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Cell CycleÀº ¼¼Æ÷ÀÇ Áõ½ÄÀ» À§ÇØ DNA¿Í º¹Á¦¿Í ¼¼Æ÷ºÐ¿ÀÌ ÀϾ±â±îÁöÀÇ ÀÏ·ÃÀÇ °úÁ¤À¸·Î, Cell CycleÀ» ¿¬±¸Çϴµ¥ ÇÊ¿äÇÑ CDK, Aurora, p53°ü·Ã inhibitor, activator¸¦ ¼Ò°³ÇÕ´Ï´Ù. |
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TOCRIS |
Aurora kinases´Â ü¼¼Æ÷ºÐ¿¿¡ ÁßÃßÀûÀÎ ¿ªÇÒÀ» ´ã´çÇϰí ÀÖÀ¸¸ç, Aurora A, Aurora B ±×¸®°í
Aurora CÀÇ 3°¡Áö isoformÀº °¢°¢ ¼·Î ´Ù¸¥ ±â´ÉÀ¸·Î ü¼¼Æ÷ ºÐ¿À» Á¶ÀýÇÕ´Ï´Ù.
Function | Cat. No. | Product Name | Activity |
Inhibitor | 4291 | CCT 137690 | Potent pan-Aurora kinase inhibitor |
Inhibitor | 3988 | Hesperadin hydrochloride | Potent Aurora kinase B inhibitor |
Inhibitor | 4821 | PF 03814735 | Aurora kinase A and B inhibitor |
Inhibitor | 4584 | SNS 314 mesylate | Potent pan-Aurora kinase inhibitor |
Inhibitor | 4066 | TC-A 2317 hydrochloride | Potent, selective Aurora kinase A inhibitor |
Inhibitor | 5286 | TC-S 7010 | Potent and selective Aurora kinase A inhibitor |
Inhibitor | 2458 | ZM 447439 | Inhibits Aurora kinase B |
Activator | 3084 | Anacardic acid | Aurora kinase A activator. Also inhibits histone acetyltransferase |
Cdc25´Â cdc25A, B ±×¸®°í C 3°¡Áö isoformÀÌ ÀÖÀ¸¸ç, Cell cycle ÁøÇà¿¡ ÁßÀ翪ÇÒÀ» ÇÕ´Ï´Ù.
Function | Cat. No. | Product Name | Activity |
Inhibitor | 1867 | NSC 663284 | Potent, selective Cdc25 phosphatase inhibitor |
Inhibitor | 1547 | NSC 95397 | Selective Cdc25 dual specificity phosphatase inhibitor |
Cell cycle inhibitor´Â ´Ù¾çÇÑ ¸ÞÄ¿´ÏÁòÀ» ÅëÇØ cell cycle ÁøÇàÀ» ´ÊÃ߰ųª ¸ØÃß°Ô ÇÕ´Ï´Ù.
Function | Cat. No. | Product Name | Activity |
Inhibitor | 5331 | CPI 203 | Arrests cell cycle at G1 phase; also BET bromodomain inhibitor |
Other | 4406 | 10058-F4 | Arrests cell cycle at G0/G1 |
Other | 4138 | ABT 751 | Inhibitor of microtubule polymerization; blocks cell cycle at G2M |
Other | 1761 | Baicalein | Induces G1 and G2 cell cycle arrest. Also lipoxygenase inhibitor |
Other | 5144 | CFM 4 | CARP-1 mimetic; induces G2/M cell cycle arrest |
Other | 1417 | Daidzein | Arrests cell cycle in G1 phase |
Other | 4761 | Plumbagin | Induces G2/M cell cycle arrest; anticancer |
Other | 5264 | Temsirolimus | mTOR inhibitor; arrests cell cycle at G1/S |
Other | 4282 | WYE 687 dihydrochloride | Potent and selective mTOR inhibitor; induces G1 cell cycle arrest |
Checkpoint control kinases´Â Cell Cycle Àü¹Ý¿¡ °ÉÃÄ ÁøÇàÀÌ ±ÔÄ¢ÀûÀ¸·Î µÉ ¼ö ÀÖµµ·Ï Á¶ÀýÇϸç, ÇÊ¿äÇÑ
¾Õ ´Ü°è°¡ ¿Ï·áµÇÁö ¾ÊÀ¸¸é ´ÙÀ½ ´Ü°è·Î ÁøÇàµÉ ¼ö ¾ø½À´Ï´Ù.
Function | Cat. No. | Product Name | Activity |
Inhibitor | 3994 | AZ 3146 | Potent and selective monopolar spindle 1 (Mps1) inhibitor |
Inhibitor | 3544 | KU 55933 | Potent and selective ATM kinase inhibitor |
Inhibitor | 3034 | NSC 109555 ditosylate | Selective Chk2 inhibitor |
Inhibitor | 3712 | NU 7441 | Potent and selective DNA-PK inhibitor |
Inhibitor | 2694 | PD 407824 | Selective inhibitor of Chk1 and Wee1 |
Inhibitor | 4277 | PF 477736 | Selective Chk1 inhibitor |
Inhibitor | 2560 | SB 218078 | Inhibitor of checkpoint kinase 1 (Chk1) |
Inhibitor | 3038 | TCS 2312 | Potent Chk1 inhibitor |
Other | 4502 | DIM | Activates Chk2; induces G2/M cell cycle arrest |
Other | 4763 | Pyridostatin pentahydrochloride | Stabilizes G-quadruplexes; induces DNA damage and cell cycle arrest |
Cdks´Â cell-cycle control system¿¡¼ °¡Àå Áß¿äÇÑ ¿ä¼ÒÁßÀÇ Çϳª·Î, Cyclin´Ü¹éÁú°ú °áÇÕÇÏ¿© cyclin D
º¹ÇÕü¸¦ Çü¼ºÇÏ¿© ¼¼Æ÷Áֱ⸦ Á¶ÀýÇÒ ¼ö ÀÖÀ¸¸ç, 12°¡Áö CDK À¯ÀüÀÚ°¡ ÀÖÀ¸³ª, Cdk1, -2, -3, -4, -6 5°¡Áö
À¯ÀüÀÚ¸¸ÀÌ Á÷Á¢ÀûÀ¸·Î ¼¼Æ÷Áֱ⸦ Á¶ÀýÇÏ´Â ´É·ÂÀÌ ÀÖ½À´Ï´Ù.
Function | Cat. No. | Product Name | Activity |
Inhibitor | 3610 | (R)-DRF053 dihydrochloride | Dual cdk1/cdk5 inhibitor. Also inhibits CK1 |
Inhibitor | 1902 | [Ala92]-p16 (84-103) | Cyclin-dependent kinase inhibitor |
Inhibitor | 1532 | 10Z-Hymenialdisine | Pan kinase inhibitor; potently inhibits Cdk1, Cdk2, Cdk3 and Cdk5 |
Inhibitor | 2457 | Arcyriaflavin A | Potent cdk4/cyclin D1 and CaM Kinase II inhibitor. Antiviral agent (anti-HCMV) |
Inhibitor | 3094 | Flavopiridol hydrochloride | Cyclin-dependent kinase inhibitor |
Inhibitor | 2152 | NSC 625987 | Cyclin-dependent kinase 4 (cdk4) inhibitor |
Inhibitor | 3135 | NU 2058 | Cdk1 and cdk2 inhibitor |
Inhibitor | 4786 | PD 0332991 isethionate | Potent, selective Cdk4/6 inhibitor; brain penetrant |
Inhibitor | 4181 | Ro 3306 | Cyclin-dependent kinase (cdk) 1 inhibitor |
Inhibitor | 2907 | SU 9516 | Potent cdk2 inhibitor |
ü¼¼Æ÷ºÐ¿Àº ÇϳªÀÇ ¸ð¼¼Æ÷·ÎºÎÅÍ µÎ °³ÀÇ µþ¼¼Æ÷¸¦ ¸¸µé¾î³»¸ç, °£±â, Àü±â, ÀüÁß±â, Èıâ, ¸»±â 5´Ü°è·Î ÁøÇàµË´Ï´Ù.
Function | Cat. No. | Product Name | Activity |
Inhibitor | 5399 | BTB1 | Selective and ATP-competitive Kif18A inhibitor |
Inhibitor | 1364 | Colchicine | Inhibitor of tubulin |
Inhibitor | 1495 | Combretastatin A4 | Inhibits tubulin polymerization. Antitumor, antiangiogenic and antimetastatic |
Inhibitor | 1643 | D-64131 | Inhibitor of tubulin polymerization. Antitumor in vivo |
Inhibitor | 5261 | Dimethylenastron | Inhibitor of mitotic motor kinesin Eg5; antimitotic |
Inhibitor | 1228 | Nocodazole | Microtubule inhibitor |
Inhibitor | 1232 | Wortmannin | Potent inhibitor of PLK1. Also inhibitor of PI 3-kinase |
Other | 3502 | Epothilone B | Microtubule stabilization agent; promotes G2-M cell cycle arrest |
Other | 3728 | Indibulin | Microtubule destabilizer |
Other | 3551 | INH1 | Hec1 inhibitor; causes arrest of mitosis |
Other | 1097 | Taxol | Promotes assembly and inhibits disassembly of microtubules |
p53Àº ¼¼Æ÷ÀÇ ¹«ºÐº°ÇÑ Áõ½Ä°ú µ¹¿¬º¯À̸¦ ¸·´Â transcription factor·Î, p53Àº ATM, ATR, Chk1, MAPKs¿¡ ÀÇÇÑ
ÀλêÈµî ¿©·¯ ¸ÞÄ¿´ÏÁò¿¡ ÀÇÇØ Ȱ¼ºÈµË´Ï´Ù.
Function | Cat. No. | Product Name | Activity |
Inhibitor | 2936 | NSC 66811 | MDM2 inhibitor. Disrupts MDM2-p53 interaction |
Inhibitor | 3843 | Cyclic Pifithrin-α hydrobromide | p53 inhibitor |
Inhibitor | 2653 | Pifithrin-μ | Inhibitor of p53-mitochondrial binding |
Inhibitor | 2443 | RITA | p53-MDM2 interaction inhibitor; antitumor |
Activator | 2185 | NSC 146109 hydrochloride | Cell-permeable, genotype-selective antitumor agent; activates p53-dependent transcription |
Activator | 3365 | Tenovin-1 | Activates p53 transcriptional activity |
Activator | 3356 | WR 1065 | p53 activator. Also ROS scavenger |
Other | 3023 | CP 31398 dihydrochloride | p53-stabilizing agent |
PARP´Â NAD¸¦ ±âÁú·Î histone µîÀÇ ÇÙ ´Ü¹éÁú¿¡ ºÎ°¡µÇ´Â polymer·Î¼, ¿°»öÁú ±¸Á¶ÀÇ Á¦¾î¿Í DNA º¹±¸¿¡
°ü¿©ÇÏ´Â °ÍÀ¸·Î ¾Ë·ÁÁ® ÀÖ½À´Ï´Ù.
Function | Cat. No. | Product Name | Activity |
Inhibitor | 0788 | 3-Aminobenzamide | PARP inhibitor |
Inhibitor | 3735 | BYK 49187 | PARP-1 and PARP-2 inhibitor |
Inhibitor | 2192 | 4-HQN | PARP inhibitor |
Inhibitor | 4514 | JW 55 | Tankyrase inhibitor; inhibits canonical Wnt signaling |
Inhibitor | 5084 | MN 64 | Potent and selective tankyrase inhibitor |
Inhibitor | 3736 | UPF 1069 | PARP-2 inhibitor |
Inhibitor | 3748 | XAV 939 | Tankyrase inhibitor; inhibits Wnt signaling |
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