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A/S
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 ǰȳ  Ű   Disease Pathway

̸ ġ (Alzheimer's disease research)

̸Ӵ ü ġ ȯ 60-70% ϰ ִ ǥ μ Űȯ, ٺ Ȯ Ը ʰ ֽϴ. ƹз̵ , Ÿ , ġ Ÿ ǰ ֽϴ.

TOCRIS
ǰ ϱ
μϱ


beta-Secretase
Small molecule 7081 LY 2886721 Hydrochloride
Description: Potent and selective β-secretase (BACE) inhibitor
Small molecule 4524 EGCG
Description: β-secretase (BACE) inhibitor; inhibits amyloid assembly
Antibody ARG41146 anti-BACE1 antibody
Reactivity:  Hu, Ms, Rat
Application:  IP, WB 
Antibody ARG54912 anti-BACE1 antibody
Reactivity:  Ms
Application:  WB 
Antibody ARG54921 anti-BACE1 antibody
Reactivity:  Hu, Ms
Application:  ELISA, ICC/IF, WB 
Antibody ARG54377 anti-BACE2 antibody
Reactivity:  Hu
Application:  WB 
Antibody 2253 anti-BACE antibody
Reactivity:  Hu, Ms
Application:  ELISA, ICC, IF, IHC-P, WB
Peptide 2253P BACE peptide
17 amino acids near the carboxy terminus of human BACE
Application:  Blocking

gamma-Secretase
Small molecule 2870 BMS 299897
Description: Potent γ-secretase inhibitor
Small molecule 4898 TC-E 5006
Description: γ-secretase modulator; reduces Aβ42 levels
Small molecule 4489 DBZ
Description: γ-secretase inhibitor; inhibits Notch pathway
Small molecule 4283 Begacestat
Description: γ-secretase inhibitor; lowers Aβ40 and Aβ42 levels
Small molecule 4000 MRK 560
Description: γ-secretase inhibitor; attenuates amyloid plaque deposition
Small molecule 6476 Compound E
Description: γ-secretase inhibitor; induces neuronal differentiation
Small molecule 2654 Compound W
Description: γ-secretase inhibitor
Small molecule 2677 JLK 6
Description: Inhibitor of γ-secretase-mediated βAPP processing
Small molecule 2627 L-685,458
Description: Potent and selective γ-secretase inhibitor
Small molecule 6363 Avagacestat
Description: Highly potent γ-secretase inhibitor; orally bioavailable
Small molecule 2634 DAPT
Description: Gamma γ-secretase inhibitor; induces neuronal differentiation; blocks Notch signaling
Antibody
Set
PSI-1820 Alzheimers Disease gamma-Secretase Detection Set
4001 - APH1 Antibody
3983 - Nicastrin Antibody
3979 - PEN2 Antibody
4203 - Presenilin1 Antibody 

Amyloid beta aggregation
Small molecule 4803 CRANAD 2
Description: Near-infrared probe that detects Aβ40 aggregates
Small molecule 4084 LPYFD-NH2
Description: Binds Aβ; protects from aggregation induced toxicity 
Small molecule 6779 Davunetide
Description: Highly potent active component of ADNP; prevents amyloid β aggregation; active in vivo
Small molecule 2442 CGP 53353
Description: Selective inhibitor of PKCβII
Small molecule 3360 CGP 52411
Description: EGFR inhibitor. Also inhibits Aβ42 fibril formation
Small molecule 2408 Ro 90-7501
Description: Inhibitor of Aβ42 fibril formation 
Small molecule 3619 Tramiprosate
Description: Targets soluble Aβ to decrease amyloid plaque deposition. Also GABA analog
Peptide 7031 Amyloid β-Peptide (1-37) (human)
Description: Amyloid β-protein fragment
Peptide 1191 Amyloid β-Peptide (1-40) (human)
Description: Amyloid β-protein fragment
Peptide 1428 Amyloid β-Peptide (1-42) (human)
Description: Predominant amyloid β-protein fragment
Peptide 3391 Amyloid β-peptide (42-1) (human)
Description: Inactive control peptide for amyloid β-peptide (1-42) (Cat. No. 1428)
Peptide 1894 Amyloid β-Peptide (12-28) (human)
Description: Amyloid β-peptide; minimum required for binding to brain proteins
Peptide 1429 Amyloid β-peptide (25-35) (human)
Description: Human amyloid β-protein fragment functionally required for neurotoxicity
Antibody ARG42049  anti-beta Amyloid (1-42) antibody [Ab42.2]
Reactivity:  Hu, Ms
Application:  ELISA, ICC/IF, IHC-P, IP, WB 
Antibody ARG42047 anti-beta Amyloid (1-16) antibody [Ab5]
Reactivity:  Hu, Ms
Application:  ELISA, ICC/IF, IHC-P, IP, WB 
Antibody ARG42048 anti-beta Amyloid (1-40) antibody [Ab40.1]
Reactivity:  Hu, Ms
Application:  ELISA, ICC/IF, IHC-P, IP, WB 
Antibody ARG65730 anti-Amyloid Precursor Protein antibody
Reactivity:  Hu, Ms, Rat
Application:  WB 
Antibody ARG22203 anti-Amyloid Oligomers (A11) antibody
Reactivity:  Hu, Ms, Rat
Application:  Dot, ELISA, ICC/IF, IHC, IP, WB 
Antibody ARG22204 anti-Amyloid Fibrils (OC) antibody
Reactivity:  Hu
Application:  Dot, ELISA, ICC/IF, IHC, IP, WB 
Antibody ARG54672 anti-Amyloid Precursor Protein antibody
Reactivity:  Hu, Ms, Rat
Application:  ELISA, ICC/IF, IHC-P, WB 
Antibody ARG66780  anti-Amyloid Precursor Protein phospho (Thr743) antibody
Reactivity:  Hu
Application:  ICC/IF, IHC-P, WB 
Antibody ARG51685 anti-Amyloid Precursor Protein phospho (Thr668) antibody
Reactivity:  Hu, Ms, Rat
Application:  WB 
Antibody ARG55556 anti-Serum amyloid P component antibody
Reactivity:  Hu
Application:  IHC-P, WB 

Tau phosphorylation
Small molecule 4431 A 1070722
Description: Highly potent, selective GSK-3 inhibitor
Small molecule 1097 Taxol
Description: Promotes assembly and inhibits disassembly of microtubules
Small molecule 3401 Vinorelbine ditartrate
Description: Selective mitotic microtubule antagonist
Small molecule 2305 Tautomycetin
Description: Selective PP1 inhibitor
Small molecule 4997 INDY
Description: DYRK1A/B inhibitor
Small molecule 4998 ProINDY
Description: DYRK1A/B inhibitor; prodrug of INDY (Cat. No. 4997)
Small molecule 4390 Thiamet G
Description: Potent O-GlcNAcase inhibitor
Small molecule 3384 (Z)-Pugnac
Description: O-GlcNAcase and β-hexosaminidase inhibitor
Stain 3213 Methylene Blue
Description: Biological stain
Antibody ARG10727 anti-Tau antibody [5B10]
Reactivity:  Hu, Ms, Rat, Cow, Hrs, Pig
Application:  ICC/IF, IHC-Fr, WB 
Antibody ARG51604 anti-Tau phospho (Ser396) antibody
Reactivity:  Hu, Ms, Rat
Application:  IHC-P, WB 
Antibody ARG51614 anti-Tau phospho (Ser404) antibody
Reactivity:  Hu, Ms, Rat
Application:  ICC/IF, IHC-P, WB 
Antibody ARG51609 anti-Tau phospho (Thr181) antibody
Reactivity:  Hu, Ms, Rat
Application:  IHC-P, WB 
Antibody ARG51610 anti-Tau phospho (Thr205) antibody
Reactivity:  Hu, Ms, Rat
Application:  IHC-P, WB
Antibody ARG51613 anti-Tau phospho (Ser262) antibody
Reactivity:  Hu, Ms, Rat
Application:  ICC/IF, IHC-P, WB
Antibody ARG51603 anti-Tau phospho (Ser356) antibody
Reactivity:  Hu, Ms, Rat
Application:  ICC/IF, WB 
Antibody ARG51612 anti-Tau phospho (Thr231) antibody
Reactivity:  Hu, Ms, Rat
Application:  IHC-P, WB

Ű汳
Antibody ARG30317 Activated Macrophage / Microglia Marker Antibody Duo
ARG63338 anti-AIF1 / Iba 1 antibody
ARG10514 anti-CD68 antibody [KP1] 
Antibody AK-625 Microglia Ion Channel Antibody Explorer Kit
A Screening Package of Antibodies to Ion Channels Expressed in Microglia 
Antibody AK-630 Microglia GPCR Antibody Explorer Kit
A Screening Package of Antibodies to GPCRs Expressed in Microglia 
Antibody AK-665 Astrocyte Antibody Marker Kit
6 vials of antibodies
Antibody ARG62364  anti-Astrocytes antibody [ASTRO1 (10E4/R5)]
Reactivity:  Hu
Application:  IHC-P 
Antibody ARG30006 NSC and Astrocyte Marker Antibody Duo (GFAP, Nestin)
ARG52312 anti-GFAP antibody
ARG52345 anti-Nestin antibody [4D11] 
Cell AX0668 Human iPSC-derived Mature Microglia, Cryopreserved
1 x vial of Human iPSC-derived Mature Microglia
Cell AX0665 Human iPSC-Derived Astrocytes
Starting material : Cord blood CD34+ cells
Cell ax0111 Human iPSC-Derived Neural Stem Cells - Alzheimer's Disease Patient (APOE4 HOM)
Cell ax0112 Human iPSC-Derived Neural Stem Cells - Alzheimer's Disease Patient (PSEN1 L286V)
Cell ax0113 Human iPSC-Derived Neural Stem Cells - Alzheimer's Disease Patient (PSEN1 M146L)
Cell ax0114 Human iPSC-Derived Neural Stem Cells - Alzheimer's Disease Patient (PSEN1 A246E)
Cell ax0018 Human iPSC-Derived Neural Stem Cells (Healthy male donor)
Cell ax0019 Human iPSC-Derived Neural Stem Cells (Healthy female donor)
Media AX0678 Microglia Complete Cell and Media Kit 
Media AX0660 Microglia Maintenance Medium Kit 
Media AX0686 Astrocyte Maintenance Medium 
Stain 5146 Sulforhodamine 101
Description: Red fluorescent dye; selective astrocyte marker
Stain 5118 SynaptoRedTM C2
Description: Fluorescent dye; stains synaptic vesicles
Stain 6406 Hydroxystilbamidine bis(methanesulfonate)
Description: Fluorescent cationic dye; used as a neuronal tracer 

Therapeutics for Alzheimer's Disease
Small molecule 0965 Tacrine hydrochloride
Description: Cholinesterase inhibitor 
Small molecule 4385 Donepezil hydrochloride
Description: Potent AChE inhibitor 
Small molecule 4440 Rivastigmine tartrate
Description: Dual AChE and BChE inhibitor 
Small molecule 0686 Galanthamine hydrobromide
Description: Cholinesterase inhibitor 
Small molecule 0773 Memantine hydrochloride
Description: NMDA antagonist; acts at ion channel site 

Drug Repurposing (๰â)
Small molecule 7150 Tocriscreen 2.0 Max
(1280 compounds library, 250uL 10 mM DMSO solutions)
Small molecule 7151 Tocriscreen 2.0 Mini
(1280 compounds library, 50uL 10 mM DMSO solutions)
Small molecule 7152 Tocriscreen 2.0 Micro
(1280 compounds library, 15uL 10 mM DMSO solutions)
Small molecule 7200 Tocriscreen FDA-Approved Drugs
(190 FDA-Approved compounds library)
Small molecule 6801 Tocriscreen Epigenetics Library
(101 epigenetic compounds library)
Small molecule 6268 Tocriscreen Kinase Inhibitor Toolbox
(160 kinase inhibitors library)