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 제품안내  면역학   Cancer Research  Epigenetics

dNucs (Modified Designer Nucleosomes)

Designer Nucleosome (dNucs)은 lycine 아세틸화 혹은 메틸화 등, 특정한 위치에서 post-translational modification을 거친 human recombinant nucleosome입니다. dNucs은 epigenetic regulators 연구에 도움을 드립니다.

EpiCypher
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특징
  • Histone의 특정한 위치에 이미 acetylation, methylation등의 PTM이 진행된 fully recombinant human nucleosome 입니다.
  • 타겟 enzyme/protein에 대한 substrate로 이용될 수 있습니다.
  • lot-to-lot variation 이 낮아 높은 재현성을 보여줍니다.
  • Free DNA가 포함되지 않아 안정성이 높습니다.
  • Biotinylated, Non-biotinylated dNucs이 있습니다. 



  • E.coli 에서 발현 된 재조합 Human histone Mononucleosomes 은 147 염기쌍의 601 Sequence DNA로 wrapped 되어 있습니다. Nucleosome은 염색질의 기본 단위이며, 밝혀진 601 Sequence는 147 염기쌍으로서 histone 8 량체에 대해 높은 친화성을 보유하고 있어 nucleosome assembly에 유용하게 적용할 수 있습니다.

  • Enzyme screening assays
  • Effector protein binding experiments
  • Protein-protein interation studies involbing the modification of interest
주문정보(Ordering Information)
CATNUM PRODUCT SIZE
16-0317Nucleosome, Recombinant Human, H3 K27me3 dNuc50ug
16-0322Nucleosome, Recombinant Human, H3 K36me1 dNuc50ug
16-1319Nucleosome, Recombinant Human, H3 K36me2 dNuc, Non-biotinylated50ug
16-0320Nucleosome, Recombinant Human, H3 K36me3 dNuc50ug
16-0321Nucleosome, Recombinant Human, H3 K4me1 dNuc50ug
16-0334Nucleosome, Recombinant Human, H3 K4me2 dNuc50ug
16-0325Nucleosome, Recombinant Human, H3 K9me1 dNuc50ug
16-0315Nucleosome, Recombinant Human, H3 K9me3 dNuc50ug
16-0341Nucleosome, Recombinant Human, H3 R2me2a dNuc50ug
16-0345Nucleosome, Recombinant Human, H3 S10phos dNuc50ug
16-0338Nucleosome, Recombinant Human, H3K27me1 dNuc50ug
16-0339Nucleosome, Recombinant Human, H3K27me2 dNuc50ug
16-1317Nucleosome, Recombinant Human, H3K27me3 dNuc, Non-biotinylated50ug
16-0319Nucleosome, Recombinant Human, H3K36me2 dNuc50ug
16-1320Nucleosome, Recombinant Human, H3K36me3 dNuc, Non-biotinylated50ug
16-1334Nucleosome, Recombinant Human, H3K4me2 dNuc50ug
16-0316Nucleosome, Recombinant Human, H3K4me3 dNuc50ug
16-1314Nucleosome, Recombinant Human, H3K9ac dNuc50ug
16-0314Nucleosome, Recombinant Human, H3K9ac dNuc50ug
16-0324Nucleosome, Recombinant Human, H3K9me2 dNuc50ug
16-0340Nucleosome, Recombinant Human, H3R2me1 dNuc50ug
16-1345Nucleosome, Recombinant Human, H3S10ph dNuc, Non-biotinylated50ug
16-0312Nucleosome, Recombinant Human, H4 K12ac dNuc 50ug
16-0331Nucleosome, Recombinant Human, H4 K20me1 dNuc50ug
16-0332Nucleosome, Recombinant Human, H4 K20me2 dNuc50ug
16-0333Nucleosome, Recombinant Human, H4 K20me3 dNuc50ug
16-0313Nucleosome, Recombinant Human, H4 Tetraacetyl (H4K5, 8, 12, 16 Ac) dNuc50ug