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 제품안내  분자생물학   Protein Research  Protein Phosphorylation Research

Protein Phosphatase Inhibitors Econokit

단백질의 phosphorylation은 signal transduction에서 cell division, cell proliferation, apoptosis와 같은 cellular process을 조절합니다.

세포나 Tissue lysate에서 phosphorylated protein을 추출할 때, 단백질의phosphorylation 상태를 유지하는 것은 매우 중요하므로, 이제 Protein Phosphatase Inhibitors를 econokit의 형태로 만나보세요.

Alomone labs
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    구성품
    Product Cat. No. Size Purity Biological Activity
    Bioallethrin B-300 1 mg >98% Although bioallethrin is a type I pryrethroid, its effects on calcineurin resemble those of Type II Pyrethrins which are very weak, bioallethrin is a potent calcinerin inhibitor, with an IC50 of about 1-2 nM.
    Calyculin A C-100 10 μg >99% Highly specific inhibitor for PP-1 and PP-2A phosphatases in comparison to its effect in various acid,alkaline,and protein tyrosine phosphatases.CA is 20-300-fold more potent than OA in inhibiting various PP-1 phosphatases.Its concentrationdependent effects in intact cells are easier to interpret than those of OA.
    Cantharidic Acid C-250 1 mg >99% Like Cantharidin, Cantharidinic Acid has been a useful tool in studying the role of protein phosphatase in regulation of various physiological functions.
    Cantharidin C-170 1 mg >98% Potent inhibitor of protein phosphatase 2A(IC50=40nM).
    Cyclosporin A C-900 25 mg >97% Cyclosporin A is a cyclic peptide that serves as an immunosuppresant, hypertension inducer and antifungal agent by its ability to inhibit Calcineurin (PP-2B).
    Cypermethrin C-470 1 mg >98% A type II pyrethrin; potent inhibitor of calcineurin, with an IC50 of about 40 pM (the dose-response curve is complex, however).
    Deltamethrin D-500 0.5 mg >99% Potent pyrethroid insecticide, specific inhibitor of Calcineurin (PP-2B) with an IC50 of about 100 pM.
    Endothall E-180 5 mg >98% Like other Cantharidin analogs, Endothall has been employed as a useful PP-2A inhibitor. In addition, protein phosphatase inhibition by Endothall has been used in the study of cardiac contractile, electrophysiological nd biochemical aspects, and characterization of hepatocellular carcinoma cell lines from diethylnitrosamine phenobarbital-trided rats.
    Fenvalerate F-420 1 mg >99% A type II pyrethroid; potent inhibitor of calcineurin, with an IC50 of about 2-4nM.
    FK-506 F-900 1 mg >98% FK 506 is potent immunosuppressive compounds that inhibit T-cell activation (10 to 100 times more potent than Cyclosporin A). FK-506 inhibits the heterodimeric Ca2+ /calmodulin-dependent phosphatase Calcineurin.
    Okadaic Acid (Ammonium Salt) O-800 25 μg >98% Okadaic Acid is a marine toxin, polyether derivative, produced by dinoflagellates. It is a potent, ell-permeable, specific inhibitor of PP-1 and PP2A, in numerous cell types.
    Okadaol O-700 10 μg >98% Okadaic acid derivate with novel pharmacological profile.
    Okadiac Acid (Sodium Salt) O-900 25 μg >98% Okadaic Acid is a marine toxin, polyether derivative, produced by dinoflagellates. It is a potent, ell-permeable, specific inhibitor of PP-1 and PP2A, in numerous cell types.
    Permethrin P-400 0.4 mg >99% A type I pyrethroid; weakly active negative control for studies of calcineurin inhibition by the more active type II pyrethroids such as Deltamethrin and Fenvalerate.
    Phenylarsine Oxide - 100 mg >99% Putative inhibitor of tyrosine phosphatases activity. Does not affect tyrosine kinase.
    Pyrophosphate (Sodium Salt) - 500 mg >98% Strong inhibitor of protein phosphatases. Effect similar to sodium fluoride and Vanadate.
    Sodium Fluoride - 500 mg >99% Strong inhibitor of protein phosphatases (acid, alkaline, P2, 2A). Effect similar to Pyro-phosphate and Vanadate.
    Vanadate (Orthovanadate) - 100 mg >95% A general potent protein phosphatases inhibitor.