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Human iPSC¿¡¼ À¯·¡ µÈ Astrocyte (¼º»ó±³¼¼Æ÷)·Î, ¾ËÃ÷ÇÏÀÌ¸Ó ¹× ÆÄŲ½¼ º´, ÀÚÆóÁõ, ±Ù À§Ã༺ Ãø»è °æÈÁõ (ALS), ·¹Æ® ÁõÈıº ¹× Á¶Çöº´°°Àº ¸¹Àº ½Å°æÇÐÀû Áõ»ó ¿¬±¸¿¡ ÀÌ¿ëµË´Ï´Ù. |
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AXOL |
¡¡ | iPSC-Derived Astrocyte Progenitor Kit |
¡¡ | iPSC-Derived Astrocyte (ax0665) NEW |
iPSC-derived astrocytes | ||
Cat. No. | Product Name | Donor |
ax0083 | Human iPSC-Derived Astrocyte Progenitor Kit | Male, newborn |
ax0084 | Human iPSC-Derived Mature Astrocyte Kit | Male, newborn |
ax0081 | Human iPSC-Derived Astrocyte Progenitor Kit | Female, newborn |
ax0082 | Human iPSC-Derived Mature Astrocyte Kit | Female, newborn |
ax0665 | Human iPSC-Derived Astrocytes | Male, newborn |
Astrocyte culture media and reagents | ||
Cat. No. | Product Name | Quantity |
ax0086 | Astrocyte Maintenance Medium | 100 mL (basal medium, pluc suplements) |
Axol iPSC-derived Mature Astrocytes express astrocyte-specific markers GFAP and S100B.
Low expression of nestin, a marker of progenitor cell phenotype and MAP2, a marker of microtubule growth
and neuritogenesis, indicates successful glial differentiation of the iPSCs. Cells seeded on Matrigel at
16,000 cells/well of a 96-well plate. Data provided Susanne Zach, Boehringer Ingelheim.
Axol iPSC-derived Mature Astrocytes express astrocyte associated markers excitatory amino
acid transporter 1 (EAAT1), glutamine synthetase (GS) and ALDH1L1. EAAT1 is active in clearly
excitatory glutamate from the extracellular space, preventing neurotoxicity where GS converts glutamate to
glutamine. The expression of these markers highlights that Axol’s Human iPSC-derived Astrocytes are
physiologically representative of human primary astrocytes. Cells seeded on Matrigel at 16,000 cells/well
of a 96-well plate. Data provided Susanne Zach, Boehringer Ingelheim.
Protocols
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