GABA Receptor Small molecules


GABA receptor 연구에 필요한 Small molecules을 소개합니다.
		TOCRIS

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	Inhibitors
	Cat. No.	Product Name / Activity
	0206	β-Alanine
		GABA uptake inhibitor (GAT-2 and -3); also glycine receptor agonist and MRGPRD agonist
	1296	CI 966 hydrochloride
		Selective inhibitor of GAT-1
	0234	Guvacine hydrochloride
		Specific GABA uptake inhibitor
	2747	NNC 05-2090 hydrochloride
		GABA uptake inhibitor; moderately BGT-1 selective
	1779	NNC 711
		Selective GAT-1 inhibitor
	0768	Riluzole hydrochloride
		GABA uptake inhibitor; also inhibits glutamate release and blocks NaV channels
	1081	SKF 89976A hydrochloride
		Potent GAT-1 inhibitor; brain penetrant
	1561	(S)-SNAP 5114
		GABA uptake inhibitor
	0181	TACA
		GABA uptake inhibitor; also GABAA agonist and substrate for GABA-T
	4256	Tiagabine hydrochloride
		Selective GAT-1 inhibitor; anticonvulsant

	Agonists
	Cat. No.	Product Name / Activity
	0344	GABA
		Endogenous agonist
	0235	Isoguvacine hydrochloride
		Selective GABAA agonist
	3250	L-838,417
		GABAA partial agonist; displays subtype selectivity
	4415	MK 0343
		GABAA partial agonist; displays subtype selectivity
	0289	Muscimol
		Potent GABAA agonist; also GABAA-ρ partial agonist
	4709	RuBi GABA trimethylphosphine
		Caged GABA; inhibits neural activity
	0181	TACA
		GABAA agonist; also GABA-T substrate and GABA uptake inhibitor
	3941	TCS 1205
		GABAA agonist; displays subtype selectivity
	0807	THIP hydrochloride
		GABAA agonist
	0180	ZAPA sulfate
		'Low affinity' GABAA agonist; also GABAA-ρ antagonist

	Inverse Agonists
	Cat. No.	Product Name / Activity
	3817	MRK 016
		α5-selective GABAA inverse agonist
	2905	TB 21007
		α5-selective GABAA inverse agonist

	Antagonists
	Cat. No.	Product Name / Activity
	2503	(-)-Bicuculline methiodide
		GABAA antagonist; more water soluble version of (+)-bicuculline (Cat. No. 0130)
	0109	(-)-Bicuculline methobromide
		GABAA antagonist; more water soluble version of (+)-bicuculline (Cat. No. 0130)
	0131	(-)-Bicuculline methochloride
		GABAA antagonist; more water soluble version of (+)-bicuculline (Cat. No. 0130)
	0130	(+)-Bicuculline
		Potent GABAA antagonist
	3109	Furosemide
		GABAA antagonist; also Na+/2Cl-/K+ cotransporter blocker
	4466	PHP 501 trifluoroacetate
		Potent GABAA antagonist
	1128	Picrotoxin
		GABAA antagonist
	2143	SCS
		Potent GABAA antagonist; β1-subunit selective
	1262	SR 95531 hydrobromide
		Competitive and selective GABAA antagonist
	1472	Suramin hexasodium salt
		Competitive α1β2γ2 GABAA antagonist; also non-selective P2 antagonist
	2745	U 93631
		GABAA antagonist

	Benzodiazepines
	Cat. No.	Product Name / Activity
	3568	Bretazenil
		Benzodiazepine partial agonist
	0405	β-CCB
		Benzodiazepine inverse agonist; putative endogenous ligand
	2467	CGS 20625
		Selective benzodiazepine partial agonist
	0456	Chlormezanone
		Positive allosteric modulator of benzodiazepine site
	1709	CL 218872
		Benzodiazepine agonist
	2805	Diazepam
		Acts at the benzodiazepine modulatory site
	0505	Dihydroergotoxine mesylate
		Binds to GABAA receptor Cl- channel; allosteric modulator of benzodiazepine site
	3083	DMCM hydrochloride
		Benzodiazepine inverse agonist
	0554	FG 7142
		Benzodiazepine inverse agonist
	0658	FGIN-1-27
		Potent ligand for mitochondrial DBI receptor; GABAA receptor modulator
	0659	FGIN-1-43
		Potent ligand for mitochondrial DBI receptor; GABAA receptor modulator
	1328	Flumazenil
		Benzodiazepine antagonist
	2174	Hispidulin
		Partial positive allosteric modulator at the benzodiazepine site
	3597	Indiplon
		Positive allosteric modulator of GABAA; acts at benzodiazepine site
	1327	L-655,708
		Benzodiazepine inverse agonist; selective for α5-containing GABAA receptors
	3087	Lorazepam
		Ligand at benzodiazepine site
	2832	Midazolam hydrochloride
		Benzodiazepine agonist
	1997	Ro 15-4513
		Benzodiazepine partial inverse agonist
	1995	Ro 19-4603
		Benzodiazepine inverse agonist
	3942	TCS 1105
		GABAA α2 benzodiazepine agonist
	4414	TP 003
		GABAA partial agonist; acts at benzodiazepine site
	3655	Zaleplon
		Benzodiazepine site agonist
	1994	ZK 93423 hydrochloride
		Potent benzodiazepine agonist
	1996	ZK 93426 hydrochloride
		Potent and competitive benzodiazepine antagonist
	0655	Zolpidem
		Benzodiazepine agonist
	1094	Zopiclone
		Benzodiazepine agonist

	Modulators
	Cat. No.	Product Name / Activity
	3972	AA 29504
		Positive allosteric modulator of GABAA receptors
	3653	Allopregnanolone
		Positive allosteric modulator of GABAA receptors
	0881	Chlormethiazole hydrochloride
		Potentiates GABAA receptor function
	3679	DS2
		Positive allosteric modulator of δ-containing GABAA receptors
	3113	Etifoxine hydrochloride
		GABAA potentiator; anxiolytic
	1471	Etomidate
		GABA-mimetic; selectively interacts with β2- and β3-subunit containing GABAA receptors
	2867	Flupirtine maleate
		GABAA modulator; also indirect NMDA antagonist and Kv7 channel activator
	2531	Ganaxolone
		Potent positive allosteric modulator of GABAA receptors
	1295	Loreclezole hydrochloride
		Subtype-selective GABAA modulator
	4949	MaxiPost
		Negative modulator of GABAA receptors; also potassium channel modulator
	4410	Ocinaplon
		GABAA modulator; anxiolytic
	2738	Org 20599
		Positive allosteric modulator of GABAA receptors; direct agonist at higher concentrations
	2681	17-PA
		Antagonist of neurosteroid potentiation and direct gating of GABAA
	3652	Pregnanolone
		Postitive allosteric modulator of GABAA receptors
	5376	Pregnenolone sulfate sodium salt
		GABAA inhibitor; displays some subunit selectivity; NMDA potentiator; also activates TRPM3 channels
	0830	Primidone
		Potentiates GABAA receptor function
	6192	PZ-II-029
		α6β3γ2-selective GABAA positive allosteric modulator
	1512	SB 205384
		GABAA modulator; slows current decay
	6334	THDOC
		Positive modulator of GABAA receptors; endogenous neurosteroid
	3620	Topiramate
		Positive allosteric modulator of GABAA receptors; GluK1 antagonist; also inhibits carbonic anhydrase (CA) II and IV
	1558	Tracazolate hydrochloride
		Allosteric modulator of GABAA receptors
	2734	U 89843A
		Positive allosteric modulator of GABAA receptors
	2733	U 90042
		GABAA ligand
	3048	Valerenic acid
		Positive allosteric modulator of GABAA receptors

	Agonists
	Cat. No.	Product Name / Activity
	0796	(R)-Baclofen
		Selective GABAB agonist; active enantiomer of (RS)-Baclofen (Cat. No. 0417)
	0417	(RS)-Baclofen
		Selective GABAB agonist
	0344	GABA
		Endogenous agonist
	3400	RuBi-GABA
		Caged GABA; excitable at visible wavelengths
	4709	RuBi GABA trimethylphosphine
		Caged GABA; inhibits neural activity
	0379	SKF 97541
		Highly potent GABAB agonist; also GABAA-ρ antagonist

	Antagonists
	Cat. No.	Product Name / Activity
	1245	CGP 35348
		Selective GABAB antagonist; brain penetrant
	3219	CGP 36216 hydrochloride
		GABAB antagonist; displays activity at presynaptic receptors
	1247	CGP 46381
		Selective GABAB antagonist; brain penetrant
	1246	CGP 52432
		Potent and selective GABAB antagonist
	1088	CGP 54626 hydrochloride
		Potent and selective GABAB antagonist
	1248	CGP 55845 hydrochloride
		Potent and selective GABAB antagonist
	0245	2-Hydroxysaclofen
		Selective GABAB antagonist; more potent than Saclofen (Cat. No. 0246)
	0178	Phaclofen
		Selective GABAB antagonist
	0246	Saclofen
		Selective GABAB antagonist
	0984	SCH 50911
		Selective and competitive GABAB antagonist; orally bioavailable

	Modulators
	Cat. No.	Product Name / Activity
	3313	rac BHFF
		Potent and selective postitive allosteric modulator of GABAB receptors
	1514	CGP 13501
		Positive allosteric modulator of GABAB receptors
	1513	CGP 7930
		Positive allosteric modulator of GABAB receptors
	2001	GS 39783
		Positive allosteric modulator of GABAB receptors

	Other
	Cat. No.	Product Name / Activity
	1814	N-ArachidonylGABA
		Inhibits pain in vivo
	0538	trans-4-Hydroxycrotonic acid
		GHB receptor ligand
	0386	3-Methyl-GABA
		Activator of GABA amino-transferase
	1811	Modafinil
		Psychostimulant
	0780	NCS-382
		Antagonist of γ-hydroxybutyric acid
	4579	Pentobarbital sodium salt
		Enhances GABAergic activity
	2687	Pentylenetetrazole
		CNS stimulant
	5518	UMB 68
		GHB receptor ligand
	2815	Valproic acid, sodium salt
		Increases GABA levels; anticonvulsant
	2625	Zonisamide
		Modulates GABA neurotransmission; anticonvulsant

	Inhibitors
	Cat. No.	Product Name / Activity
	3888	VU 0240551
		KCC2 inhibitor
	4719	VU 0463271
		Potent and selective KCC2 inhibitor

	Activators
	Cat. No.	Product Name / Activity
	5242	CLP 257
		Selective KCC2 activator

	Cat. No.	Product Name / Activity
	3400	RuBi-GABA
		Caged GABA; excitable at visible wavelengths
	4709	RuBi GABA trimethylphosphine
		Caged GABA; inhibits neural activity

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