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 Á¦Ç°¾È³»  ¼¼Æ÷¹è¾ç   Tissue & Cells

Primary Hepatocytes

Pharmacological°ú toxicological ¿¬±¸¿¡ ÀÖ¾î in vitro liver modelÀÇ gold standardÀÎ primary hepatocytes ÀÔ´Ï´Ù.

Biopredic
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  • Surgery¸¦ ÅëÇØ ¾òÀº Human primary hepatocyte ÀÔ´Ï´Ù.
  • In vivo¸¦ ´ëüÇÏ´Â gold standard·Î ÀÌ¿ëµË´Ï´Ù.
  • ³ôÀº CYP450 È°¼ºÀ» ³ªÅ¸³»¸ç poolingÀÌ °¡´ÉÇÕ´Ï´Ù.
  • CompoundÀÇ in-vitro hepatic metabolism ¹× toxicity test Æò°¡¿¡ »ç¿ëµË´Ï´Ù.
  • Cryopreseved type°ú Fresh typeÀ¸·Î Á¦°øµË´Ï´Ù.
  • Àû¿ë½ÇÇè : Metabolism, drug interactions, Hepatotoxicity, Transporter activity µî

 

Cryopreserved Human Hepatocyte

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  • Source: Surgery « residues »
  • Serology: negative for HBV, HCV and HIV
  • Method: Two step collagenase treatment
  • Viability: >70% post-thaw viability WITHOUT Percoll purification step
  • Number of viable cells / vial: ≥ 5 x 10^6
  • Controls: wide range of enzymes activities: Phase I , Phase II, transporters, CYP induction



Cat. No Product Unit
HEP187-S Cryopreserved Human  Hepatocytes, Suspension grade Vial contiaining
5x10E6 cells
HEP187-M  Cryopreserved Human  Hepatocytes, Monolayer grade Vial contiaining
5x10E6 cells
HEP187-I   Cryopreserved Human  Hepatocytes, Monolayer grade with CYP induction Vial contiaining
5x10E6 cells
HEP700 Cryopreserved Human  Hepatocytes, Monolayer grade
-Product from TRL/LONZA-		 Vial contiaining
5x10E6 cells
HEP701 Cryopreserved Human  Hepatocytes, Monolayer grade with CYP induction
-Product from TRL/LONZA-		 Vial contiaining
5x10E6 cells
HEP702 Cryopreserved Human Hepatocytes - POOL of patients, Suspension grade
-Product from TRL/LONZA-		 Vial contiaining
5x10E6 cells

 

Fresh Human Hepatocyte

  • Source: Surgery « residues »
  • Serology: negative for HBV, HCV and HIV
  • Method: Two step collagenase treatment
  • Viability: >80%
  • Controls: Broad enzymes characterization: Phase I , Phase II
  • Provided as plated hepatocytes and hepatocytes in suspension



Cat. No Product Unit
HEP000 Fresh Human Hepatocytes in suspension Tube of 10M cells
HEP200 Fresh Human hepatocytes in monolayer  -short term cultures 1st and 2nd plate
HEP200 Fresh Human hepatocytes in monolayer  -short term cultures Additional plate
HEP220 Fresh Human hepatocytes in monolayer -long term cultures 1st and 2nd plate
HEP220 Fresh Human hepatocytes in monolayer -long term cultures Additional plate


Animal Hepatocyte



Cat. No Product Unit
HEP002 Fresh Male Sprague Dawley rat  hepatocytes in suspension Tube of 10M cells
HEP007 Fresh Male Wistar rat hepatocytes in suspension Tube of 10M cells
HEP006 Fresh Male CD1 mouse hepatocytes in suspension Tube of 10M cells
HEP003 Fresh Male Beagle dog hepatocytes in suspension Tube of 10M cells
HEP004 Fresh Male Cynomolgus monkey hepatocytes in suspension Tube of 10M cells
HEP201 Male Sprague Dawley rat hepartocytes  in monolayer 1st, 2nd and 3rd plate
HEP201 Male Sprague Dawley rat hepartocytes  in monolayer Additional plate
HEP207 Fresh Male Wistar rat  in monolayer 1st, 2nd and 3rd plate
HEP207 Fresh Male Wistar rat  in monolayer Additional plate
HEP206 Fresh Male CD1 mouse  in monolayer 1st, 2nd and 3rd plate
HEP206 Fresh Male CD1 mouse  in monolayer Additional plate
HEP203 Fresh Male Beagle dog  in monolayer 1st, 2nd and 3rd plate
HEP203 Fresh Male Beagle dog  in monolayer Additional plate
HEP202 Fresh Male Cynomolgus monkey  in monolayer 1st, 2nd and 3rd plate
HEP202 Fresh Male Cynomolgus monkey  in monolayer Additional plate
HEP134-S Male Sprague Dawley rat (pool) Vial contiaining
5x10E6 cells
HEP137-S Male Wistar rat (pool) -
HEP136-S Male CD1 mouse (pool) -
HEP185-S Cryopreserved Male Beagle dog (single)
 suspension grade		 Vial contiaining
5x10E6 cells
HEP186-S Cryopreserved Male Cynomolgus monkey (single)
 suspension grade		 Vial contiaining
5x10E6 cells
HEP105-S Cryopreserved Male Göttingen minipig
suspension grade		 Vial contiaining
5x10E6 cells
HEP134-M Cryopreserved Sprague Dawley rat (pool)
monolayer grade		 Vial contiaining
5x10E6 cells
HEP137-M Cryopreserved Wistar rat (pool)
monolayer grade		 Vial contiaining
5x10E6 cells
HEP136-M Cryopreserved Male CD1 mouse (pool)
monolayer grade		 Vial contiaining
5x10E6 cells
HEP185-M Cryopreserved Male Beagle dog (single)
monolayer grade		 Vial contiaining
5x10E6 cells
HEP186-M Cryopreserved Male Cynomolgus monkey (single)
monolayer grade		 Vial contiaining
5x10E6 cells




 
ÁÖ¹®Á¤º¸(Ordering Information)
CATNUM PRODUCT SIZE
ADD222CAdditives for Hepatocytes incubation medium, for 100ml1.6ml
ADD221CAdditives for hepatocytes seeding medium, for 100ml12.6ml
ADD27111CAdditives for Long Term Maintenance Hepatocytes Medium, for 100ml11ml
ADD27155CAdditives for Long Term Maintenance Hepatocytes Medium, for 500ml55ml
ADD260Additives sandwich maintenance medium3.1ml
MIL700CBasal hepatic cell medium500ml
MIL600CBasal hepatic cell medium100 ml
PLA138CCollagen coated 12 well platePlate
PLA137CCollagen coated 24 well platePlate
PLA139CCollagen coated 48 well platePlate
PLA135CCollagen coated 6 well platePlate
PLA136CCollagen coated 96 well platePlate
PLA504Collagen coated plate without cells but with mediumPlate
HEP187-MCryopreserved Human Hepatocytes, Monolayer gradeea
HEP700Cryopreserved Human Hepatocytes, Monolayer grade -Product from TRL/LONZA-ea
HEP187-ICryopreserved Human Hepatocytes, Monolayer grade with CYP inductionea
HEP701Cryopreserved Human Hepatocytes, Monolayer grade with CYP induction -Product from TRL/LONZA-ea
HEP187-SCryopreserved Human Hepatocytes, Suspension gradeea
HEP702Cryopreserved Human Hepatocytes - POOL of patients, Suspension grade -Product from TRL/LONZA-ea
HEP185-MCryopreserved Male Beagle dog (single) monolayer gradeea
HEP185-SCryopreserved Male Beagle dog (single) suspension gradeea
HEP136-MCryopreserved Male CD1 mouse (pool) monolayer gradeea
HEP186-SCryopreserved Male Cynomolgus monkey (single) suspension gradeea
HEP186-MCryopreserved Male Cynomolgus monkey (single) monolayer gradeea
HEP105-SCryopreserved Male Göttingen minipig suspension gradeea
HEP134-MCryopreserved Sprague Dawley rat (pool) monolayer gradeea
HEP137-MCryopreserved Wistar rat (pool) monolayer gradeea
HEP200Fresh Human hepatocytes in monolayer -short term culturesea
HEP220Fresh Human hepatocytes in monolayer -long term culturesea
HEP000Fresh Human Hepatocytes in suspensionea
HEP203Fresh Male Beagle dog in monolayerea
HEP003Fresh Male Beagle dog hepatocytes in suspensionea
HEP206Fresh Male CD1 mouse in monolayerea
HEP202Fresh Male Cynomolgus monkey in monolayerea
HEP004Fresh Male Cynomolgus monkey hepatocytes in suspensionea
HEP207Fresh Male Wistar rat in monolayerea
HEP136-SMale CD1 mouse (pool)ea
HEP134-SMale Sprague Dawley rat (pool)ea
HEP201Male Sprague Dawley rat hepartocytes in monolayerea
HEP137-SMale Wistar rat (pool)ea
MAT004Matrigel AH-SW Sandwich medium (1X)13ml
MAT003Matrigel Sandwich medium (1X)13ml
MIL261CThawing medium without glucose100 ml
MIL494William E medium without additives, without Phenol red [1X], 100 mL100ml