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Pharmacology

Angiogenesis Small molecules

Angiogenesis 연구에 필요한 small moleucle을 소개합니다.

TOCRIS

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	Inhibitors
	Cat. No.	Product Name / Activity
	6840	AD 01
		FKBPL (FK506-binding protein like)-based peptide; inhibits breast cancer stem cell self-renewal; also antiangiogenic
	6305	Lenalidomide
		Angiogenesis inhibitor; also TNF-α inhibitor and cereblon binder
	6302	Pomalidomide
		Antiangiogenic; also TNF-α inhibitor and cereblon ubiquitination inhibitor
	6187	SK 216
		Angiogenesis inhibitor; Also PAI-1 inhibitor

	Other
	Cat. No.	Product Name / Activity
	5121	3PO
		PFKFB3 inhibitor; antiangiogenic
	5617	AZD 1480
		Potent and selective JAK2 inhibitor; antiangiogenic
	4706	Borrelidin
		Antiangiogenic; inhibits threonyl-tRNA synthetase
	5029	CHC
		Monocarboxylic acid transport (MCT) inhibitor; displays anti-angiogenic activities
	1495	Combretastatin A4
		Antiangiogenic
	1768	Fumagillin
		Antiangiogenic
	1629	Herbimycin A
		Antiangiogenic. Inhibits Src family kinases and Hsp90
	5981	Itraconazole
		SMO antagonist; antiangiogenic
	5260	KG 5
		Antiangiogenic; PDGFRβ, B-Raf, c-Raf, FLT3 and KIT inhibitor
	1461	Linomide
		Immunomodulator with antiangiogenic properties
	1807	2-Methoxyestradiol
		Antiangiogenic and apoptotic agent
	4664	Obtustatin
		Potent and selective α1β1 inhibitor; antiangiogenic
	2710	OGT 2115
		Antiangiogenic. Heparanase inhibitor
	4733	P005091
		USP7 inhibitor; antiangiogenic
	4744	P11
		Potent antagonist of αvβ3-vitronectin interaction; antiangiogenic
	2954	PX 12
		Thioredoxin-1 inhibitor; attenuates expression of HIF-1α
	4885	R 1530
		Multi-RTK inhibitor; inhibits angiogenesis
	1418	Resveratrol
		Cyclooxygenase inhbitor
	0652	Thalidomide
		Antiangiogenic; also inhibits TNF-α synthesis
	1098	Tranilast
		Antiangiogenic

	Inhibitors
	Cat. No.	Product Name / Activity
	2621	ARP 100
		Selective inhibitor of MMP-2
	2622	ARP 101
		Inhibitor of MMP-2
	2961	Batimastat
		Potent, broad spectrum MMP inhibitor
	2632	CL 82198 hydrochloride
		Selective inhibitor of MMP-13
	3780	CP 471474
		Broad spectrum MMP inhibitor
	4090	Doxycycline hyclate
		Broad-spectrum MMP inhibitor; tetracycline derivative
	2983	GM 6001
		Broad spectrum MMP inhibitor
	6439	JNJ 0966
		Pro-MMP9 activation inhibitor
	2631	Marimastat
		Broad spectrum MMP inhibitor
	3268	Minocycline hydrochloride
		Inhibitor of MMP activity
	4902	NSC 405020
		Inhibitor of MT1-MMP; antitumor
	2628	ONO 4817
		Broad spectrum MMP inhibitor
	2520	PD 166793
		Broad spectrum MMP inhibitor
	6088	SB 3CT
		High affinity and selective MMP2 inhibitor
	4775	SD 2590 hydrochloride
		Potent MMP inhibitor
	6134	T 26c disodium salt
		Highly potent and selective MMP13 inhibitor
	5523	TAPI 0
		ADAM-17 (TACE) and MMP inhibitor
	6162	TAPI 1
		ADAM-17 (TACE) and MMP inhibitor
	6013	TAPI 2
		ADAM-17 (TACE) and MMP inhibitor
	4187	UK 356618
		Potent and selective MMP-3 inhibitor
	2900	UK 370106
		Highly selective MMP-3 and MMP-12 inhibitor
	4188	UK 383367
		Potent and selective BMP-1 (PCP) inhibitor
	2633	WAY 170523
		Potent and selective inhibitor of MMP-13

	Other
	Cat. No.	Product Name / Activity
	3807	Disulfiram
		Inhibits expression of MMP-2 and MMP-9; displays a range of other activities
	4604	PTIQ
		Potent MMP-3 expression inhibitor; neuroprotective

	Inhibitors
	Cat. No.	Product Name / Activity
	5318	AEE 788
		Potent EGFR and VEGFR inhibitor
	6812	Afatinib dimaleate
		Potent dual specificity EGFR/HER2 inhibitor; active in vivo
	1276	AG 1478 hydrochloride
		Highly potent EGFR-kinase inhibitor
	0493	AG 18
		EGFR/PDGFR-kinase inhibitor
	0414	AG 490
		EGFR-kinase inhibitor. Also JAK2, JAK3 inhibitor
	0619	AG 494
		Potent EGFR-kinase inhibitor
	0618	AG 555
		Potent EGFR-kinase inhibitor
	0616	AG 556
		EGFR-kinase inhibitor
	1555	AG 825
		Selective ErbB2 inhibitor
	2617	AG 879
		ErbB2 inhibitor
	0497	AG 99
		EGFR-kinase inhibitor
	4397	AV 412
		Potent inhibitor of EGFR, ErbB2 and Abl receptor tyrosine kinases
	2417	BIBU 1361 dihydrochloride
		Selective inhibitor of EGFR-kinase
	2416	BIBX 1382 dihydrochloride
		Highly selective EGFR-kinase inhibitor
	5022	BMS 599626 dihydrochloride
		Potent, selective EGFR and ErbB2 inhibitor
	5916	Canertinib dihydrochloride
		Potent EGFR kinase inhibitor
	3360	CGP 52411
		EGFR inhibitor. Also inhibits Aβ42 fibril formation
	5973	CP 724714
		Potent and selective ErbB2 inhibitor
	6231	Dacomitinib
		Potent irreversible pan ErbB inhibitor
	4502	DIM
		Inhibits EGFR activation; also induces apoptosis
	1110	Genistein
		EGFR kinase inhibitor. Also estrogen and PPARγ ligand
	2239	GW 583340 dihydrochloride
		Potent dual EGFR/ErbB2 inhibitor; orally active
	3580	HKI 357
		Dual irreversible inhibitor of ErbB2 and EGFR
	3000	Iressa
		Orally active, selective EGFR inhibitor
	3352	JNJ 28871063 hydrochloride
		Potent ErbB receptor family inhibitor
	6811	Lapatinib
		Potent and selective dual ErbB2 (HER-2) and EGFR inhibitor
	1331	Lavendustin A
		EGFR, p60c-src inhibitor
	0577	Methyl 2,5-dihydroxycinnamate
		EGFR-kinase inhibitor
	1037	PD 153035 hydrochloride
		EGFR-kinase inhibitor
	2615	PD 158780
		Potent ErbB receptor family inhibitor
	6349	Pelitinib
		Potent and irreversible EGFR inhibitor; orally bioavailable
	5939	PF 6274484
		High affinity and potent covalent EGFR kinase inhibitor
	4941	PKI 166 hydrochloride
		Potent EGFR-kinase inhibitor
	2794	PP 3
		EGFR-kinase inhibitor. Also Src kinase negative control
	3599	TAK 165
		Potent and selective ErbB2 inhibitor
	0579	Tyrphostin B44, (+) enantiomer
		EGFR-kinase inhibitor
	3115	WHI-P 154
		Potent EGFR inhibitor. Also inhibits JAK3

	Other
	Cat. No.	Product Name / Activity
	6556	Anti-human EGFR aptamer, Janelia Fluor® 646 conjugate
		High affinity anti-human EGFR aptamer conjugated to Janelia Fluor® 646
	6557	Anti-human ErbB2 aptamer, Janelia Fluor® 646 conjugate
		Anti-human ErbB2 aptamer, Janelia Fluor® 646 conjugate

	Inhibitors
	Cat. No.	Product Name / Activity
	5013	AC 710
		Potent and selective PDGFR family inhibitor
	0493	AG 18
		EGFR/PDGFR-kinase inhibitor
	4274	AP 24534
		Potent multi-kinase and pan-Bcr-Abl inhibitor
	5993	CP 673451
		Potent and selective PDGFR inhibitor
	1222	DMPQ dihydrochloride
		Potent, selective inhibitor of PDGFRβ
	6056	GSK 1363089
		Potent PDGFR inhibtor; also inhibits of MET, VEGFR2, Ron and AXL
	5906	Imatinib mesylate
		PDGFR inhibitor; also inhibits v-Abl tyrosine kinase and c-kit
	5260	KG 5
		PDGFRβ, B-Raf, c-Raf, FLT3 and KIT inhibitor; antiangiogenic
	3785	PD 166285 dihydrochloride
		PDGFRβ, FGFR and Src inhibitor; also inhibits Wee1
	6814	Sorafenib
		PDGFR-β inhibitor; also inhibits Raf-1, VEGFR-2, VEGFR-3, Flt-3 and cKIT
	3304	SU 16f
		Potent and selective PDGFRβ inhibitor
	3335	SU 6668
		PDGFR, VEGFR and FGFR inhibitor
	3768	Sunitinib malate
		Potent VEGFR, PDGFRβ and KIT inhibitor
	3909	Toceranib
		Potent PDGFR and VEGFR inhibitor

	Inhibitors
	Cat. No.	Product Name / Activity
	4274	AP 24534
		Potent multi-kinase and pan-Bcr-Abl inhibitor
	4002	FIIN 1 hydrochloride
		Potent, irreversible FGFR inhibitor
	3724	PD 161570
		Selective FGFR inhibitor
	3785	PD 166285 dihydrochloride
		FGFR, PDGFRβ and Src inhibitor; also inhibits Wee1
	3044	PD 173074
		FGFR1 and -3 inhibitor
	3300	SU 5402
		Potent FGFR and VEGFR inhibitor
	3335	SU 6668
		FGFR, VEGFR and PDGFR inhibitor

	Other
	Cat. No.	Product Name / Activity
	4826	SUN 11602
		Basic fibroblast growth factor (bFGF) mimetic; neuroprotective

	Inhibitors
	Cat. No.	Product Name / Activity
	5318	AEE 788
		Potent VEGFR and EGFR inhibitor
	2617	AG 879
		VEGFR-2 inhibitor
	4274	AP 24534
		Potent multi-kinase and pan-Bcr-Abl inhibitor
	4350	Axitinib
		Potent VEGFR-1, -2 and -3 inhibitor
	6069	BMS 605541
		Potent VEGFR-2 inhibitor
	4471	DMH4
		Selective VEGFR-2 inhibitor
	3882	(E)-FeCP-oxindole
		Selective VEGFR-2 inhibitor
	3883	(Z)-FeCP-oxindole
		Selective VEGFR-2 inhibitor
	6056	GSK 1363089
		Potent inhibitor of MET, VEGFR2, Ron and AXL
	2542	Ki 8751
		Potent, selective VEGFR-2 inhibitor
	6015	RAF 265
		VEGFR-2 and Raf kinase inhibitor
	6814	Sorafenib
		VEGFR-2 and VEGFR-3 inhibitor; also inhibits Raf-1, PDGFR-β, Flt-3 and cKIT
	1459	SU 4312
		Potent inhibitor of VEGFR tyrosine kinase
	3300	SU 5402
		Potent VEGFR and FGFR inhibitor
	3037	SU 5416
		VEGFR inhibitor. Also inhibits KIT, RET, MET and FLT3
	3335	SU 6668
		VEGFR, PDGFR and FGFR inhibitor
	3768	Sunitinib malate
		Potent VEGFR, PDGFRβ and KIT inhibitor
	3909	Toceranib
		Potent PDGFR and VEGFR inhibitor
	5680	Vatalanib succinate
		Potent VEGFR inhibitor; also aromatase inhibitor
	5422	XL 184
		Potent VEGFR inhibitor; also inhibits other RTKs
	2499	ZM 306416 hydrochloride
		Inhibitor of VEGF receptor tyrosine kinase
	2475	ZM 323881 hydrochloride
		Potent, selective inhibitor of VEGFR-2

	Other
	Cat. No.	Product Name / Activity
	6986	EG 00229 trifluoroacetate
		Neuropilin 1 (NRP1) receptor antagonist; inhibits VEGFA binding to NRP1

	Inhibitors
	Cat. No.	Product Name / Activity
	6626	AP C5
		Potent and selective PKG2 inhibitor
	3028	Rp-8-Br-PET-cGMPS
		Protein kinase G inhibitor
	1883	cGMP Dependent Kinase Inhibitor Peptide
		Inhibitor of protein kinases G and A
	1289	KT 5823
		Selective protein kinase G inhibitor
	5524	Rp-8-pCPT-cGMPS sodium
		PKG inhibitor

	Activators
	Cat. No.	Product Name / Activity
	1089	8-Bromo-cGMP, sodium salt
		cGMP analog; activates protein kinase G

	Inhibitors
	Cat. No.	Product Name / Activity
	5953	Adaptaquin
		HIF-prolyl hydroxylase-2 (PHD2) inhibitor; antioxidant
	5582	TAT-cyclo-CLLFVY
		Selective HIF-1 dimerization inhibitor
	4408	DMOG
		Inhibitor of hypoxia-inducible factor α (HIF-α) prolyl hydroxylase (HIF-PH)
	5520	Echinomycin
		Highly potent and selective HIF-1α inhibitor
	6653	FM19G11
		HIF α-subunit inhibitor
	5655	GN 44028
		Potent HIF-1α inhibitor
	4451	IOX 2
		Potent, selective HIF-1α prolyl hydroxylase-2 (PHD2) inhibitor
	4324	KC7F2
		HIF-1α inhibitor; down-regulates HIF-1α protein synthesis
	2954	PX 12
		Thioredoxin-1 inhibitor; attenuates expression of HIF-1α
	5243	TC-S 7009
		High affinity and selective HIF-2α inhibitor
	6156	VH 298
		High-affinity inhibitor of VHL; blocks interaction of VHL and HIF-α

	Activators
	Cat. No.	Product Name / Activity
	4565	ML 228
		HIF pathway activator

	Other
	Cat. No.	Product Name / Activity
	4705	Chetomin
		Blocks interaction of HIF-1α, HIF-2α and STAT2 with CBP/p300
	6157	cis VH 298
		Negative control for VH 298
	5764	Deferoxamine mesylate
		Hypoxia mimetic; also iron chelator