Aurora kinases는 체세포분열에 중추적인 역할을 담당하고 있으며, Aurora A, Aurora B 그리고
         Aurora C의 3가지 isoform은 각각 서로 다른 기능으로 체세포 분열을 조절합니다.

Function	Cat. No.	Product Name	Activity
Inhibitor	4291	CCT 137690	Potent pan-Aurora kinase inhibitor
Inhibitor	3988	Hesperadin hydrochloride	Potent Aurora kinase B inhibitor
Inhibitor	4821	PF 03814735	Aurora kinase A and B inhibitor
Inhibitor	4584	SNS 314 mesylate	Potent pan-Aurora kinase inhibitor
Inhibitor	4066	TC-A 2317 hydrochloride	Potent, selective Aurora kinase A inhibitor
Inhibitor	5286	TC-S 7010	Potent and selective Aurora kinase A inhibitor
Inhibitor	2458	ZM 447439	Inhibits Aurora kinase B
Activator	3084	Anacardic acid	Aurora kinase A activator. Also inhibits histone acetyltransferase

 

• Cdc25 Phosphatase

          Cdc25는 cdc25A, B 그리고 C 3가지 isoform이 있으며, Cell cycle 진행에 중재역할을 합니다.

Function	Cat. No.	Product Name	Activity
Inhibitor	1867	NSC 663284	Potent, selective Cdc25 phosphatase inhibitor
Inhibitor	1547	NSC 95397	Selective Cdc25 dual specificity phosphatase inhibitor

 

• Cell Cycle Inhibitors

          Cell cycle inhibitor는 다양한 메커니즘을 통해 cell cycle 진행을 늦추거나 멈추게 합니다.

Function	Cat. No.	Product Name	Activity
Inhibitor	5331	CPI 203	Arrests cell cycle at G1 phase; also BET bromodomain inhibitor
Other	4406	10058-F4	Arrests cell cycle at G0/G1
Other	4138	ABT 751	Inhibitor of microtubule polymerization; blocks cell cycle at G2M
Other	1761	Baicalein	Induces G1 and G2 cell cycle arrest. Also lipoxygenase inhibitor
Other	5144	CFM 4	CARP-1 mimetic; induces G2/M cell cycle arrest
Other	1417	Daidzein	Arrests cell cycle in G1 phase
Other	4761	Plumbagin	Induces G2/M cell cycle arrest; anticancer
Other	5264	Temsirolimus	mTOR inhibitor; arrests cell cycle at G1/S
Other	4282	WYE 687 dihydrochloride	Potent and selective mTOR inhibitor; induces G1 cell cycle arrest

• Checkpoint Control Kinases

          Checkpoint control kinases는 Cell Cycle 전반에 걸쳐 진행이 규칙적으로 될 수 있도록 조절하며, 필요한
          앞 단계가 완료되지 않으면 다음   단계로 진행될 수 없습니다.

Function	Cat. No.	Product Name	Activity
Inhibitor	3994	AZ 3146	Potent and selective monopolar spindle 1 (Mps1) inhibitor
Inhibitor	3544	KU 55933	Potent and selective ATM kinase inhibitor
Inhibitor	3034	NSC 109555 ditosylate	Selective Chk2 inhibitor
Inhibitor	3712	NU 7441	Potent and selective DNA-PK inhibitor
Inhibitor	2694	PD 407824	Selective inhibitor of Chk1 and Wee1
Inhibitor	4277	PF 477736	Selective Chk1 inhibitor
Inhibitor	2560	SB 218078	Inhibitor of checkpoint kinase 1 (Chk1)
Inhibitor	3038	TCS 2312	Potent Chk1 inhibitor
Other	4502	DIM	Activates Chk2; induces G2/M cell cycle arrest
Other	4763	Pyridostatin pentahydrochloride	Stabilizes G-quadruplexes; induces DNA damage and cell cycle arrest

 

• Cyclin-Dependent Protein Kinase

          Cdks는 cell-cycle control system에서 가장 중요한 요소중의 하나로, Cyclin단백질과 결합하여 cyclin D
          복합체를 형성하여 세포주기를 조절할 수 있으며, 12가지 CDK 유전자가 있으나, Cdk1, -2, -3, -4, -6 5가지
          유전자만이 직접적으로 세포주기를 조절하는 능력이 있습니다.

Function	Cat. No.	Product Name	Activity
Inhibitor	3610	(R)-DRF053 dihydrochloride	Dual cdk1/cdk5 inhibitor. Also inhibits CK1
Inhibitor	1902	[Ala92]-p16 (84-103)	Cyclin-dependent kinase inhibitor
Inhibitor	1532	10Z-Hymenialdisine	Pan kinase inhibitor; potently inhibits Cdk1, Cdk2, Cdk3 and Cdk5
Inhibitor	2457	Arcyriaflavin A	Potent cdk4/cyclin D1 and CaM Kinase II inhibitor. Antiviral agent (anti-HCMV)
Inhibitor	3094	Flavopiridol hydrochloride	Cyclin-dependent kinase inhibitor
Inhibitor	2152	NSC 625987	Cyclin-dependent kinase 4 (cdk4) inhibitor
Inhibitor	3135	NU 2058	Cdk1 and cdk2 inhibitor
Inhibitor	4786	PD 0332991 isethionate	Potent, selective Cdk4/6 inhibitor; brain penetrant
Inhibitor	4181	Ro 3306	Cyclin-dependent kinase (cdk) 1 inhibitor
Inhibitor	2907	SU 9516	Potent cdk2 inhibitor

 

• Mitosis

          체세포분열은 하나의 모세포로부터 두 개의 딸세포를 만들어내며, 간기, 전기, 전중기, 후기, 말기 5단계로 진행됩니다.

Function	Cat. No.	Product Name	Activity
Inhibitor	5399	BTB1	Selective and ATP-competitive Kif18A inhibitor
Inhibitor	1364	Colchicine	Inhibitor of tubulin
Inhibitor	1495	Combretastatin A4	Inhibits tubulin polymerization. Antitumor, antiangiogenic and antimetastatic
Inhibitor	1643	D-64131	Inhibitor of tubulin polymerization. Antitumor in vivo
Inhibitor	5261	Dimethylenastron	Inhibitor of mitotic motor kinesin Eg5; antimitotic
Inhibitor	1228	Nocodazole	Microtubule inhibitor
Inhibitor	1232	Wortmannin	Potent inhibitor of PLK1. Also inhibitor of PI 3-kinase
Other	3502	Epothilone B	Microtubule stabilization agent; promotes G2-M cell cycle arrest
Other	3728	Indibulin	Microtubule destabilizer
Other	3551	INH1	Hec1 inhibitor; causes arrest of mitosis
Other	1097	Taxol	Promotes assembly and inhibits disassembly of microtubules

 

• p53

          p53은 세포의 무분별한 증식과 돌연변이를 막는 transcription factor로, p53은 ATM, ATR, Chk1, MAPKs에 의한
          인산화등 여러 메커니즘에 의해 활성화됩니다.

Function	Cat. No.	Product Name	Activity
Inhibitor	2936	NSC 66811	MDM2 inhibitor. Disrupts MDM2-p53 interaction
Inhibitor	3843	Cyclic Pifithrin-α hydrobromide	p53 inhibitor
Inhibitor	2653	Pifithrin-μ	Inhibitor of p53-mitochondrial binding
Inhibitor	2443	RITA	p53-MDM2 interaction inhibitor; antitumor
Activator	2185	NSC 146109 hydrochloride	Cell-permeable, genotype-selective antitumor agent; activates p53-dependent transcription
Activator	3365	Tenovin-1	Activates p53 transcriptional activity
Activator	3356	WR 1065	p53 activator. Also ROS scavenger
Other	3023	CP 31398 dihydrochloride	p53-stabilizing agent

 

• Poly(ADP-ribose) Polymerase

          PARP는 NAD를 기질로 histone 등의 핵 단백질에 부가되는 polymer로서, 염색질 구조의 제어와 DNA 복구에
          관여하는 것으로 알려져 있습니다.

Function	Cat. No.	Product Name	Activity
Inhibitor	0788	3-Aminobenzamide	PARP inhibitor
Inhibitor	3735	BYK 49187	PARP-1 and PARP-2 inhibitor
Inhibitor	2192	4-HQN	PARP inhibitor
Inhibitor	4514	JW 55	Tankyrase inhibitor; inhibits canonical Wnt signaling
Inhibitor	5084	MN 64	Potent and selective tankyrase inhibitor
Inhibitor	3736	UPF 1069	PARP-2 inhibitor
Inhibitor	3748	XAV 939	Tankyrase inhibitor; inhibits Wnt signaling