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 제품안내  세포배양   Tissue & Cells

Human Skin

약물의 경피 흡수, 투과 시험 등에 사용할 수 있는 절제 채취된 연구용 Human Skin (피부조직)입니다.

Biopredic
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  특징
  • 절제 채취된 연구용 Human Skin (피부조직)입니다.
  • 성, 인종, 적출부위 등 제품의 biological information을 함께 제공합니다.
  • 약물의 경피 흡수, 투과 시험 등에 사용하실 수 있습니다.
  • 피부의 두께에 따라 Dermatomed skin (두께 300-700um)와 Full-thickness skin (두께 약 2-3mm)의 2 종류가 있습니다.
  • Disc (직경 2-40mm) 및 sheet type으로 제공됩니다.
  • HIV, HBV, HCV에 대해 음성입니다.
  • 원하시는 Skin의 부위와 필요하신 사이즈를 알려주시면 견적제공이 가능합니다.
  • 전용 skin long-term culture medium을 함께 사용하시면, 피부 조직의 배양,해동 및 보존에 필요한 성분이 보충되어 최대 6일정도 조직이 유지됩니다.

 

 Tissue 종류
  • Fresh & Frozen Human Breast Skin (Sheets)
  • Fresh & Frozen Human Breast Skin (Disc)
  • Fresh & Frozen Human Breast Skin (stratum corneum)
  • Fresh & Frozen Scalp (standard 5-12 cm2)
  • Fresh & Frozen Human Abdominal Skin (Sheets)
  • Fresh & Frozen Human Abdominal Skin (Disc)
  • Fresh & Frozen Human Abdominal Skin (stratum corneum)
  • Fresh & Frozen Human Arm Skin (Sheets)
  • Fresh & Frozen Human Arm Skin (Disc)
  • Fresh & Frozen Human Arm Skin (stratum corneum)

 

 Cell 종류
  • Fresh in monolayers or frozen
  • Keratinocytes
  • Fibroblasts
  • Melanocytes
  • Preadipocytes and adipocytes 

 적용
  Fig. 1 & 2: Skin discs

       Fig. 3: Skin discs / ↑ Fig. 4: Fibroblasts

        Fig. 5 & 6: Keratinocytes


 Skin long term culture

The skin long-term culture medium has been developed specifically to maintain the survival of human skin explants for 6 days. This product is a sterile, liquid tissue culture medium. The specific composition of this product is more appropriate than the skin long term culture media used for UV irradiation experiments and other stress assays. This medium allows the preservation of dermal and epidermal cell populations in normal metabolic conditions for 6 days. This medium is ready-to-use and is intended to maintain survival of human skin for research purposes. It is designed for use in a 5% CO2 / 95% air incubator.
Standard MediumBiopredic_long_term_culture_medium
Fig. 1: Standard medium - Epidermis cell integrity is not conserved.
Fig. 2 (right): Epidermis and dermis cell integrities are well conserved. 



 PUBLICATIONS

Suitability of skin integrity tests for dermal absorption studies in vitroGuth K, Schäfer-Korting M, Fabian E, Landsiedel R, van Ravenzwaay B
Tox in Vitro, Feb 2015

Analysis of aquaporin 9 expression in human epidermis and cultured keratinocytesSugiyama Y, Yamazaki K, Kusaka-Kikushima A, Nakahigashi K, Hagiwara H, Miyachi Y
Open Bio, Jun 2014

Comparison of xenobiotic metabolizing enzyme activities in ex vivo human skin and reconstructed human skin models from SkinEthicEilstein J, Léreaux G, Budimir N, Hussler G, Wilkinson S, Duché D
Toxicokinetics and Metabolism, Mar 2014

Direct migration of follicular melanocyte stem cells to the epidermis after wounding or UVB irradiation is dependent on Mc1r signalingChou WC, Takeo M, Rabbani P, Hu H, Lee W, Chung YR, Carucci J, Overbeek P, Ito M
Nat Med, Jul 2013

Synthesis of New N,N'-Bis(5-arylidene-4-oxo- 4,5-dihydrothiazolin-2-yl)piperazine Derivatives Under Microwave Irradiation and Preliminary Biological EvaluationCoulibaly WK, Paquin L, Bénié A, Bekro YA, Durieux E, Meijer L, Le Guével R, Corlu A, Bazureau JP
Scientia Pharmaceutica, Sep 2012

Cleavage of Nidogen-1 by Cathepsin S Impairs Its Binding to Basement Membrane PartnersSage J, Leblanc-Noblesse E, Nizard C, Sasaki T, Schnebert S, Perrier E, Kurfurst R, Brömme D, Lalmanach G, Lecaille F
Plos One, Aug 2012

Effect of Direction (Epidermis-To-Dermis and Dermis-To-Epidermis) on the Permeation of Several chemical Compounds through full-thickness Skin and Stripped SkinOshizaka T, Todo H, Sugibayashi K
Pharm Res, May 2012

A possible regulation mechanism of water content in human stratum corneum via intercellular lipid matrixNakazama H, Ohta N, Hatta I
Chem. & Physics, Feb 2012