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COVID-19 Research

[COVID-19] SARS-Cov-2 Compound Repurposing

SARS-CoV의 homology와 80% 일치하는 COVID-19는, 최근 연구에 따르면 human mucosal 표면의 ACE2에 virus 표면의 spike가 binding 되어 virus가 숙주세포에 결합되는 mechanism으로 이러한 mechanism은 antiviral 약물 치료를 위한 target으로 알려져 있으며, COVID-19 환자 혈액에서 면역세포의 증가 또한 증명 하였습니다.

기존 연구를 통해 역할이 확인된 compound 중 COVID-19 기전과 관련이 있는 약물들을 안내드립니다.

TOCRIS

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	Cat. No.	Product Name / Activity
	6960	ABT 199
		Exhibits binding to SARS-CoV-2 3CLpro in a virtual screen; selective and high affinity Bcl-2 inhibitor;
	4274	AP 24534
		Identified as targeting human proteins in the SARS-CoV-2 interactome; potent multi-kinase and pan-Bcr-Abl inhibitor
	4139	Aprotinin
		Inhibits SARS-CoV-2 infection in vitro; serine protease inhibitor
	6358	Atovaquone
		Exhibits anti-MERS-CoV activity in vitro; DHODH inhibitor
	3771	Azithromycin
		Predicted to disrupt binding of SARS-CoV-2 spike protein to ACE2.
	3193	Camostat mesylate
		Inhibits entry of SARS-Cov-2 into lung cells; protease inhibitor
	4455	Captopril
		Targets human proteins in the SARS-CoV-2 interactome; ACE inhibitor
	4109	Chloroquine diphosphate
		Inhibits SARS-CoV-2 infection in vitro
	6357	Ciclesonide
		Inhibits replication fo SARS-CoV-2 in vitro; glucocorticoid
	1364	Colchicine
		Identified as a candidate for repurposing for COVID-19
	0970	Cycloheximide
		Exhibits anti-MERS-CoV activity in vitro; protein synthesis inhibitor
	1101	Cyclosporin A
		Inhibits coronavirus replication; cyclophilin inhibitor
	6710	Darunavir
		Predicted to bind PLpro of SARS-CoV-2; potent HIV protease inhibitor
	6793	Dasatinib
		Inhibits replication of SARS-CoV and MERS-CoV in vitro
	1467	Daunorubicin hydrochloride
		Identified as targeting human proteins in the SARS-CoV-2 interactome; DNA topoisomerase II inhibitor
	4583	Digoxin
		Exhibits anti-MERS-CoV activity in vitro; Na+/K+ ATPase inhibitor
	3807	Disulfiram
		SARS-Co-2 Mpro inhibitor; also reversibly stimulates SERCA Ca2+-ATPase
	3631	FK 506
		Identified as targeting human proteins in the SARS-CoV-2 interactome; potent calcineurin inhibitor
	3259	Gemcitabine hydrochloride
		Inhibits replication of coronaviruses; DNA synthesis inhibitor
	0931	Haloperidol hydrochloride
		Targets human proteins in the SARS-CoV-2 interactome
	5648	Hydroxychloroquine sulfate
		Inhibits SARS-CoV-2 viral infection in vitro
	5906	Imatinib mesylate
		Inhibits replication of SARS-CoV and MERS-CoV in vitro; potent and selective v-Abl tyrosine kinase inhibitor
	1708	Indomethacin
		Identified as targeting human proteins in the SARS-CoV-2 interactome
	1260	Ivermectin
		Inhibits replication of SARS-Cov-2 in vitro; antiparasitic and antiviral
	2959	Lercanidipine hydrochloride
		Exhibits anti-MERS-CoV activity in vitro; CaV1.x blocker
	3765	Linezolid
		Identified as targeting human proteins in the SARS-CoV-2 interactome; antibiotic
	0840	Loperamide hydrochloride
		Inhibits replication of coronaviruses in vitro; peripherally acting μ opioid agonist and Ca2+ channel blocker
	3798	Losartan potassium
		Reduces lung injury in a mouse model of SARS-CoV infection; Selective AT1 antagonist
	6819	Mefloquine hydrochloride
		Exhibits antiviral activities against SARS-CoV-2; also Cx36 and Cx50 gap channel blocker
	2864	Metformin hydrochloride
		Identified as targeting human proteins in the SARS-CoV-2 interactome
	3081	Nafamostat mesylate
		Inhibits SARS-CoV-2 infection in vitro; serine protease inhibitor
	3766	Nelfinavir mesylate
		Exhibits anti-MERS-CoV activity in vitro; potent HIV-1 protease inhibitor
	2583	Omeprazole
		Enhances anti-SARS-CoV-2 activity of serine protease inhibitors
	1076	Ouabain
		Exhibits anti-MERS-CoV activity in vitro; Na+/K+ ATPase inhibitor
	2992	PKC 412
		Identified as targeting human proteins in the SARS-CoV-2 interactome
	1292	Rapamycin
		Inhibits MERS-CoV infection; mTOR inhibitor and immunosuppressant
	4501	Ribavirin
		Inhibits cytopathic effect of SARS-CoV in vitro; guanosine analog and IMPDH inhibitor
	5856	Ritonavir
		Improves outcome in an animal model of MERS-CoV infection; HIV protease inhibitor
	7064	Ruxolitinib New
		Targets human proteins in the SARS-CoV-2 interactome; potent and selective JAK1/JAK2 inhibitor
	4418	Saquinavir mesylate
		Modeling predicts inhibitor action at SARS-CoV-2 3CLpro; HIV protease inhibitor
	3784	Sildenafil citrate
		Reduces pulmonary pressure and edema; potent PDE5 inhibitor; orally active
	0652	Thalidomide
		Predicted to reduce cytokine release in SARS-CoV-2 infection; inhibits synthesis of TNF-α
	2815	Valproic acid, sodium salt
		Identified as targeting human proteins in the SARS-CoV-2 interactome
	0654	Verapamil hydrochloride
		Targets human proteins in the SARS-CoV-2 interactome; CaV1.x blocker

ACE Small Molecule Compound
Cat.No.	Product	Description
2578	Benazepril hydrochloride	ACE inhibitor
4302	Perindopril erbumine	ACE inhibitor
4455	Captopril	ACE inhibitor also inhibits LTA4 hydrolase

Cathepsin B/L Small Molecule Compounds
Cat.No.	Product	Description
0448	Calpeptin	Calpain and cathepsin L inhibitor
3625	SID 26681509	Cathepsin L inhibitor
4863	CA 074	Selective cathepsin B inhibitor
0384	N-Acetyl-L-leucyl- L-leucyl-L-methional	Cathepsin inhibitor
4545	E 64d	Cathepsin inhibitor; interferes with autolysosomal digestion
1146	MDL 28170	Potent and selective Calpain and Cathepsin B inhibitor

IL-1 beta Small Molecule Compound
Cat.No.	Product	Description
1793	AF 12198	potent, selective human type IL-1 receptor antagonist

TNF-alpha Small Molecule Compound
Cat.No.	Product	Description
5484	C 87	TNF-α inhibitor

VEGFR-2 Small Molecule Compounds
Cat.No.	Product	Description
3882	(E)-FeCP-oxindole	Selective VEGFR-2 inhibitor
2542	Ki 8751	potent, selective VEGFR-2 inhibitor
Aminopeptidase Small Molecule Compounds
Cat.No.	Product	Description
3595	CHR 2797	Aminopeptidase inhibitor, also called Tosedostat

DPPIV/CD26 Small Molecule Compounds
Cat.No.	Product	Description
2783	DPPI 1c	DPPIV/CD26 inhibitor
2790	K 579	DPPIV/CD26 inhibitor
3506	NVP DPP 728	Potent DPPIV/CD26 inhibitor; orally active
6507	Saxagliptin	High affinity DPPIV/CD26 inhibitor; active in vivo

Human Neutrophil Elastase 1 (HNE1) Small Molecule Compounds
Cat.No.	Product	Description
5651	ONO 6818	High affinity and selective Human Neutrophil Elastase 1 (HNE1) inhibitor; orally active
5706	BAY 678	Potent Human Neutrophil Elastase (HNE) inhibitor; cell permeable
6389	BAY 677	Inactive control for BAY 678 (Catalog # 5706)

Furin Small Molecule Compounds
Cat.No.	Product	Description
1793	AF 12198	Potent Furin inhibitor

TMPRSS2 Small Molecule Compounds
Cat.No.	Product	Description
3193	Camostat	TMPRSS2 inhibitor
3081	Nafamostat	Inhibits SARS-CoV-2 infection in vitro
Autophagy Small Molecule Compounds
Cat.No.	Product	Description
5648	Hydroxychloroquine sulfate	Autophagy inhibitor, also inhibits TLR9; inhibits SARS-CoV-2 viral infection

Topo I inhibitor
Cat. No.	product	size
TG4100	Topotecan Hydrochloride (Hycamtin)	0.25 mL
TG4101	Irinotecan (CPT-11)	0.25 mL
TG4110	Camptothecin	0.25 mL

Topo II inhibitor
Cat. No.	product	size
TG4140	Etoposide (VP16)	0.25 mL

▷ There is current research linking the inhibition of topoisomerase and the "cytokine storm" that follows SAR CoV2 infections (COVID-19).

▶ Drug Repurposing (약물재창출) : Tocriscreen Compound Library 보러가기

CATNUM	PRODUCT	SIZE
3882	(E)-FeCp-oxdole	10mg
6960	ABT 199	10 mg
6960	ABT 199	50 mg
1793	AF 12198	1mg
4274	AP 24534	50 mg
4274	AP 24534	10 mg
4139	Aprotinin	10 mg
6358	Atovaquone	10 mg
6358	Atovaquone	50 mg
3771	Azithromycin	50mg
6389	BAY 677	5 mg
5706	BAY 678	5 mg
2578	Benazepril hydrochloride	50mg
5484	C 87	10 mg
4863	CA 074	1 mg
0448	Calpeptin	10mg
3193	Camostat mesylate	10mg
TG4110	Camptothecin 10mM	0.25ml
4455	Captopril	50 mg
4109	Chloroquine diphosphate	50 mg
3595	CHR 2797	1mg
6357	Ciclesonide	25 mg
6357	Ciclesonide	5 mg
1364	Colchicine	1g
0970	Cycloheximide	100mg
1101	Cyclosporin A	100mg
6710	Darunavir	50 mg
6710	Darunavir	10 mg
6793	Dasatinib	100 mg
1467	Daunorubicin hydrochloride	10mg
4583	Digoxin	50 mg
3807	Disulfiram	50 mg
2783	DPPI 1c hydrochloride	1mg
4545	E 64d (1 MG)	1 mg
TG4140	Etoposide 10mM	0.25ml
3631	FK 506	10mg
3259	Gemcitabine hydrochloride	10mg
3259	Gemcitabine hydrochloride	50mg
0931	Haloperidol hydrochloride	100mg
5648	Hydroxychloroquine sulfate	10 mg
5906	Imatinib mesylate	100 mg
1708	Indomethacin	100mg
TG4101	Irinotecan 10mM	0.25ml
1260	Ivermectin	100mg
2790	K 579	10mg
2542	Ki 8751	10mg
2959	Lercanidipine hydrochloride	10mg
2959	Lercanidipine hydrochloride	50mg
3765	Linezolid	10mg
0840	Loperamide hydrochloride	1g
3798	Losartan potassium	50mg
1146	MDL 28170	10mg
6819	Mefloquine hydrochloride	50 mg
2864	Metformin hydrochloride	100mg
0384	N-Acetyl-L-leucyl-L-leucyl-L-methional	10mg
3081	Nafamostat mesylate	10mg
3081	Nafamostat mesylate	50mg
3766	Nelfinavir mesylate	10mg
3766	Nelfinavir mesylate	50mg
3506	NVP DPP 728 dihydrochloride	10mg
2583	Omeprazole	50mg
5651	ONO 6818	10 mg
1076	Ouabain	100mg
4302	Perindopril erbumine	50mg
2992	PKC 412	1mg
1292	Rapamycin	1mg
4501	Ribavirin	50mg
5856	Ritonavir	50 mg
7064	Ruxolitinib	50 mg
4418	Saquinavir mesylate	50mg
4418	Saquinavir mesylate	10mg
6507	Saxagliptin hydrochloride	10 mg
3625	SID 26681509	10mg
3784	Sildenafil citrate	10mg
3784	Sildenafil citrate	50mg
0652	Thalidomide	100mg
TG4100	Topotecan 10mM	0.25ml
2815	Valproic acid, sodium salt	100mg
0654	Verapamil hydrochloride	1g