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 제품안내  신경약학   Cell Biology

Cell & Gene Therapy Small Molecules

유전자 세포 치료제 연구에 이용되는 small molecule을 소개합니다.

TOCRIS
제품 문의하기
인쇄하기

  • CRISPR 유전자 편집 프로세스의 효율을 향상시킵니다.
  Cat. No. Product Name / Activity
  6554 (+)-Abscisic Acid
    Used to control Cas9 via abscisic acid-inducible biosensor system; also endogenous LANCL2 agonist
  5199 AZD 7762 hydrochloride
    Enhances CRISPR-Cpf1-mediated genome editing; also potent and selective ATP-competitive Chk1 and Chk2 inhibitor
  4150 Azidothymidine
    Decreases CRISPR-mediated HDR efficiency
  1231 Brefeldin A
    Enhances CRISPR-mediated HDR efficiency
  3412 (Z)-4-Hydroxytamoxifen
    Activates intein-linked inactive Cas9, reducing off-target CRISPR-mediated gene editing
  4840 KU 0060648
    Enhances HDR efficiency and attenuates NHEJ frequency
  2197 L-755,507
    Enhances CRISPR-mediated HDR efficiency
  5054 ME 0328
    Enhances CRISPR-Cas9-mediated HER2 mutation frequency; PARP3 inhibitor
  1228 Nocodazole
    Enhances HDR efficiency; also increases Cas9-mediated gene editing frequencies
  3712 NU 7441
    Enhances HDR efficiency and attenuates NHEJ frequency
  5810 RS 1
    Enhances HDR efficiency and increases CRISPR-mediated knock-in efficiencies
  5342 SCR7 pyrazine
    Enhances HDR efficiency



  • Viral Transduction Enhancer는 바이러스 형질 도입과정을 향상시켜 표적 유전자 발현 증가를 유도합니다.
  Cat. No. Product Name / Activity
  5773 Akti-1/2
    Enhances CAR and TCR retroviral transduction of human T cells
  4318 BX 795
    Enhances lentiviral transduction of NK cells; also PDPK1 (PDK1) and TBK inhibitor
  1101 Cyclosporin A
    Enhances lentiviral transduction; calcineurin inhibitor
  6982 Cyclosporin H
    Enhances lentiviral transduction
  1467 Daunorubicin hydrochloride
    Enhances adenoviral transduction; RNA synthesis inhibitor
  1126 Dexamethasone
    Enhances retroviral transduction; also anti-inflammatory glucocorticoid
  4027 16,16-Dimethyl Prostaglandin E2
    Enhances lentiviral transduction; synthetic prostaglandin E2 (Cat. No. 2296) derivative
  3922 Eeyarestatin I
    Enhances AAV transduction
  1226 Etoposide
    Enhances adenoviral transduction; topoisomerase II inhibitor
  1748 MG 132
    Enhances AAV transduction efficiency of human cell lines
  4821 PF 03814735
    Enhances adenoviral transduction; aurora kinase A and B inhibitor
  2296 Prostaglandin E2
    Enhances lentiviral transduction; endogenous prostanoid
  1292 Rapamycin
    Enhances lentiviral transduction; mTOR inhibitor and immunosuppressant
  6343 Rosuvastatin calcium
    Enhances lentiviral transduction of NK cells
  4652 SAHA
    Enhances plasmid transduction; class I and II HDAC inhibitor
  1285 Staurosporine
    Enhances lentiviral transduction; non-selective protein kinase inhibitor





  • Akt (Protein kinase B, PKB)는 세포의 생존, 혈관신생, 종양형성을 조절하는데 중요한 역할을 하는 serine/threonine kinase 입니다. Akt signaling에 관여하는 small molecule을 소개합니다.
  Cat. No. Product Name / Activity
  5773 Akti-1/2
    Potent and selective dual Akt1 and 2 inhibitor
  3897 API-1
    Selective Akt/PKB inhibitor. Antitumor
  2151 API-2
    Selective inhibitor of Akt/PKB signaling. Antitumor and antiviral
  7001 AT 7867
    Potent pan-Akt and PKA inhibitor
  6978 AZD 5363
    Potent pan-AKT inhibitor
  2558 10-DEBC hydrochloride
    Selective Akt/PKB inhibitor
  2926 FPA 124
    Akt/PKB inhibitor
  4144 GSK 690693
    Akt kinase inhibitor. Antitumor
  6087 Perifosine
    PKB/Akt inhibitor; also modulates Kv2.1 current
  4598 PHT 427
    Dual Akt and PDK1 inhibitor; antitumor
  4398 SC 66
    Allosteric Akt inhibitor
  1353 Akt/SKG Substrate Peptide
    Akt/PKB substrate (synthetic)
  2422 AKTide-2T
    Akt/PKB substrate (synthetic)
  4635 SC 79
    Akt activator
  5682 OSU 03012
    Akt signaling inhibitor; inhibits PDPK1 (PDK1)
  6762 Urolithin A
    PI 3-K/Akt/mTOR signaling inhibitor; blocks phosphorylation of Akt and p70S6K in vitro


  • Immune checkpoint molecule은 면역억제 신호경로에 관여하여 면역세포의 활성을 유도합니다.
  • indoleamine 2,3-dioxygenase (IDO), tryptophan 2,3 dioxygenase (TDO), arginase 와 같은 특정 대사 효소도 면역세포 기능에 필수적인 아미노산을 국소적으로 고갈시키는 역할을 하므로 Immune checkpoint molecule로 간주됩니다.
  Cat. No. Product Name / Activity
  4392 680C91
    Potent and selective tryptophan 2,3-dioxygenase (TDO) inhibitor
  1545 (R)-(+)-Bay K 8644
    TMEM176B inhibitor; activates inflammasomes; also CaV1.x blocker
  6007 INCB 024360-analog
    Potent indoleamine 2,3-dioxygenase (IDO) inhibitor
  6068 Lin28 1632
    Lin28 inhibitor; suppresses PD-L1 expression and enhances T cell-mediated antitumor immunity; also bromodomain inhibitor
  5794 LM 10
    Selective tryptophan 2,3-dioxygenase (TDO) inhibitor
  5698 1-Methyl-D-tryptophan
    Indoleamine 2,3-dioxygenase (IDO) inhibitor
  6370 Nor NOHA monoacetate
    Arginase inhibitor
  6515 (D)-PPA 1
    PD-1/PD-L1 interaction inhibitor



  • mTOR는 세포 신호 전달 경로를 조정하는데 중요한 역할을 합니다.
  • mTOR는 분자량 280kD이상의 large multidomain protein으로 kinase domain과 FKBP12 binding domain을 갖고 있습니다.
  Cat. No. Product Name / Activity
  5615 AZD 3147
    Potent and selective dual mTORC1 and 2 inhibitor; orally bioavailable
  6791 BC-LI-0186
    Inhibits mTORC1 activity; leucyl-tRNA synthase (TRS)/Ras-related GTP-binding protein D (RagD) interaction inhibitor
  3271 Compound 401
    Selective mTOR and DNA-PK inhibitor
  5955 eCF 309
    Potent mTOR inhibitor
  4702 ETP 45658
    mTOR inhibitor; also inhibits PI 3-K and DNA-PK
  6188 Everolimus
    mTOR inhibitor; Immunosuppressant
  3725 KU 0063794
    Selective mTOR inhibitor
  4079 Niclosamide
    STAT3 inhibitor; also inhibits mTORC1 signaling
  6792 Omipalisib
    High affinity mTOR inhibitor; also highly potent PI 3-kinase and potent DNA-PK inhibitor
  4820 PF 04691502
    Dual PI 3-K/mTOR inhibitor
  4823 PF 05212384
    Potent and selective dual PI 3-kinase/mTOR inhibitor
  2930 PI 103 hydrochloride
    Inhibitor of mTOR, PI 3-kinase and DNA-PK
  3894 PP 121
    Dual kinase inhibitor; inhibits PI 3K family kinases
  4257 PP 242
    Dual mTORC1/mTORC2 inhibitor
  1292 Rapamycin
    mTOR inhibitor; immunosuppressant
  6036 STK16-IN-1
    mTOR kinase inhibitor; also inhibits PI 3Kδ, PI 3Kγ and STK16 kinases
  5264 Temsirolimus
    mTOR inhibitor; antitumor
  4247 Torin 1
    Potent and selective mTOR inhibitor
  4248 Torin 2
    Potent and selective mTOR inhibitor
  4282 WYE 687 dihydrochloride
    Potent and selective mTOR inhibitor
  4893 XL 388
    Potent and selective mTOR inhibitor; antitumor



  • Cytokine은 면역반응의 주요 매개체인 단백질성 신호 화합물 입니다.
  • 증식, 분화, 세포생존 및 apoptosis를 포함하여 다양한 세포 기능을 제어하며, 여러 병리생리학적 과정에도 관여합니다.
  Cat. No. Product Name / Activity
  6583 UCLA GP130 2
    gp130 agonist; brain penetrant and neuroprotectant
  7066 RCGD 423
    gp130 modulator; activates JAK/STAT signaling
  5430 AS 2444697
    Potent and selective IRAK4 inhibitor
  5484 C 87
    TNF-α inhibitor
  4288 ISO 1
    Macrophage migration inhibitory factor (MIF) inhibitor
  6373 PF 06650833
    Potent and selective IRAK4 inhibitor
  4963 SC 144 hydrochloride
    gp130 inhibitor; blocks cytokine-triggered gp130 signaling
  7283 Apilimod dimesylate
    Inhibits production of IL-12 and IL-23; potent and selective PIKfyve inhibitor
  2446 AS 101
    Immunomodulator; inhibits IL-10 synthesis and potentiates IL-1α, IL-2 and TNF-α release
  6438 BRD 6989
    IL-10 production enhancer; Cdk8 inhibitor
  4316 Bropirimine
    Immunomodulatory and antitumor compound
  4204 BTZO 1
    MIF binder
  0846 Chicago Sky Blue 6B
    MIF inhibitor; also inhibits L-glutamate uptake into synaptic vesicles
  6107 CP 424174
    Inhibitor of IL-1β post-translational processing; indirectly inhibits NLRP3
  4400 (±)-CPSI 1306
    Reported macrophage migration inhibitory factor (MIF) inhibitor
  5479 CRID3 sodium salt
    Potent NLRP3 inflammasome inhibitor; inhibits IL-1β production
  2471 ER 27319 maleate
    Inhibits TNF-α production
  1798 Gabexate mesylate
    Inhibits TNF-α production. Also antithrombotic agent
  3270 GIT 27
    Immunomodulator; reduces production of pro-inflammatory cytokines
  5126 iMDK
    Suppressor of MDK expression; inhibits PI 3-K signaling
  3429 4-IPP
    Inhibitor of macrophage migration inhibitory factor (MIF); suicide substrate
  5185 JTE 607 dihydrochloride
    Cytokine release inhibitor; anti-inflammatory
  6305 Lenalidomide
    TNF-α inhibitor; inhibits angiogenesis; also cereblon binder
  4656 (D)-(+)-Neopterin
    Stimulated by IFN-γ; marker of immune activation
  1093 Pirfenidone
    Antifibrotic agent; regulates cytokine levels in vivo
  6302 Pomalidomide
    TNF-α inhibitor; also cereblon ubiquitination inhibitor and antiangiogenic
  6829 (R)-Shikonin
    Blocks TNF-α and NF-κB signaling; induces necroptosis; anti-inflammatory
  3543 Suplatast tosylate
    Th2 cytokine synthesis inhibitor; antiasthmatic
  0652 Thalidomide
    TNF-α synthesis inhibitor; also binds cereblon


  • Checkpoint control kinase는 세포 주기를 통해 세포의 진행을 조절하는 효소 그룹을 말합니다. 이전 단계가 완료되기 전에 세포주기의 다음 단계로 진행되면 치명적인 유전적 손상이 발생할 수 있습니다.
  Cat. No. Product Name / Activity
  5198 AZ 20
    Potent and selective ATR kinase inhibitor; antitumor
  3994 AZ 3146
    Potent and selective Mps1 inhibitor
  6330 AZ 5704
    Potent and selective ATM kinase inhibitor; orally bioavailable.
  5199 AZD 7762 hydrochloride
    Potent and selective ATP-competitive inhibitor of Chk1 and Chk2
  4968 CCT 241533 dihydrochloride
    Potent Chk2 inhibitor
  3271 Compound 401
    Selective DNA-PK and mTOR inhibitor
  4840 KU 0060648
    Dual DNA-PK and PI 3-K inhibitor
  3544 KU 55933
    Potent and selective ATM kinase inhibitor
  6454 LY 2603618
    Potent and selective Chk1 inhibitor
  3190 Mirin
    MRN-ATM pathway inhibitor
  5142 Mps1-IN-1 dihydrochloride
    Selective Mps1 kinase inhibitor
  3034 NSC 109555 ditosylate
    Selective Chk2 inhibitor
  2828 NU 7026
    Selective DNA-PK inhibitor
  3712 NU 7441
    Potent and selective DNA-PK inhibitor
  3785 PD 166285 dihydrochloride
    Wee1 inhibitor; also inhibits Src, FGFR and PDGFRβ
  2694 PD 407824
    Potent and selective inhibitor of Chk1 and Wee1
  4277 PF 477736
    Selective Chk1 inhibitor
  2930 PI 103 hydrochloride
    Inhibitor of DNA-PK, mTOR and PI 3-kinase
  2560 SB 218078
    Chk1 inhibitor
  4750 TC Mps1 12
    Potent and selective Mps1 kinase inhibitor; orally active
  3038 TCS 2312
    Potent Chk1 inhibitor
  4502 DIM
    Activates Chk2; induces G2/M cell cycle arrest
  4763 Pyridostatin pentahydrochloride
    Stabilizes G-quadruplexes; induces DNA damage and cell cycle arrest




주문정보(Ordering Information)
CATNUM PRODUCT SIZE
3412 (Z)-4-Hydroxytamoxifen10 mg
3412 (Z)-4-Hydroxytamoxifen50 mg
5198 AZ 20 10 mg
5198 AZ 20 50 mg
5126 iMDK 50 mg
5126 iMDK 10 mg
4288 ISO 1 50 mg
4288 ISO 1 10 mg
4840 KU 0060648 10 mg
4840 KU 0060648 50 mg
4598 PHT 427 10 mg
4598 PHT 427 50 mg
4763 Pyridostatin pentahydrochloride 50 mg
4763 Pyridostatin pentahydrochloride 10 mg
4635 SC 79 10 mg
4635 SC 79 50 mg
4893 XL 388 50 mg
4893 XL 388 10 mg
6554(+)-Abscisic Acid10 mg
4656(D)-(+)-Neopterin 50 mg
4656(D)-(+)-Neopterin 10 mg
6515(D)-PPA 11 mg
1545(R)-(+)-Bay K 8644 10mg
1545(R)-(+)-Bay K 8644 50mg
6829(R)-Shikonin50 mg
6829(R)-Shikonin10 mg
5698/501-Methyl-D-tryptophan50 mg
255810-DEBC hydrochloride 10mg
255810-DEBC hydrochloride 50mg
402716,16-Dimethyl Prostaglandin E21mg
34294-IPP10mg
34294-IPP50mg
4392680C9150 mg
4392680C9110 mg
1353Akt/SKG Substrate Peptide 1mg
5773Akti-1/250 mg
5773Akti-1/210 mg
2422AKTide-2T 1mg
3897API-110 mg
2151API-2 10mg
7283Apilimod dimesylate 25 mg
7283Apilimod dimesylate 5 mg
2446AS 101 10mg
2446AS 101 50mg
7001AT 786750 mg
7001AT 786710 mg
3994AZ 314610 mg
3994AZ 314650 mg
6330AZ 57045 mg
6330AZ 570425 mg
6978AZD 53635 mg
6978AZD 536325 mg
4150Azidothymidine50 mg
6438BRD 698950 mg
6438BRD 698910 mg
1231Brefeldin A 5mg
4316Bropirimine50mg
4316Bropirimine10mg
4204BTZO 150 mg
4204BTZO 110 mg
4318BX 79510 mg
4318BX 79550 mg
5484C 8750 mg
5484C 8710 mg
4968CCT 241533 dihydrochloride10 mg
0846Chicago Sky Blue 6B 1g
3271Compound 40110mg
3271Compound 40150mg
6107CP 42417450 mg
6107CP 42417410 mg
5479CRID3 sodium salt50 mg
5479CRID3 sodium salt10 mg
1101Cyclosporin A 100mg
6982Cyclosporin H5 mg
1467Daunorubicin hydrochloride 10mg
1126Dexamethasone 100mg
4502DIM50mg
5955eCF 30910 mg
5955eCF 30950 mg
3922Eeyarestatin I10 mg
2471ER 27319 maleate 10mg
2471ER 27319 maleate 50mg
1226Etoposide 100mg
4702ETP 4565850 mg
4702ETP 4565810 mg
6188Everolimus10 mg
2926FPA 12410mg
2926FPA 12450mg
1798Gabexate mesylate 10mg
1798Gabexate mesylate 50mg
4144GSK 69069350 mg
4144GSK 69069310 mg
6007INCB 024360-analog50 mg
6007INCB 024360-analog10 mg
5185JTE 607 dihydrochloride10 mg
5185JTE 607 dihydrochloride50 mg
3725KU 006379410mg
3544KU 5593310mg
2197L-755,507 10mg
2197L-755,507 50mg
6305Lenalidomide100 mg
6068Lin28 163210mg
6068Lin28 163250mg
5794LM 1050 mg
5794LM 1010 mg
6454LY 260361810 mg
6454LY 260361850 mg
5054ME 0328 10 mg
5054ME 0328 50 mg
1748MG 132 5mg
5142Mps1-IN-1 dihydrochloride10 mg
4079Niclosamide50 mg
1228Nocodazole 10mg
3034NSC 109555 ditosylate 50mg
3034NSC 109555 ditosylate 10mg
2828NU 702610mg
2828NU 702650mg
3712NU 744110mg
3712NU 744150mg
6792Omipalisib10 mg
6792Omipalisib50 mg
5682/50OSU 0301250 mg
5682/10OSU 0301210 mg
3785PD 166285 dihydrochloride1mg
3785PD 166285 dihydrochloride10mg
2694PD 407824 1mg
2694PD 407824 10mg
4821PF 0381473510 mg
4821PF 0381473550 mg
4820PF 0469150210 mg
4820PF 0469150250 mg
4823PF 0521238410 mg
6373PF 066508335 mg
4277PF 47773650 mg
4277PF 47773610 mg
2930PI 103 hydrochloride1mg
2930PI 103 hydrochloride10mg
2930PI 103 hydrochloride50mg
1093Pirfenidone 50mg
1093Pirfenidone 10mg
6302Pomalidomide50 mg
6302Pomalidomide10 mg
3894PP 12110 mg
3894PP 12150 mg
4257PP 24250 mg
4257PP 24210 mg
2296Prostaglandin E2 10mg
1292Rapamycin 1mg
7066RCGD 42350 mg
6343Rosuvastatin calcium50 mg
6343Rosuvastatin calcium10 mg
5810RS 110 mg
5810RS 150 mg
4652SAHA 50 mg
4652SAHA 10 mg
2560SB 218078 1mg
2560SB 218078 10mg
4963SC 144 hydrochloride10 mg
4963SC 144 hydrochloride50 mg
4398SC 6650 mg
4398SC 6610 mg
1285Staurosporine 100ug
6036STK16-IN-110 mg
3543Suplatast tosylate10mg
3543Suplatast tosylate50mg
4750TC Mps1 1210 mg
4750TC Mps1 1250 mg
3038TCS 2312 dihydrochloride 1mg
5264Temsirolimus10 mg
0652Thalidomide 100mg
4248Torin 250 mg
4248Torin 210 mg
6583UCLA GP130 250 mg
6583UCLA GP130 210 mg
6762Urolithin A10 mg
6762Urolithin A50 mg
3270VGX 1027 50mg
3270VGX 1027 10mg
4282WYE 687 dihydrochloride 10 mg
4282WYE 687 dihydrochloride 50 mg