- 견적 및 주문
- 제품/실험 Q&A
고객께서 개발하신 hit or lead compounds를 다양한 IonChannel에 대해 스크리닝 해 드립니다. Functional 및 binding assay를 선택하실 수 있습니다.
Voltage-gated channels (e.g., sodium, potassium and calcium channels)
Ligand-gated channels (e.g., GABA, nAChR and TRP channels)
Agonists, antagonists, allosteric modulators
Channel state (closed, open and inactive) and use-dependent blockers
Figure 1. Comparison of data generated through IonChannelProfiler™ services with published values.
Human Nav1.2 (Cat. No. CYL3032) and Nav1.5 (Cat. No. CYL3004) PrecisION® cell lines were used to generate
IonChannelProfiler™ service data on the IonWorks® Quattro™ platform. The correlation between IonWorks® IC50 values
and published values obtained using manual patch clamp is shown for several reference compounds. Most fall on the line
of equivalence (shown in black), or within a 3-fold range of this (light blue), indicating good correlation between platforms.
Figures 1. Radioligand binding assays for hERG screening
A) Competition binding data for hERG ligands using Eurofins membrane preparations from hERG expressing
HEK293 cells(Cat. No. CYL4039) were incubated with 3.0 nM [3H]-Astemizole and increasing concentrations of
B) Kivalues obtained compared to published data.
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