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 ǰȳ  Ű   Pharmacology

Nitric Oxide Small Molecules

Nitric Oxide õ small molecule Ұմϴ.

TOCRIS
ǰ ϱ
μϱ




Nitric Oxide (NO) Donors and Precursors
Cat. No. Product Name / Activity
0663 L-Arginine
Endogenous substrate for NOS
6077 DETA NONOate
Nitric oxide donor
3105 FK 409
NO donor
4531 NCX 4040
NO-donating aspirin; anti-inflammatory and antitumor
4537 NCX 466
Cyclooxygenase-inhibiting nitric oxide donor
2147 Nicorandil
NO donor and KATP channel opener
0756 SIN-1 chloride
Water-soluble NO donor
0598 SNAP
A stable analog of endogenous S-nitroso compounds
0603 SNOG
NO carrier. Breaks down to release NO
1135 Spermine NONOate
Slow NO releasing agent


Inhibitors for eNOS, iNOS, nNOS 
Cat. No. Product Name / Activity
0546 L-NIO dihydrochloride
NOS inhibitor
0787 Aminoguanidine hydrochloride
Irreversible iNOS inhibitor
0871 AMT hydrochloride
Potent, selective iNOS inhibitor
3969 AR-C 102222
Selective iNOS inhibitor
2866 BYK 191023 dihydrochloride
Potent and selective inhibitor of iNOS
0951 2-Iminopiperidine hydrochloride
Selective iNOS inhibitor
0897 S-Isopropylisothiourea hydrobromide
iNOS inhibitor, acts at arginine binding site
0776 (S)-Methylisothiourea sulfate
Highly selective iNOS inhibitor
1139 L-NIL hydrochloride
Selective iNOS inhibitor
0546 L-NIO dihydrochloride
NOS inhibitor
1415 1400W dihydrochloride
Potent, highly selective iNOS inhibitor
3319 ARL 17477 dihydrochloride
Selective nNOS inhibitor
0735 3-Bromo-7-nitroindazole
Selective nNOS inhibitor
6226 IC 87201
nNOS-PSD95 protein-protein interaction inhibitor; also antinociceptive and antidepressant
0546 L-NIO dihydrochloride
NOS inhibitor
3277 Pentamidine isethionate
Antimicrobial; inhibits nNOS
1200 Nω-Propyl-L-arginine hydrochloride
Highly selective inhibitor of nNOS



Inhibitors
Cat. No. Product Name / Activity
0673 L-Canavanine sulfate
NOS inhibitor
0665 L-NAME hydrochloride
Non-selective NOS inhibitor
0800 7-NINA
Non-selective NOS inhibitor. Sodium salt of 7-nitroindazole (Cat. No. 0602)
0602 7-Nitroindazole
Non-selective NOS inhibitor
0771 L-NMMA acetate
Non-selective NOS inhibitor
0664 L-NNA
NOS inhibitor (nNOS = eNOS >> iNOS)
0919 TRIM
nNOS/iNOS inhibitor


Inhibitors
Cat. No. Product Name / Activity
0476 2,4-Diamino-6-hydroxypyrimidine
Inhibits tetrahydrobiopterin synthesis and thus NOS activity
3213 Methylene Blue
Soluble guanylyl cyclase inhibitor
4517 NS 2028
Potent soluble guanylyl cyclase (sGC) inhibitor
0880 ODQ
Selective inhibitor of NO-sensitive guanylyl cyclase
Activators
Cat. No. Product Name / Activity
2753 A 350619 hydrochloride
Soluble guanylyl cyclase (sGC) activator
4430 BAY 41-2272
Soluble guanylyl cyclase (sGC) activator
Others
Cat. No. Product Name / Activity
0772 Carboxy-PTIO, potassium salt
Stable, water-soluble deactivator of NO
0504 Diphenyleneiodonium chloride
GPR3 agonist; also inhibits NOS and NADPH oxidases
3415 DMPO
Nitric oxide spin trap; measures oxygen-centered free radicals
5085 L 012 sodium salt
Chemiluminescent ROS and RNS indicator
0727 Pyrrolidinedithiocarbamate ammonium
Inhibits NF-κB, prevents increase in NOS mRNA