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proteaseÀÇ ±âÁú·Î »ç¿ëµÇ´Â AMC, MCA, AFC, Rhodamine 110-based substrateµéÀ» ¼Ò°³ÇÕ´Ï´Ù. |
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Biotium |
Z-IETD-AMC is a substrate for caspase-8, which is involved at the early stage of apoptosis, acting as an initiator of the caspase activation cascade.
Z-FR-AMC is a substrate for serine proteases, including cathepsins, kallikrein and plasmin.
Z-DEVD-AMC is a fluorogenic substrate for caspase 3 and can be used to continuously measure the activity of caspase-3 in cell extracts, using a fluorometer or fluorescence microplate reader.
Z-DEVD-AFC is a fluorogenic substrate for caspase 3 and can be used to continuously measure the activity of caspase-3 in cell extracts, using a fluorometer or fluorescence microplate reader.
Z-IETD-AFC is a substrate for caspase-8, which is involved at the early stage of apoptosis, acting as an initiator of the caspase activation cascade. Absorption/emission of substrate = 340/434nm (weak fluorescence);
D2R is a general substrate for caspases including caspases 3 and 7. Unlike other fluorogenic substrates for caspases, D2R appears to be membrane-permeant, and thus can be used to measure caspase activity in live cells without osmotic shock for flow cytometry studies, as well as for cell extracts.
BZAR is a substrate for serine proteases,1-5 and is also an inhibitor for quanidinobenzoatase.6 It is 50 to 100 times more sensitive than the AMC-based substrate.
Z-DEVD-R110 is a fluorogenic substrate for caspase 3 and can be used to continuously measure the activity of caspase-3 in cell extracts, using a fluorometer or fluorescence microplate reader. Absorption/emission of end product (R110) = 496/520nm (strong fluorescence). Of-white solid soluble in DMSO. Store at -20¡É and protect from light. C72H78N10O27. Mwt: 1514.
Z-IETD-R110 is a substrate for caspase-8, which is involved at the early stage of apoptosis, acting as an initiator of the caspase activation cascade.
BZiPAR is a substrate for trypsin.1,2 The substrate has been reported to enter live cells and be hydrolyzed by lysosomal proteases.3
Z-FR-R110 is a substrate for the cysteine proteases cathepsins B and L. The substrate has been used in flow cytometry studies of human monocytes and rat macrophages.
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