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Amyloid ¥â (A¥â) peptide´Â Alzheimer ȯÀÚÀÇ ³ú¿¡¼ ¹ß°ßµÇ´Â amyloid plaqueÀÇ ÁÖ¿ä ±¸¼º¼ººÐÀÔ´Ï´Ù. A¥â´Â ¥â- ¿Í ¥ã-secretase¿¡ ÀÇÇØ¼ °Ç±¸Ã¼ ´Ü¹éÁúÀÇ Àý´ÜÀ¸·ÎºÎÅÍ À¯·¡Çϸç, A¥â40°ú A¥â42 µÎ°¡ÁöÀÇ A¥â ÆéŸÀ̵尡 Çü¼ºµË´Ï´Ù. A¥â40ÀÌ ÀϹÝÀûÀ¸·Î dzºÎÇÏ°Ô Á¸ÀçÇϸç, A¥â42´ÂAlzheimer ÁúȯÀÇ Á¶±âÁø´Ü¿¡ ÀÌ¿ëµÇ´Â°ÍÀ¸·Î º¸°íµÇ°í ÀÖ½À´Ï´Ù. Secretase ÀÛ¿ëÀ» ¾ïÁ¦ÇÏ´Â ¾à¹°À» °³¹ßÇÏ·Á´Â ½Ãµµ°¡ ´Ù¾çÇÑ ¿¬±¸¿¡ ÀÇÇØ ÁøÇàµÇ°í ÀÖ½À´Ï´Ù. |
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TOCRIS |
Cat.No | Product | Biological activity |
---|---|---|
3391 | Amyloid β-Peptide (42-1) (human) | Inactive control peptide for Cat. No. 1428 |
1892 | Amyloid β-Peptide (10-20) (human) | Amyloid β-peptide; substrate for MMP-2 |
1894 | Amyloid β-Peptide (12-28) (human) | Amyloid β-peptide; minimum required for binding to brain proteins |
1191 | Amyloid β-Peptide (1-40) (human) | Amyloid β-protein fragment |
1428 | Amyloid β-Peptide (1-42) (human) | Predominant amyloid β-protein fragment |
1938 | Amyloid β-Peptide (1-43) (human) | Amyloid β-protein fragment |
1429 | Amyloid β-Peptide (25-35) (human) | Human amyloid β-protein fragment functionally required for neurotoxicity |
2424 | Amyloid β-peptide (1-40) (rat) | Amyloid β-protein fragment |
2425 | Amyloid β-peptide (1-42) (rat) | Predominant amyloid β-protein fragment |
2442 | CGP 53353 | Inhibitor of de novo Aβ42 assesmbly |
2654 | Compound W | γ-secretase inhibitor; reduces Aβ42 levels |
3273 | Isoflurane | Anesthetic; induces β-amyloid accumulation |
2677 | JLK 6 | Inhibitor of γ-secretase-mediated βAPP processing |
3144 | K 114 | Amyloid fibril-specific fluorescent dye |
2627 | L-685,458 | Potent and selective γ-secretase inhibitor; inhibits Aβ40 and Aβ42 |
2408 | Ro 90-7501 | Inhibitor of Aβ42 fibril formation |
1634 | Y-29794 oxalate | Inhibitor of prolyl endopeptidase; prevents amyloid β-peptide-like deposition in vivo |
2634 | DAPT | γ-secretase inhibitor; reduces Aβ42 levels |
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