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 ǰȳ  Ű   Pharmacology

Angiogenesis Small molecules

Angiogenesis ʿ small moleucle Ұմϴ.

TOCRIS
ǰ ϱ
μϱ




Inhibitors
Cat. No. Product Name / Activity
6840 AD 01 
FKBPL (FK506-binding protein like)-based peptide; inhibits breast cancer stem cell self-renewal; also antiangiogenic
6305 Lenalidomide
Angiogenesis inhibitor; also TNF-α inhibitor and cereblon binder
6302 Pomalidomide
Antiangiogenic; also TNF-α inhibitor and cereblon ubiquitination inhibitor
6187 SK 216
Angiogenesis inhibitor; Also PAI-1 inhibitor
Other
Cat. No. Product Name / Activity
5121 3PO
PFKFB3 inhibitor; antiangiogenic
5617 AZD 1480
Potent and selective JAK2 inhibitor; antiangiogenic
4706 Borrelidin
Antiangiogenic; inhibits threonyl-tRNA synthetase
5029 CHC
Monocarboxylic acid transport (MCT) inhibitor; displays anti-angiogenic activities
1495 Combretastatin A4
Antiangiogenic
1768 Fumagillin
Antiangiogenic
1629 Herbimycin A
Antiangiogenic. Inhibits Src family kinases and Hsp90
5981 Itraconazole
SMO antagonist; antiangiogenic
5260 KG 5
Antiangiogenic; PDGFRβ, B-Raf, c-Raf, FLT3 and KIT inhibitor
1461 Linomide
Immunomodulator with antiangiogenic properties
1807 2-Methoxyestradiol
Antiangiogenic and apoptotic agent
4664 Obtustatin
Potent and selective α1β1 inhibitor; antiangiogenic
2710 OGT 2115
Antiangiogenic. Heparanase inhibitor
4733 P005091
USP7 inhibitor; antiangiogenic
4744 P11
Potent antagonist of αvβ3-vitronectin interaction; antiangiogenic
2954 PX 12
Thioredoxin-1 inhibitor; attenuates expression of HIF-1α
4885 R 1530
Multi-RTK inhibitor; inhibits angiogenesis
1418 Resveratrol
Cyclooxygenase inhbitor
0652 Thalidomide
Antiangiogenic; also inhibits TNF-α synthesis
1098 Tranilast
Antiangiogenic


Inhibitors
Cat. No. Product Name / Activity
2621 ARP 100
Selective inhibitor of MMP-2
2622 ARP 101
Inhibitor of MMP-2
2961 Batimastat
Potent, broad spectrum MMP inhibitor
2632 CL 82198 hydrochloride
Selective inhibitor of MMP-13
3780 CP 471474
Broad spectrum MMP inhibitor
4090 Doxycycline hyclate
Broad-spectrum MMP inhibitor; tetracycline derivative
2983 GM 6001
Broad spectrum MMP inhibitor
6439 JNJ 0966 
Pro-MMP9 activation inhibitor
2631 Marimastat
Broad spectrum MMP inhibitor
3268 Minocycline hydrochloride
Inhibitor of MMP activity
4902 NSC 405020
Inhibitor of MT1-MMP; antitumor
2628 ONO 4817
Broad spectrum MMP inhibitor
2520 PD 166793
Broad spectrum MMP inhibitor
6088 SB 3CT
High affinity and selective MMP2 inhibitor
4775 SD 2590 hydrochloride
Potent MMP inhibitor
6134 T 26c disodium salt
Highly potent and selective MMP13 inhibitor
5523 TAPI 0
ADAM-17 (TACE) and MMP inhibitor
6162 TAPI 1
ADAM-17 (TACE) and MMP inhibitor
6013 TAPI 2
ADAM-17 (TACE) and MMP inhibitor
4187 UK 356618
Potent and selective MMP-3 inhibitor
2900 UK 370106
Highly selective MMP-3 and MMP-12 inhibitor
4188 UK 383367
Potent and selective BMP-1 (PCP) inhibitor
2633 WAY 170523
Potent and selective inhibitor of MMP-13
Other
Cat. No. Product Name / Activity
3807 Disulfiram
Inhibits expression of MMP-2 and MMP-9; displays a range of other activities
4604 PTIQ
Potent MMP-3 expression inhibitor; neuroprotective


Inhibitors
Cat. No. Product Name / Activity
5318 AEE 788
Potent EGFR and VEGFR inhibitor
6812 Afatinib dimaleate 
Potent dual specificity EGFR/HER2 inhibitor; active in vivo
1276 AG 1478 hydrochloride
Highly potent EGFR-kinase inhibitor
0493 AG 18
EGFR/PDGFR-kinase inhibitor
0414 AG 490
EGFR-kinase inhibitor. Also JAK2, JAK3 inhibitor
0619 AG 494
Potent EGFR-kinase inhibitor
0618 AG 555
Potent EGFR-kinase inhibitor
0616 AG 556
EGFR-kinase inhibitor
1555 AG 825
Selective ErbB2 inhibitor
2617 AG 879
ErbB2 inhibitor
0497 AG 99
EGFR-kinase inhibitor
4397 AV 412
Potent inhibitor of EGFR, ErbB2 and Abl receptor tyrosine kinases
2417 BIBU 1361 dihydrochloride
Selective inhibitor of EGFR-kinase
2416 BIBX 1382 dihydrochloride
Highly selective EGFR-kinase inhibitor
5022 BMS 599626 dihydrochloride
Potent, selective EGFR and ErbB2 inhibitor
5916 Canertinib dihydrochloride
Potent EGFR kinase inhibitor
3360 CGP 52411
EGFR inhibitor. Also inhibits Aβ42 fibril formation
5973 CP 724714
Potent and selective ErbB2 inhibitor
6231 Dacomitinib
Potent irreversible pan ErbB inhibitor
4502 DIM
Inhibits EGFR activation; also induces apoptosis
1110 Genistein
EGFR kinase inhibitor. Also estrogen and PPARγ ligand
2239 GW 583340 dihydrochloride
Potent dual EGFR/ErbB2 inhibitor; orally active
3580 HKI 357
Dual irreversible inhibitor of ErbB2 and EGFR
3000 Iressa
Orally active, selective EGFR inhibitor
3352 JNJ 28871063 hydrochloride
Potent ErbB receptor family inhibitor
6811 Lapatinib 
Potent and selective dual ErbB2 (HER-2) and EGFR inhibitor
1331 Lavendustin A
EGFR, p60c-src inhibitor
0577 Methyl 2,5-dihydroxycinnamate
EGFR-kinase inhibitor
1037 PD 153035 hydrochloride
EGFR-kinase inhibitor
2615 PD 158780
Potent ErbB receptor family inhibitor
6349 Pelitinib
Potent and irreversible EGFR inhibitor; orally bioavailable
5939 PF 6274484
High affinity and potent covalent EGFR kinase inhibitor
4941 PKI 166 hydrochloride
Potent EGFR-kinase inhibitor
2794 PP 3
EGFR-kinase inhibitor. Also Src kinase negative control
3599 TAK 165
Potent and selective ErbB2 inhibitor
0579 Tyrphostin B44, (+) enantiomer
EGFR-kinase inhibitor
3115 WHI-P 154
Potent EGFR inhibitor. Also inhibits JAK3
Other
Cat. No. Product Name / Activity
6556 Anti-human EGFR aptamer, Janelia Fluor® 646 conjugate
High affinity anti-human EGFR aptamer conjugated to Janelia Fluor® 646
6557 Anti-human ErbB2 aptamer, Janelia Fluor® 646 conjugate
Anti-human ErbB2 aptamer, Janelia Fluor® 646 conjugate


Inhibitors
Cat. No. Product Name / Activity
5013 AC 710
Potent and selective PDGFR family inhibitor
0493 AG 18
EGFR/PDGFR-kinase inhibitor
4274 AP 24534
Potent multi-kinase and pan-Bcr-Abl inhibitor
5993 CP 673451
Potent and selective PDGFR inhibitor
1222 DMPQ dihydrochloride
Potent, selective inhibitor of PDGFRβ
6056 GSK 1363089
Potent PDGFR inhibtor; also inhibits of MET, VEGFR2, Ron and AXL
5906 Imatinib mesylate
PDGFR inhibitor; also inhibits v-Abl tyrosine kinase and c-kit
5260 KG 5
PDGFRβ, B-Raf, c-Raf, FLT3 and KIT inhibitor; antiangiogenic
3785 PD 166285 dihydrochloride
PDGFRβ, FGFR and Src inhibitor; also inhibits Wee1
6814 Sorafenib 
PDGFR-β inhibitor; also inhibits Raf-1, VEGFR-2, VEGFR-3, Flt-3 and cKIT
3304 SU 16f
Potent and selective PDGFRβ inhibitor
3335 SU 6668
PDGFR, VEGFR and FGFR inhibitor
3768 Sunitinib malate
Potent VEGFR, PDGFRβ and KIT inhibitor
3909 Toceranib
Potent PDGFR and VEGFR inhibitor


Inhibitors
Cat. No. Product Name / Activity
4274 AP 24534
Potent multi-kinase and pan-Bcr-Abl inhibitor
4002 FIIN 1 hydrochloride
Potent, irreversible FGFR inhibitor
3724 PD 161570
Selective FGFR inhibitor
3785 PD 166285 dihydrochloride
FGFR, PDGFRβ and Src inhibitor; also inhibits Wee1
3044 PD 173074
FGFR1 and -3 inhibitor
3300 SU 5402
Potent FGFR and VEGFR inhibitor
3335 SU 6668
FGFR, VEGFR and PDGFR inhibitor
Other
Cat. No. Product Name / Activity
4826 SUN 11602
Basic fibroblast growth factor (bFGF) mimetic; neuroprotective


Inhibitors
Cat. No. Product Name / Activity
5318 AEE 788
Potent VEGFR and EGFR inhibitor
2617 AG 879
VEGFR-2 inhibitor
4274 AP 24534
Potent multi-kinase and pan-Bcr-Abl inhibitor
4350 Axitinib
Potent VEGFR-1, -2 and -3 inhibitor
6069 BMS 605541
Potent VEGFR-2 inhibitor
4471 DMH4
Selective VEGFR-2 inhibitor
3882 (E)-FeCP-oxindole
Selective VEGFR-2 inhibitor
3883 (Z)-FeCP-oxindole
Selective VEGFR-2 inhibitor
6056 GSK 1363089
Potent inhibitor of MET, VEGFR2, Ron and AXL
2542 Ki 8751
Potent, selective VEGFR-2 inhibitor
6015 RAF 265
VEGFR-2 and Raf kinase inhibitor
6814 Sorafenib 
VEGFR-2 and VEGFR-3 inhibitor; also inhibits Raf-1, PDGFR-β, Flt-3 and cKIT
1459 SU 4312
Potent inhibitor of VEGFR tyrosine kinase
3300 SU 5402
Potent VEGFR and FGFR inhibitor
3037 SU 5416
VEGFR inhibitor. Also inhibits KIT, RET, MET and FLT3
3335 SU 6668
VEGFR, PDGFR and FGFR inhibitor
3768 Sunitinib malate
Potent VEGFR, PDGFRβ and KIT inhibitor
3909 Toceranib
Potent PDGFR and VEGFR inhibitor
5680 Vatalanib succinate
Potent VEGFR inhibitor; also aromatase inhibitor
5422 XL 184
Potent VEGFR inhibitor; also inhibits other RTKs
2499 ZM 306416 hydrochloride
Inhibitor of VEGF receptor tyrosine kinase
2475 ZM 323881 hydrochloride
Potent, selective inhibitor of VEGFR-2
Other
Cat. No. Product Name / Activity
6986 EG 00229 trifluoroacetate 
Neuropilin 1 (NRP1) receptor antagonist; inhibits VEGFA binding to NRP1



Inhibitors
Cat. No. Product Name / Activity
6626 AP C5
Potent and selective PKG2 inhibitor
3028 Rp-8-Br-PET-cGMPS
Protein kinase G inhibitor
1883 cGMP Dependent Kinase Inhibitor Peptide
Inhibitor of protein kinases G and A
1289 KT 5823
Selective protein kinase G inhibitor
5524 Rp-8-pCPT-cGMPS sodium
PKG inhibitor
Activators
Cat. No. Product Name / Activity
1089 8-Bromo-cGMP, sodium salt
cGMP analog; activates protein kinase G



Inhibitors
Cat. No. Product Name / Activity
5953 Adaptaquin
HIF-prolyl hydroxylase-2 (PHD2) inhibitor; antioxidant
5582 TAT-cyclo-CLLFVY
Selective HIF-1 dimerization inhibitor
4408 DMOG
Inhibitor of hypoxia-inducible factor α (HIF-α) prolyl hydroxylase (HIF-PH)
5520 Echinomycin
Highly potent and selective HIF-1α inhibitor
6653 FM19G11 
HIF α-subunit inhibitor
5655 GN 44028
Potent HIF-1α inhibitor
4451 IOX 2
Potent, selective HIF-1α prolyl hydroxylase-2 (PHD2) inhibitor
4324 KC7F2
HIF-1α inhibitor; down-regulates HIF-1α protein synthesis
2954 PX 12
Thioredoxin-1 inhibitor; attenuates expression of HIF-1α
5243 TC-S 7009
High affinity and selective HIF-2α inhibitor
6156 VH 298
High-affinity inhibitor of VHL; blocks interaction of VHL and HIF-α
Activators
Cat. No. Product Name / Activity
4565 ML 228
HIF pathway activator
Other
Cat. No. Product Name / Activity
4705 Chetomin
Blocks interaction of HIF-1α, HIF-2α and STAT2 with CBP/p300
6157 cis VH 298
Negative control for VH 298
5764 Deferoxamine mesylate
Hypoxia mimetic; also iron chelator