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 제품안내  분석 제작 서비스   신약개발 탐색 서비스

Lipid 분석서비스 (Lipid Analysis Service)

Lipid는 인체의 여러가지 대사작용에 관여하며, 지질체는 질병에 걸렸을때 질병의 예측 마커로 이용될 수 있습니다. 지질체학(lipidomics) 연구를 위해 다양한 샘플로부터 lipid를 분석해 드립니다.

Lipotype
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  • 다양한 샘플로부터 lipid의 종류와 양을 분석해 드립니다.
  • 높은 coverage : 2300여개의 individual한 lipid를 분석할 수 있습니다.
  • Chromatography가 아닌 MASS 분석을 통해 결과의 Quality를 높이고 결과시간도 빠릅니다.
  • 1ul 미만의 최소량의 샘플을 이용합니다.
  • 고유의 내부 표준을 바탕으로 개별 lipid를 직접적으로 절대정량합니다.
  • 분석 가능한 샘플 :
    - skin
    - blood/plasma/serum/erythrocyte
    - Yeast/Microorganism
    - Cultured & isolated cell
    - Tissue/organ
    - CSF
    - Drosophila 등
  • 제공되는 리포트 :  
    - Standard : Information on methodology, analysis details, used sample amounts, technical variation and quantitative lipidomics results in tabular format.
    - Extended : A graphical presentation of
     (a) averaged lipid class values with replicate standard deviations,
     (b) averaged (sub)species, double bond, chain length and hydroxylation profiles for each lipid class,
     (c) principal component analysis for un-averaged replicates.
  • 패키지 종류 : Standard, Premium (하단에서 패키지 별로 제공되는 상세 내용을 확인하세요.)
  • 샘플 준비 방법은 고마바이오텍으로 문의주세요.









  Standard Analysis Premium Analysis
Delivery time 6 weeks 4 weeks
Minimum 15 samples 20 samples
Structural Details Glycerophospholipids and glycerolipids (except TAG and CL) are reported as subspecies – e.g. PC-36:1;0(18:0;0-18:1;0) denotes PC with the total length of its fatty acids of 36, 1 double bond and 0 hydroxylations that is made up from two fatty acids: 18:0 (stearic) and 18:1 (oleic). The remaining lipid classes are reported as species e.g. – CER-34:1;2. Glycerophospholipids and glycerolipids (except TAG and CL) are reported as subspecies – e.g. PC-36:1;0(18:0;0-18:1;0) denotes PC with the total length of its fatty acids of 36, 1 double bond and 0 hydroxylations that is made up from two fatty acids: 18:0 (stearic) and 18:1 (oleic). The remaining lipid classes are reported as species e.g. – CER-34:1;2.
Approach LipotypeXplorer identifies all measurable lipids in a sample using molecular fragmentation query language without the need to rely on predefined databases. LipotypeXplorer identifies all measurable lipids in a sample using molecular fragmentation query language without the need to rely on predefined databases.
Results Quantitative
Results are expressed in absolute values - pmol per sample volume.
Quantitative
Results are expressed in absolute values - pmol per sample volume.
Standard report contains:
Information on methodology, analysis details, used sample amounts, technical variation and quantitative lipidomics results in tabular format.
contains:
Information on methodology, analysis details, used sample amounts, technical variation and quantitative lipidomics results in tabular format.
Basic coverage PA - phosphatidate
PC - phosphatidylcholine
PE - phosphatidylethanolamine
PG - phosphatidylglycerol
PI - phosphatidylinositol
PS - phosphatidylserine
DAG - diacylglycerol
TAG - triacylglycerol
SM - sphingomyelin•
CE - cholesteryl ester•
EE - ergosteryl ester••
• - animals
•• - yeast
PA - phosphatidate
PC - phosphatidylcholine
PE - phosphatidylethanolamine
PG - phosphatidylglycerol
PI - phosphatidylinositol
PS - phosphatidylserine
DAG - diacylglycerol
TAG - triacylglycerol
SM - sphingomyelin•
CE - cholesteryl ester•
EE - ergosteryl ester••
• - animals
•• - yeast
Extended coverage LPA - lyso-phosphatidate
LPC - lyso-phosphatidylcholine
LPE - lyso-phosphatidylethanolamine
LPG - lyso-phosphatidylglycerol
LPI - lyso-phosphatidylinositol
LPS - lyso-phosphatidylserine
PC O- - ether-linked PC•
PE O- - ether-linked PE•
LPC O- - ether-linked LPC•
LPE O- - ether-linked LPE•
CER - ceramide
HEXCER - hexosylceramide•
CL - cardiolipin
• - animals
LPA - lyso-phosphatidate
LPC - lyso-phosphatidylcholine
LPE - lyso-phosphatidylethanolamine
LPG - lyso-phosphatidylglycerol
LPI - lyso-phosphatidylinositol
LPS - lyso-phosphatidylserine
PC O- - ether-linked PC•
PE O- - ether-linked PE•
LPC O- - ether-linked LPC•
LPE O- - ether-linked LPE•
CER - ceramide
HEXCER - hexosylceramide•
CL - cardiolipin
• - animals
Sample amount adjustment Samples are pre-tested to ensure that the most optimal amounts are used for analysis. Samples are pre-tested to ensure that the most optimal amounts are used for analysis.
Free sterols coverage N/A Available (extra charge)
Free cholesterol or ergosterol (y)
*y - yeast only
Yeast specific coverage N/A IPC - inositolphosphorylceramide
MIPC - mannosyl-inositol phosphorylceramide
M(IP)2C - mannosyl-di-(inositolphosphoryl) ceramide
CDP-DAG - CDP-diacylglycerol
Personal support N/A Personal consultations and support regarding your analysis and results.
Turbo delivery Available 3 weeks (extra charge) Available 2 weeks (extra charge)
Extended data report Available (extra charge) Included :
Extended report contains:
A graphical presentation of
(a) averaged lipid class values with replicate standard deviations,
(b) averaged (sub)species, double bond, chain length and hydroxylation profiles for each lipid class,
(c) principal component analysis for un-averaged replicates.
The extended report can be viewed via internet browser (as an offline local webpage) or data files can be browsed manually.
Interactive data visualization and analysis Available (free of charge with the extended data report)
Interactive LipotypeZoom displays the content of the extended report and is internet-accessible via browser.
Available (free of charge with the extended data report)
Interactive LipotypeZoom displays the content of the extended report and is internet-accessible via browser.




  Standard Analysis Premium Analysis
Delivery time 6 weeks 4 weeks
Minimum 15 samples 20 samples
Structural Details Glycerophospholipids and glycerolipids (except TAG and CL) are reported as subspecies – e.g. PC-36:1;0(18:0;0-18:1;0) denotes PC with the total length of its fatty acids of 36, 1 double bond and 0 hydroxylations that is made up from two fatty acids: 18:0 (stearic) and 18:1 (oleic). The remaining lipid classes are reported as species e.g. – CER-34:1;2. Glycerophospholipids and glycerolipids (except TAG and CL) are reported as subspecies – e.g. PC-36:1;0(18:0;0-18:1;0) denotes PC with the total length of its fatty acids of 36, 1 double bond and 0 hydroxylations that is made up from two fatty acids: 18:0 (stearic) and 18:1 (oleic). The remaining lipid classes are reported as species e.g. – CER-34:1;2.
Approach LipotypeXplorer identifies all measurable lipids in a sample using molecular fragmentation query language without the need to rely on predefined databases. LipotypeXplorer identifies all measurable lipids in a sample using molecular fragmentation query language without the need to rely on predefined databases.
Results Quantitative
Results are expressed in absolute values - pmol per sample volume.
Quantitative
Results are expressed in absolute values - pmol per sample volume.
Standard report contains:
Information on methodology, analysis details, used sample amounts, technical variation and quantitative lipidomics results in tabular format.
contains:
Information on methodology, analysis details, used sample amounts, technical variation and quantitative lipidomics results in tabular format.
Basic coverage PC - phosphatidylcholine
PE - phosphatidylethanolamine
PI - phosphatidylinositol
DAG - diacylglycerol
TAG - triacylglycerol
SM - sphingomyelin
CHOL - free cholesterol
CE - cholesteryl ester
CER - ceramide
LPC - lyso-phosphatidylcholine
LPE - lyso-phosphatidylethanolamine
PC O- - ether-linked PC
PE O- - ether-linked PE
PC - phosphatidylcholine
PE - phosphatidylethanolamine
PI - phosphatidylinositol
DAG - diacylglycerol
TAG - triacylglycerol
SM - sphingomyelin
CHOL - free cholesterol
CE - cholesteryl ester
CER - ceramide
LPC - lyso-phosphatidylcholine
LPE - lyso-phosphatidylethanolamine
PC O- - ether-linked PC
PE O- - ether-linked PE
Extended coverage N/A PA - phosphatidate
PG - phosphatidylglycerol
PS - phosphatidylserine
LPA - lyso-phosphatidate
LPI - lyso-phosphatidylinositol
LPS - lyso-phosphatidylserine
LPC O- - ether-linked LPC
LPE O- - ether-linked LPE
HEXCER - hexosyl ceramide
Personal support N/A Personal consultations and support regarding your analysis and results.
Turbo delivery Available 3 weeks (extra charge) Available 2 weeks (extra charge)
Extended data report Available (extra charge) Included :
Extended report contains:
A graphical presentation of
(a) averaged lipid class values with replicate standard deviations,
(b) averaged (sub)species, double bond, chain length and hydroxylation profiles for each lipid class,
(c) principal component analysis for un-averaged replicates.
The extended report can be viewed via internet browser (as an offline local webpage) or data files can be browsed manually.
Interactive data visualization and analysis Available (free of charge with the extended data report)
Interactive LipotypeZoom displays the content of the extended report and is internet-accessible via browser.
Available (free of charge with the extended data report)
Interactive LipotypeZoom displays the content of the extended report and is internet-accessible via browser.





































  Molecular Metabolism, 2019 
Comprehensive and quantitative analysis of white and brown adipose tissue by shotgun lipidomics
Michal Grzybek, Alessandra Palladini, Vasileia I Alexaki, Michal A Surma, Kai Simons, Triantafyllos Chavakis, Christian Klose, Ünal Coskun
Read abstract : doi.org/10.1016/j.molmet.2019.01.009
  BBA Biomembranes, 2019 
Membrane cholesterol depletion reduces downstream signaling activity of the adenosine A2a receptor
Claire McGraw, Lewen Yang, Ilya Levental, Edward Lyman, Anne Skaja-Robinson
Read abstract : doi.org/10.1016/j.bbamem.2019.01.001
  Nature Communications Biology, 2018 
Dissection of metabolic reprogramming in polycystic kidney disease reveals coordinated rewiring of bioenergetic pathways
Christine Podrini, Isaline Rowe, Roberto Pagliarini, Ana S H Costa, Marco Chiaravalli, Ivano Di Meo, Hyunho Kim, Gianfranco Distefano, Valeria Tiranti, Feng Qian, Diego di Bernardo, Christian Frezza, Alessandra Boletta
Read abstract : doi.org/10.1038/s42003-018-0200
  Patent, 2018  
Compositions for facilitating membrane fusion and uses thereof
Geoffrey A Von Maltzahn, John M Milwid, Michael T Mee, Jacob Rosenblum-Rubens, Nathan Wilson-Stebbins, Molly K Gibson, Neal F Gordon, Bo Zhang, Kyle M Trudeau, Brigham J Hartley, Tamar R Putiri, Kiana Mahdaviani, Matthew Milnes-Dobbin
Read abstract : Downloadfreepatentsonline.com/WO2018208728A1.html
  Science, 2018 
Viscous control of cellular respiration by membrane lipid composition
Itay Budin, Tristan de Rond, Yan Chen, Leanne J G Chan, Christopher J Petzold, Jay D Keasling
Read abstract : doi.org/10.1126/science.aat7925
  White Paper Series, 2018 
Unlocking the Power of Multiomics
Henri Deda, Christian Klose, Kai Simons
Read abstract : Downloadlipotype.com/multiomics/
  Frontiers in Psychiatry, 2018 
Lipidomics in Major Depressive Disorder
Andreas Walther, Carlo V Cannistraci, Kai Simons, Claudio Durán, Mathias J Gerl, Susanne Wehrli, Clemens Kirschbaum
Read abstract : doi.org/10.3389/fpsyt.2018.00459
  Scientific Reports, 2018 
Cholesterol is Inefficiently Converted to Cholesteryl Esters in the Blood of Cardiovascular Disease Patients
Mathias J Gerl, Winchil L C Vaz, Neuza Domingues, Christian Klose, Michal A Surma, Júlio L Sampaio, Manuel S Almeida, Gustavo Rodrigues, Pedro Araújo-Gonçalves, Jorge Ferreira, Claudia Borbinha, João P Marto, Miguel Viana-Baptista, Kai Simons, Otilia V Vieira
Read abstract : doi.org/10.1038/s41598-018-33116-4
  Product development, 2018 
Photodamaged dry facial skin from different ethnic groups
Rainer Voegeli, Jean-Marc Monneuse, Christian Klose, Rotraut Schoop, Beverley Summers, Thomas Rudolph, Anthony V Rawlings
Read abstract : Downloadlipotype.com/2018/08/royal-dsm/
  Journal of Biological Chemistry, 2018 
An oxanthroquinone derivative that disrupts RAS plasma membrane localization inhibits cancer cell growth
Lingxiao Tan, Kwang-Jin Cho, Pratik Neupane, Robert J Capon, John F Hancock
Read abstract : doi.org/10.1074/jbc.RA118.003907
  NPJ Vaccines, 2018 
Activation of the endoplasmic reticulum stress sensor IRE1α by the vaccine adjuvant AS03 contributes to its immunostimulatory properties
Charlotte Givord, Iain Welsby, Sophie Detienne, Séverine Thomas, Assiya Assabban, Viviana Lima Silva, Céline Molle, Romain Gineste, Marjorie Vermeersch, David Perez-Morga, Oberdan Leo, Catherine Collignon, Arnaud M Didierlaurent, Stanislas Goriely
Read abstract : doi.org/10.1038/s41541-018-0058-4
  Patent, 2018 
Methods and systems for metabolite and/or lipid-based detection of colorectal cancer and/or adenomatous polyps
Marko Bitenc, Kristi Kruusmaa, Paola Hurtado-Castillo, Ana M Jiménez-Girón, Rosa Argamasilla-Martinez, Andreu Fabregat-Rossel, Antonio J Adsuar-Gomez, Juan Martinez-Barea, Christian Hense, Patricia Rodríguez-Gómez, Ángela Peralbo-Molina, Jorge Casado-Agrelo, Alejandro Sánchez-Brotons, Christina Pavón-Solís, Rosa M Delgado-Sánchez
Read abstract : Downloadfreepatentsonline.com/y2017/0343567.html
  Neuron, 2018 
ER Lipid Defects in Neuropeptidergic Neurons Impair Sleep Patterns in Parkinson’s Disease
Jorge S Valadas, Giovanni Esposito, Dirk Vandekerkhove, Katarzyna Miskiewicz, Liesbeth Deaulmerie, Susanna Raitano, Philip Seibler, Christine Klein, Patrik Verstreken
Read abstract : doi.org/10.1016/j.neuron.2018.05.022
  Biochemical Journal, 2018  
A phosphatidic acid binding protein is important for lipid homeostasis and adaption to anaerobic biofilm conditions in Pseudomonas aeruginosa
Maike K Groenewold, Marco Massmig, Stefanie Hebecker, Linna Danne, Zofia Magnowska, Manfred Nimtz, Franz Narberhaus, Dieter Jahn, Dirk W Heinz, Lothar Jänsch, Jürgen Moser Read abstract : doi.org/10.1042/BCJ20180257
  Product development, 2018 
Lipid analysis for skin penetration properties of saturated phospholipids
Dorothea Gutekunst, Christian Klose, Christoph Heidecke, Peter Van Hoogevest
Read abstract : Downloadlipotype.com/2018/05/lipoid/
  Phytochemical Analysis, 2018 
Dereplication of plant phenolics using a mass‐spectrometry database independent method
Ricardo M Borges, Rahil Taujale, Juliana Santana de Souza, Thaís de Andrade Bezerra, Eder Lana e Silva, Ronny Herzog, Francesca V Ponce, Jean-Luc Wolfender, Arthur S Edison
Read abstract : doi.org/10.1002/pca.2773
  Proteomics, 2018 
How Can Omic Science be Improved?
Kai Simons
Read abstract : doi.org/10.1002/pmic.201800039
  Cancer Research, 2018 
Organelle-derived acetyl-CoA promotes prostate cancer cell survival, migration, and metastasis via activation of calmodulin kinase II
Guoyu Yu, Chien-Jui Cheng, Song-Chang Lin, Yu-Chen Lee, Daniel E Frigo, Li-Yuan Yu-Lee, Gary E Gallick, Mark A Titus, Leta K Nutt, Sue-Hwa Lin
Read abstract : doi.org/10.1158/0008-5472.CAN-17-2392