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 ǰȳ  Ű   Pharmacology

Cell Cycle Small Molecules

Cell cycle progression ϴ small molecules ȳմϴ.

TOCRIS
ǰ ϱ
μϱ




Inhibitors
Cat. No. Product Name / Activity
5981 Itraconazole
Inhibits cell cycle at G1 phase; also SMO antagonist
5779 NSC 23005 sodium
p18INK inhibitor; promotes HSC expansion
Others
Cat. No. Product Name / Activity
4406 10058-F4
Arrests cell cycle at G0/G1
4138 ABT 751
Inhibitor of microtubule polymerization; blocks cell cycle at G2M
6827 Artesunate
Arrests cell cycle in G2/M; antimalarial
3968 AZD 5438
Blocks cell cycling at G2-M, S and G1 phases
1761 Baicalein
Induces G1 and G2 cell cycle arrest. Also lipoxygenase inhibitor
5144 CFM 4
CARP-1 mimetic; induces G2/M cell cycle arrest
4436 8-Chloroadenosine
Cytotoxic nucleoside analog; induces G2/M arrest
5800 CHMFL-FLT3-122
Arrests cell cycle in G0/G1; FLT3 inhibitor
5331 CPI 203
Arrests cell cycle at G1 phase; also BET bromodomain inhibitor
1417 Daidzein
Arrests cell cycle in G1 phase
4502 DIM
Activates Chk2; induces G2/M cell cycle arrest
3502 Epothilone B
Microtubule stabilization agent; promotes G2-M cell cycle arrest
1813 Indirubin-3'-oxime
Induces cell cycle arrest, antiproliferative
6782 Indisulam
Arrests cell cycle at G1 phase; molecular glue
1230 Methotrexate
Cytotoxic agent
5231 MPC 6827 hydrochloride
Inhibitor of microtubule polymerization; antimitotic and antitumor
3715 Narciclasine
Antiproliferative agent; slows cell cycle progression
6070 Pladienolide B
Arrests cell cycle in G1 and G2/M; mRNA splicing inhibitor
4761 Plumbagin
Induces G2/M cell cycle arrest; anticancer
4763 Pyridostatin pentahydrochloride
Stabilizes G-quadruplexes; induces DNA damage and cell cycle arrest
4817 SKPin C1
Inhibits Skp2-mediated p27 degradation; induces cell cycle arrest
5264 Temsirolimus
mTOR inhibitor; arrests cell cycle at G1/S
3909 Toceranib
Potent PDGFR and VEGFR inhibitor; induces cell cycle arrest
4282 WYE 687 dihydrochloride
Potent and selective mTOR inhibitor; induces G1 cell cycle arrest
5493 XL 413 hydrochloride
Potent and selective Cdc7 inhibitor
4307 YC 1
Soluble guanylyl cyclase (sGC) activator; induces G1 cell cycle arrest



Inhibitors
Cat. No. Product Name / Activity
5199 AZD 7762 hydrochloride
Potent and selective ATP-competitive inhibitor of Chk1 and Chk2
4968 CCT 241533 dihydrochloride
Potent Chk2 inhibitor
6454 LY 2603618
Potent and selective Chk1 inhibitor
3034 NSC 109555 ditosylate
Selective Chk2 inhibitor
2694 PD 407824
Potent and selective inhibitor of Chk1 and Wee1
4277 PF 477736
Selective Chk1 inhibitor
2560 SB 218078
Chk1 inhibitor
3038 TCS 2312
Potent Chk1 inhibitor
Activator
Cat. No. Product Name / Activity
4502 DIM
Activates Chk2; induces G2/M cell cycle arrest