant protein 23-025 50 ug EUROFINS DISCOVERX
UbcH5a active, recombinant protein 23-029 50 ug EUROFINS DISCOVERX
UbcH5c active, recombinant protein 23-035 10 ug EUROFINS DISCOVERX
UbcH6 active, recombinant protein 23-036 10 ug EUROFINS DISCOVERX
UbcH7 active, recombinant protein 23-047 10 ug EUROFINS DISCOVERX
UBE1 active, recombinant protein 23-021 10 ug EUROFINS DISCOVERX
VHL complex active, recombinant protein 23-044 10 ug EUROFINS DISCOVERX
XIAP active, recombinant protein 23-056 10 ug EUROFINS DISCOVERX
전체보기
Maker
EUROFINS DISCOVERX
Cat.No.
23-027
Product
b-catenin activated, recombinant protein
Size
10 ug
Qty
Data Sheet
Maker
EUROFINS DISCOVERX
Cat.No.
23-061
Product
c-Cbl (c-Myc tagged) activated, recombinant protein
Size
10 ug
Qty
Data Sheet
Maker
EUROFINS DISCOVERX
Cat.No.
23-041
Product
c-Cbl active, recombinant protein
Size
10 ug
Qty
Data Sheet
Maker
EUROFINS DISCOVERX
Cat.No.
23-055
Product
Cardiac Troponin I, recombinant protein
Size
10 ug
Qty
Data Sheet
Maker
EUROFINS DISCOVERX
Cat.No.
23-053
Product
CHIP (c-Myc tagged) active, recombinant protein
Size
10 ug
Qty
Data Sheet
Maker
EUROFINS DISCOVERX
Cat.No.
23-050
Product
CHIP active, recombinant protein
Size
10 ug
Qty
Data Sheet
Maker
EUROFINS DISCOVERX
Cat.No.
23-031
Product
Cyclin E1 complex, recombinant protein
Size
10 ug
Qty
Data Sheet
Maker
EUROFINS DISCOVERX
Cat.No.
23-045
Product
HIF-1a, recombinant protein
Size
10 ug
Qty
Data Sheet
Maker
EUROFINS DISCOVERX
Cat.No.
23-052
Product
Hsp70, recombinant protein
Size
10 ug
Qty
Data Sheet
Maker
EUROFINS DISCOVERX
Cat.No.
23-064
Product
Idol (c-Myc tagged) active, recombinant protein
Size
10 ug
Qty
Data Sheet
Maker
EUROFINS DISCOVERX
Cat.No.
23-028
Product
IkBa activated, recombinant protein
Size
10 ug
Qty
Data Sheet
Maker
EUROFINS DISCOVERX
Cat.No.
23-060
Product
IKKg active, recombinant protein
Size
10 ug
Qty
Data Sheet
Maker
EUROFINS DISCOVERX
Cat.No.
23-043
Product
Kit, recombinant protein
Size
10 ug
Qty
Data Sheet
Maker
EUROFINS DISCOVERX
Cat.No.
23-033
Product
MDM2 (c-Myc tagged) active, recombinant protein
Size
10 ug
Qty
Data Sheet
Maker
EUROFINS DISCOVERX
Cat.No.
23-032
Product
MDM2/CK1d active, recombinant protein
Size
10 ug
Qty
Data Sheet
Maker
EUROFINS DISCOVERX
Cat.No.
23-054
Product
MuRF1 active, recombinant protein
Size
10 ug
Qty
Data Sheet
Maker
EUROFINS DISCOVERX
Cat.No.
23-024
Product
p27 complex activated, recombinant protein
Size
10 ug
Qty
Data Sheet
Maker
EUROFINS DISCOVERX
Cat.No.
23-049
Product
p38/JTV-1, recombinant protein
Size
10 ug
Qty
Data Sheet
Maker
EUROFINS DISCOVERX
Cat.No.
23-034
Product
p53, recombinant protein
Size
10 ug
Qty
Data Sheet
Maker
EUROFINS DISCOVERX
Cat.No.
23-046
Product
Parkin (c-Myc tagged) active, recombinant protein
Size
10 ug
Qty
Data Sheet
Maker
EUROFINS DISCOVERX
Cat.No.
23-048
Product
Parkin active, recombinant protein
Size
10 ug
Qty
Data Sheet
Maker
EUROFINS DISCOVERX
Cat.No.
23-026
Product
SCFbTrCP1 complex active, recombinant protein
Size
10 ug
Qty
Data Sheet
Maker
EUROFINS DISCOVERX
Cat.No.
23-030
Product
SCFFbw7 complex active, recombinant protein
Size
10 ug
Qty
Data Sheet
Maker
EUROFINS DISCOVERX
Cat.No.
23-023
Product
SCFSkp2/Cks1 complex active, recombinant protein
Size
10 ug
Qty
Data Sheet
Maker
EUROFINS DISCOVERX
Cat.No.
23-057
Product
Smac/DIABLO, recombinant protein
Size
10 ug
Qty
Data Sheet
Maker
EUROFINS DISCOVERX
Cat.No.
23-058
Product
Smurf1 active, recombinant protein
Size
10 ug
Qty
Data Sheet
Maker
EUROFINS DISCOVERX
Cat.No.
23-042
Product
Src, recombinant protein
Size
10 ug
Qty
Data Sheet
Maker
EUROFINS DISCOVERX
Cat.No.
23-059
Product
TRAF6 active, recombinant protein
Size
10 ug
Qty
Data Sheet
Maker
EUROFINS DISCOVERX
Cat.No.
23-051
Product
UbcH13/Uev1A active, recombinant protein
Size
10 ug
Qty
Data Sheet
Maker
EUROFINS DISCOVERX
Cat.No.
23-022
Product
UbcH3 active, recombinant protein
Size
10 ug
Qty
Data Sheet
Maker
EUROFINS DISCOVERX
Cat.No.
23-025
Product
UbcH4 active, recombinant protein
Size
50 ug
Qty
Data Sheet
Maker
EUROFINS DISCOVERX
Cat.No.
23-029
Product
UbcH5a active, recombinant protein
Size
50 ug
Qty
Data Sheet
Maker
EUROFINS DISCOVERX
Cat.No.
23-035
Product
UbcH5c active, recombinant protein
Size
10 ug
Qty
Data Sheet
Maker
EUROFINS DISCOVERX
Cat.No.
23-036
Product
UbcH6 active, recombinant protein
Size
10 ug
Qty
Data Sheet
Maker
EUROFINS DISCOVERX
Cat.No.
23-047
Product
UbcH7 active, recombinant protein
Size
10 ug
Qty
Data Sheet
Maker
EUROFINS DISCOVERX
Cat.No.
23-021
Product
UBE1 active, recombinant protein
Size
10 ug
Qty
Data Sheet
Maker
EUROFINS DISCOVERX
Cat.No.
23-044
Product
VHL complex active, recombinant protein
Size
10 ug
Qty
Data Sheet
Maker
EUROFINS DISCOVERX
Cat.No.
23-056
Product
XIAP active, recombinant protein
Size
10 ug
Qty
Data Sheet
전체보기

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주문정보 - Cat No, PRODUCT, SIZE, 수량 등 항목으로 구성되어있습니다.
  Product Cat.No. Size Maker Qty Data Sheet MSDS

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 0.5 ml Elite Pre-stained Protein Ladder (2 x 0.25 ml) PAL-EPL-500 0.5ml 500
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Data Sheet
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