• Home
  • About us
  • Log-In
  • Join Us
  • Sitemap
  • Recruit
ǰ/ Q&A
ڷû
Ŭ
A/S
Ŭ ȸ
 ǰȳ  Ű   Pharmacology

Cytokine and NF-kB Signaling Small Molecules

Cytokine NF-kB ñ׳θ õ small molecule Ұմϴ.

TOCRIS
ǰ ϱ
μϱ




Inhibitors
Cat. No. Product Name / Activity
1989 c-JUN peptide
JNK/c-Jun interaction inhibitor
5309 SP 100030
NF-κB and AP-1 dual inhibitor
2476 SR 11302
AP-1 inhibitor; antitumor agent


Agonists
Cat. No. Product Name / Activity
6583 UCLA GP130 2
gp130 agonist; brain penetrant and neuroprotectant
Modulators
Cat. No. Product Name / Activity
7066 RCGD 423
gp130 modulator; activates JAK/STAT signaling
Inhibitors
Cat. No. Product Name / Activity
5430 AS 2444697
Potent and selective IRAK4 inhibitor
5484 C 87
TNF-α inhibitor
4288 ISO 1
Macrophage migration inhibitory factor (MIF) inhibitor
6373 PF 06650833
Potent and selective IRAK4 inhibitor
4963 SC 144 hydrochloride
gp130 inhibitor; blocks cytokine-triggered gp130 signaling
Others
Cat. No. Product Name / Activity
2446 AS 101
Immunomodulator; inhibits IL-10 synthesis and potentiates IL-1α, IL-2 and TNF-α release
6438 BRD 6989
IL-10 production enhancer; Cdk8 inhibitor
4316 Bropirimine
Immunomodulatory and antitumor compound
4204 BTZO 1
MIF binder
0846 Chicago Sky Blue 6B
MIF inhibitor; also inhibits L-glutamate uptake into synaptic vesicles
6107 CP 424174
Inhibitor of IL-1β post-translational processing; indirectly inhibits NLRP3
4400 (±)-CPSI 1306
Reported macrophage migration inhibitory factor (MIF) inhibitor
5479 CRID3 sodium salt
Potent NLRP3 inflammasome inhibitor; inhibits IL-1β production
2471 ER 27319 maleate
Inhibits TNF-α production
1798 Gabexate mesylate
Inhibits TNF-α production. Also antithrombotic agent
3270 GIT 27
Immunomodulator; reduces production of pro-inflammatory cytokines
5126 iMDK
Suppressor of MDK expression; inhibits PI 3-K signaling
3429 4-IPP
Inhibitor of macrophage migration inhibitory factor (MIF); suicide substrate
5185 JTE 607 dihydrochloride
Cytokine release inhibitor; anti-inflammatory
6305 Lenalidomide
TNF-α inhibitor; inhibits angiogenesis; also cereblon binder
4656 (D)-(+)-Neopterin
Stimulated by IFN-γ; marker of immune activation
1093 Pirfenidone
Antifibrotic agent; regulates cytokine levels in vivo
6302 Pomalidomide
TNF-α inhibitor; also cereblon ubiquitination inhibitor and antiangiogenic
6829 (R)-Shikonin
Blocks TNF-α and NF-κB signaling; induces necroptosis; anti-inflammatory
2008 SKF 86002 dihydrochloride
Inhibits human monocyte IL-1 and TNF-α production; p38 MAP kinase inhibitor
3543 Suplatast tosylate
Th2 cytokine synthesis inhibitor; antiasthmatic
0652 Thalidomide
TNF-α synthesis inhibitor; also binds cereblon


Inhibitors
Cat. No. Product Name / Activity
0414 AG 490
JAK2, JAK3 inhibitor. Also EGFR-kinase inhibitor
4580 Atiprimod dihydrochloride
JAK2 inhibitor
5617 AZD 1480
Potent and selective JAK2 inhibitor; antiangiogenic
4500 Cercosporamide
Potent Mnk2 inhibitor; also inhibits JAK3
4556 CP 690550 citrate
Potent JAK inhibitor
1571 Cucurbitacin I
Selective inhibitor of STAT3/JAK2 signaling
2291 1,2,3,4,5,6-Hexabromocyclohexane
Inhibits JAK2 autophosphorylation
3395 Lestaurtinib
JAK2, FLT3 and TrkA inhibitor; also inhibits AurA and AurB
4338 NSC 33994
JAK2 inhibitor
5818 NVP BSK 805
Potent JAK2 inhibitor; orally bioavailable
6506 PF 06551600 malonate
Potent and selective JAK3 inhibitor
6577 Pyridone 6
Potent pan-JAK inhibitor; induces intermediate mesoderm; cell-permeable
7064 Ruxolitinib
Potent and selective JAK1/JAK2 inhibitor; orally bioavailable
7048 Ruxolitinib phosphate
Phosphate salt of Ruxolitinib (Cat. No. 7064); potent and selective JAK1/JAK2 inhibitor
3035 SD 1008
JAK2/STAT3 signaling pathway inhibitor
6125 TC JL 37
Potent TYK2 inhibitor
4221 TCS 21311
Potent JAK3 inhibitor. Also inhibits GSK-3β and PKC
3115 WHI-P 154
JAK3 kinase inhibitor. Also inhibits EGFR
1367 ZM 39923 hydrochloride
Potent, selective JAK3 inhibitor
1366 ZM 449829
Potent, selective JAK3 inhibitor


Inhibitors
Cat. No. Product Name / Activity
2651 AEG 3482
Inhibitor of JNK signaling
3314 BI 78D3
Selective, competitive JNK inhibitor
1989 c-JUN peptide
Peptide inhibitor of JNK/c-Jun interaction
6258 CC 401 dihydrochloride
High affinity JNK inhibitor; also inhibits HCMV replication
4924 CEP 1347
Inhibitor of JNK signaling
5575 IQ 1S
JNK inhibitor; anti-inflammatory; also NO donor
4550 IQ 3
Selective JNK3 inhibitor
1565 JIP-1 (153-163)
JNK-selective inhibitor peptide
1496 SP 600125
Selective JNK inhibitor
5044 SR 3576
Highly potent and selective JNK3 inhibitor
3607 SU 3327
Selective JNK inhibitor
2827 TCS JNK 5a
Selective inhibitor of JNK2 and JNK3
3222 TCS JNK 6o
Selective JNK inhibitor
Activators
Cat. No. Product Name / Activity
1290 Anisomycin
JNK, SAPK and p38 activator
Others
Cat. No. Product Name / Activity
6558 CP 43
Inhibits TAOK activation of JNK



Inhibitors
Cat. No. Product Name / Activity
4547 ACHP
Selective IKKα and IKKβ inhibitor; blocks NF-κB-DNA binding
4857 Amlexanox
Inhibitor of TBK1 and IKKε; antiallergic agent
4626 Andrographolide
Inhibits NFκB; blocks androgen receptor (AR) expression
1777 Arctigenin
Inhibitor of IκBα phosphorylation. Also inhibits MEK1
1743 Bay 11-7085
Irreversible inhibitor of TNF-α-induced IκBα phosphorylation
1744 Bay 11-7821
Indirect inhibitor of IκBα phosphorylation
5273 Bengamide B
Potent inhibitor of NF-κB activation
5300 BI 605906
Selective IKKβ inhibitor
4806 BMS 345541
Selective allosteric inhibitor of IKK; anti-inflammatory
5821 C-DIM 12
Inhibits NF-κB-dependent gene expression; Nurr1 activator
2743 Caffeic acid phenethyl ester
Specific inhibitor of NF-κB activation
2509 Cardamonin
Inhibitor of NF-κB activation; anti-inflammatory
6646 CDDO-Me
NF-κB pathway inhibitor; inhibits IKKβ; also Nrf2 pathway activator
3203 Celastrol
Inhibits TNF-α-induced NF-κB activation
4246 CID 2858522
Selectively inhibits PKC-induced NF-κB activation
6237 FPS ZM1
High affinity antagonist of the receptor for advanced glycation end products (RAGE)
2637 Gliotoxin
Immunosuppressant; inhibits NF-κB and cytokine production
5672 GSK 319347A
Potent and selective IKKε inhibitor
4590 Honokiol
Blocks NF-κB activation; also anti-inflammatory and antioxidant
2861 HU 211
NF-κB inhibitor; decreases TNF-α, IL-6 and NO production. Also NMDA antagonist
2539 IKK 16
Selective inhibitor of IKK
2611 IMD 0354
Inhibitor of IKKβ
5699 IP7e
Blocks NF-κB pathway; also potent Nurr1 activator
5846 IT 901
NF-κB c-Rel subunit inhibitor
2874 Luteolin
Blocks NF-κB activation
1748 MG 132
Inhibits NF-κB activation; proteasome and calpain inhibitor
4899 ML 120B dihydrochloride
Novel IKK2-selective inhibitor
4354 ML 130
Inhibits NOD1-induced NF-κB activation
0610 Parthenolide
NF-κB inhibitor; also 5-HT release inhibitor
4238 PF 184
Potent and selective IKKβ inhibitor
1554 Piceatannol
Inhibits TNF-induced NF-κB activation
1947 PR 39 (porcine)
IκBα inhibitor
3731 Pristimerin
Suppresses NF-κB activation
4569 PS 1145 dihydrochloride
Selective IKK inhibitor; orally active
0727 Pyrrolidinedithiocarbamate ammonium
Inhibits NF-κB, prevents increase in NOS mRNA
6259 RAGE antagonist peptide
Receptor for advanced glycation end products (RAGE) antagonist
1778 Ro 106-9920
Inhibitor of NF-κB activation
3318 SC 514
IKKβ inhibitor; attenuates NF-κB-induced gene expression
6829 (R)-Shikonin
Blocks TNF-α and NF-κB signaling; induces necroptosis; anti-inflammatory
5309 SP 100030
NF-κB and AP-1 dual inhibitor
4935 Sulfasalazine
Inhibitor of NF-κB activation; also inhibits SXC and folate transporter 1
4426 Tanshinone IIA
Inhibits NF-κB and AP-1 DNA binding. Displays antioxidant properties
2559 TPCA-1
Potent, selective inhibitor of IKKβ
2816 Withaferin A
Inhibits NF-κB activation
6111 Zoledronic Acid
NF-κB signaling inhibitor; also potent farnesyl diphosphate (FPP) synthase inhibitor
Activators
Cat. No. Product Name / Activity
3906 Betulinic acid
Activates NF-κB; antitumor and anti-HIV agent. Also TGR5 agonist
6124 (R)-2-Hydroxyglutaric acid disodium salt
NF-κB activator; also KDM4A inhibitor
5739 Prostratin
NF-κB activator; also PKC activator



Inhibitors
Cat. No. Product Name / Activity
3713 Cryptotanshinone
STAT3 inhibitor. Also displays multiple other activities
1571 Cucurbitacin I
Selective inhibitor of STAT3/JAK2 signaling
6218 Galiellalactone
STAT3 inhibitor; active in vivo
6110 HJC 0416 hydrochloride New
STAT3 inhibitor
5522 Napabucasin
STAT3 inhibitor; also blocks cancer stem cell self-renewal
4079 Niclosamide
STAT3 inhibitor; also inhibits mTORC1 signaling
4655 NSC 74859
Selective STAT3 inhibitor
3918 Pyrimethamine
STAT3 inhibitor; also potent inhibitor of multidrug and toxin extrusion (MATE) transporters and DHFR inhibitor
5138 RSVA 405
STAT3 inhibitor; also AMPK activator
3035 SD 1008
JAK2/STAT3 signaling pathway inhibitor
2798 Stattic
Selective STAT3 inhibitor
Activators
Cat. No. Product Name / Activity
3945 Colivelin
STAT3 activator; also protects against β-amyloid neurotoxicity
Others
Cat. No. Product Name / Activity
3495 Fludarabine
Purine analog; inhibits cytokine-induced STAT1 activation
6994 HODHBt
STAT5-SUMO protein-protein interaction inhibitor