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 제품안내  면역학   Cancer Research  Epigenetics

Histone Antibodies & Peptide, Array

Epigenetics 연구에 필요한 Histone Antibody, Modified Histone Peptide, Nucleosome 및, Histone modification 스크리닝에 이용되는 Histone Peptide Array를 소개합니다.

EpiCypher
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특징



  • Histone Antibodies :
    H2A, H2AX, H2B, H3, H4 Histone과 modified peptide에 대한 ChIP-Validated antibody를 제공합니다.

    -
    Histone Modifying Enzyme Antibodies
    - Arginine Methylation Antibodies
    - Chromatin Protein Antibodies
    - Histone and Histone Modification Antibodies
    - Lysine Methylation Antibodies

  • EpiTitan Histone Peptide Array :
    275개의 modified histone peptide spot으로 구성된 array를 이용하여 손쉽게 Histone Modification을 스크리닝 할 수 있습니다.

    - Array상의 peptide와 effector protein간의 작용을 확인하는데 이용합니다.
    - 형광이나 enzyme 코팅된 항체를 이용하여 반응결과를 측정합니다.
    - 4가지 histones (H2A, H2B, H3 and H4)에 대한 95가지의 unique modification과 다양한 histone variants를 포함합니다.
    - 각 Array는 275개의 histone peptide spot을 가집니다.
    - 모든 peptide들은 spotting전에 validation을 거칩니다.
    - Histone antibody, protein binding, enzyme activity등의 분석과 측정에 효과적입니다.
    - Multi-well gasket을 이용하여, 하나의 array에서 두가지 다른 실험을 병행할수 있습니다.

 

  • Histone Peptide :
    철저한 QC를 통해 직접 생산한 H2A, H2AX, H2B, H3, H4 modified histone peptide를 제공합니다.

    - 300여가지의 펩타이드를 제공합니다.
    - Array에 이용된 highly purified & validated peptide 입니다.
    - 모두 biotinylated 상태로 제공됩니다.
    - Protein binding, pull-down assay에 이용됩니다.
    - Complete list 보기


  • Nucleosomes :
    Enzyme screening assay를 위한 고순도의 nucleosome을 제공합니다.


    - Highly purified recombinant nucleosomes
    - Biotinylated recombinant nucleosomes
    - HeLa nucleosomes
    - Recombinant human histone octamers

 

  • Recombinant Proteins and Enzymes :
    Genome 기능과 Drug 연구에 필요한 고순도의 modifying enzyme을 제공합니다.

    - Bromodomain Proteins
    - Histone Modifying Enzymes
    - MBT Domain Proteins
    - Recombinant Histones

 

  • Epigenetics Sevices :

    - Histone Peptide Array Screening
    - Histone Peptide Pull-down Services
    - Fluorescence Polarization Determination of Dissociation Constant (Kd)


  • Histone Peptide Array 사용 논문
    - Cai L et al (2013). An H3K36 Methylation-Engaging Tudor Motif of Polycomb-like Proteins Mediates PRC2 Complex Targeting. Mol Cell 49: 571-582.
    - Rothbart SB et al (2013). Multivalent histone engagement by the linked tandem Tudor and PHD domains of UHRF1 is required for the epigenetic inheritance of DNA methylation. Genes Dev 27: 1288-1298.
    - Rothbart SB, Krajewski K, Strahl BD, Fuchs, SM (2012). Peptide microarrays to interrogate the histone code. Methods Enzymol 512: 107-135.
    - Rothbart SB et al (2012). Association of UHRF1 with methylated H3K9 directs the maintenance of DNA methylation. Nat Struct Mol Biol 19: 1155-1160.
    - Fuchs SM, Krajewski K, Baker RW, Miller VL, Strahl BD (2011). Influence of combinatorial histone modifications on antibody and effector protein recognition. Curr Biol 21: 53-58.

  • 브로셔 보기

 

주문정보(Ordering Information)
CATNUM PRODUCT SIZE
15-0001ACF1 / BAZ1A Bromodomain100ug
15-0045AF9 YEATS Domain, Recombinant Human100ug
13-0011Asymmetric Dimethyl-arginine Antibody (ADMA) Asym26100ul
13-1011Asymmetric Dimethyl-arginine Antibody (ADMA) Asym2610ul
15-0004BATZFD Bromodomain100ug
15-0042BAZ2B Bromodomain100ug
15-0007BPTF Bromodomain100ug
15-0009BRD2 Bromodomain 1100ug
15-0010BRD2 Bromodomain 2100ug
15-0011BRD3 Bromodomain 1100ug
15-0057BRD3 Bromodomain 2, Recombinant Human100 ug
15-0012BRD4 Bromodomain 1100ug
15-0049BRD4 Bromodomain 1, His-Tagged100 ug
15-0013BRD4 Bromodomain 2100ug
15-0047BRD4 Bromodomain 2, His-Tagged100 ug
15-0067BRD7 Bromodomain, Recombinant Human100 ug
15-0068BRD9 Bromodomain, Recombinant Human100 ug
15-0017BRDT Bromodomain 2100ug
15-0018BRG1 / SMCA4 Bromodomain100ug
13-0006CARM1 / PRMT4 Antibody100ul
13-1006CARM1 / PRMT4 Antibody10ul
15-0023CBP Bromodomain100ug
15-0048CBP Bromodomain, His-Tagged100 ug
15-0024CECR2 Bromodomain100ug
16-0019Chicken Mononucleosomes, Purified50 ug
16-0004Chicken Oligonucleosomes, Purified50ug
15-1001DOT1 Catalytic Domain, human50ug
15-0069ENL YEATS Domain, Recombinant Human100 ug
15-0070ENL YEATS Domain, Y78A, Recombinant Human100 ug
16-4101EpiDyne Nucleosome Remodeling Assay Substrate ST601-GATC150 ug
16-4111EpiDyne Nucleosome Remodeling Assay Substrate ST601-GATC1, Biotinylated50 ug
18-4100EpiDyne Remodeling Assay Substrate DNA ST601-GATC050 ug
18-4101EpiDyne Remodeling Assay Substrate DNA ST601-GATC150 ug
18-4110EpiDyne Remodeling Assay Substrate DNA ST601-GATC0, Biotinylated 50 ug
18-4111EpiDyne Remodeling Assay Substrate DNA ST601-GATC1, Biotinylated50 ug
16-4201EpiDyne-FRET Nucleosome Remodeling Assay Substrate50 ug
11-2005EpiTitan Histone Peptide Array ver25 ea
11-2001EpiTitan Histone Peptide Array ver21 ea
15-1008G9a, human50ug
15-1010G9a, Recombinant Human, His-Tagged50 ug
15-0026GCN5 Bromodomain100ug
16-0002HeLa Mononucleosomes, Purified50ug
17-0001HeLa Nuclear Extract250ug
16-0003HeLa Polynucleosomes, Purified50ug
16-0010Histone CENP-A/H4 Tetramer, Recombinant Human50 ug
12-0044Histone H2A K5Ac Peptide, Biotinylated50 ug
12-0043Histone H2A N-terminal Peptide, Biotinylated50 ug
15-0301Histone H2A, Recombinant Human100ug
15-0311Histone H2A/H2B Dimer, Recombinant Human50 ug
12-0039Histone H2AX C-terminal Peptide, Biotinylated50ug
12-0062Histone H2AX N-terminal Peptide, Biotinylated50ug
12-0040Histone H2AX S139P Peptide, Biotinylated50ug
15-0307Histone H2AX, Recombinant Human100 ug
15-0305Histone H2AZ.1, Recombinant Human100 ug
15-0306Histone H2AZ.2, Recombinant Human100 ug
15-0302Histone H2B, Recombinant Human100ug
12-0016Histone H3 aa15-34 Peptide, Biotinylated50ug
12-0020Histone H3 aa27-45 Peptide, Biotinylated50ug
12-0025Histone H3 aa74-84 Peptide, Biotinylated50ug
13-0001Histone H3 C-terminal Antibody100ul
13-1001Histone H3 C-terminal Antibody10ul
12-0004Histone H3 K14Ac Peptide, Biotinylated50ug
12-0005Histone H3 K18Ac Peptide, Biotinylated50ug
12-0104Histone H3 K18bu Peptide, Biotinylated50 ug
12-0013Histone H3 K18Me1 Peptide, Biotinylated50ug
12-0014Histone H3 K18Me2 Peptide, Biotinylated50ug
12-0015Histone H3 K18Me3 Peptide, Biotinylated50ug
12-0056Histone H3 K23Ac Peptide, Biotinylated50ug
12-0042Histone H3 K27Ac Peptide, Biotinylated50ug
12-0049Histone H3 K27Ac S28P Peptide, Biotinylated50ug
13-1015Histone H3 K27Me1 Antibody10 ug
13-0015Histone H3 K27Me1 Antibody100ug
12-0017Histone H3 K27Me1 Peptide, Biotinylated50ug
12-0018Histone H3 K27Me2 Peptide, Biotinylated50ug
12-0019Histone H3 K27Me3 Peptide, Biotinylated50ug
12-0055Histone H3 K27Me3 S28P Peptide, Biotinylated50ug
12-0021Histone H3 K36Ac Peptide, Biotinylated50ug
12-0022Histone H3 K36Me1 Peptide, Biotinylated50ug
12-0023Histone H3 K36Me2 Peptide, Biotinylated50ug
12-0024Histone H3 K36Me3 Peptide, Biotinylated50ug
12-0006Histone H3 K4,9,14,18Ac Peptide, Biotinylated50ug
12-0002Histone H3 K4Ac Peptide, Biotinylated50ug
12-0074Histone H3 K4Ac, K14Ac, K18Ac Peptide, Biotinylated50 ug
12-0007Histone H3 K4Me1 Peptide, Biotinylated50ug
13-0013Histone H3 K4Me2 Antibody100ug
13-1013Histone H3 K4Me2 Antibody, Sample10 ug
12-0008Histone H3 K4Me2 Peptide, Biotinylated50ug
13-0004Histone H3 K4Me3 Antibody100ul
13-1004Histone H3 K4Me3 Antibody10ul
12-0048Histone H3 K4Me3 K9Ac Peptide, Biotinylated50ug
12-0009Histone H3 K4Me3 Peptide, Biotinylated50ug
12-0098Histone H3 K56Ac Peptide, Biotinylated50 ug
12-0026Histone H3 K79Me1 Peptide, Biotinylated50ug
12-0027Histone H3 K79Me2 Peptide, Biotinylated50ug
12-0028Histone H3 K79Me3 Peptide, Biotinylated50ug
12-0066Histone H3 K9, 14Ac Peptide, Biotinylated50 ug
13-0020Histone H3 K9Ac Antibody100 ug
13-1020Histone H3 K9Ac Antibody, Sample10 ug
12-0003Histone H3 K9Ac Peptide, Biotinylated50ug
12-0061Histone H3 K9Ac, S10P Peptide, Biotinylated50ug
13-0014Histone H3 K9Me1 Antibody100ug
13-1014Histone H3 K9Me1 Antibody, Sample10 ug
12-0010Histone H3 K9Me1 Peptide, Biotinylated50ug
12-0011Histone H3 K9Me2 Peptide, Biotinylated50ug
12-0093Histone H3 K9Me2 S10P Peptide, Biotinylated50 ug
12-0012Histone H3 K9Me3 Peptide, Biotinylated50ug
12-0054Histone H3 K9Me3 S10P Peptide, Biotinylated50ug
12-0001Histone H3 N-terminal Peptide, Biotinylated50ug
13-0016Histone H3 R17Me2a Antibody100ug
13-1016Histone H3 R17Me2a Antibody, Sample10 ug
12-0060Histone H3 R2Me2a Peptide, Biotinylated50ug
13-0017Histone H3 R8Me1 Antibody100ug
13-0018Histone H3 R8Me2a Antibody100ug
13-1018Histone H3 R8Me2a Antibody, Sample10 ug
13-0019Histone H3 R8Me2s Antibody100ug
12-0041Histone H3 S10P Peptide, Biotinylated50ug
12-0084Histone H3 S28P Peptide, Biotinylated50 ug
12-0053Histone H3 T3P K4Me3 Peptide, Biotinylated50ug
12-0065Histone H3.1 aa1-43 Peptide, Biotinylated50 ug
12-0105Histone H3.1 K27Ac Peptide, Biotinylated50 ug
12-0106Histone H3.1 K27bu Peptide, Biotinylated50 ug
12-0709Histone H3.1 K4Me3 (aa1-43) Peptide, Biotinylated50 ug
12-0712Histone H3.1 K9Me3 (aa1-43) Peptide, Biotinylated50 ug
15-0303Histone H3.1, Recombinant Human100ug
12-0064Histone H3.3 aa15-34 Peptide, Biotinylated50ug
12-0213Histone H3.3 aa27-45 Peptide, Biotinylated50 ug
12-0063Histone H3.3 aa75-94 Peptide, Biotinylated50ug
18-0004Histone H3.3 Expression Vector pEPI-H3.3K27M20ug
18-0003Histone H3.3 Expression Vector pEPI-H3.3K9M20ug
18-0002Histone H3.3 Expression Vector pEPI-H3.3WT20ug
15-0312Histone H3.3, Recombinant Human100 ug
12-0115Histone H3.3K36me2 Peptide, Biotinylated50 ug
16-0008Histone H3/H4 Tetramer, Recombinant Human50 ug
12-0123Histone H3K14, K18ac Peptide, Biotinylated50 ug
12-0120Histone H3K4, K14ac Peptide, Biotinylated50 ug
12-0121Histone H3K4, K18ac Peptide, Biotinylated50 ug
12-0119Histone H3K4, K9ac Peptide, Biotinylated50 ug
12-0122Histone H3K9, K18ac Peptide, Biotinylated50 ug
12-0052Histone H4 K20Ac Peptide, Biotinylated50ug
12-0035Histone H4 aa11-27 Peptide, Biotinylated50ug
12-0051Histone H4 K12,16Ac K20Me2 Peptide, Biotinylated50ug
12-0050Histone H4 K12,16Ac K20Me3 Peptide, Biotinylated50ug
12-0032Histone H4 K12Ac Peptide, Biotinylated50ug
12-0033Histone H4 K16Ac Peptide, Biotinylated50ug
12-0036Histone H4 K20Me1 Peptide, Biotinylated50ug
12-0037Histone H4 K20Me2 Peptide, Biotinylated50ug
12-0038Histone H4 K20Me3 Peptide, Biotinylated50ug
12-0034Histone H4 K5,8,12,16Ac Peptide, Biotinylated50ug
12-0030Histone H4 K5Ac Peptide, Biotinylated50ug
12-0045Histone H4 K5Ac, K12Ac Peptide, Biotinylated50ug
12-0047Histone H4 K5Ac, K8Ac, K12Ac Peptide, Biotinylated50ug
13-0021Histone H4 K8Ac Antibody100 ug
13-1021Histone H4 K8Ac Antibody, Sample10 ug
12-0031Histone H4 K8Ac Peptide, Biotinylated50ug
12-0046Histone H4 K8Ac, K16Ac Peptide, Biotinylated50ug
12-0057Histone H4 N-term Peptide, Biotinylated (No -Ac)50ug
12-0029Histone H4 N-terminal Peptide, Biotinylated50ug
12-0058Histone H4 R3Me2a Peptide, Biotinylated50ug
12-0059Histone H4 R3Me2s Peptide, Biotinylated50ug
15-0304Histone H4, Recombinant Human100 ug
16-0001Histone Octamer, Recombinant Human50ug
16-8313Histone Octamer, Recombinant Human, H4 Tetraacetyl (H4 K5, 8, 12, 16 Ac) 50 ug
15-0058HP1棺 Chromodomain, Recombinant Human100 ug
15-0056L3MBTL1 3xMBT Domain, D355N, Recombinant Human100 ug
15-0043L3MBTL1 3xMBT Domain, Recombinant Human100ug
16-0013Mononucleosomes (H2AX), Human Recombinant Biotinylated50 ug
16-0014Mononucleosomes (H2AZ.1), Human Recombinant Biotinylated50 ug
16-1014Mononucleosomes (H2AZ.1), Human Recombinant, Non-biotinylated50 ug
16-0015Mononucleosomes (H2AZ.2), Human Recombinant Biotinylated50 ug
16-0016Mononucleosomes (H3.1 50 ug
16-0017Mononucleosomes (H3.3 50 ug
16-1323Mononucleosomes (H3.3 K27M), Recombinant Human100 ug
16-0323Mononucleosomes (H3.3 K27M), Recombinant Human100 ug
16-0344Mononucleosomes (H3.3 K36M), Recombinant Human Biotinylated50 ug
16-0349Mononucleosomes (H3.3 K4M), Recombinant Human Biotinylated50 ug
16-0350Mononucleosomes (H3.3 K9M), Recombinant Human Biotinylated50 ug
16-0012Mononucleosomes (H3.3), Human Recombinant100 ug
16-0011Mononucleosomes (H3.3), Human Recombinant Biotinylated50 ug
16-1323Mononucleosomes (H3.3K27M), Recombinant Human, Biotinylated50 ug
16-0018Mononucleosomes (H4 50 ug
16-0020Mononucleosomes H2A Ubiquityl, Recombinant Human, Biotinylated50 ug
16-0006Mononucleosomes, Human Recombinant Biotinylated25ug
16-0005Mononucleosomes, Recombinant25ug
16-1005Mononucleosomes, Recombinant5ug
16-0009Mononucleosomes, Recombinant Human100 ug
11-3001Multiwell Array Gasket1 ea
13-0002NSD2 / MMSET Antibody100ug
13-1002NSD2 / MMSET Antibody10ug
15-1002NSD2 / MMSET Catalytic Domain, Recomb. Human50 ug
18-0006Nucleosome Assembly 601 Sequence DNA50 ug
18-0005Nucleosome Assembly 601 Sequence DNA, Biotinylated50ug
15-0037P300 Bromodomain100ug
15-0046P300 Bromodomain, His-Tagged100ug
15-0027PB1 Bromodomain 1100ug
13-0007PRMT1 Antibody100ul
13-1007PRMT1 Antibody10ul
13-0008PRMT5 / JBP1 Antibody100ul
13-1008PRMT5 / JBP1 Antibody10ul
13-0009PRMT7 Antibody100ul
13-1009PRMT7 Antibody10ul
15-0066RAG2 PHD Domain, Recombinant100 ug
15-0050SAP145 F3 Fragment100 ug
15-1012SETD2, Recombinant Human50 ug
15-1011SETD2, Recombinant Human GST-tagged50 ug
13-0003SETD6 Antibody100ug
13-1003SETD6 Antibody10ug
15-1004SETD6, Recombinant Human50ug
15-1005SETD8 / PR-SET7, Recombinant Human50 ug
15-1006SMYD2, Recombinant Human25ug
15-1007SMYD3, Recombinant Human25ug
13-0012Symmetric Dimethyl-arginine Antibody (SDMA) Sym10100ul
13-1012Symmetric Dimethyl-arginine Antibody (SDMA) Sym10100ul