다양한 Disease 및 pathway 에 관련된 inhibitor를 소개드립니다.
Blood, bone marrow, PBMC, T cell, B cell 등 AllCells사에서 제공하는 cell에 대하여 안내해 드립니다.
고마에서 제공하는 분석 및 제작서비스에 대한 안내자료입니다.
Neuroscience, Cardiovascular iPSC-derived cell 및 primary cell을 제공합니다.
Oxidative Stress, Virus kit 등 다양한 Cell based Assay kit을 제공합니다.
다양한 분야의 ELISA kit을 제공합니다.
Veterinary, Serum protein, Epitope tag등에 대한 항원, 항체, ELISA kit을 제공합니다.
Culture media, Antibody, Chemical등을 제공합니다.
IVD 제품 개발 및 생산에 필요한 제품군을 소개합니다.
DNA, RNA 전기영동을 위한 다양한 Pre-cast gel을 소개합니다.
DNA 전기영동장치, Casting 시스템이 수록되어 있습니다.
효과가 뛰어난 핵산 및 단백질 Labeling용 fluorescent CF dyes를 소개합니다.
다양한 cell 제품/서비스 및 세포 연구 관련 assay kit 내용이 소개되어 있는 미니카달로그입니다.
총 4900여개의 Small Molecules이 수록되어 있습니다.
Neuroscience 관련 Kit, 항체, biochemical 등의 제품이 소개되어 있는 미니 카달로그입니다.
신약개발연구를 위한 Kinase, Ion channel, GPCR 관련 제품과 서비스 내용이 수록되어 있습니다.
다양한 분야의 ELISA kit와 Assay Kit 목록이 수록된 미니카탈로그 입니다.
아데노바이러스, 렌티바이러스, AAV 서비스 및 제품이 소개되어 있는 미니 카달로그입니다.
단백질 및 DNA 전기영동장치, pre-cast gel, Marker, 각종 reagent들이 소개되어 있는 미니 카달로그입니다.
PCR 및 분자생물학 관련 제품들이 수록된 미니카탈로그 입니다.
전기영동, ELISA Kit, PCR Kit등의 고마 제품들이 수록된 미니카탈로그 입니다.
고마에서 제공하는 Multiplex 서비스 Analyte 목록입니다.
Luminex 기기와 비드를 소개합니다.
R&D사의 Luminex Screening Assay와 Performance Assay Kit을 소개합니다.
Luminex xMAP을 이용한 다양한 실험방법과 프로토콜을 소개합니다.
Alzheimer’s Disease, Parkinson’s Disease, Huntington’s Disease 에 대한 정보 및 관련 제품에 대한 정보를 제공합니다.
Modulator 및 Ion channel 관련 제품이 수록되어 있습니다.
NGF, BDNF, GDNF 제품의 실험정보와 Neutrophic factor 제품을 소개합니다.
450여가지 이상의 질병관련된 그룹별 agonist & antagonist를 제공합니다.
Ion Channels, G-Protein-Coupled Receptors 와 관련된 다양한 제품 정보를 제공합니다.
GPCR study에 필요한 GPCR Antibody를 소개합니다.
ELISA 실험에 대한 hint, tip, troubleshooting 등 자세한 가이드를 제공합니다.
MP Biomedicals의 Monoclonal, Polyclonal Antibody 및 Purified Protein을 소개합니다.
Chemokine, Integrin, Cytokine Receptors 등에 대한 agonist, antagonist, inhibitor를 소개합니다.
신약개발 스크리닝에 필요한 FDA승인된 compound Library와 Stem cell, Epigenetic,
Kinase inhibitor toolbox를 소개합니다.
Cardiovascular 연구와 관련된 기본적인 정보와 Agonist, Antagonist, Inhibitor 등 다양한 관련 제품이 수록되어 있습니다.
Kinome group별로 다양한 protein kinase inhibitors의 정보를 제공합니다.
호르몬의 group에 따른 정보와 관련된 다양한 제품을 확인 할 수 있습니다.
Physiological activity에 따른 peptide hormone receptor 관련 제품이 수록되어 있습니다.
250여가지의 Peptide, Steroid Hormone, Insulin, Hypothalamic Receptors등을 소개합니다.
retinoid receptor의 pharmacological review를 제공합니다.
MAPKs activation에 수반된 여러 단백질의 인산화와 inhibitor등에 대한 자료를 제공합니다.
P2 receptors family에 대한 agonist, antagonist 정보를 제공합니다.
5-HT receptors family에 대한 agonist, antagonist 정보를 제공합니다.
GABA receptor subtypes과 ligands의 구조와 기능에 대한 review를 제공합니다.
식욕조절과 에너지 향상성에 관련한 펩타이드들의 개요를 제공합니다.
Dopamine receptor subtype의 요약 및 ligand에 대한 가이드를 제공합니다.
여러종류의 histamine receptor subtype과 ligand에 대한 개요를 제공합니다.
nAChRs의 연구에 관련된 overview를 제공합니다.
가장 광범위하게 연구되는 ligand에 대한 review를 제공합니다.
mGluR의 pharmacological review를 제공합니다.
동물세포 배양을 위한 Media, Serum, Supplement 등 다양한 제품이 수록되어 있습니다.
마이코플라즈마 제거에 효과적인 MRA를 소개합니다.
MP Biomedicals의 다양한 Culture Growth Media를 소개합니다.
Stem cell proliferation과 differentiation에 관여하는 compound에 대한 review를 제공합니다.
Cancer research를 위한 다양한 종류의 agonist와 antagonist를 소개합니다.
Histone Antibody, Peptide, Array등 Histone Assay reagent를 소개합니다.
Written by Rebecca Quelch and Stefan Przyborski from Durham University (UK), this poster describes the isolation of pluripotent stem cells, their maintenance in culture, differentiation, and the generation and potential uses of organoids.
Developed in-house, our Stem Cell Workflow poster summarizes how small molecules have been used in protocols across the stem cell workflow, and highlights some of the key advantages of using small molecules. Compounds available from Tocris for stem cell research are listed.
Autophagy is a cellular process used by cells for degradation and recycling. Written by Patricia Boya and Patrice Codogno, this poster summarizes the molecular machinery, physiology and pathology of autophagy. Compounds available from Tocris are listed.
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.
Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.
Alzheimer's disease (AD) is a degenerative brain disease and the most common cause of dementia, affecting approximately 47 million people worldwide. Updated in 2015, this poster summarizes the structural and functional changes observed in the progression of this neurodegenerative disease, as well as classic AD drug targets.
Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the main targets for cancer metabolism researchers. Genetic changes and epigenetic modifications in cancer cells alter the regulation of cellular metabolic pathways. These distinct metabolic circuits could provide viable cancer therapeutic targets.
Cardiovascular disease remains one of the major causes of morbidity and mortality in the Western world and therefore this therapeutic area continues to be of great interest to researchers. This poster highlights the key GPCRs regulating vascular reactivity.
In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.
Adapted from the 2015 Cancer Product Guide Edition 3, this poster summarizes the main epigenetic targets in cancer. The dysregulation of epigenetic modifications has been shown to result in oncogenesis and cancer progression. Unlike genetic mutations, epigenetic alterations are considered to be reversible and thus make promising therapeutic targets.
Epilepsy is a brain disease that affects 60 million people globally. More than 20 anti-seizure drugs are currently available, but these do not address the underlying causes of the condition. This poster summarizes current knowledge about the development of the condition and highlights some approaches that have disease-modifying effects in proof-of-concept studies.
The gastrointestinal tract is the largest endocrine gland in the human body, secreting hormones that affect digestion, appetite and energy expenditure. Neuropeptide modulators and gut hormones that influence appetite are reviewed in this poster.
Huntington's disease (HD) is a monogenic neurodegenerative disorder, which is characterized by the prevalent loss of GABAergic medium spiny neurons (MSN) in the striatum. This poster summarizes the MSN intracellular signaling pathways implicated in the pathology of HD, as well as highlighting the use of iPSCs for HD modeling.
Recognition memory enables us to make judgements about whether or not we have encountered a particular stimulus before. This poster outlines the cellular mechanisms underlying recognition memory and its links to long-term depression, as well as the use of pharmacological intervention to assess the role of neurotransmitters in recognition memory.
Multiple sclerosis (MS) is an autoimmune disease that is characterized by focal demyelination and axon degeneration in the central nervous system. This poster summarizes the neurobiology and current therapies of MS.
Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.
There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.
Rheumatoid arthritis (RA) is a chronic destructive inflammatory autoimmune disease that results from a breakdown in immune tolerance, for reasons that are as yet unknown. This poster summarizes the pathology of RA and the inflammatory processes involved, as well as describing some of the epigenetic modifications associated with the disease and the potential for targeting these changes in the discovery of new treatments.
Schizophrenia is a debilitating psychiatric disorder that affects 1% of the worldwide population. This poster describes the neurobiology of Schizophrenia, as well as highlighting the genetic and environmental factors that play a fundamental role in the etiology of the disease. The current and emerging drug targets are also discussed.
Cytokine의 signaling pathway를 확인하세요.
The Akt signalling pathway plays a key role in the mediation of protein synthesis, metabolism, proliferation and cell cycle progression. It may be referred to as a 'prosurvival' pathway.
AMPK signalling pathway plays an important role in the cellular reponse to low levels of available ATP, often caused by stresses such as heat shock, ischemia or hypoxia.
Apoptosis is a physiological process for cell death that is critical during ageing and development. It may also be referred to as cell 'suicide'. Apoptosis can be triggered by events both inside and outside of the cell.
Estrogen is a steroid hormone that is responsible for the regulation of growth, differentiation and function of the reproductive system. Estrogen signalling is often dysregulated in breast cancer and osteoporosis.
The Hedgehog (Hh) pathway is involved in development. It induces cellular proliferation and morphogenesis in developing tissues and organs. Hh signalling has been implicated in cancer.
Signalling through the insulin pathway is fundamental for the regulation of intracellular glucose levels. This pathway can become dysregulated in diabetes.
The JAK-STAT signalling pathway has several roles, including the control of cell proliferation and hematopoiesis. It is the main signal transduction cascade from cytokine receptors.
The mitogen-activated protein kinase pathway evokes an intracellular signalling cascade in response to extracellular stimuli such as heat and stress. It can influence cell division, metabolism and survival.
mTOR is a serine/threonine kinase that nucleates at multiprotein complexes mTORC1 and mTORC2. Signalling by these complexes regulates cell growth, proliferation and survival.
NF-κB signalling plays an important role in inflammation, the innate and adaptive immune response and stress. Dysregulated signalling can occur in inflammatory and autoimmune diseases.
The Notch pathway is involved in determination of cell fate, regulation of pattern formation and other developmental settings. Disrupted signalling can cause developmental defects and a range of adult pathologies.
p53 signalling plays an important role in the co-ordination of the cellular response different types of stress such as DNA damage and hypoxia. The downstream signals lead to apoptosis, senescence and cell cycle arrest.
The TGF-β signalling pathway is involved in the regulation of growth and proliferation of cells along with migration, differentiation and apoptosis.
TLR signalling is involved in the cellular response to threatening molecules such as bacteria and viruses. It results in an inflammatory and immmunological response.
The Wnt pathway is involved in cellular differentiation and proliferation in adult tissues and also during embryogenesis. Disturbances within the pathway may lead to the formation of tumors and promote metastasis.
p53 tumour suppressor response에 대한 정보를 담았습니다.
Human Ion Channelome 정보를 담았습니다.
Human GPCRome 정보를 담았습니다.
Human Kinome 정보를 담았습니다.
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