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제품안내 
항체,항원,킷트 Cell Signaling GPCR Product GPCR Inhibitor & Activator
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질병등에 관련된 class별 450여가지 이상의 G-Protein Coupled Receptors(GPCR) 타겟에 대한 agonist와 antagonist를 제공합니다. |
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| Tocris | |||
제품 문의하기
인쇄하기
| Class A: Rhodopsin-like | ||
| ▶ CXC Chemokine Receptors | ||
| Cat. No. | Product Name | Description |
| Agonist | ||
| 4780 | VUF 11207 | Potent CXCR7 (ACKR3) agonist |
| 5668 | VUF 11222 | High affinity non-peptide CXCR3 agonist |
| Antagonist | ||
| 3299 | AMD 3100 | Highly selective CXCR4 antagonist |
| 4179 | AMD 3465 | Potent, selective CXCR4 antagonist |
| 4487 | (±)-AMG 487 | CXCR3 antagonist; inhibits cell migration and metastasis |
| 5130 | CTCE 9908 | CXCR4 antagonist; antitumor |
| 4596 | IT1t | Potent CXCR4 antagonist |
| ▶ Estrogen (GPER) Receptors | ||
| Cat. No. | Product Name | Description |
| Agonist | ||
| 3577 | G-1 | Potent and selective GPER agonist |
| 1047 | ICI 182,780 | High affinity GPER agonist |
| Antagonist | ||
| 3678 | G-15 | High affinity and selective GPER antagonist |
| ▶ Angiotensin Receptors | ||
| Cat. No. | Product Name | Description |
| Agonist | ||
| 1158 | Angiotensin II | Potent vasoconstrictor peptide |
| 5728 | EXP 3174 | Potent and selective AT1 antagonist |
| Antagonist | ||
| 5798 | Irbesartan | Potent AT1 antagonist |
| 3798 | Losartan potassium | Selective, non-peptide AT1 antagonist |
| 1361 | PD 123319 | Potent, selective non-peptide AT2 antagonist |
| ▶ Bradykinin Receptors | ||
| Cat. No. | Product Name | Description |
| Agonist | ||
| 3004 | Bradykinin | Endogenous agonist at bradykinin receptors (B2 > B1) |
| Antagonist | ||
| 3014 | HOE 140 | Potent and selective B2 antagonist |
| ▶ δ Opioid Receptor | ||
| Cat. No. | Product Name | Description |
| Agonist | ||
| 0764 | SNC 80 | Highly selective non-peptide δ agonist |
| Antagonist | ||
| 0740 | Naltrindole | Selective non-peptide δ antagonist |
| ▶ κ Opioid Receptor | ||
| Cat. No. | Product Name | Description |
| Agonist | ||
| 3195 | Dynorphin A | Endogenous κ agonist |
| 5519 | (-)-Pentazocine | κ agonist; antinociceptive |
| 0496 | (-)-U-50488 | Standard selective κ agonist; more active enantiomer of (±)-U-50488 (Cat. No. 0495) |
| 0495 | (±)-U-50488 | Standard selective κ agonist |
| Antagonist | ||
| 0347 | nor-Binaltorphimine | Standard selective κ antagonist |
| ▶ μ Opioid Receptor | ||
| Cat. No. | Product Name | Description |
| Agonist | ||
| 1171 | DAMGO | Selective μ agonist |
| Antagonist | ||
| 1560 | CTAP | Selective and potent μ antagonist |
| 2601 | Cyprodime | Selective μ antagonist |
| 0926 | β-Funaltrexamine | Irreversible μ-selective antagonist |
| ▶ Orexin Receptors | ||
| Cat. No. | Product Name | Description |
| Agonist | ||
| 1455 | Orexin A (human, rat, mouse) | Endogenous agonist at OX1 and OX2 |
| 2142 | [Ala11,D-Leu15]-Orexin B | Potent, selective OX2 receptor agonist |
| 1456 | Orexin B (human) | Endogenous agonist at OX1 and OX2 |
| 1457 | Orexin B (mouse) | Endogenous agonist at OX1 and OX2 |
| Antagonist | ||
| 4983 | ACT 335827 | Potent and selective OX1 antagonist |
| 5319 | ACT 462206 | Potent, dual orexin receptor antagonist |
| 4558 | EMPA | Highly potent and selective OX2 antagonist; brain penetrant |
| 5645 | IPSU | OX2 receptor antagonist; orally bioavailable and brain penetrant |
| 4317 | JNJ 10397049 | Selective OX2 receptor antagonist |
| ▶ Ghrelin Receptor | ||
| Cat. No. | Product Name | Description |
| Agonist | ||
| 1463 | Ghrelin (human) | Endogenous ghrelin receptor agonist |
| 1465 | Ghrelin (rat) | Endogenous ghrelin receptor agonist |
| 5272 | MK 0677 | High affinity ghrelin receptor agonist |
| Antagonist | ||
| 1922 | [D-Lys3]-GHRP-6 | Ghrelin receptor antagonist |
| 3959 | YIL 781 | Ghrelin receptor (GHS-R1a) antagonist |
| ▶ Motilin Receptor | ||
| Cat. No. | Product Name | Description |
| Agonist | ||
| 2264 | Motilin (human, porcine) | Endogenous motilin receptor agonist |
| Antagonist | ||
| 5074 | ANQ 11125 | Selective motilin receptor antagonist |
| 4934 | MA 2029 | Potent and selective motilin receptor antagonist; orally active |
| ▶ Dopamine D1/D5 Receptors | ||
| Cat. No. | Product Name | Description |
| Agonist | ||
| 1701 | A 77636 | Potent, selective D1-like agonist; orally active |
| 0884 | Dihydrexidine | Selective D1-like agonist |
| 0922 | SKF 38393 | Selective D1-like agonist |
| 1447 | SKF 81297 | D1 agonist |
| 2074 | SKF 83959 | D1-like partial agonist |
| Antagonist | ||
| 0925 | SCH 23390 | Standard selective D1-like antagonist; also 5-HT2C and 5-HT1C agonist |
| 2299 | SCH 39166 | High affinity D1/D5 antagonist |
| 1586 | SKF 83566 | Potent, selective D1-like antagonist |
| ▶ Dopamine D2/D3/D4 Receptors | ||
| Cat. No. | Product Name | Description |
| Agonist | ||
| 4552 | A 412997 | Selective D4 agonist |
| 1243 | (+)-PD 128907 | D3 agonist (D3 ≥ D2 > D4) |
| 1065 | PD 168077 | High affinity, selective D4 agonist |
| 2773 | Sumanirole | D2-selective agonist |
| Antagonist | ||
| 1847 | Eticlopride | Selective D2/D3 antagonist |
| 1003 | L-741,626 | High affinity D2 antagonist |
| 1004 | L-741,742 | Highly selective D4 antagonist |
| 1002 | L-745,870 | Highly selective D4 antagonist |
| 4207 | SB 277011A | Selective D3 antagonist |
| ▶ Histamine Receptors | ||
| Cat. No. | Product Name | Description |
| Agonist | ||
| 0646 | HTMT | H1 / H2 agonist |
| 0569 | (R)-(-)-α-Methylhistamine | Potent, standard H3 agonist |
| 2342 | 4-Methylhistamine | Selective, high affinity H4 agonist |
| 2478 | 2-Pyridylethylamine | H1 receptor agonist |
| Antagonist | ||
| 3489 | Astemizole | Orally active, potent H1 antagonist; also KV11.1 (hERG) channel blocker |
| 3743 | BF 2649 | H3 receptor inverse agonist/antagonist |
| 0508 | Doxepin | Highly potent H1 antagonist; also binds to H4 receptor |
| 4021 | JNJ 7777120 | Selective H4 receptor antagonist |
| 0660 | Mepyramine | Selective H1 inverse agonist |
| 1070 | Zolantidine | Potent, centrally active H2 antagonist |
| Class B: Secretin-like | ||
| ▶ Glucagon Receptor | ||
| Cat. No. | Product Name | Description |
| Antagonist | ||
| 2216 | des-His1-[Glu9]-Glucagon (1-29) | Glucagon receptor antagonist |
| 2311 | L-168,049 | Potent, human glucagon receptor antagonist; orally active |
| Other | ||
| 2094 | Oxyntomodulin | Endogenous gut peptide; modulates feeding and metabolism |
| ▶ Glucagon-like Peptide Receptors | ||
| Cat. No. | Product Name | Description |
| Agonist | ||
| 1933 | Exendin-4 | Potent GLP-1 receptor agonist |
| 2082 | Glucagon-like peptide 1 (7-36) (human, rat) |
Potent insulinotropic peptide |
| 5374 | GLP-1 (7-37) | Endogenous bioactive GLP-1 receptor ligand |
| Antagonist | ||
| 2081 | Exendin-3 (9-39) | Potent GLP-1 receptor antagonist |
| 3266 | GLP-1 (9-36) | Metabolite of GLP-1-(7-36) (Cat. No. 2082) |
| Modulators | ||
| 4778 | BETP | Positive allosteric modulator of GLP-1 receptors |
| ▶ Parathyroid Hormone (PTH) Receptors | ||
| Cat. No. | Product Name | Description |
| Agonist | ||
| 5487 | DPC AJ1951 | Potent PTH receptor agonist |
| 3011 | Parathyroid Hormone (1-43) (hunan) | PTH receptor agonist |
| Class C: Glutamate | ||
| ▶ GABAB Receptor | ||
| Cat. No. | Product Name | Description |
| Agonist | ||
| 0796 | (R)-Baclofen | Selective GABAB agonist; active enantiomer of (RS)-Baclofen |
| 3400 | RuBi-GABA | Caged GABA; excitable by visible wavelength |
| Antagonist | ||
| 1245 | CGP 35348 | Brain penetrant, selective GABAB antagonist |
| 1246 | CGP 52432 | Potent, selective GABAB antagonist |
| 1088 | CGP 54626 | Potent, selective GABAB antagonist |
| 1248 | CGP 55845 | Potent, selective GABAB antagonist |
| 0984 | SCH 50911 | Selective, competitive, orally active GABAB antagonist |
| Modulators | ||
| 1513 | CGP 7930 | Positive modulator at GABAB receptors |
| ▶ Glutamate (Metabotropic) Receptors | ||
| Cat. No. | Product Name | Description |
| Agonist | ||
| 0187 | (±)-trans-ACPD | Group I/group II mGlu agonist |
| 1049 | CHPG | mGlu5 selective agonist |
| 3695 | CHPG Sodium salt | Selective mGlu5 agonist; sodium salt of CHPG |
| 0342 | (RS)-3,5-DHPG | Selective group I mGlu agonist |
| 0805 | (S)-3,5-DHPG | Selective group I mGlu agonist; active enantiomer of 3,5-DHPG |
| 0188 | L-Quisqualic acid | Group I mGlu agonist; also AMPA receptor agonist |
| Antagonist | ||
| 5614 | AZD 2066 | mGlu5 antagonist; orally bioavailable and brain penetrant |
| 2501 | Bay 36-7620 | Non-competitive mGlu1 antagonist with inverse agonist activity |
| 0323 | (S)-4-Carboxyphenylglycine | Competitive group I mGlu antagonist/weak group II agonist |
| 1028 | CPCCOEt | Selective non-competitive mGlu1 receptor antagonist |
| 2333 | JNJ 16259685 | Highly potent, mGlu1-selective non-competitive antagonist |
| 1237 | LY 367385 | Selective mGlu1a antagonist |
| Modulators | ||
| 5322 | VU 0409106 | Potent and selective negative allosteric modulator at mGlu5 |
| GPCR Signaling | ||
| ▶ Adenylyl Cyclase | ||
| Cat. No. | Product Name | Description |
| Activators | ||
| 1099 | Forskolin | Adenylyl cyclase activator |
| 1603 | NKH 477 | Water-soluble adenylyl cyclase activator |
| Inhibitors | ||
| 1435 | SQ 22536 | Adenylyl cyclase inhibitor |
| ▶ cAMP | ||
| Cat. No. | Product Name | Description |
| Others | ||
| 5255 | 6-Bnz-cAMP sodium salt | Cell permeable cAMP analog |
| 1140 | 8-Bromo-cAMP, sodium salt | Cell-permeable cAMP analog |
| 1337 | cAMPS | cAMP antagonist |
| 1333 | cAMPS-Sp | Cell-permeable cAMP analog |
| 1141 | Dibutyryl-cAMP, sodium salt | Cell-permeable cAMP analog |
| ▶ Phospholipases | ||
| Cat. No. | Product Name | Description |
| Inhibitors | ||
| 1437 | D609 | Selective PC-PLC inhibitor |
| 3022 | Edelfosine | Selective PI-PLC inhibitor; also PAF receptor agonist |
| 3600 | FIPI | Phospholipase D inhibitor |
| 1268 | U 73122 | Phospholipase C inhibitor |
| 3575 | VU 0155069 | Potent and selective PLD1 inhibitor |
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