사이토카인 폭풍 분석서비스 | Cytokine Storm Assay Service | 고마바이오텍

Figure 1. Mechanism model of cytokine release data describing cytokine storm induction. A. Superagonist, therapeutic mAb TGN1412 binds cell surface receptors CD28 or variant CD28 and simultaneously FcɣRI on vascular endothelial cells, promoting rapid release of multiple proinflammatory cytokines from monocytes (mono), natural killer (NK), and T cells. Subsequent exponential release of cytokines leads to endothelial cell damage, loss of capillary integrity, and multiple organ failure. B. Immobilized superagonist anti-CD28 mAb (clone ANC28.1/5D10) stimulates robust induction of pro-inflammatory cytokines in human PBMCs. Induction levels of each cytokine were interpolated from a standard curve using 5-point non-linear regression analysis.