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 제품안내  면역학   Neuroscience  Ion Channel

TOP 10 Cav channel Pharmacological Reagents

Voltage-Gated Ca2+ (Cav) Channel 연구에 많이 사용되는 best seller top 10가지 제품을 소개합니다.

Alomone Labs
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Activators


Target: L-Type (Ca
V1.2, CaV1.3)

(±)-Bay K8644 (#B-350)

B-350

Alomone Labs (±)-Bay K8644 increases L-type Ca2+ currents:

B-350

Left: I-V relation before (squares) and during (circles), bath perfusion of 5 μM (±)-Bay K8644 (#B-350). Right: An example of current response to 200 ms depolarization to +20mV (from holding potential of -100 mV) before (black) and during (pink) perfusion of (±)-Bay K8644.

Target: P/Q-Type (CaV2.1) & N-Type (CaV2.2)

GV-58 (#G-140)

g-140

Alomone Labs GV-58 activates presynaptic Ca2+ influx in rat neuronal cells:

g-140

Representative whole cell recordings of evoked neurotransmission in cultures treated with vehicle or GV-58 (#G-140).

Adapted from Beske, P.H. et al. (2017) Sci. rep. 7, 15862. with permission of SPRINGER NATURE.

 

For all CaV channel activators

Blockers


Target: P/Q-Type (Ca
V2.1)

ω-Agatoxin IVA (#STA-500)

ω-Agatoxin TK (#STA-530)

ω-Conotoxin MVIIC (#C-150)
ω-Agatoxin IVA (#STA-500)

sta-500

Alomone Labs ω-Agatoxin IVA blocks CaV2.1 channel in mouse calyx of Held:

sta-500

Calyxes were whole-cell voltage-clamped at -80 mV. Traces were recorded in the presence of 1 mM CaCl2, pharmacological isolation of VGCC subtypes was performed in 2 mM CaCl2. 200 nM ω-Agatoxin IVA (#STA-500) was applied to selectively block CaV2.1.

Adapted from Lubbert, M. et al. (2017) eLife 6, e28412. with permission of eLife Sciences.

Target: N-Type (CaV2.2)

ω-Conotoxin GVIA (#C-300)

ω-Conotoxin MVIIA (#C-670)

ω-Conotoxin MVIIC (#C-150) 
ω-Conotoxin MVIIC (#C-150)

c-150

Alomone Labs ω-Conotoxin MVIIC partially affects [Ca2+]i in nicotine-treated PC12 cells:

c-150

Cells were loaded with fura 2 and incubated without (control) or with 500 nM ω-Conotoxin MVIIC (#C-150). Intracellular Ca2+ was measured at 15 sec intervals before and after addition of nicotine. ω-Conotoxin MVIIC reduced [Ca2+]i in response to nicotine by 65%.

Adapted from Gueorguiev, V.D. et al. (1999) Am. J. Physiol. 276, C54. with permission of the American Physiological Society.

Target: R-Type (CaV2.3)

SNX-482 (#RTS-500)

rts-500

Alomone Labs Nifedipine and SNX-482 block L-type and R-type CaV channels respectively in rat pancreatic INS-1 832/13 β-cells:

rts-500

Representative CaV currents from INS-1 832/13 cells before and after treatment with Nifedipine (#N-120), a general L-type CaV channel blocker and SNX-482 (#RTS-500), a CaV2.3 channel blocker. 52% of the currents were blocked by Nifedipine (n = 8; p < 0.05) while 31% (n = 10; p < 0.001) of currents were blocked by SNX-482. Cells were held at −70 mV for 2 min after formation of whole-cell mode, and currents elicited by stepped 300 or 500 milliseconds depolarizations in 10 mV increments.

Adapted from Xie, L. et al. (2016) PLoS ONE 11, e0147862. with permission of PLoS.

Target: T-Type (CaV3.1, CaV3.2, CaV3.3)

TTA-A2 (#T-140) 

TTA-P2 (#T-155) 
TTA-A2 (#T-140) 

t-140

Alomone Labs TTA-A2 inhibits T-type CaV channels in response to hypoxia:

t-140

Representative example of sensory nerve response (impulses (imp)/s) to hypoxia in the presence of vehicle or 25 μM TTA-A2 (#T-140), and 5 min after washout (left panel). Effect of TTA-A2 on sensory nerve response to hypoxia (right panel).

Adapted from Makarenko, V.V. et al. (2015) Am. J. Physiol. 308, C146. with permission of the American Physiological Society.

 

For all CaV channel blockers