BRD 6989 (CDK8 inhibitor and IL-10 production enhancer)

• 활성화된 human & mouse macrophage 및 dendritic cell 에서 IL-10 생산을 증가시킵니다.  
• Cyclin C와 결합하여 CDK8 및 CDK19를 inhibition 합니다.
• Description: Cdk8 inhibitor; enhances IL-10 production
• Chemical Name: 2-Amino-5,6,7,8-tetrahydro-6-methyl-4-(3-pyridinyl)-3-quinolinecarbonitrile
• Biological activity : Binds and inhibits Cdk8 in complex with cyclin C (IC₅₀ ~ 200 nM). Enhances IL-10 production in activated human and murine macrophages and dendritic cells (EC₅₀ is approximately 1 μM for IL-10 production in bone marrow-derived dendritic cells). Also inhibits CDK19 in complex with cyclin C.

• M. Wt :  264.33 
• Formula : C16H16N4 
• Storage : Store at +4°C 
• Purity : ≥98% (HPLC) 
• CAS Number : 642008-81-9 
• Smiles : CC1CCC2=NC(N)=C(C(C3=CN=CC=C3)=C2C1)C#N 

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