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 ǰȳ  Ű   Pharmacology

Peptide Hormone Receptor Small Molecules

Peptide Hormone Receptor ʿ Small Molecules Ұմϴ.

TOCRIS
ǰ ϱ
μϱ





Agonists
Cat. No. Product Name / Activity
5600 BA 1
Potent bombesin agonist
2716 BIM 187
Bombesin/GRP receptor agonist
1149 Bombesin
Involved in gastrointestinal tract function
1789 GRP (human)
Endogenous GRP receptor agonist
1788 GRP (porcine)
Endogenous GRP receptor agonist
Antagonists
Cat. No. Product Name / Activity
2717 BIM 189
Bombesin antagonist
3237 BIM 23042
Selective neuromedin B receptor antagonist (NMB-R, BB1)
3422 [D-Phe12,Leu14]-Bombesin
Bombesin receptor antagonist
5599 ML 18
BRS-3 antagonist; also GRPR agonist
2602 PD 176252
GRP (BB2) and NMB (BB1) receptor antagonist
Others
Cat. No. Product Name / Activity
1893 Alytesin
Amphibian bombesin-like peptide
1916 Litorin
Amphibian bombesin-like peptide
1908 Neuromedin B (porcine)
Mammalian bombesin-like peptide



Agonists
Cat. No. Product Name / Activity
2257 GIP (1-39)
Highly potent insulinotropic peptide; GIP agonist
2084 GIP (human)
Potent insulinotropic gut hormone; GIP agonist
6699 [D-Ala2]-GIP (human)
Highly potent GIP agonist
5837 [Pro3]-GIP (Rat)
High affinity rat GIP partial agonist
Antagonists
Cat. No. Product Name / Activity
5838 [Pro3]-GIP (Mouse)
GIP receptor antagonist



Agonists
Cat. No. Product Name / Activity
1463 Ghrelin (human)
Endogenous ghrelin receptor agonist
1465 Ghrelin (rat)
Endogenous ghrelin receptor agonist
2261 L-692,585
Potent, non-peptide ghrelin receptor agonist
5272 MK 0677
High affinity ghrelin receptor agonist
2308 Tabimorelin hemifumarate
Potent, orally active ghrelin receptor agonist
Inverse Agonists
Cat. No. Product Name / Activity
5830 K-(D-1-Nal)-FwLL-NH2
High affinity and potent ghrelin receptor inverse agonist
6347 PF 04628935
Potent ghrelin receptor inverse agonist
6350 PF 05190457
High affinity and selective ghrelin receptor inverse agonist
1946 [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P
Potent ghrelin receptor inverse agonist; Antagonist at other neuropeptide receptors
Antagonists
Cat. No. Product Name / Activity
1922 [D-Lys3]-GHRP-6
Ghrelin receptor antagonist
3959 YIL 781
Ghrelin receptor (GHS-R1a) antagonist
Others
Cat. No. Product Name / Activity
3374 Cortistatin 14
Endogenous neuropeptide; binds ghrelin receptor and sst1 - sst5
2951 [Des-octanoyl]-Ghrelin (rat)
Major circulating form of ghrelin; devoid of activity at GHS receptor
1346 des-Gln14-Ghrelin (rat)
Endogenous ghrelin receptor ligand
2260 [Des-octanoyl]-Ghrelin (human)
Major circulating form of ghrelin; devoid of activity at ghrelin receptor but is active in vivo
5560 Obestatin (human)
Endogenous anorexigenic peptide; opposes actions of ghrelin
2445 Obestatin (rat)
Endogenous anorexigenic peptide; opposes actions of ghrelin


Agonists
Cat. No. Product Name / Activity
1933 Exendin-4
Potent GLP-1 receptor agonist
5374 GLP-1 (7-37)
Endogenous bioactive GLP-1 receptor ligand
1851 Glucagon-like peptide 1 (1-37) (human, rat)
Endogenous pancreatic peptide
2082 Glucagon-like peptide 1 (7-36) amide (human, rat)
Potent insulinotropic peptide
6517 Liraglutide
Highly potent, long-acting GLP-1 receptor agonist
2094 Oxyntomodulin (porcine, bovine)
GLP-1 receptor agonist; endogenous preproglucagon derived peptide; modulates feeding and metabolism
Antagonists
Cat. No. Product Name / Activity
2081 Exendin-3 (9-39) amide
Potent GLP-1 receptor antagonist
3266 GLP-1 (9-36) amide
Metabolite of GLP-1-(7-36) (Cat. No. 2082)
6355 VU 0650991
Non-competitive GLP-1 antagonist; orally bioavailable and brain penetrant
Modulators
Cat. No. Product Name / Activity
4778 BETP
Positive allosteric modulator of GLP-1 receptors


Agonists
Cat. No. Product Name / Activity
6927 Glucagon (Human, Porcine)
Endogenous glucagon receptor agonist
Antagonists
Cat. No. Product Name / Activity
2216 des-His1-[Glu9]-Glucagon (1-29) amide
Glucagon receptor antagonist
2311 L-168,049
Potent, orally active human glucagon receptor antagonist
Others
Cat. No. Product Name / Activity
2094 Oxyntomodulin (porcine, bovine)
Endogenous gut peptide; modulates feeding and metabolism



Agonists
Cat. No. Product Name / Activity
1918 Secretin (human)
Gastrointestinal peptide
1919 Secretin (rat)
Gastrointestinal peptide