AMPA and Kainate Receptors Small molecules

AMPA and Kainate Receptors 연구에 필요한 Small molecules을 소개합니다.

TOCRIS

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	Agonist
	Cat. No.	Product Name / Activity
	1074	(RS)-AMPA hydrobromide
		Selective AMPA agonist; more water soluble form of (RS)-AMPA (Cat. No. 0169)
	0253	(R)-AMPA
		Inactive isomer of (RS)-AMPA (Cat. No. 0169)
	0169	(RS)-AMPA
		Selective AMPA agonist
	0254	(S)-AMPA
		Selective AMPA agonist; active isomer of (RS)-AMPA (Cat. No. 0169)
	1673	Cl-HIBO
		GluA1 and GluA2 selective AMPA agonist
	1543	(S)-CPW 399
		Subtype-selective weakly desensitizing AMPA agonist
	3840	NPEC-caged-(S)-AMPA
		Caged (S)-AMPA
	0188	L-Quisqualic acid
		AMPA agonist; also group I mGlu agonist

	Antagonist
	Cat. No.	Product Name / Activity
	1082	CFM-2
		Non-competitive AMPA antagonist
	0190	CNQX
		Potent and selective non-NMDA iGluR antagonist
	1045	CNQX disodium salt
		Potent non-NMDA iGluR antagonist; more water soluble form of CNQX (Cat. No. 0190)
	2932	CP 465022 hydrochloride
		Selective and non-competitive AMPA antagonist
	0189	DNQX
		Selective non-NMDA iGluR antagonist
	2312	DNQX disodium salt
		Selective non-NMDA iGluR antagonist; water-soluble salt of DNQX (Cat. No. 0189)
	0845	Evans Blue tetrasodium salt
		Non-NMDA iGluR antagonist; P2X antagonist; also inhibits L-glutamate uptake into synaptic vesicles
	3099	GYKI 47261 dihydrochloride
		Non-competitive AMPA antagonist
	1454	GYKI 52466 dihydrochloride
		Selective non-competitive AMPA antagonist
	2555	GYKI 53655 hydrochloride
		Non-competitive non-NMDA iGluR antagonist
	4198	IEM 1925 dihydrobromide
		Voltage- and use-dependent open-channel AMPA blocker
	2766	Naspm trihydrochloride
		Ca2+-permeable AMPA antagonist
	0373	NBQX
		Potent AMPA antagonist; more selective than CNQX (Cat. No. 0190)
	1044	NBQX disodium salt
		Potent AMPA antagonist; more water soluble form of NBQX (Cat. No. 0373)
	2770	Philanthotoxin 74
		GluA1 and GluA3 selective AMPA antagonist
	0961	SYM 2206
		Non-competitive AMPA antagonist
	5032	Talampanel
		Non-competitive non-NMDA iGluR antagonist
	1765	UBP 282
		Non-NMDA iGluR antagonist; distinguishes between motoneuron and dorsal root kainate receptors
	2701	YM 90K hydrochloride
		Selective AMPA antagonist
	2345	ZK 200775
		Competitive non-NMDA iGluR antagonist

	Modulator
	Cat. No.	Product Name / Activity
	4373	CMPDA
		Positive allosteric modulator of GluA2 receptors
	2980	CX 546
		AMPA potentiator
	5149	CX 614
		Positive allosteric modulator of AMPA receptors
	0713	Cyclothiazide
		Positive allosteric modulator of AMPA receptors; inhibits AMPA desensitization
	6278	JNJ 55511118
		High affinity and selective negative modulator of AMPA receptors containing TARP-γ8
	5297	LY 404187
		Selective positive allosteric modulator of AMPA receptors
	4900	PF 4778574
		Positive allosteric modulator of AMPA receptors
	3911	S 18986
		Positive allosteric modulator of AMPA receptors
	6353	UoS 12258
		Positive allosteric modulator of AMPA receptors

	Inhibitors
	Cat. No.	Product Name / Activity
	867	Aniracetam
		Inhibits desensitization; AMPA > kainate
	1219	IDRA 21
		Inhibits AMPA desensitization
	1600	pep2-AVKI
		Peptide inhibitor of GluA2 subunit binding to PICK1
	1599	pep2-EVKI
		Peptide inhibitor of GluA2 subunit binding to PICK1
	1597	pep2-SVKI
		Peptide inhibitor of GluA2 subunit binding to GRIP, ABP and PICK1; increases AMPA current amplitude
	3801	Pep2m, myristoylated
		Peptide inhibitor of GluA2 subunit binding to NSF; myristoylated form of pep2m (Cat. No. 1595).

	Blockers
	Cat. No.	Product Name / Activity
	1636	IEM 1460
		Open-channel blocker of AMPA currents; selective for non-GluA2-containing receptors
	4199	IEM 1754 dihydrobromide
		Voltage-dependent, open-channel AMPA blocker

	Others
	Cat. No.	Product Name / Activity
	1048	1-BCP
		Modulates AMPA-mediated responses
	0964	Diazoxide
		Inhibits AMPA desensitization
	6094	2R,6R-Hydroxynorketamine hydrochloride
		Ketamine metabolite; enhances AMPA currents; lacks ketamine-related side effects
	6095	2S,6S-Hydroxynorketamine hydrochloride
		Ketamine metabolite; decreases D-serine (a NMDA co-agonist); antidepressant
	5982	cis-6-Hydroxynorketamine hydrochloride
		Metabolite of ketamine (Cat.No. 3131); enhances AMPA currents
	1602	Pep1-AGL
		GluA1 subunit C-terminus peptide analog; also analog of Pep1-TGL (Cat. No. 1601)
	1601	Pep1-TGL
		GluA1 subunit C-terminus peptide analog
	1598	pep2-SVKE
		Inactive control peptide for pep2-SVKI (Cat. No. 1597)
	1596	pep4c
		Inactive control peptide for pep2m (Cat. No. 1595)
	2973	Piracetam
		Modulates Na+-flux at AMPA receptors; nootropic

	Agonist
	Cat. No.	Product Name / Activity
	1107	ATPA
		Potent and selective GluK1 kainate agonist
	0269	Domoic acid
		Potent and selective kainate agonist
	0307	(S)-(-)-5-Iodowillardiine
		Highly potent and subtype-selective kainate agonist
	0222	Kainic acid
		Kainate agonist; excitant and neurotoxin
	2225	MNI caged kainic acid
		Caged kainic acid
	0903	SYM 2081
		Highly selective kainate agonist

	Antagonist
	Cat. No.	Product Name / Activity
	2728	ACET
		Potent kainate antagonist; displays selectivity for GluK1-containing receptors
	0190	CNQX
		Potent and selective non-NMDA iGluR antagonist
	1045	CNQX disodium salt
		Potent non-NMDA iGluR antagonist; more water soluble form of Cat. No. 0190
	0189	DNQX
		Selective non-NMDA iGluR antagonist
	2312	DNQX disodium salt
		Selective non-NMDA iGluR antagonist; water-soluble salt of DNQX (Cat. No. 0189)
	0845	Evans Blue tetrasodium salt
		Non-NMDA iGluR antagonist; P2X antagonist; also inhibits L-glutamate uptake into synaptic vesicles
	2555	GYKI 53655 hydrochloride
		Non-competitive non-NMDA iGluR antagonist
	2187	NS 3763
		GluK1 selective and non-competitive kainate antagonist
	5032	Talampanel
		Non-competitive non-NMDA iGluR antagonist
	3620	Topiramate
		GluK1 antagonist; inhibits carbonic anhydrase (CA) II and IV; also positive allosteric modulator of GABAA receptors
	1765	UBP 282
		Non-NMDA iGluR antagonist; distinguishes between motoneuron and dorsal root kainate receptors
	2078	UBP 296
		Potent and selective kainate antagonist; selective for GluK1-containing receptors
	1766	UBP 301
		Kainate antagonist
	2079	UBP 302
		Potent and selective kainate antagonist; active enantiomer of UBP 296 (Cat. No. 2078)
	3621	UBP 310
		GluK1-selective kainate antagonist
	2345	ZK 200775
		Competitive non-NMDA iGluR antagonist

	Ligand Sets
	Cat. No.	Product Name / Activity
	1824	Kainate Receptor Tocriset™
		Selection of 5 kainate receptor ligands (Cat. Nos. 0222, 1107, 0903, 1045 and 1454)

	Others
	Cat. No.	Product Name / Activity
	1777	Arctigenin
		Binds to kainate receptors; neuroprotective. Also inhibits IκBα phosphorylation and MEK1
	2207	PDZ1 Domain inhibitor peptide
		Disrupts interaction between GluK2 and PSD-95 PDZ1 domain

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