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 ǰȳ  Ű   Pharmacology

Adrenergics Receptors Small molecules

Adrenergics Receptors ʿ Small molecules Ұմϴ.

TOCRIS
ǰ ϱ
μϱ





Agonists
Cat. No. Product Name / Activity
1052 A 61603 hydrobromide
α1A agonist
0888 Cirazoline hydrochloride
Selective α1 agonist
1142 Oxymetazoline hydrochloride
α1A agonist
2838 (R)-(-)-Phenylephrine hydrochloride
α1 agonist
Antagonists
Cat. No. Product Name / Activity
5940 AdTx1
Selective, high affinity, non-competitive α1A adrenoceptor antagonist
3305 Alfuzosin hydrochloride
Uroselective α1 antagonist
1006 BMY 7378 dihydrochloride
Selective α1D antagonist
2685 Carvedilol
Potent α1 antagonist; also potent and non-selective β antagonist
2964 Doxazosin mesylate
α1 antagonist
0535 HEAT hydrochloride
Highly selective α1 antagonist
0545 Ifenprodil hemitartrate
α1 antagonist. Also NMDA antagonist and σ ligand
0661 2-MPMDQ
Potent, selective α1 antagonist. Also σ2 ligand
0597 Naftopidil hydrochloride
α1 antagonist
1124 (R)-(-)-Niguldipine hydrochloride
α1 antagonist, L-type Ca2+ channel blocker. Less active enantiomer of Niguldipine hydrochloride (Cat. No. 1123)
1123 (S)-(+)-Niguldipine hydrochloride
α1 antagonist, L-type Ca2+ channel blocker
0627 2-PMDQ
Potent, selective α1 antagonist
0623 Prazosin hydrochloride
α1 and α2B antagonist; also MT3 antagonist
3284 Rec 15/2615 dihydrochloride
Selective α1B antagonist
1325 RS 100329 hydrochloride
Potent, subtype-selective α1A antagonist
0985 RS 17053 hydrochloride
α1A antagonist
6663 Silodosin
Selective α1A antagonist
2398 SNAP 5089
Subtype-selective α1A antagonist
3050 Tamsulosin hydrochloride
Selective α1A antagonist
1506 Terazosin hydrochloride
α1 and α2B antagonist (α1 > α2B). Orally active
6336 Trazodone hydrochloride
5-HT2A and α1 adrenoceptor antagonist; also enhances neural differentiation; antidepressant and neuroprotectant
1772 Urapidil hydrochloride
α1 antagonist; also 5-HT1A receptor agonist
0946 WB 4101 hydrochloride
α1A antagonist
Ligand Sets
Cat. No. Product Name / Activity
1871 α1-Adrenoceptor Tocriset™
Selection of 5 α1-adrenoceptor ligands (Cat. Nos. 1052, 0888, 1006, 0946 and 0623)
1875 Mixed Adrenergic Tocriset™
Selection of 5 mixed adrenoceptor ligands (Cat. Nos. 0888, 0425, 1747, 0623 and 0952)
Ligand
Cat. No. Product Name / Activity
0998 AH 11110 hydrochloride
Subtype-selective α1B ligand


Agonists
Cat. No. Product Name / Activity
2759 B-HT 920
α2-adrenoceptor agonist; also 5-HT3 antagonist and D2 agonist
2758 B-HT 933 dihydrochloride
Selective α2 agonist
0690 Clonidine hydrochloride
α2 agonist. Also I1 ligand
2749 Dexmedetomidine hydrochloride
Potent, highly selective α2 agonist. Active isomer of medetomidine (Cat. No. 5160)
0885 Guanabenz acetate
α2 agonist. Also I2 selective ligand
1030 Guanfacine hydrochloride
α2A agonist
5160 Medetomidine hydrochloride
Potent and highly selective α2 agonist
2282 Moxonidine hydrochloride
α2 agonist. Also I1 agonist
2242 Octopamine hydrochloride
Invertebrate biogenic amine: activates α2A and β3 adrenoceptors
1142 Oxymetazoline hydrochloride
α2A partial agonist
0790 Rilmenidine hemifumarate
α2 agonist. Also I1 ligand
3935 RWJ 52353
α2D agonist
2638 ST 91
α2 agonist, putative α2C agonist
5021 TC-G 1000
Potent and selective α2D agonist
3609 Tizanidine hydrochloride
α2 agonist
0425 UK 14,304
α2 agonist
2466 UK 14,304 tartrate
α2 agonist. Water-soluble form of UK 14,304 (Cat. No. 0425)
Antagonists
Cat. No. Product Name / Activity
2341 A 80426 mesylate
High affinity α2 antagonist. Also 5-HT uptake inhibitor
0928 ARC 239 dihydrochloride
α2B antagonist
2937 Atipamezole hydrochloride
Selective α2 antagonist
1133 BRL 44408 maleate
Selective α2A antagonist
0792 Efaroxan hydrochloride
α2 antagonist and I1, I3 ligand
0793 Idazoxan hydrochloride
α2 antagonist. Also I2 ligand
0986 Imiloxan hydrochloride
Highly selective α2B antagonist
2666 JP 1302 dihydrochloride
Potent and selective α2C antagonist
2018 Mirtazapine
α2 antagonist; also potent 5-HT2, 5-HT3 and H1 antagonist; antidepressant
0623 Prazosin hydrochloride
α2B and α1 antagonist; also MT3 antagonist
0891 Rauwolscine hydrochloride
α2 antagonist
0987 RS 79948 hydrochloride
Potent and selective α2 antagonist
1324 RX 821002 hydrochloride
Potent, selective α2D antagonist
4508 S 32212 hydrochloride
α2-adrenoceptor antagonist; 5-HT2C inverse agonist
3866 SKF 86466 hydrochloride
Potent and selective α2 antagonist
0631 Spiroxatrine
Potent α2C antagonist
1127 Yohimbine hydrochloride
Selective α2 antagonist
Ligand Sets
Cat. No. Product Name / Activity
1872 α2-Adrenoceptor Tocriset™
Selection of 5 α2-adrenoceptor ligands (Cat. Nos. 1030042509281133 and 0891)
1875 Mixed Adrenergic Tocriset™
Selection of 5 mixed adrenoceptor ligands (Cat. Nos. 0888042517470623 and 0952)
Ligand
Cat. No. Product Name / Activity
0842 Agmatine sulfate
α2 ligand. Also imidazoline ligand


Agonists
Cat. No. Product Name / Activity
0950 Xamoterol hemifumarate
Selective β1 partial agonist
Antagonists
Cat. No. Product Name / Activity
0387 (RS)-Atenolol
β1 antagonist
0906 Betaxolol hydrochloride
Selective β1 antagonist
0914 (±)-Bisoprolol hemifumarate
β1 antagonist
1024 CGP 20712 dihydrochloride
Highly potent and selective β1 antagonist
3256 Metoprolol tartrate
Selective β1 antagonist
3517 Nebivolol hydrochloride
Highly selective β1-adrenoceptor antagonist
0649 (S)-Timolol maleate
β1 antagonist
Ligand Sets
Cat. No. Product Name / Activity
1874 β-Adrenoceptor Antagonist Tocriset™
Selection of 3 β-adrenoceptor antagonists (Cat. Nos. 10240821 and 1511)


Agonists
Cat. No. Product Name / Activity
6219 Arformoterol tartrate
Long-acting β2 agonist (LABA)
1448 Formoterol hemifumarate
Potent and selective β2 agonist
1102 Procaterol hydrochloride
Potent β2 agonist
0634 Salbutamol hemisulfate
β agonist (β2 > β1)
4712 Salmeterol xinafoate
Long-acting β2 agonist; bronchodilator
1051 Zinterol hydrochloride
Selective β2 agonist
Invers Antagonists
Cat. No. Product Name / Activity
0821 ICI 118,551 hydrochloride
Highly selective β2 inverse agonist
Ligand Sets
Cat. No. Product Name / Activity
1873 β-Adrenoceptor Agonist Tocriset™
Selection of 3 β-adrenoceptor agonists (Cat. Nos. 09481747 and 1660)
1874 β-Adrenoceptor Antagonist Tocriset™
Selection of 3 β-adrenoceptor antagonists (Cat. Nos. 10240821 and 1511)


Agonists
Cat. No. Product Name / Activity
0948 BRL 37344, sodium salt
β3 agonist
1134 CGP 12177 hydrochloride
β3 partial agonist. β1/β2 antagonist
1499 CL 316243 disodium salt
Highly selective β3 agonist
2197 L-755,507
Very potent and selective β3 partial agonist
2242 Octopamine hydrochloride
Invertebrate biogenic amine: activates β3 adrenoceptors
1060 (S)-(-)-Pindolol
β3 partial agonist; also 5-HT1A and 5-HT1B antagonist; more active enantiomer of pindolol (Cat. No. 0994)
3986 SR 58611A hydrochloride
β3 agonist; displays anxiolytic and antidepressant effects
2154 ZD 2079
β3-adrenoceptor agonist
0930 ZD 7114 hydrochloride
β3 agonist
Antagonists
Cat. No. Product Name / Activity
2760 L-748,337
Selective β3 antagonist
1511 SR 59230A hydrochloride
Potent and selective β3 antagonist
Ligand Sets
Cat. No. Product Name / Activity
1873 β-Adrenoceptor Agonist Tocriset™
Selection of 3 β-adrenoceptor agonists (Cat. Nos. 09481747 and 1660)
1874 β-Adrenoceptor Antagonist Tocriset™
Selection of 3 β-adrenoceptor antagonists (Cat. Nos. 10240821 and 1511)


Inhibitors
Cat. No. Product Name / Activity
4456 Amitriptyline hydrochloride
5-HT and noradrenalin re-uptake inhibitor; also TrkA/B agonist
4357 Bicifadine hydrochloride
Noradrenalin, 5-HT and dopamine re-uptake inhibitor
2322 BTS 54-505 hydrochloride
Potent 5-HT and NA reuptake inhibitor (SNRI); active metabolite of sibutramine (Cat. No. 2290)
2831 Bupropion hydrochloride
Non-selective inhibitor of dopamine and noradrenalin transporters
2833 Cocaine hydrochloride
Inhibitor of monoamine transporters
3067 Desipramine hydrochloride
Selective inhibitor of noradrenalin transporters
4798 (S)-Duloxetine hydrochloride
Potent 5-HT and NA reuptake inhibitor; also blocks dopamine reuptake
1588 Indatraline hydrochloride
Potent noradrenalin uptake inhibitor; also inhibits 5-HT and dopamine uptake
2545 Lofepramine
5-HT and NA reuptake inhibitor (SNRI)
0935 Maprotiline hydrochloride
Noradrenalin re-uptake inhibitor
2148 (±)-McN 5652
Potent, orally active 5-HT uptake inhibitor. Also inhibits noradrenalin and dopamine uptake in vitro
1812 Threo-methylphenidate hydrochloride
Inhibitor of dopamine and noradrenalin transporters. Psychomotor stimulant
3286 Milnacipran hydrochloride
5-HT and NA reuptake inhibitor (SNRI)
1025 Nisoxetine hydrochloride
Noradrenalin re-uptake inhibitor
1992 Nomifensine
Potent noradrenalin and dopamine uptake inhibitor. Antidepressant
1982 Reboxetine mesylate
Potent and selective noradrenalin uptake inhibitor; orally active
2290 Sibutramine hydrochloride
5-HT and NA reuptake inhibitor (SNRI)
3145 Talopram hydrochloride
Potent, selective inhibitor of noradrenalin transporters
4352 Talsupram hydrochloride
Selective inhibitor of noradrenalin transporters
2175 Tetrabenazine
Potent inhibitor of vesicular monoamine transport; depletes noradrenalin stores
2011 Tomoxetine hydrochloride
Potent and selective noradrenalin re-uptake inhibitor
2917 Venlafaxine hydrochloride
5-HT and NA reuptake inhibitor (SNRI)
4194 WY 45233 succinate
5-HT and NA reuptake inhibitor (SNRI)
Substrates
Cat. No. Product Name / Activity
5169 Noradrenaline bitartrate
Endogenous adrenergic hormone and neurotransmitter
Others
Cat. No. Product Name / Activity
6717 FFN 270
Fluorescent substrate for NET and VMAT2


Agonists
Cat. No. Product Name / Activity
0474 Dihydroergocristine mesylate
α partial agonist
0475 Dihydroergotamine mesylate
α partial agonist; also D2-like partial agonist and 5-HT antagonist
5169 Noradrenaline bitartrate
Endogenous adrenergic hormone and neurotransmitter
Antagonists
Cat. No. Product Name / Activity
3737 Asenapine maleate
Non-selective 5-HT, dopamine, adrenalin and histamine receptor antagonist; antipsychotic agent
0604 Nicergoline
α antagonist
6431 Phentolamine Mesylate
Adrenergic α receptor antagonist; antihypertensive



Agonists
Cat. No. Product Name / Activity
0435 Cimaterol
β agonist
0515 Dobutamine hydrochloride
α1, β1 and β2 agonist
1747 Isoproterenol hydrochloride
Standard selective β agonist
5169 Noradrenaline bitartrate
Endogenous adrenergic hormone and neurotransmitter
Antagonists
Cat. No. Product Name / Activity
2806 Alprenolol hydrochloride
β antagonist; also 5-HT1A antagonist
2685 Carvedilol
Potent and non-selective β antagonist; also potent α1 antagonist
0993 Cyanopindolol hemifumarate
β-adrenoceptor antagonist; also 5-HT1A and 5-HT1B antagonist
0832 ICI 89406
β antagonist
0829 Pronethalol hydrochloride
β antagonist
0624 Propranolol hydrochloride
β antagonist
0851 Propranolol glycol
Propranolol (Cat. No. 0624) metabolite
0835 (R)-(+)-Propranolol hydrochloride
β antagonist. Less active enantiomer of propranolol (Cat. No. 0624)
0834 (S)-(-)-Propranolol hydrochloride
β antagonist. More active enantiomer of propranolol (Cat. No. 0624)
1516 SDZ 21009
β-adrenoceptor antagonist; also 5-HT1A and 5-HT1B antagonist
0952 Sotalol hydrochloride
β antagonist
Ligand Sets
Cat. No. Product Name / Activity
1873 β-Adrenoceptor Agonist Tocriset™
Selection of 3 β-adrenoceptor agonists (Cat. Nos. 09481747 and 1660)
1874 β-Adrenoceptor Antagonist Tocriset™
Selection of 3 β-adrenoceptor antagonists (Cat. Nos. 10240821 and 1511)
1875 Mixed Adrenergic Tocriset™
Selection of 5 mixed adrenoceptor ligands (Cat. Nos. 0888042517470623 and 0952)