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 제품안내  세포배양   Tissue & Cells

Human Skin

약물의 경피 흡수, 투과 시험 등에 사용할 수 있는 절제 채취된 연구용 Human Skin (피부조직)입니다.

Biopredic
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  특징
  • 절제 채취된 연구용 Human Skin (피부조직)입니다.
  • 성, 인종, 적출부위 등 제품의 biological information을 함께 제공합니다.
  • 약물의 경피 흡수, 투과 시험 등에 사용하실 수 있습니다.
  • 피부의 두께에 따라 Dermatomed skin (두께 300-700um)와 Full-thickness skin (두께 약 2-3mm)의 2 종류가 있습니다.
  • Disc (직경 2-40mm) 및 sheet type으로 제공됩니다.
  • HIV, HBV, HCV에 대해 음성입니다.
  • 원하시는 Skin의 부위와 필요하신 사이즈를 알려주시면 견적제공이 가능합니다.
  • 전용 skin long-term culture medium을 함께 사용하시면, 피부 조직의 배양,해동 및 보존에 필요한 성분이 보충되어 최대 6일정도 조직이 유지됩니다.


  • Compound penetration
  • Skin irritation
  • Toxicology e.g. genotoxicity and sensitization
  • Metabolism
  • Primary cell isolation…

 

  • Fresh & Frozen Human Breast Skin (Sheets)
  • Fresh & Frozen Human Breast Skin (Disc)
  • Fresh & Frozen Human Breast Skin (stratum corneum)
  • Fresh & Frozen Scalp (standard 5-12 cm2)
  • Fresh & Frozen Human Abdominal Skin (Sheets)
  • Fresh & Frozen Human Abdominal Skin (Disc)
  • Fresh & Frozen Human Abdominal Skin (stratum corneum)
  • Fresh & Frozen Human Arm Skin (Sheets)
  • Fresh & Frozen Human Arm Skin (Disc)
  • Fresh & Frozen Human Arm Skin (stratum corneum)
  • Fresh in monolayers or frozen
  • Keratinocytes
  • Fibroblasts
  • Melanocytes
  • Preadipocytes and adipocytes 


       Fig. 1 & 2: Skin discs

       Fig. 3: Skin discs / Fig. 4: Fibroblasts

        Fig. 5 & 6: Keratinocytes



 

  Reversible opening of the blood-brain barrier by claudin-5-binding variants of Clostridium perfringens enterotoxin's claudin-binding domain.
Neuhaus W,  Piontek A,  Protze J,  Eichner M, Mahringer A, Subileau EA, Lee IM, Schulzke JD, Krause G, Piontek J
Biomaterials, Feb 2018


Suitability of skin integrity tests for dermal absorption studies in vitro
Guth K, Schäfer-Korting M, Fabian E, Landsiedel R, van Ravenzwaay B
Tox in Vitro, Feb 2015

Analysis of aquaporin 9 expression in human epidermis and cultured keratinocytes
Sugiyama Y, Yamazaki K, Kusaka-Kikushima A, Nakahigashi K, Hagiwara H, Miyachi Y
Open Bio, Jun 2014

Comparison of xenobiotic metabolizing enzyme activities in ex vivo human skin and reconstructed human skin models from SkinEthic
Eilstein J, Léreaux G, Budimir N, Hussler G, Wilkinson S, Duché D
Toxicokinetics and Metabolism, Mar 2014

Direct migration of follicular melanocyte stem cells to the epidermis after wounding or UVB irradiation is dependent on Mc1r signaling
Chou WC, Takeo M, Rabbani P, Hu H, Lee W, Chung YR, Carucci J, Overbeek P, Ito M
Nat Med, Jul 2013
  Synthesis of New N,N'-Bis(5-arylidene-4-oxo- 4,5-dihydrothiazolin-2-yl)piperazine Derivatives Under Microwave Irradiation and Preliminary Biological Evaluation
Coulibaly WK, Paquin L, Bénié A, Bekro YA, Durieux E, Meijer L, Le Guével R, Corlu A, Bazureau JP
Scientia Pharmaceutica, Sep 2012

Cleavage of Nidogen-1 by Cathepsin S Impairs Its Binding to Basement Membrane Partners
Sage J, Leblanc-Noblesse E, Nizard C, Sasaki T, Schnebert S, Perrier E, Kurfurst R, Brömme D, Lalmanach G, Lecaille F
Plos One, Aug 2012

Effect of Direction (Epidermis-To-Dermis and Dermis-To-Epidermis) on the Permeation of Several chemical Compounds through full-thickness Skin and Stripped Skin
Oshizaka T, Todo H, Sugibayashi K
Pharm Res, May 2012

A possible regulation mechanism of water content in human stratum corneum via intercellular lipid matrix
Nakazama H, Ohta N, Hatta I
Chem. & Physics, Feb 2012