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 제품안내  면역학   Neuroscience  Ion Channel

Ion Channel Cell Line

Ion channel cell line은 CHO, HEK 293, ND7-23 세포주에 유전자 재조합을 통하여 원하는 이온 채널을 관찰함으로서, 약물의 효능을 탐색하도록 도와드립니다.

Eurofins
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 제품 종류
  • Potassium Channels: CHO, HEK 293 세포주에 human Kv1.1 유전자 등을 재조합하여 칼륨채널을 발현합니다.
  • Sodium Channels: CHO, HEK 293, ND7-23세포주에 human Nav1.1 유전자 등을 재조합하여 나트륨 채널을 발현합니다.
  • HCN Channels: CHO, HEK 293 세포주에 human HCN 유전자 등을 재조합하여 hyperpolarization-activated, cyclic nucleotide-gated potassium 채널을 발현합니다.
  • TRP Channels: HEK 293 세포주에 human TRPA1 유전자 등을 재조합하여 transient receptor potential cation 채널을 발현합니다.
  • Calcium Channels: HEK 293 세포주에 human Cav1.2 유전자 등을 재조합하여 칼슘 채널을 발현합니다.
  • PrecisION® hERG membrane preps: hERG stable cell lines으로부터 유도되어 랏간의 재현성이 우수하며, 뛰어난 functional expression과 specific binding을 보여줍니다.


  PrecisION® Recombinant Cell Lines의 장점

  • 60가지 이상의 다양하고 stable한 Ion Channel 세포주를 제공합니다.
  • 25 passages이상에서도 약물학적으로 혹은 기능적인 면에서 안정함을 보여줍니다.
  • 우수한 벡터 기술로 안정하고, 변함없이 일정하게 발현됩니다.
  • Eurofins의 electrophysiologist 전문가로부터 기숙적인 support를 제공받을 수 있습니다.


  적용




 

Figure 1. Measuring 'resting-state' block on PatchXpress® platform.

Lamotrigine, mexiletine and flecainide were tested by five-point dose response against the Nav1.5 (CYL3004) PrecisION® recombinant cell line on the PatchXpresss® platform, yielding IC50 values of 71.9 ± 30 μM, 69.4 ± 24 μM and 14 ± 2 μM, respectively. 

주문정보(Ordering Information)
CATNUM PRODUCT Channel
CYL3055MShASIC3-HEK Multi SL
CYL3055SShASIC3-HEK Single SL
CYL3055TShASIC3-HEK Two SL
CYL3075MShCav3.2-HEK Multi SL
CYL3075SShCav3.2-HEK Single SL
CYL3075TShCav3.2-HEK Two SL
CYL3088TShCFTR-HEK Two SL
CYL3088MShCFTR-HEK Multiple SL
CYL3088SShCFTR-HEK Single SL
CYL4039hERG Membrane Preparation
CYL3038TShERG-CHO Two SL
CYL3038MShERG-CHO Multi SL
CYL3038SShERG-CHO Single SL
CYL3039MShERG-HEK Multi SL
CYL3039SShERG-HEK Single SL
CYL3039TShERG-HEK Two SL
CYL3049MShGluR6-HEK Multi SL
CYL3049SShGluR6-HEK Single SL
CYL3049TShGluR6-HEK Two SL
CYL3056MShGlyRA1-HEK Multi SL
CYL3056SShGlyRA1-HEK Single SL
CYL3056TShGlyRA1-HEK Two SL
CYL3040MShHCN1-HEK Multi SL
CYL3040SShHCN1-HEK Single SL
CYL3040TShHCN1-HEK Two SL
CYL3041MShHCN2-HEK Multi SL
CYL3041SShHCN2-HEK Single SL
CYL3041TShHCN2-HEK Two SL
CYL3042MShHCN3-HEK Multi SL
CYL3042SShHCN3-HEK Single SL
CYL3042TShHCN3-HEK Two SL
CYL3012MShHCN4-CHO Multi SL
CYL3012SShHCN4-CHO Single SL
CYL3012TShHCN4-CHO Two SL
CYL3063TShhTRPV1-HEK Two SL
CYL3007MShKCNQ1/hminK-CHO Multi SL
CYL3007SShKCNQ1/hminK-CHO Single SL
CYL3007TShKCNQ1/hminK-CHO Two SL
CYL3032MShKir2.1-HEK Multi SL
CYL3032SShKir2.1-HEK Single SL
CYL3032TShKir2.1-HEK Two SL
CYL3014MShKv1.1-CHO Multi SL
CYL3014SShKv1.1-CHO Single SL
CYL3014TShKv1.1-CHO Two SL
CYL3015MShKv1.2-CHO Multi SL
CYL3015SShKv1.2-CHO Single SL
CYL3015TShKv1.2-CHO Two SL
CYL3016MShKv1.3-CHO Multi SL
CYL3016SShKv1.3-CHO Single SL
CYL3016TShKv1.3-CHO Two SL
CYL3017MShKv1.4-CHO Multi SL
CYL3017SShKv1.4-CHO Single SL
CYL3017TShKv1.4-CHO Two SL
CYL3018MShKv1.5-CHO Multi SL
CYL3018SShKv1.5-CHO Single SL
CYL3018TShKv1.5-CHO Two SL
CYL3019MShKv1.6-CHO Multi SL
CYL3019SShKv1.6-CHO Single SL
CYL3019TShKv1.6-CHO Two SL
CYL3020MShKv1.7-CHO Multi SL
CYL3020SShKv1.7-CHO Single SL
CYL3020TShKv1.7-CHO Two SL
CYL3021MShKv1.8-CHO Multi SL
CYL3021SShKv1.8-CHO Single SL
CYL3021TShKv1.8-CHO Two SL
CYL3089MShKv12.2-HEK Multiple SL
CYL3089SShKv12.2-HEK Single SL
CYL3089TShKv12.2-HEK Two SL
CYL3022MShKv2.1-CHO Multi SL
CYL3022SShKv2.1-CHO Single SL
CYL3022TShKv2.1-CHO Two SL
CYL3067MShKv2.1/hKv9.2-CHO Multi SL
CYL3067SShKv2.1/hKv9.2-CHO Single SL
CYL3067TShKv2.1/hKv9.2-CHO Two SL
CYL3043SShKv3.1-CHO Single SL
CYL3043MShKv3.1-CHO Multi SL
CYL3043TShKv3.1-CHO Two SL
CYL3044MShKv3.2-CHO Multi SL
CYL3044SShKv3.2-CHO Single SL
CYL3044TShKv3.2-CHO Two SL
CYL3045MShKv3.3-CHO Multi SL
CYL3045SShKv3.3-CHO Single St
CYL3045TShKv3.3-CHO Two SL
CYL3026MShKv4.2/hKChIP2-CHO Multi SL
CYL3026SShKv4.2/hKChIP2-CHO Single SL
CYL3026TShKv4.2/hKChIP2-CHO Two SL
CYL3027MShKv4.3/hKChIP1-CHO Multi SL
CYL3027SShKv4.3/hKChIP1-CHO Single SL
CYL3027TShKv4.3/hKChIP1-CHO Two SL
CYL3069MShKv4.3/hKChIP2-CHO Multi SL
CYL3069SShKv4.3/hKChIP2-CHO Single SL
CYL3069TShKv4.3/hKChIP2-CHO Two SL
CYL3059MShKv7.2/hKv7.3-CHO Multi SL
CYL3059SShKv7.2/hKv7.3-CHO Single SL
CYL3059TShKv7.2/hKv7.3-CHO Two SL
CYL3060MShKv7.3/hKv7.5-CHO Multiple SL
CYL3060SShKv7.3/hKv7.5-CHO Single SL
CYL3060TShKv7.3/hKv7.5-CHO Two SL
CYL3092MShKv7.4-HEK Multi SL
CYL3092SShKv7.4-HEK Single SL
CYL3092TShKv7.4-HEK Two SL
CYL3096MShKv7.4/hKv7.5-HEK Multi SL
CYL3096SShKv7.4/hKv7.5-HEK Single SL
CYL3096TShKv7.4/hKv7.5-HEK Two SL
CYL3009MShNav1.1-HEK Multi SL
CYL3009SShNav1.1-HEK Single SL
CYL3009TShNav1.1-HEK Two SL
CYL3023MShNav1.2-CHO Multi SL
CYL3023SShNav1.2-CHO Single SL
CYL3023TShNav1.2-CHO Two SL
CYL3003MShNav1.3-CHO Multi SL
CYL3003SShNav1.3-CHO Single SL
CYL3003TShNav1.3-CHO Two SL
CYL3024MShNav1.4-HEK Multi SL
CYL3024SShNav1.4-HEK Single SL
CYL3024TShNav1.4-HEK Two SL
CYL3004MShNav1.5-HEK Multiple SL
CYL3004SShNav1.5-HEK Single SL
CYL3004TShNav1.5-HEK Two SL
CYL3010MShNav1.6-HEK Multi SL
CYL3010SShNav1.6-HEK Single SL
CYL3010TShNav1.6-HEK Two SL
CYL3011MShNav1.7-HEK Multi SL
CYL3011SShNav1.7-HEK Single SL
CYL3011TShNav1.7-HEK Two SL.
CYL3025MShNav1.8/?1-HEK Multi SL
CYL3025SShNav1.8/?1-HEK Single SL
CYL3025TShNav1.8/?1-HEK Two SL
CYL3066MShTRPA1-HEK Multi SL
CYL3066SShTRPA1-HEK Single SL
CYL3066TShTRPA1-HEK Two SL
CYL3063MShTRPV1-HEK Multi SL
CYL3063SShTRPV1-HEK Single SL
CYL3065MShTRPV3-HEK Multi SL
CYL3065SShTRPV3-HEK Single SL
CYL3065TShTRPV3-HEK Two SL
CYL3099MSPrecisION hKir6.2/SUR2A-HEK Recom
CYL3099SSPrecisION hKir6.2/SUR2A-HEK Recom
CYL3099TSPrecisION hKir6.2/SUR2A-HEK Recombin
CYL3064SSPrecisION hTRPV4-HEK Recombinant
CYL3064TSPrecisION hTRPV4-HEK Recombinant
CYL3064MSPrecisION hTRPV4-HEK Recombinant
CYL3050MSrNav1.8-ND7 Multi SL
CYL3050SSrNav1.8-ND7 Single SL
CYL3050TSrNav1.8-ND7 Two SL