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 제품안내  면역학   Cancer Research  Apoptosis

Tocris Caspase Inhibitors & Substrates

Tocris의 Apoptosis pathway중 caspase를 blocking하는 inhibitor list와 substrates를 소개합니다.

TOCRIS
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Caspase Inhibitors
TargetProductCat.NoBiological Activity
Caspase 1 Z-VAD-FMK 2163 Cell-permeable, irreversible pan-caspase inhibitor. Inhibits caspase processing and apoptosis induction in tumour cells in vitro (IC50 = 0.0015-5.8 μM). Active in vivo.
Z-YVAD-FMK 2164 Inhibitor of caspase-1 (ICE); inhibits apoptosis.
Caspase 2 Z-VDVAD-FMK 2165 Irreversible caspase-2 inhibitor. Attenuates oxyhemoglobin-induced cleavage of PARP and apoptosis in endothelial cells.
Caspase 3 Z-DQMD-FMK 2168 Caspase-3 inhibitor. Inhibits MG 132-induced small cell lung cancer cell death in vitro.
Ac-DEVD-AFC 1573 Fluorogenic caspase substrate. Analog of the caspase-3-like substrate, DEVD-AFC.
Z-DEVD-FMK 2166 Cell-permeable, irreversible inhibitor of caspase-3/CPP32; inhibits tumour cell apoptosis. Neuroprotective in rat hippocampus following seizures in vivo.
Ivachtin 2636 Potent, reversible inhibitor of caspase-3 (IC50 = 23 nM) that displays moderate selectivity over other caspases. Exhibits antiapoptotic activity in human Jurkat T cells treated with staurosporine; exhibits a higher level of protection than Z-VAD-FMK (Cat. No. 2163).
Caspase 5 Z-WEHD-FMK 2167 Caspase-5 inhibitor. Inhibits ECyd-induced rRNA fragmentation in mouse mammary tumour and human fibrosarcoma cells.
Caspase 6 Z-VEID-FMK 2169 Irreversible caspase-6 inhibitor. Inhibits nuclear protein cleavage in Fas antibody-treated HeLa cells.
Caspase 8 Z-IETD-FMK 2170 Inhibitor of caspase-8. Blocks TNFα-induced cytochrome c release and apoptosis in human leukemic U937 cells. Also inhibits nuclear protein cleavage in Jurkat, MCF-7 and HeLa cells in vitro.
Caspase 9 Z-LEHD-FMK 2171 Cell-permeable inhibitor of caspase-9. Inhibits MG 132-induced cancer cell death and protects isolated rat hearts against ischaemia-reperfusion injury. Neuroprotective following cerebral ischaemia in rats in vivo.
Caspase 10 Z-AEVD-FMK N/A  
Caspase 12 Z-ATAD-FMK N/A  
Caspase 13 Z-LEED-FMK N/A  
Caspase Substrates
TargetProductCat.NoBiological Activity
Caspase 1 Ac-YVAD-AFC 1572 Fluorogenic peptide substrate for caspase-1 (ICE). M.Wt:719.67 Formula:C33H36F3N5O10
Caspase 3 Ac-DEVD-AFC 1573 Fluorogenic caspase substrate. Analog of the caspase-3-like substrate, DEVD-AFC. M.Wt:729.62 Formula:C30H34F3N5O13
Caspase 9 Ac-LEHD-AFC 1575 Fluorogenic caspase substrate. Analog of the caspase-9 substrate, LEHD-AFC. M.Wt:765.7 Formula:C33H38F3N7O11
Granzyme B Ac-IEPD-AFC 1576 Peptide sequence shown to be preferred recognition motif for the serine protease granzyme B. Fluorogenic substrate. M.Wt:725.67 Formula:C32H38F3N5O11
주문정보(Ordering Information)
CATNUM PRODUCT SIZE
1573Ac-DEVD-AFC 5mg
1576Ac-IEPD-AFC 5mg
1575Ac-LEHD-AFC 5mg
2636Ivachtin 1mg
2636Ivachtin 10mg
2166Z-DEVD-FMK 1mg
2168Z-DQMD-FMK 1mg
2170Z-IETD-FMK 1mg
2171Z-LEHD-FMK 1mg
2163Z-VAD-FMK 1mg
2165Z-VDVAD-FMK 1mg
2169Z-VEID-FMK 1mg
2164Z-YVAD-FMK 1mg