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 제품안내  신경약학   Pharmacology

Inflammation research compounds

Inflammation 연구에 필요한 compounds를 소개합니다.

Tocris
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특징
  • 염증성 질환 기전의 연구에 필요한 inhibitor, agonist, antagonist 등을 소개합니다.

 

COX (Cyclooxygenase)
Inhibitors  4522 Flufenamic acid  Cyclooxygenase inhibitor; NSAID 
0942 NS 398  Selective COX-2 inhibitor 
1418 Resveratrol  Cyclooxygenase inhibitor 
1550 SC 560  COX-1 inhibitor
4206 Valdecoxib  Potent and selective COX-2 inhibitor 
Other 4531 NCX 4040  NO-donating aspirin; decreases COX-2 expression 
     
Glucocorticoid Receptors
Agonists  3685 Corticosterone  Endogenous glucocorticoid 
2007 Fluticasone propionate  High affinity and selective glucocorticoid agonist 
Antagonists  1479 Mifepristone  Glucocorticoid receptor and progesterone receptor antagonist
Other  1126 Dexamethasone  Anti-inflammatory glucocorticoid 
4093 Hydrocortisone  Adrenal glucocorticoid; immunosuppressant 
     
H1 and H2 Histamine Receptors
Agonists  0646 HTMT dimaleate  H1 and H2 agonist 
2478 2-Pyridylethylamine dihydrochloride  H1 agonist
Antagonists  2429 Fexofenadine hydrochloride  H1 antagonist; non-sedating antiallergic agent 
1944 Loratidine  Peripheral H1 antagonist; antiallergic agent
     
H3 and H4 Histamine Receptors
Agonists  0729 Imetit dihydrobromide  Standard H3 and H4 agonist (H3 > H4) 
0932 Immepip dihydrobromide  Standard H3 agonist; also H4 agonist 
0569 (R)-(-)-α-Methylhistamine dihydrobromide Potent H3 agonist 
4769 VUF 10460  Selective H4 agonist 
Antagonists  3753 A 943931 dihydrochloride  Potent and selective H4 antagonist 
3743 BF 2649 hydrochloride  H3 inverse agonist/antagonist 
0752 Clobenpropit dihydrobromide  Highly potent H3 antagonist and H4 partial agonist 
4019 JNJ 10181457 dihydrochloride  H3 antagonist 
2441 JNJ 10191584 maleate  Selective H4 antagonist; orally active 
     
Leukotriene and Related Receptors
Agonists  2307 Leukotriene B4  BLT1/BLT2 receptor agonist; potent chemotactic factor 
Antagonists  3138 BAY-u 9773  Dual CysLT1 and CysLT2 antagonist
2208 LY 255283  Selective, competitive BLT2 receptor antagonist 
2338 MK 571  Potent CysLT1 (LTD4) inverse agonist; also MRP1 inhibitor 
1804 SR 2640 hydrochloride  Potent, selective LTD4/LTE4 receptor antagonist 
Other  2709 Cilastatin sodium  Dipeptidase inhibitor 
0607 17-ODYA  LTB4 ω-hydroxylase inhibitor 
     
LOX (Lipoxygenase)
Inhibitors  1761 Baicalein  5/12-LOX inhibitor 
2850 PD 146176  Selective 15-LOX inhibitor 
3308 Zileuton  Orally active 5-LOX inhibitor 
Other  1311 MK 886  Inhibitor of 5-lipoxygenase-activating protein (FLAP) 
     
Platelet-activating Factor (PAF) Receptors
Agonists  3022 Edelfosine  PAF receptor agonist; also inhibits PI-PLC 
2940 PAF (C16)  Endogenous PAF 
Antagonists  0571 PCA 4248  PAF receptor antagonist 
2339 WEB 2086  Potent PAF receptor antagonist
     
Prostanoid Receptors
Agonists  2038 Iloprost  Prostacyclin (PGI2) analog 
3351 NS 304  Selective prostacyclin IP1 receptor agonist 
2296 Prostaglandin E2  Major endogenous prostanoid 
4214 Prostaglandin F2α  Naturally-occurring prostanoid; potent vasoconstrictor 
1932 U 46619  Potent, stable thromboxane A2 (TP) receptor agonist 
Antagonists  0671 AH 6809  EP1 and EP2 antagonist 
4668 GW 627368  Selective EP4 competitive antagonist 
2514 L-161,982  Selective EP4 antagonist 
3342 L-798,106  Potent and highly selective EP3 antagonist
3565 ONO AE3 208  High affinity and selective EP4 antagonist 
4818 PF 04418948  Potent and selective EP2 antagonist 
3758 SC 51089  Selective EP1 antagonist