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 Á¦Ç°¾È³»  ½Å°æ¾àÇР  Cell Biology

BRD 6989 (CDK8 inhibitor and IL-10 production enhancer)

IL-10 »ý»êÀ» Áõ°¡½Ã۰í CDK8À» inhibitionÇÏ´Â small molecule ÀÔ´Ï´Ù.

TOCRIS
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  • Ȱ¼ºÈ­µÈ human & mouse macrophage ¹× dendritic cell ¿¡¼­ IL-10 »ý»êÀ» Áõ°¡½Ãŵ´Ï´Ù.  
  • Cyclin C¿Í °áÇÕÇÏ¿© CDK8 ¹× CDK19¸¦ inhibition ÇÕ´Ï´Ù.
  • Description: Cdk8 inhibitor; enhances IL-10 production
  • Chemical Name: 2-Amino-5,6,7,8-tetrahydro-6-methyl-4-(3-pyridinyl)-3-quinolinecarbonitrile
  • Biological activity : Binds and inhibits Cdk8 in complex with cyclin C (IC50 ~ 200 nM). Enhances IL-10 production in activated human and murine macrophages and dendritic cells (EC50 is approximately 1 μM for IL-10 production in bone marrow-derived dendritic cells). Also inhibits CDK19 in complex with cyclin C.


  • M. Wt :  264.33 
  • Formula : C16H16N4 
  • Storage : Store at +4°C 
  • Purity : ≥98% (HPLC) 
  • CAS Number : 642008-81-9 
  • Smiles : CC1CCC2=NC(N)=C(C(C3=CN=CC=C3)=C2C1)C#N 

 

ÁÖ¹®Á¤º¸(Ordering Information)
CATNUM PRODUCT SIZE
6438BRD 698950 mg
6438BRD 698910 mg