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 제품안내  신경약학   Cell Biology

BRD 6989 (CDK8 inhibitor and IL-10 production enhancer)

IL-10 생산을 증가시키고 CDK8을 inhibition하는 small molecule 입니다.

TOCRIS
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특징
  • 활성화된 human & mouse macrophage 및 dendritic cell 에서 IL-10 생산을 증가시킵니다.  
  • Cyclin C와 결합하여 CDK8 및 CDK19를 inhibition 합니다.
  • Description: Cdk8 inhibitor; enhances IL-10 production
  • Chemical Name: 2-Amino-5,6,7,8-tetrahydro-6-methyl-4-(3-pyridinyl)-3-quinolinecarbonitrile
  • Biological activity : Binds and inhibits Cdk8 in complex with cyclin C (IC50 ~ 200 nM). Enhances IL-10 production in activated human and murine macrophages and dendritic cells (EC50 is approximately 1 μM for IL-10 production in bone marrow-derived dendritic cells). Also inhibits CDK19 in complex with cyclin C.


  • M. Wt :  264.33 
  • Formula : C16H16N4 
  • Storage : Store at +4°C 
  • Purity : ≥98% (HPLC) 
  • CAS Number : 642008-81-9 
  • Smiles : CC1CCC2=NC(N)=C(C(C3=CN=CC=C3)=C2C1)C#N 

 

주문정보(Ordering Information)
CATNUM PRODUCT SIZE
6438BRD 698950 mg
6438BRD 698910 mg