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 Á¦Ç°¾È³»  ½Å°æ¾àÇР  Disease Pathway

Angiogenesis Agonist & Antagonist

½Å»ýÇ÷°ü»ý¼º (Angiogenensis)Àº Á¾¾çÀÌ °è¼Ó ¼ºÀåÇÏ°í ÆÛÁö´Âµ¥ ÇʼöÀûÀÎ ¿ä¼Ò·Î, ¾Ï¿¬±¸¿¡ ÀÖ¾î Áß¿äÇÑ Ç¥ÀûÀÔ´Ï´Ù. Angiogenesis ¿¬±¸¿¡ ÀÖ¾î ÇÊ¿äÇÑ inhibitor, activator µîÀ» ¼Ò°³ÇÕ´Ï´Ù.
TOCRIS
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Antiangiogenic Products ¡¡
Cat. No. Product Name Activity
5121 3PO  PFKFB3 inhibitor; antiangiogenic 
5617 AZD 1480 Potent and selective JAK2 inhibitor; antiangiogenic
4706 Borrelidin  Antiangiogenic; inhibits threonyl-tRNA synthetase 
5029 CHC Monocarboxylic acid transport (MCT) inhibitor;
displays anti-angiogenic activities 
1495 Combretastatin A4  Antiangiogenic 
1768 Fumagillin  Antiangiogenic 
1629 Herbimycin A  Antiangiogenic. Inhibits Src family kinases and Hsp90 
5981 Itraconazole  SMO antagonist; antiangiogenic 
5260 KG 5 Antiangiogenic; PDGFRβ, B-Raf, c-Raf, FLT3 and KIT inhibitor 
1461 Linomide  Immunomodulator with antiangiogenic properties 
1807 2-Methoxyestradiol  Antiangiogenic and apoptotic agent 
4664 Obtustatin  Potent and selective α1β1 inhibitor; antiangiogenic 
2710 OGT 2115  Antiangiogenic. Heparanase inhibitor 
4733 P005091  USP7 inhibitor; antiangiogenic 
4744 P11  Potent antagonist of αvβ3-vitronectin interaction; antiangiogenic 
2954 PX 12  Thioredoxin-1 inhibitor; attenuates HIF-1α 
4885 R 1530  Multi-RTK inhibitor; inhibits angiogenesis 
1418 Resveratrol  Cyclooxygenase inhbitor 
0652 Thalidomide  Antiangiogenic. Inhibits TNF-α synthesis 
1098 Tranilast  Antiangiogenic 
3101 XRP44X  Antiangiogenic; microtubule depolymerization agent 
Matrix Metalloprotease Products ¡¡
2621 ARP 100  Selective inhibitor of MMP-2 
2622 ARP 101  Inhibitor of MMP-2 
2961 Batimastat  Potent, broad spectrum MMP inhibitor 
2632 CL 82198 hydrochloride  Selective inhibitor of MMP-13 
3780 CP 471474  Broad spectrum MMP inhibitor 
4090 Doxycycline hyclate  Broad-spectrum MMP inhibitor; tetracycline derivative 
2983 GM 6001  Broad spectrum MMP inhibitor 
2631 Marimastat  Broad spectrum MMP inhibitor 
3268 Minocycline hydrochloride  Inhibitor of MMP activity 
4902 NSC 405020  Inhibitor of MT1-MMP; antitumor 
2628 ONO 4817   Broad spectrum MMP inhibitor 
2520 PD 166793  Broad spectrum MMP inhibitor 
2916 Ro 32-3555 Potent, collagenase-selective MMP inhibitor 
6088 SB 3CT   Selective high affinity MMP2 inhibitor 
4775 SD 2590 hydrochloride  Potent MMP inhibitor 
4187 UK 356618  Potent and selective MMP-3 inhibitor 
2900 UK 370106  Highly selective MMP-3 and MMP-12 inhibitor 
4188 UK 383367  Potent and selective BMP-1 (PCP) inhibitor 
2633 WAY 170523  Potent and selective inhibitor of MMP-13 
3807 Disulfiram  Inhibits expression of MMP-2 and MMP-9;
displays a range of other activities 
4604 PTIQ  Potent MMP-3 expression inhibitor; neuroprotective 
EGFR Products ¡¡
5318 AEE 788  Potent EGFR and VEGFR inhibitor 
1276 AG 1478 hydrochloride  Highly potent EGFR-kinase inhibitor 
0493 AG 18  EGFR/PDGFR-kinase inhibitor 
0414 AG 490  EGFR-kinase inhibitor. Also JAK2, JAK3 inhibitor 
0619 AG 494  Potent EGFR-kinase inhibitor 
0618 AG 555 Potent EGFR-kinase inhibitor 
0616 AG 556 EGFR-kinase inhibitor 
1555 AG 825  Selective ErbB2 inhibitor 
2617 AG 879 ErbB2 inhibitor 
0497 AG 99 EGFR-kinase inhibitor 
4397 AV 412  Potent inhibitor of EGFR, ErbB2 and Abl receptor tyrosine kinases 
2417 BIBU 1361 dihydrochloride  Selective inhibitor of EGFR-kinase 
2416 BIBX 1382 dihydrochloride  Highly selective EGFR-kinase inhibitor 
5022 BMS 599626 dihydrochloride  Potent, selective EGFR and ErbB2 inhibitor 
5916 Canertinib dihydrochloride  Potent EGFR kinase inhibitor 
3360 CGP 52411  EGFR inhibitor. Also inhibits Aβ42 fibril formation 
5973 CP 724714  Potent and selective ErbB2 inhibitor 
4502 DIM Induces apoptosis; also inhibits EGFR activation 
1110 Genistein  EGFR kinase inhibitor. Also estrogen and PPARγ ligand 
2239 GW 583340 dihydrochloride  Potent dual EGFR/ErbB2 inhibitor; orally active 
2646 HDS 029  Potent inhibitor of the ErbB receptor family 
3580 HKI 357  Dual irreversible inhibitor of ErbB2 and EGFR 
3000 Iressa  Orally active, selective EGFR inhibitor 
3352 JNJ 28871063 hydrochloride  Potent ErbB receptor family inhibitor 
1331 Lavendustin A  EGFR, p60c-src inhibitor 
0577 Methyl 2,5-dihydroxycinnamate  EGFR-kinase inhibitor 
1037 PD 153035 hydrochloride  EGFR-kinase inhibitor 
2615 PD 158780  Potent ErbB receptor family inhibitor 
5939 PF 6274484  High affinity and potent covalent EGFR kinase inhibitor 
4941 PKI 166 hydrochloride  Potent EGFR-kinase inhibitor 
2794 PP 3  EGFR-kinase inhibitor. Also Src kinase negative control 
3599 TAK 165 Potent and selective ErbB2 inhibitor 
0578 Tyrphostin B44, (-) enantiomer  EGFR-kinase inhibitor 
0579 Tyrphostin B44, (+) enantiomer  EGFR-kinase inhibitor 
3115 WHI-P 154  Potent EGFR inhibitor. Also inhibits JAK3 
PDGFR Products ¡¡
5013 AC 710  Potent and selective PDGFR family inhibitor 
0493 AG 18  EGFR/PDGFR-kinase inhibitor 
4274 AP 24534  Potent multi-kinase and pan-Bcr-Abl inhibitor 
5993 CP 673451 Potent and selective PDGFR inhibitor 
1222 DMPQ dihydrochloride  Potent, selective inhibitor of PDGFRβ 
6056 GSK 1363089 Potent PDGFR inhibtor; also inhibits of MET, VEGFR2, Ron and AXL 
5906 Imatinib mesylate  PDGFR inhibitor; also inhibits v-Abl tyrosine kinase and c-kit 
5260 KG 5  PDGFRβ, B-Raf, c-Raf, FLT3 and KIT inhibitor; antiangiogenic 
3785 PD 166285 dihydrochloride  PDGFRβ, FGFR and Src inhibitor; also inhibits Wee1 
3304 SU 16f  Potent and selective PDGFRβ inhibitor 
3335 SU 6668  PDGFR, VEGFR and FGFR inhibitor 
3768 Sunitinib malate  Potent VEGFR, PDGFRβ and KIT inhibitor 
3909 Toceranib  Potent PDGFR and VEGFR inhibitor 
FGFR Products ¡¡
4274 AP 24534  Potent multi-kinase and pan-Bcr-Abl inhibitor 
4002 FIIN 1 hydrochloride  Potent, irreversible FGFR inhibitor 
3724 PD 161570  Selective FGFR inhibitor 
3785 PD 166285 dihydrochloride  FGFR, PDGFRβ and Src inhibitor; also inhibits Wee1 
3044 PD 173074  FGFR1 and -3 inhibitor 
3300 SU 5402  Potent FGFR and VEGFR inhibitor 
3335 SU 6668  FGFR, VEGFR and PDGFR inhibitor 
4826 SUN 11602  Basic fibroblast growth factor (bFGF) mimetic; neuroprotective 
Protein Kinase G Products ¡¡
3028 Rp-8-Br-PET-cGMPS  Protein kinase G inhibitor 
1883 cGMP Dependent Kinase Inhibitor Peptide  Inhibitor of protein kinases G and A 
1289 KT 5823  Selective protein kinase G inhibitor 
5524 Rp-8-pCPT-cGMPS sodium  PKG inhibitor 
Hypoxia Inducible Factor Products ¡¡
5953 Adaptaquin  HIF-prolyl hydroxylase-2 (PHD2) inhibitor; antioxidant 
5582 TAT-cyclo-CLLFVY  Selective HIF-1 dimerization inhibitor 
4408 DMOG  Inhibitor of hypoxia-inducible factor α (HIF-α) prolyl hydroxylase
(HIF-PH) 
5520 Echinomycin  Highly potent and selective HIF-1α inhibitor 
5655 GN 44028  Potent HIF-1α inhibitor 
4451 IOX 2  Potent, selective HIF-1α prolyl hydroxylase-2 (PHD2) inhibitor 
4324 KC7F2  HIF-1α inhibitor; down-regulates HIF-1α protein synthesis 
2954 PX 12  Thioredoxin-1 inhibitor; attenuates expression of HIF-1α 
5243 TC-S 7009  High affinity and selective HIF-2α inhibitor 
6156 VH 298 High-affinity inhibitor of VHL 
4565 ML 228  HIF pathway activator 
4705 Chetomin  Blocks interaction of HIF-1α, HIF-2α and STAT2 with CBP/p300 
6155 cis MZ 1 Negative Control for MZ1 
6157 cis VH 298 Negative control for VH 298 
5764 Deferoxamine mesylate  Hypoxia mimetic; also iron chelator 
6154 MZ 1 (+)-JQ1 based PROTAC that selectively degrades BRD4 in cells. 
VEGFR Products ¡¡
5318 AEE 788  Potent VEGFR and EGFR inhibitor 
2617 AG 879  VEGFR-2 inhibitor 
4274 AP 24534  Potent multi-kinase and pan-Bcr-Abl inhibitor 
4350 Axitinib  Potent VEGFR-1, -2 and -3 inhibitor 
4471 DMH4  Selective VEGFR-2 inhibitor 
3882 (E)-FeCP-oxindole  Selective VEGFR-2 inhibitor 
3883 (Z)-FeCP-oxindole  Selective VEGFR-2 inhibitor 
6056 GSK 1363089 Potent inhibitor of MET, VEGFR2, Ron and AXL 
2542 Ki 8751  Potent, selective VEGFR-2 inhibitor 
6015 RAF 265 VEGFR-2 and Raf kinase inhibitor 
1459 SU 4312  Potent inhibitor of VEGFR tyrosine kinase 
3300 SU 5402  Potent VEGFR and FGFR inhibitor 
3037 SU 5416  VEGFR inhibitor. Also inhibits KIT, RET, MET and FLT3 
3335 SU 6668  VEGFR, PDGFR and FGFR inhibitor 
3768 Sunitinib malate  Potent VEGFR, PDGFRβ and KIT inhibitor 
3909 Toceranib  Potent PDGFR and VEGFR inhibitor 
5680 Vatalanib succinate  Potent VEGFR inhibitor; also aromatase inhibitor 
5422 XL 184  Potent VEGFR inhibitor; also inhibits other RTKs 
2499 ZM 306416 hydrochloride  Inhibitor of VEGF receptor tyrosine kinase 
2475 ZM 323881 hydrochloride  Potent, selective inhibitor of VEGFR-2 
4931 EG 00229  Neuropilin 1 (NRP1) receptor antagonist;
inhibits VEGFA binding to NRP1