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 ǰȳ  Ű   Pharmacology

Opioid Receptor Small Molecules

Opiod receptor small molecule Ұմϴ.

TOCRIS
ǰ ϱ
μϱ




Agonists
Cat. No. Product Name / Activity
4335 AR-M 1000390 hydrochloride
Low-internalizing δ agonist
1663 BW 373U86
Potent, selective non-peptide δ agonist
3790 DADLE
Prototypical δ agonist
4591 Deltorphin I
Potent δ agonist
1180 [D-Ala2]-Deltorphin II
Selective δ agonist peptide
1431 DPDPE
Selective δ agonist
2962 6'-GNTI dihydrochloride
Selective κ/δ opioid heterodimer receptor agonist
0921 SB 205607 dihydrobromide
Selective, high affinity non-peptide δ1 agonist
1529 SNC 162
Potent, selective non-peptide δ agonist
0764 SNC 80
Highly selective non-peptide δ agonist
Antagonists
Cat. No. Product Name / Activity
0754 N-Benzylnaltrindole hydrochloride
Selective non-peptide δ2 antagonist
0899 BNTX maleate
Standard δ1 selective antagonist
0827 ICI 154,129
δ selective peptide antagonist
0820 ICI 174,864
δ selective peptide antagonist
0892 Naltriben mesylate
Standard δ2 selective antagonist
1410 SDM25N hydrochloride
Potent, selective non-peptide δ antagonist; also inhibits dengue virus replication
6729 TAN 452
Potent and selective peripherally acting δ opioid antagonist; antianalgesic.
Modulators
Cat. No. Product Name / Activity
5983 BMS 986187
Potent positive allosteric modulator of δ receptors



Agonists
Cat. No. Product Name / Activity
0699 BRL 52537 hydrochloride
Potent and selective κ agonist
3195 Dynorphin A
Endogenous κ agonist
3196 Dynorphin B
Endogenous κ agonist
2962 6'-GNTI dihydrochloride
Selective κ/δ opioid heterodimer receptor agonist
1483 GR 89696 fumarate
Subtype-selective κ agonist
0778 ICI 199,441 hydrochloride
Potent κ agonist
0822 ICI 204,448 hydrochloride
κ agonist, acts peripherally
0783 N-MPPP Hydrochloride
Selective κ agonist
5519 (-)-Pentazocine
κ-agonist; antinociceptive
2134 Salvinorin A
Highly potent and selective κ agonist
0471 (+)-U-50488 hydrochloride
Selective κ agonist; less active enantiomer of (±)-U-50488 (Cat. No. 0495)
0495 (±)-U-50488 hydrochloride
Selective κ agonist
0496 (-)-U-50488 hydrochloride
Selective κ agonist; more active enantiomer of (±)-U-50488 (Cat. No. 0495)
Antagonists
Cat. No. Product Name / Activity
0347 nor-Binaltorphimine dihydrochloride
Selective κ antagonist
0794 DIPPA hydrochloride
Selective and irreversible κ antagonist
1282 GNTI dihydrochloride
Potent, selective κ antagonist
4866 ML 190
Selective κ opioid receptor antagonist
Others
Cat. No. Product Name / Activity
5611 Salvinorin B
Activates the κ-opioid DREADD (KORD)



Agonists
Cat. No. Product Name / Activity
1171 DAMGO
Selective μ agonist
1055 Endomorphin-1
Potent and selective μ agonist
1056 Endomorphin-2
Potent and selective μ agonist
0840 Loperamide hydrochloride
Peripherally acting μ agonist; Ca2+ channel blocker
3636 Meptazinol hydrochloride
μ1 partial agonist
2024 PL 017
Selective μ agonist
3848 Sinomenine hydrochloride
μ agonist; antinociceptive and anti-inflammatory
Antagonists
Cat. No. Product Name / Activity
0898 Clocinnamox mesylate
Irreversible μ antagonist
1560 CTAP
Potent and selective μ antagonist
1578 CTOP
Potent and selective μ antagonist
2601 Cyprodime hydrochloride
Selective μ antagonist
0926 β-Funaltrexamine hydrochloride
Irreversible and selective μ antagonist
6109 Methylnaltrexone bromide
μ antagonist; peripherally restricted
0591 Naloxonazine dihydrochloride
Selective μ1 antagonist



Agonists
Cat. No. Product Name / Activity
2808 Buprenorphine hydrochloride
NOP agonist; also displays mixed action δ, κ and μ receptors
3763 MCOPPB trihydrochloride
Potent NOP receptor agonist
1780 NNC 63-0532
Potent non-peptide NOP agonist; brain penetrant
0910 Nociceptin
Endogenous NOP agonist
1590 [Arg14,Lys15]Nociceptin
Highly potent and selective NOP agonist
1566 [(pF)Phe4]Nociceptin(1-13)NH2
Potent, selective nociceptin receptor agonist
1092 [Phe1Ψ(CH2-NH)Gly2]Nociceptin(1-13)NH2
Selective nociceptin receptor agonist
3932 Orphanin FQ (1-11)
Potent NOP agonist; displays analgesic properties
1387 Ac-RYYRWK-NH2
Potent, selective NOP partial agonist peptide
3240 SCH 221510
Potent and selective NOP agonist
Antagonists
Cat. No. Product Name / Activity
3661 BAN ORL 24
Potent and selective NOP antagonist
2598 (±)-J 113397
Potent and selective NOP antagonist
2481 JTC 801
Selective NOP antagonist
1308 [Nphe1]Nociceptin(1-13)NH2
Selective, competitive nociceptin antagonist
1118 Nocistatin (bovine)
Opposes action of nociceptin
1198 Nocistatin (human)
Human putative counterpart of nocistatin
3573 SB 612111 hydrochloride
Selective NOP antagonist
2508 Trap 101
Potent and selective NOP antagonist; active in vivo
1552 UFP-101
Potent, selective silent antagonist for NOP
Ligand
Cat. No. Product Name / Activity
1239 Ac-RYYRIK-NH2
High affinity NOP ligand
Others
Cat. No. Product Name / Activity
1266 Nociceptin (1-7)
Bioactive metabolite of nociceptin
1119 NocII
Orphan neuropeptide