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 제품안내  신경약학   Pharmacology

Antiviral Drugs

바이러스 감염을 억제하고, 바이러스의 진입, 조립, 복제를 표적으로 하는 약물을 소개합니다.

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특징
  • 바이러스 감염을 억제하고, 바이러스의 진입, 조립, 복제를 표적으로 하는 약물을 소개합니다.
  • DNA 중합 억제, protease 억제, 바이러스 복제 차단 등의 항바이러스 매카니즘에 관여합니다.
  • HIV, CMV와 같은 viral infection의 치료에도 사용됩니다.
  • Antiviral Target Files
    - Coronavirus Antivirals
    - Herpes Simplex Viruses
    - Cytomegalovirus
    - HIV
    - Flaviviruses
    - Influenza Viruses
    - Hepatitis Viruses
    - Non-selective Antivirals

 

  Cat. No. Product Name / Activity
  4274 AP 24534
    Identified as targeting human proteins in the SARS-CoV-2 interactome; potent multi-kinase and pan-Bcr-Abl inhibitor
  7283 Apilimod dimesylate 
    Inhibits cellular entry by SARS-CoV-2, MERS-CoV and MHV S pseudovirions; potent and selective PIKfyve inhibitor
  7235 Arbidol
    Inhibits replication of SARS-CoV-2 in vitro; broad spectrum antiviral
  4600 Auranofin
    Inhibits SARS-CoV-2 infection in vitro
  7222 Baricitinib
    In silico modelling predicts inhibition of SARS-CoV-2 cell entry; highly potent JAK inhibitor
  3193 Camostat mesylate
    Inhibits entry of SARS-Cov-2 into lung cells; TMPRSS2 inhibitor
  4109 Chloroquine diphosphate
    Inhibits SARS-CoV-2 infection in vitro
  6357 Ciclesonide
    Inhibits replication of SARS-CoV-2 in vitro; glucocorticoid
  0460 Cinanserin hydrochloride
    Inhibits replication of SARS-CoV; Mpro inhibitor and 5-HT2 antagonist
  0970 Cycloheximide
    Exhibits anti-MERS-CoV activity in vitro; protein synthesis inhibitor
  1101 Cyclosporin A
    Inhibits coronavirus replication; cyclophilin inhibitor
  7223 Dabrafenib mesylate
    Targets human proteins in the SARS-CoV-2 interactome; potent and selective B-Raf, CDK16 and NEK9 inhibitor
  1467 Daunorubicin hydrochloride
    Identified as targeting human proteins in the SARS-CoV-2 interactome; DNA topoisomerase II inhibitor
  4583 Digoxin
    Exhibits anti-MERS-CoV activity in vitro; Na+/K+ ATPase inhibitor
  3807 Disulfiram
    SARS-CoV-2 Mpro inhibitor; also reversibly stimulates SERCA Ca2+-ATPase
  4545 E 64d
    Inhibts entry of SARS-CoV-2 into lung cells in combination with Camostat (Cat. No. 3193); cathepsin inhibitor
  6986 EG 00229 trifluoroacetate
    Inhibits binding of cleaved spike protein of SARS-CoV-2 to neuropilin 1 (NRP1); neuropilin 1 antagonist
  3631 FK 506
    Identified as targeting human proteins in the SARS-CoV-2 interactome; potent calcineurin inhibitor
  3259 Gemcitabine hydrochloride
    Inhibits replication of coronaviruses; DNA synthesis inhibitor
  7280 GRL 0617
    Coronavirus PLpro inhibitor
  7227 GS 441524
    Displays antiviral activity against MERS-CoV, SARS-CoV and SARS-CoV-2; viral RNA-dependent RNA polymerase (RdRp) inhibitor; active metabolite of Remdesivir (Cat. No. 7226)
  1416 Homoharringtonine
    Inhibits SARS-CoV-2 infection in vitro; inhibits protein synthesis
  5648 Hydroxychloroquine sulfate
    Inhibits SARS-CoV-2 viral infection in vitro
  1708 Indomethacin
    Identified as targeting human proteins in the SARS-CoV-2 interactome
  1260 Ivermectin
    Inhibits replication of SARS-Cov-2 in vitro; antiparasitic and antiviral
  2959 Lercanidipine hydrochloride
    Exhibits anti-MERS-CoV activity in vitro; CaV1.x blocker
  3765 Linezolid
    Identified as targeting human proteins in the SARS-CoV-2 interactome; antibiotic
  0840 Loperamide hydrochloride
    Inhibits replication of coronaviruses in vitro; peripherally acting μ opioid agonist and Ca2+ channel blocker
  7052 Lopinavir
    Inhibits SARS-CoV-2 replication in vitro; highly potent and selective HIV-1 protease inhibitor
  6819 Mefloquine hydrochloride
    Exhibits antiviral activities against SARS-CoV-2; also Cx36 and Cx50 gap channel blocker
  2864 Metformin hydrochloride
    Identified as targeting human proteins in the SARS-CoV-2 interactome; antidiabetic
  7230 MPro N3
    Coronavirus Mpro inhibitor
  3766 Nelfinavir mesylate
    Exhibits anti-MERS-CoV activity in vitro; potent HIV-1 protease inhibitor
  2583 Omeprazole
    Enhances anti-SARS-CoV-2 activity of serine protease inhibitors
  1076 Ouabain
    Exhibits anti-MERS-CoV activity in vitro; Na+/K+ ATPase inhibitor
  1125 Quercetin
    Inhibits SARS-CoV Mpro; also non-selective PI 3-kinase inhibitor
  1292 Rapamycin
    Inhibits MERS-CoV infection; mTOR inhibitor and immunosuppressant
  7226 Remdesivir
    Displays antiviral activity against MERS-CoV, SARS-CoV and SARS-CoV-2; viral RNA-dependent RNA polymerase (RdRp) inhibitor
  4501 Ribavirin
    Inhibits cytopathic effect of SARS-CoV in vitro; guanosine analog and IMPDH inhibitor
  7064 Ruxolitinib
    Targets human proteins in the SARS-CoV-2 interactome; potent and selective JAK1/JAK2 inhibitor
  7191 Santacruzamate A 
    Identified as targeting human host proteins that interact with SARS-CoV-2
  7189 Saracatinib
    Inhibits MERS-CoV, other coronaviruses and dengue virus
  7192 SMIP 004 
    S-phase kinase-associated protein 2 (SKP2) inhibitor; inhibits MERS-CoV replication and induces autophagy in infected cells
  1138 Thapsigargin
    Inhibits SARS-CoV-2 infection in vitro; SERCA inhibitor
  2815 Valproic acid, sodium salt
    Identified as targeting human proteins in the SARS-CoV-2 interactome; HDAC inhibitor
  0654 Verapamil hydrochloride
    Targets human proteins in the SARS-CoV-2 interactome; CaV1.x blocker
     


  Cat. No. Product Name / Activity
  2513 Acyclovir
    Antiviral agent; active against herpes simplex viruses
  6244 OG-L002
    Inhibits herpes simplex infection in vivo; LSD1 inhibitor


  Cat. No. Product Name / Activity
  2457 Arcyriaflavin A
    Inhibits human CMV replication in vitro; also Cdk4 and CaM kinase II inhibitor
  6258 CC 401 dihydrochloride
    Inhibits human CMV replication; JNK inhibitor
  2287 K-252c
    Displays antiviral activity against human CMV



  Cat. No. Product Name / Activity
  4148 Abacavir hemisulfate
    Inhibits reverse transcriptase (RNA-dependent DNA polymerase); antiretroviral
  5852 Acetyl Pepstatin
    Inhibits HIV-1 and -2 proteases
  2151 API-2
    Displays antiviral activity against HIV-1 and -2
  1777 Arctigenin
    Inhibits HIV replication in vitro
  4150 Azidothymidine
    Selectively inhibits HIV reverse transcriptase (RNA-dependent DNA polymerase)
  2711 Bay 55-9837
    Inhibits HIV-1 viral replication; VPAC2 agonist
  5009 BMS 509744
    Inhibits HIV infection of primary CD4+ T cells
  2423 DAPTA
    Inhibits HIV-1 viral cell entry
  6710 Darunavir
    Highly potent HIV protease inhibitor
  4149 Delavirdine mesylate
    Selectively inhibits HIV reverse transcriptase (RNA-dependent DNA polymerase)
  7290 Famotidine
    Inhibits HIV replication in vitro; potent H2 receptor inverse agonist
  6994 HODHBt
    Reactivates latent HIV-1 reservoir in central memory T cells (TCM)
  4596 IT1t dihydrochloride
    Blocks interaction of CXCR4 with the HIV envelope protein gp120
  6126 KRH 3955 hydrochloride
    Inhibits replication of HIV in vitro and in vivo; CXCR4 antagonist
  7052 Lopinavir
    Highly potent and selective HIV-1 protease inhibitor
  3756 Maraviroc
    Inhibits HIV-1 cell entry; CCR5 antagonist
  5811 NBD 556
    Blocks HIV-1 viral cell entry; CD4 mimetic
  3766 Nelfinavir mesylate
    Potent HIV-1 protease inhibitor
  5856 Ritonavir
    HIV-1 and HIV-2 protease inhibitor
  4418 Saquinavir mesylate
    HIV protease inhibitor
  6829 (R)-Shikonin
    Inhibits HIV-1 replication
  4990 Stavudine
    Inhibis HIV-1 replication in vitro; nucleoside analog
  3666 Tenofovir
    Selectively inhibits HIV reverse transcriptase (RNA-dependent DNA polymerase)



  Cat. No. Product Name / Activity
  6652 NGI 1
    Antiflaviviral; active against Zika, West Nile and dengue viruses
  6045 NITD 008
    Antiflaviviral; active against Zika, Dengue and Hepatitis C viruses
  1410 SDM25N hydrochloride
    Inhibits dengue virus replication; also high affinity and selective δ antagonist




  Cat. No. Product Name / Activity
  2404 Ambroxol hydrochloride
    Inhibits influenza (H3N2) viral replication; Na+ channel blocker
  7225 Favipiravir
    Displays antiviral activity against influenza viruses; viral RNA-dependent RNA polymerase inhibitor
  3988 Hesperadin hydrochloride
    Displays broad spectrum antiviral activity against influenza viruses
  7224 Oseltamivir phosphate
    Influenza virus neuraminidase inhibitor; antiviral prodrug
  4611 PBP 10
    Displays antiviral activity against influenza viruses
  4107 Probenecid
    Inhibits influenza A infection in vitro and in vivo; MRP and OAT3 inhibitor
  1125 Quercetin
    Non-selective PI 3-kinase inhibitor; blocks cellular entry by influenza A virus
  1138 Thapsigargin
    Inhibits influenza A infection in vitro; SERCA inhibitor
  7187 Zanamivir
    Potent influenza virus neuraminidase inhibitor




  Cat. No. Product Name / Activity
  6974 BMS 986094
    Hepatitis C virus RNA-dependent RNA polymerase NS5b inhibitor
  6234 Entecavir
    Potent and selective hepatitis B reverse transcriptase (RNA-dependent DNA polymerase) inhibitor
  5741 25-Hydroxycholesterol
    Inhibits hepatitis C viral life cycle; also α-crystallin (cryAB) chaperone
  6045 NITD 008
    Inhibits cell entry of HCV; also active against Dengue and Zika viruses
  6658 Telaprevir
    Hepatitis C virus (HCV) protease NS3/4A inhibitor




  Cat. No. Product Name / Activity
  5736 Aphidicolin
    Antiviral; inhibits DNA polymerase α, β and ε
  7235 Arbidol
    Broad spectrum antiviral
  2743 Caffeic acid phenethyl ester
    Antiviral; inhibits NF-κB activation
  2483 Costunolide
    Antiviral; human telomerase inhibitor
  1437 D609
    Antiviral; PC-PLC inhibitor
  5601 DMXAA
    Antiviral; mSTING antagonist
  7231 EIDD 1931
    Viral RNA-dependent RNA polymerase inhibitor; broad spectrum antiviral nucelotide prodrug
  6494 Galangin
    Broad spectrum antiviral; induces autophagy and inhibits TRPC5
  7227 GS 441524
    Viral RNA-dependent RNA polymerase (RdRp) inhibitor; broad spectrum antiviral; active metabolite of remdesivir
  3700 Imiquimod
    Displays antiviral activity; immunomodulator
  2307 Leukotriene B4
    Displays antiviral activity against DNA viruses and retroviruses
  5604 MI 14
    Displays antiviral activity against single-stranded positive sense RNA viruses
  3117 Miglustat hydrochloride
    Displays broad spectrum antiviral activity; α-glucosidase I and II inhibitor
  1505 Mycophenolic acid
    Antiviral and immunosuppressant
  7234 Nitazoxanide
    Broad spectrum antiviral and antiparasitic; pyruvate flavodoxin/ferredoxin oxidoreductase inhibitor; also stabilizes PAD2 and inhibits Wnt signaling
  3354 PF 429242 dihydrochloride
    Displays antiviral activity; competitive inhibitor of SREBP site 1 protease
  7226 Remdesivir
    Broad spectrum antiviral nucelotide prodrug; viral RNA-dependent RNA polymerase inhibitor
  4536 Resiquimod
    Antiviral and proimflammatory; TLR7 agonist
  4501 Ribavirin
    Antiviral guanosine ribonucleoside analog
  0630 Rosmarinic acid
    Antiviral, anti-inflammatory and cytostatic
  3356 WR 1065 dihydrochloride
    Displays broad spectrum antiviral activity in vitro



  Cat. No. Product Name / Activity
  6246 BF 738735
    Broad spectrum enterovirus replication inhibitor; PI 4-kinase IIIβ inhibitor
  5389 Ro 48-8071 fumarate
    Inhibits cell entry by Ebola virus
  6414 Rupintrivir
    Potent and selective irreversible human rhinovirus 3C protease inhibitor



  • 240개의 antiviral compound로 구성된 library
  • 100 ul 10 mM DMSO solutions으로 제공
  • 용도: high throughput screening, chemical biology applications, drug repurposing
  • 96-well racks with Matrix storage tubes & SepraSeal caps
  • 구성: compounds for cytokine storm (48%), viral replication (24%), drug repurposing (23%), viral cell entry (5%)

       

  Cat. No. Product Name / Activity
  7350 Tocriscreen Antiviral Library 
    Antiviral compound library for high throughput screening, chemical biology applications and drug repurposing; contains 240 bioactive compounds (100 μL 10 mM DMSO solutions)