Amyloid β Peptides


Amyloid β (Aβ) peptide는 Alzheimer 환자의 뇌에서 발견되는 amyloid plaque의 주요 구성성분입니다. Aβ는 β- 와 γ-secretase에 의해서 건구체 단백질의 절단으로부터 유래하며, Aβ40과 Aβ42 두가지의 Aβ 펩타이드가 형성됩니다. Aβ40이 일반적으로 풍부하게 존재하며, Aβ42는Alzheimer 질환의 조기진단에 이용되는것으로 보고되고 있습니다. Secretase 작용을 억제하는 약물을 개발하려는 시도가 다양한 연구에 의해 진행되고 있습니다.
		TOCRIS

Amyloid β Peptide Products

Cat.No	Product	Biological activity
3391	Amyloid β-Peptide (42-1) (human)	Inactive control peptide for Cat. No. 1428
1892	Amyloid β-Peptide (10-20) (human)	Amyloid β-peptide; substrate for MMP-2
1894	Amyloid β-Peptide (12-28) (human)	Amyloid β-peptide; minimum required for binding to brain proteins
1191	Amyloid β-Peptide (1-40) (human)	Amyloid β-protein fragment
1428	Amyloid β-Peptide (1-42) (human)	Predominant amyloid β-protein fragment
1938	Amyloid β-Peptide (1-43) (human)	Amyloid β-protein fragment
1429	Amyloid β-Peptide (25-35) (human)	Human amyloid β-protein fragment functionally required for neurotoxicity
2424	Amyloid β-peptide (1-40) (rat)	Amyloid β-protein fragment
2425	Amyloid β-peptide (1-42) (rat)	Predominant amyloid β-protein fragment
2442	CGP 53353	Inhibitor of de novo Aβ42 assesmbly
2654	Compound W	γ-secretase inhibitor; reduces Aβ42 levels
3273	Isoflurane	Anesthetic; induces β-amyloid accumulation
2677	JLK 6	Inhibitor of γ-secretase-mediated βAPP processing
3144	K 114	Amyloid fibril-specific fluorescent dye
2627	L-685,458	Potent and selective γ-secretase inhibitor; inhibits Aβ40 and Aβ42
2408	Ro 90-7501	Inhibitor of Aβ42 fibril formation
1634	Y-29794 oxalate	Inhibitor of prolyl endopeptidase; prevents amyloid β-peptide-like deposition in vivo
2634	DAPT	γ-secretase inhibitor; reduces Aβ42 levels

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