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 ǰȳ  Ű   Pharmacology

Dopamine Receptor Small molecules

Dopamine receptor ʿ small moleucle Ұմϴ.

TOCRIS
ǰ ϱ
μϱ




Agonists
Cat. No. Product Name / Activity
1534 A 68930 hydrochloride
Potent and selective D1-like agonist
1701 A 77636 hydrochloride
Potent and selective D1-like agonist; orally active
2073 (R)-(-)-Apomorphine hydrochloride
Dopamine agonist; non-subtype-selective
1249 CY 208-243
Selective D1-like agonist
0884 Dihydrexidine hydrochloride
Selective D1-like agonist
3548 Dopamine hydrochloride
Endogenous agonist at dopamine D1-5 receptors
1659 Fenoldopam hydrochloride
Selective D1-like partial agonist
3992 NPEC-caged-dopamine
Caged version of dopamine (Cat. No. 3548)
0922 SKF 38393 hydrobromide
Selective D1-like agonist
1662 SKF 77434 hydrobromide
Selective D1-like partial agonist
1447 SKF 81297 hydrobromide
D1 agonist
5719 SKF 82958 hydrobromide
D1 agonist
2075 SKF 83822 hydrobromide
Selective D1-like agonist
2074 SKF 83959 hydrobromide
D1-like partial agonist
Antagonists
Cat. No. Product Name / Activity
1674 LE 300
Potent and selective D1 antagonist
0925 SCH 23390 hydrochloride
Selective D1-like antagonist; also 5-HT2C agonist and Kir3 channel blocker
2299 SCH 39166 hydrobromide
High affinity D1-like antagonist
1586 SKF 83566 hydrobromide
Potent and selective D1-like antagonist; also inhibits adenylyl cyclase 2



Agonists
Cat. No. Product Name / Activity
5584 Aripiprazole
High affinity D2 and 5-HT1A receptor partial agonist; also 5-HT2A antagonist
2759 B-HT 920
D2 agonist; also α2-adrenoceptor agonist and 5-HT3 antagonist
3940 GSK 789472 hydrochloride
D2 partial agonist; D3 antagonist
6171 MLS 1547
G protein-biased D2 partial agonist
3896 Rotigotine hydrochloride
D2 and D3 agonist
2773 Sumanirole maleate
Selective D2 agonist
Antagonists
Cat. No. Product Name / Activity
5858 Droperidol
D2 antagonist
1003 L-741,626
High affinity D2 antagonist
2495 Melperone hydrochloride
D2 antagonist; also 5-HT2A antagonist; neuroleptic
4349 Olanzapine
D2 antagonist; also 5-HT2A antagonist; atypical antipsychotic
4493 Paliperidone
D2 antagonist; also 5-HT2A antagonist; atypical antipsychotic
3287 Prochlorperazine dimaleate
D2 receptor antagonist; also 5-HT3 and nAChR antagonist
4735 Quetiapine hemifumarate
D2 antagonist; also 5-HT2 antagonist; atypical antipsychotic
2865 Risperidone
D2 antagonist; also 5-HT2A antagonist; atypical antipsychotic
0775 (+)-UH 232 maleate
D2 autoreceptor antagonist. Also D3 partial agonist
3085 Ziprasidone hydrochloride
D2 antagonist; also 5-HT2A antagonist; atypical antipsychotic
3996 Zotepine
D2 antagonist; also 5-HT2A and H1 antagonist; atypical antipsychotic
Modulators
Cat. No. Product Name / Activity
5041 PAOPA
Allosteric modulator of D2 receptors


Agonists
Cat. No. Product Name / Activity
0706 7-Hydroxy-DPAT hydrobromide
Dopamine agonist (D3 ≥ D2 < > D4)
1243 (+)-PD 128907 hydrochloride
High affinity D3 agonist (D3 ≥ D2 > D4)
4174 Pramipexole dihydrochloride
Selective D3 agonist
3896 Rotigotine hydrochloride
D2 and D3 agonist
Antagonists
Cat. No. Product Name / Activity
1847 Eticlopride hydrochloride
D3 antagonist (D3 > D2)
3940 GSK 789472 hydrochloride
D3 antagonist. Also D2 partial agonist
1347 Nafadotride
Highly potent, preferential D3 antagonist
2635 NGB 2904
Potent and selective D3 antagonist
3887 PG 01037 dihydrochloride
Selective D3 antagonist
3355 PNU 177864 hydrochloride
Highly selective D3 antagonist
4207 SB 277011A dihydrochloride
Selective D3 antagonist
1357 U 99194 maleate
Potent and selective D3 antagonist


Agonists
Cat. No. Product Name / Activity
4552 A 412997 dihydrochloride
Selective D4 agonist
2214 ABT 724 trihydrochloride
Potent and selective D4 partial agonist; proerectile
1065 PD 168077 maleate
High affinity, selective D4 agonist
2329 Ro 10-5824 dihydrochloride
Selective D4 partial agonist
4380 WAY 100635 maleate
D4 agonist; also potent 5-HT1A antagonist
Antagonists
Cat. No. Product Name / Activity
2645 Fananserin
D4 antagonist; also 5-HT2A antagonist
1004 L-741,742 hydrochloride
Highly selective D4 antagonist
1002 L-745,870 trihydrochloride
Highly selective D4 antagonist
3529 PD 168568 dihydrochloride
Potent and selective D4 antagonist
2735 PNU 96415E
D4 and 5-HT2A antagonist; antipsychotic
4185 Sonepiprazole
Selective D4 antagonist
Ligands
Cat. No. Product Name / Activity
3298 NGD 94-1
Selective D4 receptor ligand



Inhibitors
Cat. No. Product Name / Activity
4357 Bicifadine hydrochloride
Noradrenalin, 5-HT and dopamine re-uptake inhibitor
0918 3α-Bis-(4-fluorophenyl) methoxytropane hydrochloride
Potent dopamine uptake inhibitor
2831 Bupropion hydrochloride
Non-selective inhibitor of dopamine and noradrenalin transporters
2833 Cocaine hydrochloride
Inhibitor of monoamine transporters
0917 3-CPMT
Dopamine uptake inhibitor
4798 (S)-Duloxetine hydrochloride
Potent 5-HT and NA reuptake inhibitor; also blocks dopamine reuptake
0513 GBR 12783 dihydrochloride
Potent and selective DA uptake inhibitor
0421 GBR 12909 dihydrochloride
Selective DA uptake inhibitor; also σ ligand
0514 GBR 12935 dihydrochloride
Selective dopamine uptake inhibitor
0420 GBR 13069 dihydrochloride
Potent dopamine uptake inhibitor
1588 Indatraline hydrochloride
Potent dopamine uptake inhibitor; also inhibits 5-HT and noradrenalin uptake
4351 JHW 007 hydrochloride
High affinity dopamine uptake inhibitor
2148 (±)-McN 5652
Potent, orally active 5-HT uptake inhibitor. Also inhibits noradrenalin and dopamine uptake in vitro
3027 (±)-MDMA hydrochloride
Inhibitor of dopamine and 5-HT uptake; hallucinogenic
1812 Threo-methylphenidate hydrochloride
Inhibitor of dopamine and noradrenalin transporters. Psychomotor stimulant
6131 (R)-Modafinil
Dopamine uptake inhibitor
1992 Nomifensine
Potent noradrenalin and dopamine uptake inhibitor. Antidepressant
2742 Reserpine
Inhibitor of vesicular monoamine transport
1497 Rimcazole dihydrochloride
DAT inhibitor. Also σ2 antagonist
2175 Tetrabenazine
Potent inhibitor of vesicular monoamine transport; depletes dopamine stores
Other
Cat. No. Product Name / Activity
4946 AIM 100
Promotes endocytosis and oligomerization of DAT; also Ack1 inhibitor
5200 FFN 102 mesylate
Selective fluorescent substrate of DAT and VMAT2



Agonists
Cat. No. Product Name / Activity
2073 (R)-(-)-Apomorphine hydrochloride
Dopamine agonist; non-subtype-selective
0427 Bromocriptine mesylate
D2-like agonist (D2>D3>D4)
2664 Cabergoline
D2-like agonist (D2>D3>D4)
2193 Carmoxirole hydrochloride
Selective, peripherally acting D2-like agonist
0474 Dihydroergocristine mesylate
Dopamine partial agonist; also adrenergic partial agonist and 5-HT antagonist
0475 Dihydroergotamine mesylate
D2-like partial agonist; also α-adrenergic partial agonist and 5-HT antagonist
3548 Dopamine hydrochloride
Endogenous agonist at dopamine D1-5 receptors
4052 Lisuride maleate
Dopamine agonist; antiparkinson's agent
1644 Mesulergine hydrochloride
D2-like partial agonist; also 5-HT2A and 5-HT2C antagonist
3992 NPEC-caged-dopamine
Caged dopamine
1031 Piribedil dihydrochloride
Dopamine agonist
1519 Quinelorane hydrochloride
D2 and D3 agonist
1061 (-)-Quinpirole hydrochloride
Selective D2-like agonist
3680 Ropinirole
Selective D2-like agonist
1559 Roxindole hydrochloride
Dopamine D2 autoreceptor agonist. Also has affinity for D3, D4, 5-HT1A receptors and the 5-HT transporter
Antagonists
Cat. No. Product Name / Activity
0678 (+)-AJ 76 hydrochloride
Antagonist; preferential action at D2-like autoreceptors
0524 AMI-193
D2-like antagonist; also selective 5-HT2 antagonist
2132 Amisulpride
Selective D2 and D3 antagonist; atypical antipsychotic
3737 Asenapine maleate
Non-selective 5-HT, dopamine, adrenalin and histamine receptor antagonist; antipsychotic agent
0444 Clozapine
Dopamine antagonist with some D4 selectivity; also 5-HT2A/2C antagonist
0782 2-CMDO
D2-like antagonist; displays some D4 selectivity
2536 Domperidone
Peripheral D2-like antagonist
1847 Eticlopride hydrochloride
D2 and D3 antagonist (D3 > D2)
4057 Flupenthixol dihydrochloride
Dopamine antagonist
0931 Haloperidol hydrochloride
Dopamine antagonist; displays some D2 selectivity
1746 Nemonapride
Highly potent D2-like antagonist; also 5-HT1A agonist
0937 Pimozide
D2-like antagonist; also high affinity 5-HT7 antagonist
1810 Raclopride
Potent and selective D2 and D3 antagonist
0916 Remoxipride hydrochloride
Selective D2-like antagonist
0995 Spiperone hydrochloride
D2-like antagonist; also 5-HT2A antagonist
0894 (RS)-(±)-Sulpiride
Standard selective D2-like antagonist
0895 (S)-(-)-Sulpiride
Standard selective D2-like antagonist
3070 Thioridazine hydrochloride
Dopamine receptor antagonist; antipsychotic
0775 (+)-UH 232 maleate
D2 autoreceptor antagonist. Also D3 partial agonist
Ligands
Cat. No. Product Name / Activity
0701 3'-Fluorobenzylspiperone maleate
D2-like receptor ligand
Other
Cat. No. Product Name / Activity
3788 L-DOPA
Dopamine precursor


Inhibitors
Cat. No. Product Name / Activity
2742 Reserpine
Inhibitor of vesicular monoamine transport
5168 Rose Bengal
Potent VGlut and VMAT inhibitor; cell permeable
2175 Tetrabenazine
Potent inhibitor of vesicular monoamine transport
Other
Cat. No. Product Name / Activity
5200 FFN 102 mesylate
Selective fluorescent substrate of VMAT2 and DAT
5911 FFN 200 dihydrochloride
Selective fluorescent VMAT2 substrate
5043 FFN 206 dihydrochloride
Fluorescent VMAT2 substrate
6717 FFN 270 New
Fluorescent substrate for NET and VMAT2
3878 FFN 511
Fluorescent substrate for VMAT2