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신경약학

Disease Pathway

Angiogenesis Agonist & Antagonist


신생혈관생성 (Angiogenensis)은 종양이 계속 성장하고 퍼지는데 필수적인 요소로, 암연구에 있어 중요한 표적입니다. Angiogenesis 연구에 있어 필요한 inhibitor, activator 등을 소개합니다.
		TOCRIS

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Antiangiogenic Products
Cat. No.	Product Name	Activity
5121	3PO	PFKFB3 inhibitor; antiangiogenic
5617	AZD 1480	Potent and selective JAK2 inhibitor; antiangiogenic
4706	Borrelidin	Antiangiogenic; inhibits threonyl-tRNA synthetase
5029	CHC	Monocarboxylic acid transport (MCT) inhibitor; displays anti-angiogenic activities
1495	Combretastatin A4	Antiangiogenic
1768	Fumagillin	Antiangiogenic
1629	Herbimycin A	Antiangiogenic. Inhibits Src family kinases and Hsp90
5981	Itraconazole	SMO antagonist; antiangiogenic
5260	KG 5	Antiangiogenic; PDGFRβ, B-Raf, c-Raf, FLT3 and KIT inhibitor
1461	Linomide	Immunomodulator with antiangiogenic properties
1807	2-Methoxyestradiol	Antiangiogenic and apoptotic agent
4664	Obtustatin	Potent and selective α1β1 inhibitor; antiangiogenic
2710	OGT 2115	Antiangiogenic. Heparanase inhibitor
4733	P005091	USP7 inhibitor; antiangiogenic
4744	P11	Potent antagonist of αvβ3-vitronectin interaction; antiangiogenic
2954	PX 12	Thioredoxin-1 inhibitor; attenuates HIF-1α
4885	R 1530	Multi-RTK inhibitor; inhibits angiogenesis
1418	Resveratrol	Cyclooxygenase inhbitor
0652	Thalidomide	Antiangiogenic. Inhibits TNF-α synthesis
1098	Tranilast	Antiangiogenic
3101	XRP44X	Antiangiogenic; microtubule depolymerization agent

Matrix Metalloprotease Products
2621	ARP 100	Selective inhibitor of MMP-2
2622	ARP 101	Inhibitor of MMP-2
2961	Batimastat	Potent, broad spectrum MMP inhibitor
2632	CL 82198 hydrochloride	Selective inhibitor of MMP-13
3780	CP 471474	Broad spectrum MMP inhibitor
4090	Doxycycline hyclate	Broad-spectrum MMP inhibitor; tetracycline derivative
2983	GM 6001	Broad spectrum MMP inhibitor
2631	Marimastat	Broad spectrum MMP inhibitor
3268	Minocycline hydrochloride	Inhibitor of MMP activity
4902	NSC 405020	Inhibitor of MT1-MMP; antitumor
2628	ONO 4817	Broad spectrum MMP inhibitor
2520	PD 166793	Broad spectrum MMP inhibitor
2916	Ro 32-3555	Potent, collagenase-selective MMP inhibitor
6088	SB 3CT	Selective high affinity MMP2 inhibitor
4775	SD 2590 hydrochloride	Potent MMP inhibitor
4187	UK 356618	Potent and selective MMP-3 inhibitor
2900	UK 370106	Highly selective MMP-3 and MMP-12 inhibitor
4188	UK 383367	Potent and selective BMP-1 (PCP) inhibitor
2633	WAY 170523	Potent and selective inhibitor of MMP-13
3807	Disulfiram	Inhibits expression of MMP-2 and MMP-9; displays a range of other activities
4604	PTIQ	Potent MMP-3 expression inhibitor; neuroprotective

EGFR Products
5318	AEE 788	Potent EGFR and VEGFR inhibitor
1276	AG 1478 hydrochloride	Highly potent EGFR-kinase inhibitor
0493	AG 18	EGFR/PDGFR-kinase inhibitor
0414	AG 490	EGFR-kinase inhibitor. Also JAK2, JAK3 inhibitor
0619	AG 494	Potent EGFR-kinase inhibitor
0618	AG 555	Potent EGFR-kinase inhibitor
0616	AG 556	EGFR-kinase inhibitor
1555	AG 825	Selective ErbB2 inhibitor
2617	AG 879	ErbB2 inhibitor
0497	AG 99	EGFR-kinase inhibitor
4397	AV 412	Potent inhibitor of EGFR, ErbB2 and Abl receptor tyrosine kinases
2417	BIBU 1361 dihydrochloride	Selective inhibitor of EGFR-kinase
2416	BIBX 1382 dihydrochloride	Highly selective EGFR-kinase inhibitor
5022	BMS 599626 dihydrochloride	Potent, selective EGFR and ErbB2 inhibitor
5916	Canertinib dihydrochloride	Potent EGFR kinase inhibitor
3360	CGP 52411	EGFR inhibitor. Also inhibits Aβ42 fibril formation
5973	CP 724714	Potent and selective ErbB2 inhibitor
4502	DIM	Induces apoptosis; also inhibits EGFR activation
1110	Genistein	EGFR kinase inhibitor. Also estrogen and PPARγ ligand
2239	GW 583340 dihydrochloride	Potent dual EGFR/ErbB2 inhibitor; orally active
2646	HDS 029	Potent inhibitor of the ErbB receptor family
3580	HKI 357	Dual irreversible inhibitor of ErbB2 and EGFR
3000	Iressa	Orally active, selective EGFR inhibitor
3352	JNJ 28871063 hydrochloride	Potent ErbB receptor family inhibitor
1331	Lavendustin A	EGFR, p60c-src inhibitor
0577	Methyl 2,5-dihydroxycinnamate	EGFR-kinase inhibitor
1037	PD 153035 hydrochloride	EGFR-kinase inhibitor
2615	PD 158780	Potent ErbB receptor family inhibitor
5939	PF 6274484	High affinity and potent covalent EGFR kinase inhibitor
4941	PKI 166 hydrochloride	Potent EGFR-kinase inhibitor
2794	PP 3	EGFR-kinase inhibitor. Also Src kinase negative control
3599	TAK 165	Potent and selective ErbB2 inhibitor
0578	Tyrphostin B44, (-) enantiomer	EGFR-kinase inhibitor
0579	Tyrphostin B44, (+) enantiomer	EGFR-kinase inhibitor
3115	WHI-P 154	Potent EGFR inhibitor. Also inhibits JAK3

PDGFR Products
5013	AC 710	Potent and selective PDGFR family inhibitor
0493	AG 18	EGFR/PDGFR-kinase inhibitor
4274	AP 24534	Potent multi-kinase and pan-Bcr-Abl inhibitor
5993	CP 673451	Potent and selective PDGFR inhibitor
1222	DMPQ dihydrochloride	Potent, selective inhibitor of PDGFRβ
6056	GSK 1363089	Potent PDGFR inhibtor; also inhibits of MET, VEGFR2, Ron and AXL
5906	Imatinib mesylate	PDGFR inhibitor; also inhibits v-Abl tyrosine kinase and c-kit
5260	KG 5	PDGFRβ, B-Raf, c-Raf, FLT3 and KIT inhibitor; antiangiogenic
3785	PD 166285 dihydrochloride	PDGFRβ, FGFR and Src inhibitor; also inhibits Wee1
3304	SU 16f	Potent and selective PDGFRβ inhibitor
3335	SU 6668	PDGFR, VEGFR and FGFR inhibitor
3768	Sunitinib malate	Potent VEGFR, PDGFRβ and KIT inhibitor
3909	Toceranib	Potent PDGFR and VEGFR inhibitor

FGFR Products
4274	AP 24534	Potent multi-kinase and pan-Bcr-Abl inhibitor
4002	FIIN 1 hydrochloride	Potent, irreversible FGFR inhibitor
3724	PD 161570	Selective FGFR inhibitor
3785	PD 166285 dihydrochloride	FGFR, PDGFRβ and Src inhibitor; also inhibits Wee1
3044	PD 173074	FGFR1 and -3 inhibitor
3300	SU 5402	Potent FGFR and VEGFR inhibitor
3335	SU 6668	FGFR, VEGFR and PDGFR inhibitor
4826	SUN 11602	Basic fibroblast growth factor (bFGF) mimetic; neuroprotective

Protein Kinase G Products
3028	Rp-8-Br-PET-cGMPS	Protein kinase G inhibitor
1883	cGMP Dependent Kinase Inhibitor Peptide	Inhibitor of protein kinases G and A
1289	KT 5823	Selective protein kinase G inhibitor
5524	Rp-8-pCPT-cGMPS sodium	PKG inhibitor

Hypoxia Inducible Factor Products
5953	Adaptaquin	HIF-prolyl hydroxylase-2 (PHD2) inhibitor; antioxidant
5582	TAT-cyclo-CLLFVY	Selective HIF-1 dimerization inhibitor
4408	DMOG	Inhibitor of hypoxia-inducible factor α (HIF-α) prolyl hydroxylase (HIF-PH)
5520	Echinomycin	Highly potent and selective HIF-1α inhibitor
5655	GN 44028	Potent HIF-1α inhibitor
4451	IOX 2	Potent, selective HIF-1α prolyl hydroxylase-2 (PHD2) inhibitor
4324	KC7F2	HIF-1α inhibitor; down-regulates HIF-1α protein synthesis
2954	PX 12	Thioredoxin-1 inhibitor; attenuates expression of HIF-1α
5243	TC-S 7009	High affinity and selective HIF-2α inhibitor
6156	VH 298	High-affinity inhibitor of VHL
4565	ML 228	HIF pathway activator
4705	Chetomin	Blocks interaction of HIF-1α, HIF-2α and STAT2 with CBP/p300
6155	cis MZ 1	Negative Control for MZ1
6157	cis VH 298	Negative control for VH 298
5764	Deferoxamine mesylate	Hypoxia mimetic; also iron chelator
6154	MZ 1	(+)-JQ1 based PROTAC that selectively degrades BRD4 in cells.

VEGFR Products
5318	AEE 788	Potent VEGFR and EGFR inhibitor
2617	AG 879	VEGFR-2 inhibitor
4274	AP 24534	Potent multi-kinase and pan-Bcr-Abl inhibitor
4350	Axitinib	Potent VEGFR-1, -2 and -3 inhibitor
4471	DMH4	Selective VEGFR-2 inhibitor
3882	(E)-FeCP-oxindole	Selective VEGFR-2 inhibitor
3883	(Z)-FeCP-oxindole	Selective VEGFR-2 inhibitor
6056	GSK 1363089	Potent inhibitor of MET, VEGFR2, Ron and AXL
2542	Ki 8751	Potent, selective VEGFR-2 inhibitor
6015	RAF 265	VEGFR-2 and Raf kinase inhibitor
1459	SU 4312	Potent inhibitor of VEGFR tyrosine kinase
3300	SU 5402	Potent VEGFR and FGFR inhibitor
3037	SU 5416	VEGFR inhibitor. Also inhibits KIT, RET, MET and FLT3
3335	SU 6668	VEGFR, PDGFR and FGFR inhibitor
3768	Sunitinib malate	Potent VEGFR, PDGFRβ and KIT inhibitor
3909	Toceranib	Potent PDGFR and VEGFR inhibitor
5680	Vatalanib succinate	Potent VEGFR inhibitor; also aromatase inhibitor
5422	XL 184	Potent VEGFR inhibitor; also inhibits other RTKs
2499	ZM 306416 hydrochloride	Inhibitor of VEGF receptor tyrosine kinase
2475	ZM 323881 hydrochloride	Potent, selective inhibitor of VEGFR-2
4931	EG 00229	Neuropilin 1 (NRP1) receptor antagonist; inhibits VEGFA binding to NRP1