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Neuro Ephys System for Rodent, Human, Primate Research

Blackrock»çÀÇ neurosingal detection systemÀ» ÀÌ¿ëÇÏ¿© rodent, human, primateµî¿¡ ÀÀ¿ëÇÒ ¼ö ÀÖ½À´Ï´Ù. °¢ ¸ñÀû¿¡ ¸Â´Â set up°ú ÇÊ¿äÇÑ Á¦Ç°À» °ËÅäÇϼ¼¿ä!

Blackrock Microsystems
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Rodent Neuroscience Research

1) Freely moving opto/electric setup
  • Small animalÀÇ neural activity¿Í behavior change¸¦ °üÂûÇϴµ¥ À¯¿ë
  • ƯÈ÷ CerePlex mu systemÀ» »ç¿ëÇÏ¿© Àü±âÀû, ±¤ÇÐÀû ÀÚ±ØÀ» °¢ channel¿¡ Á¤È®È÷ Àü´Þ
  • NSP´Â closed loop feedbackÀ» À§ÇÑ real time controlÀ» Á¦°ø




      A. Blackrock Probe : Utah Array
      B. Stimulation Y-Adapter : Àڱذú ±â·ÏÀ» µ¿½Ã¿¡.
      C. CerePlex™ µ : mouse¿¡ ÀûÇÕÇÑ »çÀÌÁîÀÇ ¼ÒÇü headstage
      D. Doric Lenses Commutator : free moving½Ã headstage cable°ú fiberoptic ¼±ÀÌ ²¿ÀÌ´Â °ÍÀ» ¹æÁö
      E. Digital Hub : NSP·Î µðÁöÅÐ ½Ã±×³Î Àü¼Û
      F. Cerebus™ System : µ¥ÀÌÅÍ ¼öÁý ÀåÄ¡
      G. Optogenetics Stimulation System : targeted cell¿¡ optical stimulationÀ» Á¦°øÇÏ´Â ÀåÄ¡
      H. Optogenetics LED Source
      I.  CereStim™ 96 : electric stimulationÀ» Á¦°øÇÏ´Â ÀåÄ¡



2) Plug-and-play setup
  • Head-fixed ¹× free moving animal¿¡¼­ÀÇ ephys recordingÀ» À§ÇÑ ½ÉÇÃÇÑ ±¸¼ºÀÇ ½Ã½ºÅÛ
  • °¡°ÝÀûÀ¸·Î È¿À²ÀûÀÎ ±¸¼ºÀ» Á¦°ø


       A. Blackrock Probe : deep brain °üÂû¿¡ À¯¿ë

       B. CerePlex M (32 channel)
       C. CerePlex Direct : ½ÉÇÃÇÏ°í °£°áÇÑ neural signal recording system






























































 
Human Neuroscience Research

1) Brain-Machine Interface (BMI) setup
  • HumanÀÇ neural activity¿Í behavior change¸¦ °üÂûÇϴµ¥ À¯¿ë
  • Utah Array´Â human patient¿¡¼­ÀÇ single-unit recordingÀÇ gold standard ÀÓ
  • Blackrock»çÀÇ Á¦Ç°Àº BrainGate, DARPA Revolutionizing Prosthetics, DARPA Restoring Active Memory, DARPA HAPTIX °°Àº Àΰ£½Å°æº¸Ã¶¿¬±¸ (human neuroprosthetics)¿¡ ¸¹ÀÌ ÀÌ¿ëµÇ°í ÀÖÀ½.




      A. Utah Electrode Arrays : 2°³ÀÇ array »ç¿ë½Ã 2°¡Áö brain À§Ä¡¿¡¼­ ¼ö¹éÀÇ ½Å°æÀÚ±Ø ±â·Ï °¡´É
      B. Patient Cable: Utah array¿Í Neuroport system ¿¬°á
      C. Front-End-Amplifier : ¾Æ³¯·Î±× headstageÀÇ ½ÅÈ£¸¦ µðÁöÅзΠº¯È­
      D. Front-End-Amplifier Power supply : front-end-amplifier¿¡ Àü¿ø °ø±Þ
      E. NeuroPort System : µ¥ÀÌÅÍ ¼öÁý ÀåÄ¡


2) Epilepsy monitoring using ECoG

 

   A.ECoG Grid Array : a flexible, customizable electrocorticography grid array for mapping a targeted
      brain area.

   B.Cabrio headstages : these compact headstages connect directly to the lead from the ECoG to provide
      a noise-free link to the NeuroPort System.
   C.Front-End Amplifier :amplifies and digitizes inputs from analog headstages (up to 128 channels)
      before sending them via fiberoptic link to the NeuroPort System.
   D.Front-End Amplifier Power Supply : low-noise medical grade power supply for front-end amplifier.
   E.NeuroPort System (128-channel) : acquires, displays and saves up to 128 ECoG channels














































































Priamte Neuroscience Research

1) High-Channel-Count setup
  • Blackrock»çÀÇ Á¦Ç°Àº Primate ¿¬±¸¿¡ ÃÖÀûÈ­µÇ¾î ÀÖÀ½. ¸¹Àº ¿¬±¸ °æÇèÀ» º¸À¯ÇÔ.
  • core 2°³ÀÇ Utah array¿Í CerePlex E¸¦ ÅëÇÑ ½Ã±×³Î ¼öÁý°ú Ãß°¡ÀûÀÎ electrode¿Í CerePlex MÀ» ÅëÇØ high-channel-count recordingÀ» µµ¸ð
  • °¢ ´Ù¸¥ ºÎÀ§ÀÇ ½Å°æ±×·ì µ¿½ÃÀûÀÎ ·¹ÄÚµùÀÌ ¼ö¿ùÇÔ (¿¹, cortical recording°ú deeper target µ¿½ÃÃøÁ¤)



    A.Electrode Array
    B.CerePlex™ M (2) :32-channel configuration provides access to additional electrodes and brain regions as needed.
    C.Utah Arrays (2) : multiple brain regionÀ¸·ÎºÎÅÍ ÀÚ±Ø ¼öÁý
    D.CerePlex™ E (96 channel) : provides an optimized profile for primate research such that multiple devices fit on the head easily.
    E.Digital Hub : accepts inputs from up to four CerePlex headstages (up to 128 channels. Optical transmission to the NSP facilitates isolation and long-distance transmission.
    F.Cerebus™ System (256-channel) - serves as the data processing system for high-channel-count devices, acquiring, conditioning and syncing data from multiple devices simultaneously.



2) Wireless setup
 



     A.Utah Arrays : their fixed geometry is ideal for cortical recordings in primates.
    
B.CerePlex W Transmitter :provides wireless communication with the data acquisition device. 
        This opens up new research avenues for social behavior, free moving primates and sleep studies.
    
C.Receiving Antenna
     D.CerePlex W Receiver 
     E.Digital Hub :accepts inputs from up to four CerePlex headstages (up to 128 channels.
        Optical transmission to the NSP facilitates isolation and long-distance transmission.
    
F.Cerebus™ System (128 channel) : the optimum data processing engine for high-channel-count
        devices. It properly acquires and syncs data from multiple devices simultaneously.