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 제품안내  분자생물학   Protein Research  Protein Kinase Research

Protein Kinase Inhibitors & Activators

Kinase 타겟별 Inhibitor, Activator를 소개합니다.

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특징

AGC Group
Akt/PKB (Protein Kinase B)
Cat. No. Product Name Description
Activators    
4635 SC 79 Akt activator
Inhibitors    
3897 API-1 Selective Akt/PKB inhibitor; antitumor
2151 API-2 Selective inhibitor of Akt/PKB signalling; antitumor and antiviral
2558 10-DEBC hydrochloride Selective Akt/PKB inhibitor
2926 FPA 124 Akt/PKB inhibitor
4144 GSK 690693 Akt kinase inhibitor; antitumor
4598 PHT 427 Dual Akt and PDK1 inhibitor; antitumor
MSK (Mitogen- and Stress-activated Protein Kinase)
Cat. No. Product Name Description
Inhibitors    
4630 SB 747651A dihydrochloride Potent MSK1 inhibitor; also inhibits other AGC group kinases
PDK1 (Phosphoinositide-dependent Kinase 1)
Cat. No. Product Name Description
Activators    
4087 PS 48 PDK1 activator
Inhibitors    
3606 BAG956 Dual PDK1 and PI 3-kinase inhibitor
4318 BX 795 PDK1 inhibitor
4143 GSK 2334470 Potent and selective PDK1 inhibitor
4598 PHT 427 Dual PDK1 and Akt inhibitor; antitumor
PKA (Protein Kinase A)
Cat. No. Product Name Description
Activators    
1140 8-Bromo-cAMP, sodium salt Cell permeable cAMP analog; activates PKA
1333 cAMPS-Sp, triethylammonium salt Cell permeable cAMP analog; activates PKA
Inhibitors    
1337 cAMPS-Rp, triethylammonium salt cAMP antagonist; inhibits PKA activation
2910 H 89 dihydrochloride PKA inhibitor
1288 KT 5720 Selective PKA inhibitor
1904 PKA inhibitor fragment (6-22) amide Potent PKA inhibitor
2546 PKI 14-22 amide, myristoylated Cell-permeable PKA inhibitor
PKC (Protein Kinase C)
Cat. No. Product Name Description
Activators    
2383 Bryostatin 1 High affinity PKC activator
5237 Bryostatin 2 PKC activator; analog of Bryostatin 1
5238 Bryostatin 3 Potent PKC activator
3091 FR 236924 Selective PKCε activator
4054 PEP 005 PKC activator
4153 Phorbol 12, 13-dibutyrate PKC activator
1201 Phorbol 12-myristate 13-acetate PKC activator
1790 Pseudo RACK1 PKC activator peptide (attached to cell permeable vector)
Inhibitors    
4128 Bisindolylmalemide II Potent PKC inhibitor; also nicotinic receptor antagonist
1626 Calphostin C Potent, selective and photo-dependent PKC inhibitor
2442 CGP 53353 Selective inhibitor of PKCβII
1330 Chelerythrine chloride Cell-permeable PKC inhibitor
0741 GF 109203X PKC inhibitor
2253 Go 6976 Potent PKC inhibitor; selective for α and β isozymes
2285 Go 6983 Broad spectrum PKC inhibitor
2287 K-252c PKC inhibitor
4738 LY 333531 hydrochloride PKC inhibitor; selective for β isozymes
0609 (±)-Palmitorylcarnitine chloride PKC inhibitor
4058 PKC (19-36) Pseudosubstrate peptide; inhibitor of PKC
2992 PKC 412 PKC inhibitor
1792 PKCβ pseudosubstrate Selective PKC inhibitor peptide (attached to vector); cell-permeable
1791 PKCζ pseudosubstrate PKCζ inhibitor peptide (attached to cell-permeable vector)
1587 Ro 32-0432 hydrochloride Potent PKC inhibitor; orally active
1610 Rottlerin Reported PKCδ inhibitor
2549 ZIP Cell-permeable inhibitor of atypical PKC isozyme PKMζ
3290 ZIP, Biotinylated Biotinylated peptide for ZIP
3215 ZIP (Scrambled) Control peptide for ZIP
PKG (Protein Kinase G)
Cat. No. Product Name Description
Inhibitors    
1289 KT 5823 Selective PKG inhibitor
3028 Rp-8-Br-PET-cDMPS PKG inhibitor
ROCK (Rho-kinase)
Cat. No. Product Name Description
Inhibitors    
4927 AS 1892802 Potent ROCK inhibitor; orally bioavailable
0541 Fasudil hydrochloride ROCK inhibitor; also inhibits PKA
2485 Glycyl-H 1152 dihydrochloride Selective ROCK inhibitor; more selective analog of H 1152 dihydrochloride
4009 GSK 269962 Potent and selective ROCK inhibitor
3726 GSK 429286 Selective ROCK inhibitor
2414 H 1152 dihydrochloride Selective ROCK inhibitor
5061 RKI 1447 dihydrochloride Potent and selective ROCK inhibitor; antitumor
4118 SB 772077B dihydrochloride Potent ROCK inhibitor; vasodilator
3667 SR 3677 dihydrochloride Potent, selective ROCK inhibitor
1254 Y-27632 dihydrochloride Selective p160ROCK inhibitor
RSK (Ribosomal S6 Protein Kinase)
Cat. No. Product Name Description
Inhibitors    
4037 BRD 7389 p90 RSK inhibitor
4032 PF 4708671 S6K1 inhibitor
2250 SL 0101-1 Selective p90 RSK inhibitor
SGK (Serum- and Glucocorticoid-regulated Kinase)
Cat. No. Product Name Description
Inhibitors    
3572 GSK 650394 Selective SGK inhibitor

CAMP Group
AMPK (AMP-activated Protein Kinase)
Cat. No. Product Name Description
Activators    
3336 A 769662 Potent AMPK activator
2840 AICAR AMPK activator; cell permeable
3713 Cryptotanshinone AMPK activator; displays multiple other activities
2864 Metformin hydrochloride Activator of LKB1/AMPK; antidiabetic agent
4039 PT 1 AMPK activator
5138 RSVA 405 AMPK activator; also STAT3 inhibitor
5285 ZLN 024 hydrochloride Allosteric AMPK activator
Inhibitors    
3093 Dorsomorphin dihydrochloride Potent and selective AMPK inhibitor
CaMK II (Calmodulin-dependent Kinase II)
Cat. No. Product Name Description
Inhibitors    
2457 Arcyriaflavin A Potent CaMK II and cdk4/cyclin D1 inhibitor; antiviral agent
1688 Autocamtide020related inhibitory peptide Selective CaMK II inhibitor
1277 KN-62 CaMK II inhibitor; also P2X7 antagonist
1278 KN 93 CaMK II inhibitor; also K+ channel blocker (Kv)
5215 KN 93 phosphate CaMK II inhibitor; water soluble version of KN 93
Chk (Checkpoint Kinase)
Cat. No. Product Name Description
Inhibitors    
5199 AZD 7762 hydrochloride Potent and selective Chk1 and Chk2 inhibitor
3034 NSC 109555 ditosylate Selective Chk2 inhibitor
2694 PD 407824 Selective inhibitor of Chk1 and Wee1
4277 PF 477736 Selective Chk1 inhibitor
2560 SB 218078 Chk1 inhibitor
3038 TCS 2312 Potent Chk1 inhibitor
DAPK (Death-associated Protein Kinase)
Cat. No. Product Name Description
Inhibitors    
4301 TC-DAPK 6 Potent and selective inhibitor of DAPK1
MK2 (MAPK-activated Protein Kinase 2)
Cat. No. Product Name Description
Inhibitors    
4279 PF 3644022 Potent MK2 inhibitor
3140 PHA 767491 hydrochloride MK2 inhibitor ; also inhibits cdc7/cdk9
MLCK (Myosin Light Chain Kinase)
Cat. No. Product Name Description
Inhibitors    
4310 ML 7 hydrochloride Selective inhibitor of MLCK
0431 ML 9 hydrochloride MLCK inhibitor
1885 MLCK inhibitor peptide 18 Selective inhibitor of MLCK
0369 W-7 hydrochloride MLCK inhibitor; also calmodulin antagonist
MNK (MAPK-interacting Kinase)
Cat. No. Product Name Description
Inhibitors    
4500 Cercosporamide Potent Mnk2 inhibitor
2731 CGP 57380 Selective inhibitor of Mnk1
5183 ETP 45835 dihydrochloride Mnk1 and Mnk2 inhibitor
NUAK
Cat. No. Product Name Description
Inhibitors    
5177 WZ 4003 Potent and selective NUAK1/2 inhibitor
Pim Kinase
Cat. No. Product Name Description
Inhibitors    
3589 PIM-1 inhibitor 2 Pim-1 kinase inhibitor
2979 TCS PIN-1 1 Selective, ATP-competitive Pim-1 inhibitor
PKD (Protein Kinase D)
Cat. No. Product Name Description
Inhibitors    
4644 CID 2011756 Pan PKD inhibitor; cell permeable
3327 CID 755673 Selective PKD inhibitor
4975 CRT 0066101 Potent PKD inhibitor
3962 kb NB 142-70 Selective PKD inhibitor; analog og CID 755673
SIK (Salt Inducible Kinase)
Cat. No. Product Name Description
Inhibitors    
5134 MRT 67307 dihydrochloride SIK inhibitor
STK33 (Serine/Threonine Kinase 33)
Cat. No. Product Name Description
Inhibitors    
4880 ML 281 STK33 inhibitor
CK1 Group
CK1 (Casein Kinase 1)
Cat. No. Product Name Description
Inhibitors    
5329 CKI 7 dihydrochloride CK1 inhibitor
3605 (R)-CR8 CK1 inhibitor; also inhibits cdk1/cdk5
2902 D 4476 Selective CK1 inhibitor; also inhibits TGF-βRI
3610 (R)-DRF053 dihydrochloride Dual CK1/cdk inhibitor
4896 LH 846 Selective CK1δ inhibitor 
4281 PF 4800567 hydrochloride Selective CK1ε inhibitor
3316 PF 670462 Potent and selective CK1ε and CK1δ inhibitor
CMGC Group
Cdk (Cyclin-dependent Kinase)
Cat. No. Product Name Description
Inhibitors    
2072 Aminopurvalanol A Cdk inhibitor
2457 Arcyriaflavin A Potent cdk4/cyclin D1 and CaM kinase II inhibitor; antiviral agent
3968 AZD 5438 Potent cdk1, cdk2 and cdk9 inhibitor
3605 (R)-CR8 Dual cdk1/cdk5 inhibitor; also inhibits CK1
3610 (R)-DRF053 dihydrochloride Dual cdk/CK1 inhibitor
1398 Kenpaullone Potent cdk inhibitor; also inhibits GSK-3 
2152 NSC 625987 Cdk4 inhibitor
3135 NU 2058 Cdk1 and cdk2 inhibitor
3301 NU 6140 Cdk2 inhibitor
1284 Olomoucine Cdk inhibitor
4786 PD 0332991 isethionate Potent, selective cdk4/6 inhibitor; brain penetrant
3140 PHA 767491 hydrochloride Dual cdk9/cdc7 inhibitor; also inhibits MK2
1580 Purvalanol A Cdk inhibitor
1581 Purvalanol B Cdk inhibitor
4181 Ro 3306 Cdk1 inhibitor
2609 Ryuvidine Cdk4 inhibitor; also SETD8 inhibitor
4875 Senexin A Cdk8 inhibitor
4075 SNS 032 Potent cdk2, cdk7 and cdk9 inhibitor
2907 SU 9516 Potent cdk2 inhibitor
CK2 (Casein Kinase 2)
Cat. No. Product Name Description
Inhibitors    
2275 TBB Selective CK2 inhibitor; cell-permeable
4432 TTP 22 High affinity, selective CK2 inhibitor
Clk (Cdc2-like Kinase)
Cat. No. Product Name Description
Inhibitors    
4336 TG 003 Potent, ATP-competitive inhibitor of Clk-family kinases
DYRK (Dual-specificity Tyrosine Phosphorylation-regulated Kinase)
Cat. No. Product Name Description
Inhibitors    
5075 Harmine Potent and selective DYRK1A inhibitor
4997 INDY DYRK1A/B inhibitor
4998 ProINDY DYRK1A/B inhibitor; prodrug of INDY
ERK (Extracellular Signal-regulated Kinase)
Cat. No. Product Name Description
Inhibitors    
3706 FR 180204 Selective ERK inhibitor
4433 Pluripotin Dual ERK1/RasGAP inhibitor; maintains ESC self-renewal
4465 TCS ERK 11e Potent and selective ERK2 inhibitor
3675 TMCB Dual ERK8 and CK2 inhibitor
4132 XMD 8-92 Selective ERK5/BMK1 inhibitor
GSK-3 (Glycogen Synthase Kinase)
Cat. No. Product Name Description
Inhibitors    
4083 3F8 Potent and selective GSK-3β inhibitor
4431 A 1070722 Highly potent, selective GSK-3 inhibitor
3966 AR-A 014418 Selective GSK-3 inhibitor
3194 BIO Potent, selective GSK-3 inhibitor
3874 BIO-acetoxime Selective GSK-3α/β inhibitor
4423 CHIR 99021 Highly selective GSK-3 inhibitor
4953 CHIR 99021 trihydrochloride Hydrochloride salt of CHIR 99021; selective GSK-3 inhibitor
2256 L803-mts Selective inhibitor of  GSK-3
1616 SB 216763 Potent, selective GSK-3 inhibitor
1617 SB 215286 Potent, selective GSK-3 inhibitor
4353 TC-G 24 Potent and selective GSK-3β inhibitor
3969 TCS 2002 Potent GSK-3β inhibitor
4221 TCS 21311 Potent GSK-3β inhibitor; also inhibits JAK3 and PKC
3835 TWS 119 GSK-3β inhibitor; induces neuronal differentiation in ESCs
JNK (c-Jun N-terminal Kinase)
Cat. No. Product Name Description
Activator    
1290 Anisomycin JNK, SAPK and p38 activator
Inhibitors    
2651 AEG 3482 Inhibitor of JNK signaling
3314 BI 78D3 Selective, competitive JNK inhibitor
4924 CEP 1347 Inhibitor of JNK signaling; neuroprotective
1989 c-JUN peptide Peptide inhibitor of JNK/c-Jun interaction
4550 IQ 3 Selective JNK3 inhibitor
1496 SP 600125 Selective JNK inhibitor
5044 SR 3576 Highly potent and selective JNK3 inhibitor
3607 SU 3327 Selective JNK inhibitor
2827 TCS JNK 5a Selective inhibitor of JNK2 and JNK3
3222 TCS JNK 6o Selective JNK inhibitor
p38 MAPK
Cat. No. Product Name Description
Inhibitors    
4753 AL 8697 Potent and selective p38α inhibitor
2186 CMPD-1 Non-ATP-competitive p38α inhibitor
5095 DBM 1285 dihydrochloride p38 MAPK inhibitor; anti-inflammatory
2908 EO 1428 Selective inhibitor of p38α and p38β2
2657 JX 401 Potent, reversible p38α inhibitor
4586 ML 3403 p38 inhibitor
2999 RWJ 67657 Potent, selective p38α  and p38β inhibitor
1264 SB 202190 Potent, selective inhibitor of p38 MAPK
1202 SB 203580 Selective inhibitor of p38 MAPK
1402 SB 203580 hydrochloride Selective inhibitor of p38 MAPK; water-soluble
1962 SB 239063 Potent, selective p38 MAPK inhibitor; orally active
5040 SB 706504 p38 MAPK inhibitor
3528 SCIO 469 hydrochloride Selective p38 MAPK inhibitor
2008 SKF 86002 dihydrochloride p38 MAPK inhibitor; anti-inflammatory agent
4254 TAK 715 Potent p38 MAPK inhibitor; anti-inflammatory
3916 VX 702 Orally active p38α and p38β inhibitor
3915 VX 745 Potent and selective p38α inhibitor
SRPK (Serine Arginine Protein Kinase)
Cat. No. Product Name Description
Inhibitors    
5063 SRPIN340 Selective SRPK1 inhibitor

STE Group
ASK (Apoptosis Signal-regulated Kinase 1)
Cat. No. Product Name Description
Inhibitors    
4429 NQDI 1 ASK1 inhibitor
4825 TC ASK 10 Potent and selective ASK1 inhibitor; orally bioavailable
MEK (Mitogen-activated Protein Kinase Kinase)
Cat. No. Product Name Description
Inhibitors    
1777 Arctigenin Potent MEK1 inhibitor; also inhibits IκBα phosphorylation
4842 BIX 02189 Selective MEK5 and ERK5 inhibitor
4192 PD 0325901 Potent inhibitor of MEK1/2
4237 PD 184352 Selective MEK inhibitor
2605 PD 198306 Selective inhibitor of MEK1/2
4824 PD 334581 MEK1 inhibitor
1213 PD 98059 MEK inhibitor
1969 SL 327 Selective inhibitor of MEK1 and MEK2; brain penetrant
1868 U0124 Inactive analog of U0126
1144 U0126 Potent, selective inhibitor of MEK1/2
Cat. No. Product Name Description
Inhibitors    
5190 FRAX 486 Potent PAK inhibitor; brain penetrant and orally bioavailable
3622 IPA 3 Group I PAK inhibitor
4212 PIR 3.5 Negative control of IPA 3
TK Group
Abl
Cat. No. Product Name Description
Inhibitors    
 3716 Adaphostin  p210Bcr-Abl kinase inhibitor
4274 AP 24534 Potent multi-kinase and pan-Bcr-Abl inhibitor
4361 Bosutinib Dual Abl/Src inhibitor; antiproliferative
4399 GNF 2 Selective allosteric inhibitor of Bcr-Abl tyrosine kinase activity
4908 GNF 5 Selective allosteric inhibitor of Bcr-Abl; analog of GNF 2 (Cat. No. 4399)
4730 PPY A Potent inhibitor of Abl T315l mutant and wild-type Abl kinases
Ack (Activated Cdc42 Kinase)
Cat. No. Product Name Description
Inhibitors    
4946 AIM 100 Potent and selective Ack1 inhibitor
5098 KRCA 0008 Potent Ack1 and ALK dual inhibitor; orally bioavailable
ALK (Anaplastic Lymphoma Kinase)
Cat. No. Product Name Description
Inhibitors    
 5310 ASP 3026 ALK inhibitor 
4368 Crizotinib Potent ALK/c-MET inhibitor
5111 GSK 1838705 Potent ALK inhibitor; also IR and IGF1R inhibitor 
5098 KRCA 0008 Potent ALK and Ack1 dual inhibitor; orally bioavailable
BTK (Bruton’s Tyrosine Kinase)
Cat. No. Product Name Description
Inhibitors    
 1300 LFM-A13 Potent, selective BTK inhibitor
4710 PF 06465469 Potent BTK inhibitor; also inhibits interleukin-2 inducible T cell kinase (ITK)
1405 (-)-Terreic acid Selective inhibitor of BTK
EGFR (Epidermal Growth Factor Receptor)
Cat. No. Product Name Description
Inhibitors    
1276 AG 1478 hydrochloride Highly potent EGFR-kinase inhibitor
0414 AG 490 EGFR-kinase inhibitor; also JAK2/3 inhibitor
2417 BIBU 1361 dihydrochloride Selective inhibitor of EGFR-kinase
2416 BIBX 1382 dihydrochloride Highly selective EGFR-kinase inhibitor 
5022 BMS 599626 dihydrochloride Potent, selective EGFR and ErbB2 inhibitor 
3360 CGP 52411 EGFR inhibitor; also inhibits Aβ42 fibril formation
1110 Genistein EGFR-kinase inhibitor; also estrogen and PPARγ ligand
2239 GW 583340 dihydrochloride Potent dual EGFR/ErbB2 inhibitor; orally active
2646 HDS 029 Potent inhibitor of the ErbB receptor family
3580 HKI 357 Dual irreversible inhibitor of ErbB2 and EGFR
3000 Iressa Selective EGFR inhibitor; orally active
3352 JNJ 28871063 hydrochloride Potent ErbB receptor family inhibitor 
1037 PD 153035 hydrochloride EGFR-kinase inhibitor
2615 PD 158780 Potent ErbB receptor family inhibitor
4941 PKI 166 hydrochloride Potent EGFR-kinase inhibitor
2794 PP 3 EGFR-kinase inhibitor
3599 TAK 165 Potent and selective ErbB2 inhibitor 
3115 WHI-P 154 Potent EGFR inhibitor; also inhibits JAK3
Ephrins
Cat. No. Product Name Description
Inhibitors    
5290 KYL EphA4 receptor inhibitor; neuroprotective
4405 NVP BHG 712 Potent EphB4 kinase inhibitor
FAK (Focal Adhesion Kinase)
Cat. No. Product Name Description
Inhibitors    
3414 FAK Inhibitor 14  Selective FAK inhibitor
4278 PF 431396 Dual FAK/PYK2 inhibitor
3239 PF 573228 Potent and selective FAK inhibitor
4498  Y 11 Potent and selective FAK inhibitor
FGFR (Fibroblast Growth Factor Receptor)
Cat. No. Product Name Description
Inhibitors    
4002 FIIN 1 hydrochloride Potent, irreversible FGFR inhibitor
3724 PD 161570 Selective FGFR inhibitor 
3785 PD 166285 dihydrochloride FGFR1 inhibitor; also inhibits Src, PDGFRβ and Wee1
3044 PD 173074 FGFR1/3 inhibitor
3300 SU 5402 Potent FGFR and VEGFR inhibitor
Other    
 4826 SUN 11602 Basic FGF (bFGF) mimetic; neuroprotective
FLT3 (Fms-like Receptor Tyrosine Kinase-3)
Cat. No. Product Name Description
Inhibitors    
4033 5ʹ-Fluoroindirubinoxime  FLT3 inhibitor; displays antiproliferative activity
3395 Lestaurtinib JAK2, FLT3 and TrkA inhibitor
2591 TCS 359 Potent FLT3 inhibitor
IRs and IGFRs (Insulin and Insulin-like Receptors)
Cat. No. Product Name Description
Activators    
1819 Demethylasterriquinone B1 Selective IR activator
3435 Insulin (human) recombinant Endogenous peptide agonist
Inhibitors    
4774 BMS 536924 Dual IR/IGF1R inhibitor 
5111 GSK 1838705 Potent IR and IGF1R inhibitor; also inhibits anaplastic lymphoma kinase (ALK)
5247 NVP ADW 742 ATP-competitive inhibitor of IGF1R
2956 Picropodophyllotoxin Selective IGF1R inhibitor 
2768 PQ 401 IGF1R inhibitor
ITK (IL-2-inducible T cell kinase)
Cat. No. Product Name Description
Inhibitors    
 5009 BMS 509744 Potent and selective ITK kinase inhibitor 
JAK (Janus Kinase)
Cat. No. Product Name Description
Inhibitors    
4580 Atiprimod dihydrochloride JAK2 inhibitor
4556 CP 690550 citrate Potent JAK inhibitor
1571 Cucurbitacin I Selective inhibitor of JAK2/STAT3 signaling
4338 NSC 33994 JAK2 inhibitor
3035 SD 1008 JAK2/STAT3 signaling pathway inhibitor
3115 WHI-P 154 JAK3 kinase inhibitor; also inhibits EGFR
1367 ZM 39923 hydrochloride Potent, selective JAK3 inhibitor
1366 ZM 449829 Potent, selective JAK3 inhibitor
MET Receptor
Cat. No. Product Name Description
Inhibitors    
4368 Crizotinib Potent c-MET/ALK inhibitor
4239 PF 04217903 mesylate Highly selective c-MET inhibitor 
2693 PHA 665752 Potent and selective MET inhibitor
4101 SU 11274 Selective inhibitor of MET kinase activity
PDGFR (Platelet-derived Growth Factor Receptor)
Cat. No. Product Name Description
Inhibitors    
1222 DMPQ dihydrochloride Potent, selective inhibitor of PDGFRβ
3304 SU 16f Potent and selective PDGFRβ inhibitor
Src
Cat. No. Product Name Description
Inhibitors    
4582 MLR 1023 Selective allosteric activator of Lyn kinase
3914 A 419259 trihydrochloride Inhibitor of Src family kinases
3963 AZM 475271 Src kinase inhibitor
4361 Bosutinib Dual Src/Abl inhibitor; antiproliferative
4660 KB SRC 4 Potent and selective c-Src inhibitor
3063 1-Naphthyl PP1 Src family kinase inhibitor; also inhibits c-Abl
1554 Piceatannol p56lck and Syk kinase inhibitor
1397 PP 1 Potent, selective Src family kinase inhibitor
1407 PP 2 Potent, selective Src family kinase inhibitor
2794 PP 3 Negative control for PP 2
3642 Src I1 Dual site Src kinase inhibitor
Other    
 2265 Lyn peptide inhibitor Inhibits Lyn-dependent activities of IL-5 receptor; cell-permeable
Syk (Spleen Tyrosine Kinase)
Cat. No. Product Name Description
Inhibitors    
2471 ER 27319 maleate Selective Syk kinase inhibitor
1554 Piceatannol Syk and p56lck kinase inhibitor
Trk Receptors
Cat. No. Product Name Description
Agonists    
2837 BDNF (human)  Activates TrkB and p75 receptors 
3826 7,8-Dihydroxyflavon e TrkB agonist
4607 LM 22A4 Potent TrkB agonist
Antagonists    
4781 ANA 12 TrkB receptor antagonist
5062 Cyclotraxin B TrkB receptor antagonist
Inhibitors    
 4559 GNF 5837  Potent Trk inhibitor; inhibits TrkA, TrkB and TrkC 
2238 GW 441756 Potent, selective TrkA inhibitor
Other    
5046 LM11A 31 dihydrochloride Nonpeptide p75NTR ligand; neuroprotective
5101 PD 90780 Inhibits NGF binding to p75NTR
2272 Ro 08-2750 Inhibits NGF binding to p75NTR and TrkA
VEGFR (Vascular Endothelial Growth Factor)
Cat. No. Product Name Description
Inhibitors    
4350 Axitinib Potent VEGFR-1, -2 and -3 inhibitor
4471 DMH4 Selective VEGFR-2 inhibitor
2542 Ki 8751 Potent, selective VEGFR-2 inhibitor
3768 Sunitinib malate Potent VEGFR, PDGFRβ and KIT inhibitor
5422 XL 184 Potent VEGFR inhibitor; also inhibits other RTKs
2499 ZM 306416 hydrochloride VEGFR inhibitor
2475 ZM 323881 hydrochloride Potent, selective inhibitor of VEGFR-2
Other RTKs
Cat. No. Product Name Description
Inhibitors    
5077 DDR1-IN-1 dihydrochloride Selective DDR1 inhibitor 
4481 Ki 20227 c-Fms inhibitor; suppresses osteolysis and osteoclast accumulation
5102 PLX 647 dihydrochloride Potent dual Fms/KIT inhibitor
Multi-TK Inhibitors
Cat. No. Product Name Description
Inhibitors    
5318 AEE 788 Potent EGFR and VEGFR inhibitor
2086 GTP 14564 Class III receptor tyrosine kinase (RTK) inhibitor
4965 PD 180970 p210Bcr/Abl kinase inhibitor; also inhibits c-Src and KIT 
4885 R 1530 Multi-RTK inhibitor; inhibits angiogenesis
3037 SU 5416 VEGFR inhibitor; also inhibits KIT, RET, MET and FLT3
3335 SU 6668 PDGFR, VEGFR and FGFR inhibitor
3909 Toceranib Potent PDGFR and VEGFR inhibitor
TKL Group
BMP and Other Activin Receptors
Cat. No. Product Name Description
Inhibitors    
4126 DMH-1 Selective ALK2 inhibitor
4986 K 02288 Type 1 BMP receptor inhibitor
4945 ML 347 Potent and selective ALK1 and ALK2 inhibitor
Other    
4490 Alantolactone Antiproliferative; induces activin/SMAD3 signaling
LIMK
Cat. No. Product Name Description
Inhibitors    
4745 LIMKi 3 Potent LIM kinase inhibitor; antitumor
5269 T 5601640 Selective LIMK2 inhibitor; antitumor
LRRK2 (Leucine-rich Repeat Kinase 2)
Cat. No. Product Name Description
Inhibitors    
4534 CZC 54252 hydrochloride Potent LRRK2 inhibitor; neuroprotective
4629 GSK2578215A Potent, selective LRRK2 inhibitor; brain penetrant
4273 LRRK2-IN-1 Potent and selective LRRK2 inhibitor
Raf
Cat. No. Product Name Description
Inhibitors    
4836 AZ 628 Potent Raf kinase inhibitor
4453 GDC 0879 Potent B-Raf inhibitor
1381 GW 5074 Potent, selective c-Raf1 kinase inhibitor
3185 L-779,450 Potent Raf kinase inhibitor
5036 ML 786 dihydrochloride Potent Raf kinase inhibitor; orally bioavailable 
2650 SB 590885 Potent B-Raf inhibitor
1321 ZM 336372 Potent, selective c-Raf inhibitor
RIPK1 (Receptor-interacting Protein Kinase 1)
Cat. No. Product Name Description
Inhibitors    
2324 Necrostatin-1 RIPK1 inhibitor; inhibits necroptosis
TAK1 (TGF-β-activated Kinase 1)
Cat. No. Product Name Description
Inhibitors    
3604 (5Z)-7-Oxozeaenol Potent and selective TAK1 MAPKKK inhibitor
TGF-β Receptors (Transforming Growth Factor-β Receptors)
Cat. No. Product Name Description
Inhibitors    
2939 A 83-01 Selective inhibitor of TGF-βRI, ALK4 and ALK7
2902 D 4476 Selective TGF-βRI; also CK1 inhibitor
3264 GW 788388 Selective inhibitor of TGF-βRI; orally active
2718 LY 364947 Selective inhibitor of TGF-βRI 
5288 R 268712 Potent and selective inhibitor of TGF-βRI 
3742 RepSox Selective inhibitor of TGF-βRI; enhances cellular reprogramming efficiency
1614 SB 431542 Potent, selective inhibitor of TGF-βRI, ALK4 and ALK7
3263 SB 505124 Selective inhibitor of TGF-βRI, ALK4 and ALK7
3211 SB 525334 Selective inhibitor of TGF-βRI
3269 SD 208 Potent ATP-competitive TGF-βRI inhibitor
Other    
5068  ITD 1 Selective inhibitor of TGF-β signaling; induces cardiomyocyte differentiation in ESCs
Other Protein Kinases
Aurora Kinase
Cat. No. Product Name Description
Inhibitors    
4291 CCT 137690 Potent pan-Aurora kinase inhibitor
3988 Hesperadin hydrochloride Potent Aurora kinase B inhibitor
4821 PF 03814735 Aurora kinase A and B inhibitor
4584 SNS 314 mesylate Potent pan-Aurora kinase inhibitor
4066 TC-A 2317 hydrochloride Potent, selective Aurora kinase A inhibitor
5286 TC-S 7010 Potent and selective Aurora kinase A inhibitor
2458 ZM 447439 Inhibits Aurora kinase B
CAMKK (Calmodulin-dependent Kinase Kinase)
Cat. No. Product Name Description
Inhibitors    
 1551 STO-609 acetate Selective CAMKK inhibitor
Haspin Kinase
Cat. No. Product Name Description
Inhibitors    
5326 CHR 6494 trifluoroacetate Potent and selective haspin kinase inhibitor
4828 LDN 209929 dihydrochloride Potent and selective haspin kinase inhibitor
IKK (IκB kinase)
Cat. No. Product Name Description
Inhibitors    
4547 ACHP Selective IKKα and IKKβ inhibitor
4857 Amlexanox Inhibitor of TBK1 and IKKε; antiallergic agent
2539 IKK 16 Selective inhibitor of IKK
2611 IMD 0354 Inhibitor of IKKβ
4899 ML 120B dihydrochloride IKK2-selective inhibitor 
4238 PF 184 Potent and selective IKKβ inhibitor
4569 PS 1145 dihydrochloride Selective IKK inhibitor; orally active
3318 SC 514 IKKβ inhibitor; attenuates NF-κB-induced gene expression 
2559 TPCA-1 Potent, selective inhibitor of IKKβ
Mps1 (Monopolar Spindle 1)
Cat. No. Product Name Description
Inhibitors    
3994 AZ 3146 Potent and selective Mps1 kinase inhibitor
5142 Mps1-IN-1 dihydrochloride Selective Mps1 kinase inhibitor
4750 TC Mps1 12 Potent and selective Mps1 kinase inhibitor; orally active
PERK (PKR-like ER kinase)
Cat. No. Product Name Description
Inhibitors    
5107 GSK 2606414 Potent and selective PERK inhibitor; orally bioavailable
PLK (Polo-like Kinase)
Cat. No. Product Name Description
Inhibitors    
3116 Cyclapolin 9 Selective, ATP-competitive PLK1 inhibitor
2977 GW 843682X Selective inhibitor of PLK1 and PLK3
4292 SBE 13 hydrochloride Potent and selective PLK1 inhibitor
4459 TC-S 7005 Potent and selective PLK2 inhibitor

Atypical Kinases
ATM/ATR
Cat. No. Product Name Description
Inhibitors    
 5198 AZ 20 Potent and selective ATR kinase inhibitor; antitumor
3544 KU 55933 Potent and selective ATM kinase inhibitor
4176 KU 60019 Potent ATM kinase inhibitor 
3190 Mirin MRN-ATM pathway inhibitor
DNA-PK (DNA-dependent Protein Kinase)
Cat. No. Product Name Description
Inhibitors    
3271 Compound 401 Selective DNA-PK and mTOR inhibitor
4840 KU 0060648 Dual DNA-PK and PI 3-K inhibitor 
2828 NU 7026 Selective DNA-PK inhibitor
3712 NU 7441 Potent and selective DNA-PK inhibitor
eEF2K (CAM Kinase III)
Cat. No. Product Name Description
Inhibitors    
4483 A 484954 eEF2K (CaM kinase III) inhibitor
3439 NH 125 eEF2K (CaM kinase III) inhibitor
mTOR (Mammalian Target of Rapamycin)
Cat. No. Product Name Description
Inhibitors    
3725 KU 0063794 Selective mTOR inhibitor
4079 Niclosamide mTORC1 signaling inhibitor; also inhibits STAT3
4820 PF 04691502 Potent and selective dual mTOR/PI 3-K inhibitor
4823 PF 05212384 Potent and selective dual mTOR/PI 3-K inhibitor
2930 PI 103 hydrochloride Inhibitor of mTOR, PI 3-kinase and DNA-PK
4257 PP 242 Dual mTORC1/mTORC2 inhibitor
1292 Rapamycin mTOR inhibitor; immunosuppressant 
5264 Temsirolimus mTOR inhibitor; antitumor
4247 Torin 1 Potent and selective mTOR inhibitor
4248 Torin 2 Potent and selective mTOR inhibitor
4282 WYE 687 dihydrochloride Potent and selective mTOR inhibitor 
4893 XL 388 Potent and selective mTOR inhibitor; antitumor
Lipid Kinases
CerK (Ceramide Kinase)
Cat. No. Product Name Description
Inhibitors    
3960 NVP 231 Potent, selective and reversible CerK inhibitor
DGK (Diacylglycerol Kinase)
Cat. No. Product Name Description
Inhibitors    
0484 Dioctanoylglycol DGK inhibitor
2194 R 59-022 DGK inhibitor; increases PKC activity
PI 3-kinase
Cat. No. Product Name Description
Activators     
1983 740 Y-P Cell-permeable PI 3-kinase activator 
Inhibitors    
3671 AS 252424 Selective inhibitor of PI 3-kinase γ 
3578 AS 605240 Potent and selective PI 3-kinase γ inhibitor
4839 AZD 6482 Potent and selective PI 3-Kβ inhibitor
3606 BAG 956 Dual PI 3-kinase and PDK1 inhibitor
4674 CZC 24832 Selective inhibitor of PI 3-kinase γ
4026 GSK 1059615 Potent PI 3-kinase inhibitor
4840 KU 0060648 Dual PI 3-kinase and DNA-PK inhibitor
1130 LY 294002 hydrochloride Selective PI 3-kinase inhibitor
2418 LY 303511 Negative control of LY 294002 (Cat. No. 1130)
3977 3-Methyladenine Class III PI 3-kinase inhibitor; also inhibits autophagy
4820 PF 04691502 Potent and selective dual PI 3-K/mTOR inhibitor
4823 PF 05212384 Potent and selective dual PI 3-K/mTOR inhibitor
2814 PI 828 PI 3-kinase inhibitor; more potent than LY 294002 (Cat. No. 1130)
3894 PP 121 PI 3-kinase family inhibitor; also inhibits tyrosine kinase receptors
1125 Quercetin Non-selective PI 3-kinase inhibitor
4264 TG 100713 PI 3-kinase inhibitor
1232 Wortmannin  Potent, irreversible inhibitor of PI 3-kinase; also PLK1 inhibitor
SphK (Sphingosine Kinase)
Cat. No. Product Name Description
Inhibitors    
4640 N,N-Dimethylsphingosine  SphK inhibitor
3711 SK1-I SphK1 inhibitor; antiproliferative
2097 SKI II Selective non-lipid inhibitor of SphK

Broad Spectrum Kinases Inhibitors
Broad Spectrum
Cat. No. Product Name Description
Inhibitors    
1227 Apigenin  Protein kinase inhibitor
0542 H-7 dihydrochloride Protein kinase inhibitor
1520 Hypericin Inhibits tyrosine kinases
1813 Indirubin-3’-oxime GSK-3β inhibitor; also inhibits other protein kinases
1745 5-Iodotubercidin Potent adenosine kinase inhibitor; also inhibits nucleoside transporters and a range of other kinases
1683 K 252a Protein kinase inhibitor
2992 PKC 412 Broad spectrum protein kinase inhibitor
2002 Ro 31-8220 mesylate Protein kinase inhibitor
1285 Staurosporine Non-selective protein kinase inhibitor
Phosphatases
Cdc25 Phosphatase
Cat. No. Product Name Description
Inhibitors    
1867 NSC 663284 Potent, selective Cdc25 phosphatase inhibitor
1547 NSC 95397  Selective Cdc25 dual specificity phosphatase inhibitor
Inositol Phosphatase
Cat. No. Product Name Description
Inhibitors    
3718 AS 1949490 SH2 domain-containing inositol 5ʹ-phosphatase 2 (SHIP2) inhibitor
1420 D-myo-Inositol-1,3,4,5-tetrakisphosphate, octapotassium salt Potent inhibitor of Ins(1,4,5)P3 5-phosphatase; metabolite of Cat. No. 1482
0681 L-690,330 Inositol monophosphatase inhibitor
Other    
0682 L-690,488  Cell permeable prodrug of the IMPase inhibitor L-690,330 (Cat. No. 0681)
Protein Ser/Thr Phosphatase
Cat. No. Product Name Description
Activators    
0744 Ceramide Ser/Thr protein phosphatase activator
Inhibitors    
4210 Ascomycin Calcineurin phosphatase inhibitor; analog of FK 506 (Cat. No. 3631)
1336 Calyculin A  Protein phosphatase 1 and 2A inhibitor 
1548 Cantharidin Protein phosphatase 1 and 2A inhibitor
1101 Cyclosporin A Calcineurin inhibitor
3631 FK 506 Potent calcineurin inhibitor; immunosuppressant
1840 Fostriecin sodium salt Potent PP2A and PP4 inhibitor 
5140 GSK 2830371  Potent and selective allosteric inhibitor of Wip1 phosphatase
3930 NFAT Inhibitor Inhibitor of calcineurin-mediated NFAT activation
1136 Okadaic acid Protein phosphatase 1 and 2A inhibitor
2347 Salubrinal  Selective inhibitor of eIF2α dephosphorylation
2302 Sanguinarine chloride Inhibitor of protein phosphatase 2C (PP2C)
2305 Tautomycetin Selective PP1 inhibitor
Protein Tyrosine Phosphatase
Cat. No. Product Name Description
Inhibitors    
3979 Alexidine dihydrochloride Selective inhibitor of PTPMT1 
2613 NSC 87877 Potent inhibitor of shp2 and shp1 PTP
2754 TCS 401 Selective inhibitor of PTP1B
3591 VO-OHpic  Potent PTEN inhibitor