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 Á¦Ç°¾È³»  Ç×ü,Ç׿ø,ŶƮ   Neuroscience  Neuroscience Products

Amyloid ¥â Peptides

Amyloid ¥â (A¥â) peptide´Â Alzheimer ȯÀÚÀÇ ³ú¿¡¼­ ¹ß°ßµÇ´Â amyloid plaqueÀÇ ÁÖ¿ä ±¸¼º¼ººÐÀÔ´Ï´Ù. A¥â´Â ¥â- ¿Í ¥ã-secretase¿¡ ÀÇÇØ¼­ °Ç±¸Ã¼ ´Ü¹éÁúÀÇ Àý´ÜÀ¸·ÎºÎÅÍ À¯·¡Çϸç, A¥â40°ú A¥â42 µÎ°¡ÁöÀÇ A¥â ÆéŸÀ̵尡 Çü¼ºµË´Ï´Ù. A¥â40ÀÌ ÀϹÝÀûÀ¸·Î dzºÎÇÏ°Ô Á¸ÀçÇϸç, A¥â42´ÂAlzheimer ÁúȯÀÇ Á¶±âÁø´Ü¿¡ ÀÌ¿ëµÇ´Â°ÍÀ¸·Î º¸°íµÇ°í ÀÖ½À´Ï´Ù. Secretase ÀÛ¿ëÀ» ¾ïÁ¦ÇÏ´Â ¾à¹°À» °³¹ßÇÏ·Á´Â ½Ãµµ°¡ ´Ù¾çÇÑ ¿¬±¸¿¡ ÀÇÇØ ÁøÇàµÇ°í ÀÖ½À´Ï´Ù.

TOCRIS
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Amyloid β Peptide Products
Cat.NoProductBiological activity
3391 Amyloid β-Peptide (42-1) (human) Inactive control peptide for Cat. No. 1428
1892 Amyloid β-Peptide (10-20) (human) Amyloid β-peptide; substrate for MMP-2
1894 Amyloid β-Peptide (12-28) (human) Amyloid β-peptide; minimum required for binding to brain proteins
1191 Amyloid β-Peptide (1-40) (human) Amyloid β-protein fragment
1428 Amyloid β-Peptide (1-42) (human) Predominant amyloid β-protein fragment
1938 Amyloid β-Peptide (1-43) (human) Amyloid β-protein fragment
1429 Amyloid β-Peptide (25-35) (human) Human amyloid β-protein fragment functionally required for neurotoxicity
2424 Amyloid β-peptide (1-40) (rat) Amyloid β-protein fragment
2425 Amyloid β-peptide (1-42) (rat) Predominant amyloid β-protein fragment
2442 CGP 53353 Inhibitor of de novo Aβ42 assesmbly
2654 Compound W γ-secretase inhibitor; reduces Aβ42 levels
3273 Isoflurane Anesthetic; induces β-amyloid accumulation
2677 JLK 6 Inhibitor of γ-secretase-mediated βAPP processing
3144 K 114 Amyloid fibril-specific fluorescent dye
2627 L-685,458 Potent and selective γ-secretase inhibitor; inhibits Aβ40 and Aβ42
2408 Ro 90-7501 Inhibitor of Aβ42 fibril formation
1634 Y-29794 oxalate Inhibitor of prolyl endopeptidase; prevents amyloid β-peptide-like deposition in vivo
2634 DAPT γ-secretase inhibitor; reduces Aβ42 levels