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Kinases Screening & Profiling

Ͻ Kinase inhibitor, New drug(compound) Ͻô kinase, phosphatase г ũϿ inhibition activity IC50 ص帳ϴ.

Eurofins
ǰ ϱ
μϱ




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  • Upstate, Millipore ̾ ° Ͽ ŷڼִ մϴ. 
  • ȭչ ҿ , 1 ̳ żϰ ͸ ޾ƺ ֽϴ.
  • QC ݺ谣 variation ſ ϴ.
  • ATP substrate active site ϵ ȯ , inhibitor ȿ Ȯϴ Functional assay Ȯϰ ȿԴϴ.
  • set upϱ ð Ͻ , ʿ enzyme þ ʾƵ ǹǷ Դϴ.
  • kinase family Panel service ̿Ͽ ũ Ͻø մϴ. 
  • Standard ܿ non-standard solvents Ȥ pre-incubation Flexible assay մϴ.

 



KinaseProfiler 1 Kinase/phosphatase panel list Ͽ, ϴ Kinase/phosphatase ׽Ʈ
IC50 Profiler Express 1 ϴ Kinase/phosphatase Ͽ IC50



  • 452 kinase/phosphatase (Kinase 430, Phosphatase 22)
AAK1(h) Fms(h) PI3 Kinase(p110α/p85α)(h)
Abl(h) Fms(Y969C)(h) PI3 Kinase(p110α/p85α)(m)
Abl(H396P)(h) Fyn(h) PI3 Kinase(p110β/p85α)(h)
Abl(m) GCK(h) PI3 Kinase(p110β/p85α)(m)
Abl(M351T)(h) GCN2(h) PI3 Kinase(p110β/p85β)(m)
Abl(Q252H)(h) GRK1(h) PI3 Kinase(p110δ/p85α)(h)
Abl(T315I)(h) GRK2(h) PI3 Kinase(p110δ/p85α)(m)
Abl(Y253F)(h) GRK3(h) PI3 Kinase(p120γ)(h)
ACK1(h) GRK5(h) PI3KC2α(h)
ACTR2(h) GRK6(h) PI3KC2γ(h)
ALK(h) GRK7(h) Pim-1(h)
ALK1(h) GSK3α(h) Pim-2(h)
ALK2(h) GSK3β(h) Pim-3(h)
ALK4(h) haspin(h) PIP4K2α(h)
ALK6(h) Hck activated(h) PIP5K1α(h)
AMPKα1(h) Hck(h) PIP5K1γ(h)
AMPKα2(h) HePTP(h) PKA(h)
A-Raf(h) HIPK1(h) PKAcb(h)
Arg(h) HIPK2(h) PKBα(h)
Arg(m) HIPK3(h) PKBβ(h)
ARK5(h) HIPK4(h) PKBγ(h)
ASK1(h) HPK1(h) PKCα(h)
ATM(h) HRI(h) PKCβI(h)
ATR/ATRIP(h) ICK(h) PKCβII(h)
Aurora-A(h) IGF-1R activated(h) PKCγ(h)
Aurora-B(h) IGF-1R(h) PKCδ(h)
Aurora-C(h) IKKα(h) PKCε(h)
Axl(h) IKKβ(h) PKCζ(h)
BIKe(h) IKKε(h) PKCη(h)
Blk(h) IR activated(h) PKCθ(h)
Blk(m) IR(h) PKCι(h)
BMPR2(h) IRAK1(h) PKCμ(h)
Bmx(h) IRAK4(h) PKD2(h)
B-Raf(h) IRE1(h) PKD3(h)
B-Raf(V599E)(h) IRR(h) PKG1α(h)
BRK(h) Itk(h) PKG1β(h)
BrSK1(h) JAK1(h) PKR(h)
BrSK2(h) JAK2(h) Plk1(h)
BTK(h) JAK3(h) Plk3(h)
BTK(R28H)(h) JNK1α1(h) Plk4(h)
CaMKI(h) JNK2α2(h) PP1α(h)
CaMKIb(h) JNK3(h) PP2A(h)
CaMKIIα(h) KDR(h) PP5(h)
CaMKIIβ(h) Lambda PP(Phage) PRAK(h)
CaMKIIγ(h) LATS1(h) PRK1(h)
CaMKIIδ(h) LATS2(h) PRK2(h)
CaMKIV(h) Lck activated(h) PRKG2(h)
CaMKIγ(h) Lck(h) PrKX(h)
CaMKIδ(h) LIMK1(h) PRP4(h)
CaMKK1(h) LIMK2(h) PTK5(h)
CaMKK2(h) LKB1(h) PTP MEG1(h)
CD45(h) LMPTP-A(h) PTP MEG2(h)
Cdc7/cyclinB1(h) LMPTP-B(h) PTP-1B(h)
CDK1/cyclinB(h) LOK(h) PTPN22(h)
CDK12/cyclinK(h) LRRK2(h) PTPβ(h)
CDK13/cyclinK(h) LTK(h) Pyk2(h)
CDK14/cyclinY(h) Lyn(h) Ret(h)
CDK16/cyclinY(h) Lyn(m) Ret(V804L)(h)
CDK17/cyclinY(h) MAK(h) Ret(V804M)(h)
CDK18/cyclinY(h) MAP4K3(h) RIPK1(h)
CDK2/cyclinA(h) MAP4K4(h) RIPK2(h)
CDK2/cyclinE(h) MAP4K5(h) ROCK-I(h)
CDK3/cyclinE(h) MAPK1(h) ROCK-II(h)
CDK4/cyclinD3(h) MAPK2(h) ROCK-II(r)
CDK5/p25(h) MAPK2(m) Ron(h)
CDK5/p35(h) MAPKAP-K2(h) Ros(h)
CDK6/cyclinD3(h) MAPKAP-K3(h) RPTPμ(h)
CDK7/cyclinH/MAT1(h) MARK1(h) Rse(h)
CDK9/cyclinT1(h) MARK3(h) Rsk1(h)
CDKL1(h) MARK4(h) Rsk1(r)
CDKL2(h) MEK1 (h) Rsk2(h)
CDKL3(h) MEK2(h) Rsk3(h)
CDKL4(h) MEKK2(h) Rsk4(h)
ChaK1(h) MEKK3(h) SAPK2a(h)
CHK1(h) MELK(h) SAPK2a(T106M)(h)
CHK2(h) Mer(h) SAPK2b(h)
CHK2(I157T)(h) Met(D1246H)(h) SAPK3(h)
CHK2(R145W)(h) Met(D1246N)(h) SAPK4(h)
CK1(y) Met(h) SBK1(h)
CK1α(h) Met(M1268T)(h) SGK(h)
CK1γ1(h) Met(Y1248C)(h) SGK2(h)
CK1γ2(h) Met(Y1248D)(h) SGK3(h)
CK1γ3(h) Met(Y1248H)(h) SHP-1(h)
CK1δ(h) MINK(h) SHP-2(h)
CK1ε(h) MKK3(h) SIK(h)
CK2(h) MKK4(m) SIK2(h)
CK2α1(h) MKK6(h) SIK3(h)
CK2α2(h) MKP5(h) SLK(h)
c-Kit (V654A)(h) MLCK(h) Snk(h)
c-Kit(D816H)(h) MLK1(h) SNRK(h)
c-Kit(D816V)(h) MLK2(h) Src(1-530)(h)
c-Kit(h) MLK3(h) Src(T341M)(h)
c-Kit(V560G)(h) MLK4(h) SRMS(h)
CLIK1(h) Mnk2(h) SRPK1(h)
CLK1(h) MOK(h) SRPK2(h)
CLK2(h) MRCKα(h) STK16(h)
CLK3(h) MRCKβ(h) STK25(h)
CLK4(h) MRCKγ(h) STK32A(h)
c-RAF(h) MSK1(h) STK32B(h)
CRIK(h) MSK2(h) STK32C(h)
CSK(h) MSSK1(h) STK33(h)
cSRC(h) MST1(h) STK39(h)
DAPK1(h) MST2(h) Syk(h)
DAPK2(h) MST3(h) TAF1L(h)
DCAMKL1(h) MST4(h) TAK1(h)
DCAMKL2(h) mTOR(h) TAO1(h)
DCAMKL3(h) mTOR/FKBP12(h) TAO2(h)
DDR1(h) MuSK(h) TAO3(h)
DDR2(h) MYLK2(h) TBK1(h)
DMPK(h) MYO3B(h) TCPTP(h)
DNA-PK(h) NDR1(h) Tec activated(h)
DRAK1(h) NDR2(h) TGFBR1(h)
DRAK2(h) NEK1(h) TGFBR2(h)
DUSP22(h) NEK11(h) Tie2(h)
DYRK1A(h) NEK2(h) Tie2(R849W)(h)
DYRK1B(h) NEK3(h) Tie2(Y897S)(h)
DYRK2(h) NEK4(h) TLK1(h)
DYRK3(h) NEK6(h) TLK2(h)
eEF-2K(h) NEK7(h) TMDP(h)
EGFR(h) NEK9(h) TNIK(h)
EGFR(L858R)(h) NIM1(h) TRB2(h)
EGFR(L861Q)(h) NLK(h) TrkA(h)
EGFR(T790M)(h) NUAK2(h) TrkB(h)
EGFR(T790M, L858R)(h) OSR1(h) TrkC(h)
EphA1(h) p70S6K(h) TSSK1(h)
EphA2(h) PAK1(h) TSSK2(h)
EphA3(h) PAK2(h) TSSK3(h)
EphA4(h) PAK3(h) TSSK4(h)
EphA5(h) PAK4(h) TTBK1(h)
EphA7(h) PAK5(h) TTBK2(h)
EphA8(h) PAK6(h) TTK(h)
EphB1(h) PAR-1Bα(h) Txk(h)
EphB2(h) PASK(h) TYK2(h)
EphB3(h) PDGFRα(D842V)(h) ULK1(h)
EphB4(h) PDGFRα(h) ULK2(h)
ErbB2(h) PDGFRα(V561D)(h) ULK3(h)
ErbB4(h) PDGFRβ(h) VHR(h)
FAK(h) PDHK2(h) VRK1(h)
Fer(h) PDHK4(h) VRK2(h)
Fes(h) PDK1(h) Wee1(h)
FGFR1(h) PEK(h) Wee1B(h)
FGFR1(V561M)(h) PhKγ1(h) WNK1(h)
FGFR2(h) PhKγ2(h) WNK2(h)
FGFR2(N549H)(h) PI3 Kinase(p110α(E542K)/p85α)(h) WNK3(h)
FGFR3(h) PI3 Kinase(p110α(E542K/p85α)(m) WNK4(h)
FGFR4(h) PI3 Kinase(p110α(E545K)/p85α)(h) Yes(h)
Fgr(h) PI3 Kinase(p110α(E545K)/p85α)(m) YopH (Yersinia)
Flt1(h) PI3 Kinase(p110α(H1047R)/p85α)(h) ZAK(h)
Flt3(D835Y)(h) PI3 Kinase(p110α(H1047R)/p85α)(m) ZAP-70(h)
Flt3(h) PI3 Kinase(p110α/p65α)(h) ZIPK(h)
Flt4(h) PI3 Kinase(p110α/p65α)(m)



 
  •  Kinase, Phosphatase : Scintiation 缺 ī

         

  • PI3 Kinase : HTRF ̿ - TR-FRET (time-resolved fluorescence resonance energy transfer)
         



 

 
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  • ȭ: 02-579-8787, ѽ : 02-578-7042
  • ̸Ϲ: koma@komabiotech.co.kr