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 제품안내  항체,항원,킷트   Immunoassays  Cytokine Research

Immunology Research Inhibitors

Chemokine receptor, COX, Cytokine Receptor, Histamine Receptor, Immune Cell Signaling등 Immunology Research에 필요한 agonist, antagonist등을 소개합니다.

TOCRIS
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Antivirals
2513 Acyclovir Inhibits viral DNA polymerase; antiherpetic agent
1777 Arctigenin Potent MKK1 inhibitor. Also inhibits IκBα phosphorylation
2457 Arcyriaflavin A Potent cdk4/cyclin D1 and CaM Kinase II inhibitor. Antiviral agent (anti-HCMV)
3666 Tenofovir Reverse transcriptase inhibitor
Chemokine Receptors
3299 AMD 3100 octahydrochloride Highly selective CXCR4 antagonist
3444 Anti-DARC Antibody recognizing DARC
3129 BMS CCR2 22 High affinity, potent CCR2 antagonist
2769 BX 513 hydrochloride Selective CCR1 antagonist
3581 C 021 dihydrochloride Potent CCR4 antagonist
2423 DAPTA Chemokine receptor 5 (CCR5) antagonist
2595 J 113863 Potent CCR1 chemokine receptor antagonist
2089 RS 102895 hydrochloride CCR2b chemokine receptor antagonist
2517 RS 504393 Highly selective CCR2 chemokine receptor antagonist
2725 SB 225002 Potent and selective CXCR2 antagonist
2724 SB 265610 Potent CXCR2 antagonist
3650 SB 328437 Potent and selective CCR3 antagonist
3664 Teijin compound 1 Potent CCR2b antagonist
2757 UCB 35625 Potent CCR1 and CCR3 antagonist
2565 ZK 756326 Selective, non-peptide CCR8 agonist
Complement
2585 Compstatin C3-binding protein, inhibits complement activation
3796 Compstatin control peptide Control peptide for Compstatin (Cat. No. 2585)
COX
2796 (S)-(+)-Ibuprofen Cyclooxygenase inhibitor (COX-1 > COX-2)
1706 Acetaminophen Cyclooxygenase inhibitor; may be selective for COX-3
3461 Anti-COX-1 Antibody recognizing COX-1
3462 Anti-COX-2 Antibody recognizing COX-2
3786 Celecoxib Selective cyclooxygenase-2 (COX-2) inhibitor
1430 DuP 697 Cyclooxygenase-2 (COX-2) inhibitor
3871 Etodolac Selective cyclooxygenase-2 (COX-2) inhibitor; NSAID
2776 FK 3311 Cyclooxygenase-2 (COX-2) inhibitor
1769 Flurbiprofen Cyclooxygenase inhibitor
1507 FR 122047 hydrochloride Cyclooxygenase (COX-1) inhibitor
1708 Indomethacin Cyclooxygenase inhibitor (COX-1 > COX-2)
2655 Naproxen sodium Cyclooxygenase inhibitor
2470 Nimesulide Cyclooxygenase-2 (COX-2) inhibitor
0942 NS 398 Cyclooxygenase (COX-2) inhibitor
0960 Piroxicam Cyclooxygenase (COX-1) inhibitor
1418 Resveratrol Cyclooxygenase inhibitor
1550 SC 560 Cyclooxygenase (COX-1) inhibitor
2895 SC 58125 Selective cyclooxygenase-2 (COX-2) inhibitor
1707 Sulindac Cyclooxygenase inhibitor (following metabolism to sulindac sulfide)
2580 Tenidap NSAID, cyclooxygenase (COX-1) inhibitor. Also opener of KIR2.3
Cytokines and Cytokine Receptors
1793 AF 12198 Potent, selective human type I IL-1 receptor antagonist
0414 AG 490 EGFR-kinase inhibitor. Also JAK2, JAK3 inhibitor
2446 AS 101 Immunomodulator; inhibits IL-10 synthesis and potentiates IL-1α, IL-2 and TNF-α release
1743 Bay 11-7085 Irreversible inhibitor of TNF-α-induced IκBα phosphorylation
1744 Bay 11-7821 Irreversible inhibitor of TNF-α-induced IκBα phosphorylation
2743 Caffeic acid phenethyl ester Specific inhibitor of NF-κB activation
3203 Celastrol Antioxidant and anti-inflammatory
2471 ER 27319 maleate Selective Syk kinase inhibitor
1798 Gabexate mesylate Serine protease inhibitor; inhibits thrombin, trypsin, kallikrein and plasmin
3270 GIT 27 Immunomodulator; reduces production of pro-inflammatory cytokines
2637 Gliotoxin Immunosuppressant; inhibits NF-κB and cytokine production
2861 HU 211* NMDA receptor antagonist. Also NF-κB inhibitor
2539 IKK 16 Selective inhibitor of IKK
2611 IMD 0354 Inhibitor of IKK-2
2265 Lyn peptide inhibitor Inhibits Lyn-dependent activities of IL-5 receptor; cell-permeable
1554 Piceatannol Inhibits TNF-induced NF-κB activation
1093 Pirfenidone Antifibrotic agent; regulates cytokine levels in vivo
1794 Ro 26-4550 trifluoroacetate Competitive inhibitor of IL-2/ IL-2Rα receptor interaction
3318 SC 514 IKK-2 inhibitor; attenuates NF-κB-induced gene expression
2008 SKF 86002 dihydrochloride p38 MAP kinase inhibitor; anti-inflammatory agent
2798 Stattic Selective STAT3 inhibitor
3543 Suplatast tosylate Th2 cytokine synthesis inhibitor; antiasthmatic
0652 Thalidomide TNF-α synthesis inhibitor
2559 TPCA-1 Potent, selective inhibitor of IKK-2
3253 Triptolide Inhibits TNF-α-induced NF-κB activation
2816 Withaferin A Inhibits NF-κB activation
1675 YM 90709 Interleukin-5 receptor antagonist
Glococorticoid Receptors
2671 Budesonide Synthetic glucocorticoid; anti-inflammatory and chemopreventive
3685 Corticosterone Endogenous glucocorticoid
1126 Dexamethasone Anti-inflammatory glucocorticoid
2007 Fluticasone propionate Selective high affinity glucocorticoid agonist
3572 GSK 650394 Serum- and glucocorticoid-regulated kinase (SGK) inhibitor
1479 Mifepristone Progesterone and glucocorticoid antagonist
3570 Z-Guggulsterone Broad spectrum steroid receptor ligand. More active isomer of Cat. No 2013
Histamine Receptors
0569 (R)-(-)-α-Methylhistamine dihydrobromide Potent, standard H3 agonist
1425 (S)-(+)-Dimethindene maleate M2-selective antagonist
0572 (S)-(+)-α-Methylhistamine dihydrobromide H3 agonist, less active enantiomer
2478 2-Pyridylethylamine dihydrochloride H1 receptor agonist
2342 4-Methylhistamine dihydrochloride Selective, high affinity H4 agonist
3753 A 943931 dihydrochloride Potent and selective H4 antagonist
3640 A 987306 Potent and selective H4 receptor antagonist
0721 Aminopotentidine H2 antagonist
0668 Amthamine dihydrobromide Highly selective standard H2 agonist
0791 Antazoline hydrochloride Imidazoline ligand
3489 Astemizole Orally active, potent H1 antagonist. Also hERG K+ channel blocker.
1857 Burimamide oxalate Mixed H2/H3 antagonist
2211 Carcinine ditrifluoroacetate Highly selective H3 antagonist
2577 Cetirizine dihydrochloride Selective H1 antagonist
0902 Cimetidine H2 antagonist, I1 agonist
1453 Clemastine fumarate H1 antagonist
0752 Clobenpropit dihydrobromide Highly potent H3 antagonist and H4 partial agonist
2409 Conessine Potent and selective H3 receptor antagonist
0506 Dimaprit dihydrochloride Standard H2 selective agonist
3072 Diphenhydramine hydrochloride H1 receptor antagonist
0508 Doxepin hydrochloride Highly potent H1 antagonist. Also binds to H4 receptor
0743 DPPE fumarate Inhibitor of histamine binding at the intracellular binding site
2429 Fexofenadine hydrochloride H1 receptor antagonist; non-sedating antiallergic agent
3545 Histamine dihydrochloride Endogenous histamine receptor agonist
0646 HTMT dimaleate H1 / H2 agonist
0833 ICI 162,846 Potent H2 antagonist, active in vivo
0729 Imetit dihydrobromide Standard H3 and H4 agonist (H3 > H4)
0932 Immepip dihydrobromide Standard H3 agonist. Also H4 agonist
2315 Immethridine dihydrobromide Potent H3 agonist, highly selective over H4
1858 Impentamine dihydrobromide Selective H3 antagonist
0779 Iodophenpropit dihydrobromide Potent, selective H3 antagonist
2441 JNJ 10191584 maleate Selective H4 receptor antagonist; orally active
0784 Ketotifen fumarate H1 antagonist
1944 Loratidine Peripheral H1 antagonist; antiallergic agent
0660 Mepyramine maleate Selective H1 inverse agonist
2947 Methimepip dihydrobromide Extremely selective H3 agonist
2018 Mirtazapine Potent 5-HT2 antagonist. Also 5-HT3, H1 and α2-antagonist. Antidepressant
0573 Nα-Methylhistamine dihydrochloride Non-selective H3 agonist
2477 Proxyfan oxalate High affinity H3 ligand
1967 Ranitidine hydrochloride Selective H2 antagonist
2034 ROS 234 dioxalate Potent H3 antagonist
0512 SKF 91488 dihydrochloride Histamine N-methyltransferase inhibitor
0644 Thioperamide H3 antagonist and H4 inverse agonist
0826 Tiotidine Potent, selective H2 antagonist
0662 trans-Triprolidine hydrochloride Standard H1 antagonist, highly potent
2493 VUF 5681 dihydrobromide Potent H3 receptor silent antagonist
2494 VUF 8430 dihydrobromide Potent, high affinity H4 agonist
1070 Zolantidine dimaleate Potent, centrally active H2 antagonist
iNOS Siganling
0776 (S)-Methylisothiourea sulfate Highly selective iNOS inhibitor
1415 1400W dihydrochloride Potent, highly selective iNOS inhibitor
0951 2-Iminopiperidine hydrochloride Selective iNOS inhibitor
0787 Aminoguanidine hydrochloride Irreversible iNOS inhibitor
0871 AMT hydrochloride Potent, selective iNOS inhibitor
2866 BYK 191023 dihydrochloride Potent and selective inhibitor of iNOS
0873 EIT hydrobromide Selective iNOS inhibitor, acts arginine binding site
1139 L-NIL hydrochloride Selective iNOS inhibitor
0897 S-Isopropylisothiourea hydrobromide iNOS inhibitor, acts arginine binding site
JAK Siganling
2291 1,2,3,4,5,6-Hexabromocyclohexane Inhibits JAK2 autophosphorylation
0414 AG 490 EGFR-kinase inhibitor. Also JAK2, JAK3 inhibitor
1571 Cucurbitacin I Selective inhibitor of STAT3/JAK2 signaling
3395 Lestaurtinib JAK2, FLT3 and TrkA inhibitor
3115 WHI-P 154 JAK3 kinase inhibitor. Also inhibits EGFR
1367 ZM 39923 hydrochloride Potent, selective JAK3 inhibitor
1366 ZM 449829 Potent, selective JAK3 inhibitor
JNK Signaling
2651 AEG 3482 Inhibitor of JNK signaling
1290 Anisomycin Protein synthesis inhibitor
3314 BI 78D3 Selective, competitive JNK inhibitor
1989 c-JUN peptide Peptide inhibitor of JNK/c-Jun interaction
1565 JIP-1 (153-163) JNK-selective inhibitor peptide
1496 SP 600125 Novel and selective JNK inhibitor
3607 SU 3327 Selective JNK inhibitor
2827 TCS JNK 5a Selective inhibitor of JNK2 and JNK3
p38 Signaling
1290 Anisomycin Protein synthesis inhibitor
3465 Anti-ERK2 Antibody recognizing ERK2
3314 BI 78D3 Selective, competitive JNK inhibitor
2344 CGH 2466 dihydrochloride A1, A2B and A3 antagonist and inhibitor of p38 MAPK and PDE4
2186 CMPD-1 Non-ATP-competitive p38α inhibitor
2908 EO 1428 Selective inhibitor of p38α and p38β2
2657 JX 401 Potent, reversible p38α inhibitor
2244 p38 MAPK Inhibitor TocrisetTM Selection of 3 p38 MAPK inhibitors (Cat. Nos. 1264, 1202 and 1962)
2999 RWJ 67657 Potent, selective p38α and p38β inhibitor
1264 SB 202190 Potent, selective inhibitor of p38 MAPK
1202 SB 203580 Selective inhibitor of p38 MAPK
1402 SB 203580 hydrochloride Selective inhibitor of p38 MAPK; water-soluble
1962 SB 239063 Potent, selective p38 MAP kinase inhibitor; orally active
2938 SD 169 Selective, orally active p38α inhibitor
2008 SKF 86002 dihydrochloride p38 MAP kinase inhibitor; anti-inflammatory agent
Raf Signaling
1850 Exo1 Inhibits Golgi-ER traffic; blocks exocytosis
3631 FK 506 Potent calcineurin inhibitor; immunosuppressant
1381 GW 5074 Potent, selective c-Raf1 kinase inhibitor
3143 KM 11060 Corrects F508del-CFTR trafficking
3185 L-779,450 Potent Raf kinase inhibitor
1899 Sarafotoxin S6a Endothelin receptor agonist
1174 Sarafotoxin S6b Endothelin receptor agonist, non-selective
1175 Sarafotoxin S6c Selective ETB agonist
1321 ZM 336372 Potent, selective c-Raf inhibitor
Src Signaling
3063 1-Naphthyl PP1 Src family kinase inhibitor; also inhibits c-Abl
1935 Caffeic acid-pYEEIE Phosphopeptide ligand for src SH2 domain
1629 Herbimycin A Src family kinase inhibitor. Also Hsp90 inhibitor
1331 Lavendustin A EGFR, p60c-src inhibitor
2265 Lyn peptide inhibitor Inhibits Lyn-dependent activities of IL-5 receptor; cell-permeable
2877 MNS Selective inhibitor of Src and Syk
1930 N-Acetyl-O-phosphono-Tyr-Glu Dipentylamide Phosphopeptide ligand for src SH2 domain
1927 N-Acetyl-O-phosphono-Tyr-Glu-Glu-Ile-Glu Phosphopeptide ligand for src SH2 domain
1397 PP 1 Potent, selective Src inhibitor
1407 PP 2 Potent, selective Src inhibitor
2794 PP 3 Negative control for PP 2 (Cat. No. 1407)
1923 pp60 c-src (521-533) (phosphorylated) Inhibits tyrosine kinase activity of pp60c-src and pp60v-src
1155 RR-src Tyrosine kinase substrate peptide
3642 Src I1 Dual site Src kinase inhibitor
Syk Signaling
3446 Anti-14.3.3σ DLHTLSEDSYKDST
2471 ER 27319 maleate Selective Syk kinase inhibitor
2877 MNS Selective inhibitor of Src and Syk
1554 Piceatannol Inhibits TNF-induced NF-κB activation
Integrin Receptors
3202 Echistatin, α1 isoform αVβ3 and glycoprotein IIb/IIIa (αIIbβ3) inhibitor
1263 GR 144053 trihydrochloride Glycoprotein IIb/IIIa (αIIbβ3) receptor antagonist. Antithrombotic
3498 RGDS peptide Integrin binding sequence; inhibits integrin receptor function
Leukotriene Receptors
1796 5-Oxo-ETE Oxoeicosanoid receptor agonist
2756 Arachidonic acid (in TocrisolveTM 100) Endogenous free fatty acid (in water-soluble emulsion)
3138 BAY-u 9773 Dual CysLT1 and CysLT2 antagonist
2025 Cinalukast Potent, selective CysLT1 (LTD4) antagonist; orally active
2276 FPL 55712 Leukotriene receptor antagonist
2307 Leukotriene B4 BLT1/BLT2 receptor agonist and potent chemotactic factor
2208 LY 255283 Selective, competitive BLT2 receptor antagonist
2338 MK 571 Potent CysLT1 (LTD4) inverse agonist. Also MRP inhibitor
3026 ONO 1078 Selective CysLT1 antagonist
1804 SR 2640 hydrochloride Potent, selective LTD4 /LTE4 receptor antagonist
LOX
0645 2-TEDC 5-, 12-, 15-Lipoxygenase inhibitor
1761 Baicalein 5- and 12-Lipoxygenase inhibitor
1304 BW-B 70C 5-Lipoxygenase inhibitor
1311 MK 886 Inhibitor of 5-lipoxygenase-activating protein (FLAP)
2850 PD 146176 Selective 15-lipoxygenase inhibitor
2204 STEARDA Endogenous inhibitor of 5-lipoxygenase
3308 Zileuton Orally active 5-LOX inhibitor
PAF Receptors
3022 Edelfosine Selective PI-PLC inhibitor, also PAF receptor agonist
1657 Ginkgolide B PAF receptor antagonist
2940 PAF (C16) Endogenous platelet-activating factor (PAF)
0571 PCA 4248 PAF receptor antagonist
2339 WEB 2086 Potent PAF receptor antagonist
Prostanoid Receptors
2295 (±)-Cloprostenol sodium salt Water-soluble PGF2α analog and potent FP receptor agonist
3025 AA 2414 Thromboxane A2 (TP) receptor antagonist
0671 AH 6809 EP1 and EP2 receptor antagonist
1620 Alprostadil Prostaglandin. Vasodilator and antiplatelet agent in vivo
2756 Arachidonic acid (in TocrisolveTM 100) Endogenous free fatty acid (in water-soluble emulsion)
2732 BAY-u 3405 Dual TP/DP2 (CRTH2) receptor antagonist
1442 BMY 45778 Non-prostanoid prostacyclin IP receptor partial agonist
2989 Epoprostenol Endogenous IP receptor agonist
0836 ICI 185,282 Potent thromboxane receptor antagonist
2038 Iloprost Prostacyclin (PGI2) analog
2514 L-161,982 Selective EP4 receptor antagonist
3342 L-798,106 Potent and highly selective EP3 antagonist
2297 Misoprostol Cytoprotective PGE1 analog
2296 Prostaglandin E2 Major endogenous prostanoid
1206 SC 19220 Selective EP1 receptor antagonist
3758 SC 51089 Selective EP1 receptor antagonist
TGF-beta Receptors
2939 A 83-01 Selective inhibitor of TGF-βRI, ALK4 and ALK7
2902 D 4476 Selective CK1 inhibitor. Also inhibits TGF-βRI
2718 LY 364947 Selective inhibitor of TGF-βRI
1614 SB 431542 Potent, selective inhibitor of TGF-βRI, ALK4 and ALK7
3211 SB 525334 Selective inhibitor of TGF-βRI
3269 SD 208 Potent ATP-competitive TGF-βRI inhibitor
Toll-like Receptors
3270 GIT 27 Immunomodulator; reduces production of pro-inflammatory cytokines
3700 Imiquimod Toll-like receptor 7 (TLR7) agonist
2719 RWJ 21757 Toll-like receptor 7 (TLR7) agonist