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 제품안내  신경약학   Pharmacology

Opioid Receptor

Opioid recptor agonist & antagonist를 소개합니다.

TOCRIS
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    Opioid Receptor Data
    Receptor Subtype μ (MOP, OP3) δ (DOP, OP1) κ (KOP, OP2) NOP (ORL1, OP4)
    G protein Gi/o Gi/o Gi/o Gi/o
    Transduction Mechanism Activation of inwardly rectifying K+ channels, inhibition of Ca2+ channels, inhibition of adenylyl cyclase
    Localization CNS (neocortex, thalamus, nucleus accumbens, hippocampus, amygdala), myenteric neuons in the gut and vas deferens Olfactory bulb, nucleus accumbens, caudate putamen, neocortex Cerebral cortex, nucleus accumbens, claustrum, hypothalamus Cortex, anterior olfactory nucleus, lateral septum, hypothalamus, hippocampus, amygdala, central grey, pontine nuclei, interpeduncular nucleus, substantia nigra, raphe complex, locus coeruleus and spinal cord
    Likely Physiological Roles Respiration, cardiovascular functions, feeding, learning and memory, intestinal transit, locomotor activity, thermoregulation, hormone secretion, immune functions Analgesia, motor integration, gastrointestinal motility, olfaction, respiration, cognitive function, mood driven behavior Regulation of nociception, diuresis, feeding, neuroendocrine secretions Motor and balance control, reinforcement and reward, nociception, the stress response, sexual behavior, aggression, autonomic control of physiological processes
    Key Selective Agonists Endomorphine-1 (1055)
    Endomorphine-2 (1056)
    DAMGO (1171)
    Fentanyl citrate (3247)
    [D-Ala2]-Deltorphin II (1180)
    SNC 80 (0764)
    SB 205607 (0921)
    (±)-U-50488 (0495)
    BRL 52537 (0699)
    Dynorphin A (3195)
    Dynorphin B (3196)
    Nociceptin (0910)
    Ac-RYYRIK-NH2* (1239) Nociceptin(1-13)NH2 (1358)
    Key Selective Antagonists Naloxonazine (0591)
    β-Funaltrexamine (0926)
    CTOP (1578)
    Cyprodime (2601)
    Naltrindole (0740) nor-Binaltorphimine (0347)
    DIPPA (0794)
    GNTI (1282)
    [Nphe1]Nociceptin(1-13)NH2 (1308)
    UFP-101 (1552)
    Trap 101 (2508)
    (±)-J 113397 (2598)
    * Agonist and antagonist actions of Ac-RYYRIK-NH2 have been reported