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 제품안내  항체,항원,킷트   Neuroscience  Ion Channel

Ion Channel Cell Line

Ion channel cell line은 CHO, HEK 293, ND7-23 세포주에 유전자 재조합을 통하여 원하는 이온 채널을 관찰함으로서, 약물의 효능을 탐색하도록 도와드립니다.

Eurofins DiscoverX
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  • Potassium Channels: CHO, HEK 293 세포주에 human Kv1.1 유전자 등을 재조합하여 칼륨채널을 발현합니다.
  • Sodium Channels: CHO, HEK 293, ND7-23세포주에 human Nav1.1 유전자 등을 재조합하여 나트륨 채널을 발현합니다.
  • HCN Channels: CHO, HEK 293 세포주에 human HCN 유전자 등을 재조합하여 hyperpolarization-activated, cyclic nucleotide-gated potassium 채널을 발현합니다.
  • TRP Channels: HEK 293 세포주에 human TRPA1 유전자 등을 재조합하여 transient receptor potential cation 채널을 발현합니다.
  • Calcium Channels: HEK 293 세포주에 human Cav1.2 유전자 등을 재조합하여 칼슘 채널을 발현합니다.
  • PrecisION® hERG membrane preps: hERG stable cell lines으로부터 유도되어 랏간의 재현성이 우수하며, 뛰어난 functional expression과 specific binding을 보여줍니다.


 

  • 60가지 이상의 다양하고 stable한 Ion Channel 세포주를 제공합니다.
  • 25 passages이상에서도 약물학적으로 혹은 기능적인 면에서 안정함을 보여줍니다.
  • 우수한 벡터 기술로 안정하고, 변함없이 일정하게 발현됩니다.
  • Eurofins의 electrophysiologist 전문가로부터 기숙적인 support를 제공받을 수 있습니다.

 



 

     Figure 1. Measuring 'resting-state' block on PatchXpress® platform.

     Lamotrigine, mexiletine and flecainide were tested by five-point dose response against the Nav1.5
    (CYL3004) PrecisION® recombinant cell line on the PatchXpresss® platform, yielding IC50 values of 
    71.9 ± 30
μM, 69.4 ± 24 μM and 14 ± 2 μM, respectively. 

 

 

주문정보(Ordering Information)
CATNUM PRODUCT SIZE
CYL3055PrecisION hASIC3 Recombinant Stable Cell LineClone
CYL3054PrecisION hCav2.2 α1B/β3/α2/δ1 Recombinant Stable Cell LineClone
CYL3075PrecisION hCav3.2 Recombinant Stable Cell LineClone
CYL3088PrecisION hCFTR Recombinant Stable Cell LineClone
CYL3039PrecisION hERG Recombinant Stable Cell LineClone
CYL3038PrecisION hERG Recombinant Stable Cell LineClone
CYL3053PrecisION hGABAA α1/β3/γ2 Recombinant Stable Cell LineClone
CYL3068PrecisION hGABAA α3/β3/γ2 Recombinant Stable Cell LineClone
CYL3085PrecisION hGABAA α4/β3/γ2 Recombinant Stable Cell LineClone
CYL3073PrecisION hGABAA α5/β3/γ2 Recombinant Stable Cell LineClone
CYL3086PrecisION hGABAA α6/β3/γ2 Recombinant Stable Cell LineClone
CYL3049PrecisION hGluR6 Recombinant Stable Cell LineClone
CYL3056PrecisION hGlyRA1 Recombinant Stable Cell LineClone
CYL3040PrecisION hHCN1 Recombinant Stable Cell LineClone
CYL3041PrecisION hHCN2 Recombinant Stable Cell LineClone
CYL3042PrecisION hHCN3 Recombinant Stable Cell LineClone
CYL3012PrecisION hHCN4 Recombinant Stable Cell LineClone
CYL3007PrecisION hKCNQ1/hminK Recombinant Stable Cell LineClone
CYL3032PrecisION hKir2.1 Recombinant Stable Cell LineClone
CYL3099PrecisION hKir6.2/SUR2A Recombinant Stable Cell LineClone
CYL3014PrecisION hKv1.1 Recombinant Stable Cell LineClone
CYL3015PrecisION hKv1.2 Recombinant Stable Cell LineClone
CYL3016PrecisION hKv1.3 Recombinant Stable Cell LineClone
CYL3017PrecisION hKv1.4 Recombinant Stable Cell LineClone
CYL3018PrecisION hKv1.5 Recombinant Stable Cell LineClone
CYL3019PrecisION hKv1.6 Recombinant Stable Cell LineClone
CYL3020PrecisION hKv1.7 Recombinant Stable Cell LineClone
CYL3021PrecisION hKv1.8 Recombinant Stable Cell LineClone
CYL3089PrecisION hKv12.2 Recombinant Stable Cell LineClone
CYL3022PrecisION hKv2.1 Recombinant Stable Cell LineClone
CYL3067PrecisION hKv2.1/hKv9.2 Recombinant Stable Cell LineClone
CYL3043PrecisION hKv3.1 Recombinant Stable Cell LineClone
CYL3044PrecisION hKv3.2 Recombinant Stable Cell LineClone
CYL3045PrecisION hKv3.3 Recombinant Stable Cell LineClone
CYL3026PrecisION hKv4.2/hKChIP2 Recombinant Stable Cell LineClone
CYL3027PrecisION hKv4.3/hKChIP1 Recombinant Stable Cell LineClone
CYL3069PrecisION hKv4.3/hKChIP2 Recombinant Stable Cell LineClone
CYL3059PrecisION hKv7.2/hKv7.3 Recombinant Stable Cell LineClone
CYL3060PrecisION hKv7.3/hKv7.5 Recombinant Stable Cell LineClone
CYL3092PrecisION hKv7.4 Recombinant Stable Cell LineClone
CYL3096PrecisION hKv7.4/hKv7.5 Recombinant Stable Cell LineClone
CYL3052PrecisION hnAChR α1/β1/δ/ε Recombinant Stable Cell LineClone
CYL3057PrecisION hnAChR α3/β4 Recombinant Stable Cell LineClone
CYL3107PrecisION hnAChR α4/α6/β2 Recombinant Stable Cell LineClone
CYL3106PrecisION hnAChR α4/β2 Recombinant Stable Cell LineClone
CYL3097PrecisION hnAChR α7/ric3 Recombinant Stable Cell LineClone
CYL3009PrecisION hNav1.1 Recombinant Stable Cell LineClone
CYL3023PrecisION hNav1.2 Recombinant Stable Cell LineClone
CYL3003PrecisION hNav1.3 Recombinant Stable Cell LineClone
CYL3024PrecisION hNav1.4 Recombinant Stable Cell LineClone
CYL3004PrecisION hNav1.5 Recombinant Stable Cell LineClone
CYL3010PrecisION hNav1.6 Recombinant Stable Cell LineClone
CYL3011PrecisION hNav1.7 Recombinant Stable Cell LineClone
CYL3025PrecisION hNav1.8/β1 Recombinant Stable Cell LineClone
CYL3066PrecisION hTRPA1 Recombinant Stable Cell LineClone
CYL3063PrecisION hTRPV1 Recombinant Stable Cell LineClone
CYL3065PrecisION hTRPV3 Recombinant Stable Cell LineClone
CYL3064PrecisION hTRPV4 Recombinant Stable Cell LineClone
CYL4039PrecisION Recombinant hERG Potassium Ion Channel Membrane PreparationMembrane Prep
CYL3050PrecisION rNav1.8 Recombinant Stable Cell LineClone